Adult desmoid tumors: biology, management and ongoing trials.


PURPOSE OF REVIEW:To summarize the current knowledge about the biology and clinical management of adult desmoid tumors. RECENT FINDINGS:In the past decade, we have learned that desmoid tumors are driven by alterations of the Wnt/APC/β-catenin pathway, sporadic desmoid tumors are associated with somatic mutations of CTNNB1, and germline mutations of APC and somatic mutations of CTNNB1 are probably mutually exclusive. One-third of desmoid tumors are misdiagnosed; a second pathological opinion is therefore of major importance for desmoid tumor. Surgery is no longer regarded as the cornerstone of desmoid tumors; several retrospective studies have demonstrated the safety of a 'wait and see' policy in sporadic abdominal wall desmoid tumor. Desmoid tumors is no longer regarded as an absolute contraindication for pregnancy. At least two new investigational drugs targeting the Wnt/APC/β-catenin pathway are currently being developed. SUMMARY:The management of desmoid tumors requires multidisciplinary expertise by an experienced team. We must fully understand the physiopathology of the disease (factors influencing the natural history of the disease) and learn how to avoid desmoid tumors occurrence in patients with APC germline mutations, identify reliable prognostic/predictive factors and better assess the efficacy of systemic treatment.


Curr Opin Oncol


Penel N,Chibon F,Salas S




Has Abstract


2017-07-01 00:00:00












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    abstract:PURPOSE OF REVIEW:Human immunodeficiency virus infection is associated with an increased risk of non-Hodgkin lymphoma. Even with a decrease in AIDS-defining illnesses after the advent of highly active antiretroviral therapy, HIV-associated non-Hodgkin lymphoma remains an important problem. RECENT FINDINGS:Low CD4+ T-l...

    journal_title:Current opinion in oncology

    pub_type: 杂志文章,评审


    authors: Behler CM,Kaplan LD

    更新日期:2006-09-01 00:00:00

  • Surgical chores and approach in the management of endometrial cancer.

    abstract::Carcinoma of the uterine corpus is the most common malignancy in the female pelvis. Surgical resection and staging are now the accepted approach to therapy, with excellent survival compared with other gynecologic malignancies. Several controversies exist, however, regarding optimal surgical management. Some of these c...

    journal_title:Current opinion in oncology

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    authors: McAlpine JN,Spirtos NM,Chen MD

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  • Adjuvant therapy of operable nonsmall cell lung cancer: an update.

    abstract:PURPOSE OF REVIEW:The current status of postoperative adjuvant therapy for nonsmall cell lung cancer (NSCLC) is reviewed. RECENT FINDINGS:Cisplatin-based postoperative chemotherapy is a current standard of care for patients with stage II-III NSCLC who underwent complete resection. However, its benefit is limited. In t...

    journal_title:Current opinion in oncology

    pub_type: 杂志文章


    authors: Mitsudomi T,Soh J

    更新日期:2021-01-01 00:00:00

  • Narrative ethics in the field of oncology.

    abstract:PURPOSE OF REVIEW:To evaluate the application of narrative within medical practice. Illness like cancer constitutes a biographical disruption that occurs several times during the disease, from diagnosis to complications and treatments. This review analyzes the interest of narrative ethics in medicine with a focus on ca...

    journal_title:Current opinion in oncology

    pub_type: 杂志文章,评审


    authors: Lossignol D

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  • New developments in bone marrow transplantation.

    abstract::A better understanding of the immunobiology after transplantation and of the available recombinant cytokines that enhance hematopoietic reconstitution following autologous and allogeneic bone marrow transplantation is likely to result in safer application of bone marrow transplantation. Residual tumor cells escaping c...

    journal_title:Current opinion in oncology

    pub_type: 杂志文章,评审


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    journal_title:Current opinion in oncology

    pub_type: 杂志文章,评审


    authors: Oberg K

    更新日期:2012-07-01 00:00:00

  • Human papillomavirus-associated anogenital neoplasia and other solid tumors in human immunodeficiency virus-infected individuals.

    abstract::The incidence and variety of solid tumors reported among human immunodeficiency virus (HIV)-infected individuals are increasing. Among the most common of these tumors are anogenital malignant and premalignant tumors associated with human papillomavirus infection. Cervical intraepithelial neoplasia is one such human pa...

    journal_title:Current opinion in oncology

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  • Recent advances in telomere biology: implications for human cancer.

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    journal_title:Current opinion in oncology

    pub_type: 杂志文章,评审


    authors: Meeker AK,De Marzo AM

    更新日期:2004-01-01 00:00:00

  • Immune escape mechanisms in head and neck squamous cell carcinoma and implication for new immunotherapy approach.

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    journal_title:Current opinion in oncology

    pub_type: 杂志文章,评审


    authors: Merlano MC,Denaro N,Garrone O

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  • Vandetanib and the management of advanced medullary thyroid cancer.

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    pub_type: 杂志文章,评审


    authors: Campbell MJ,Seib CD,Gosnell J

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  • The type II transforming growth factor-beta receptor as a tumor-suppressor gene.

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    journal_title:Current opinion in oncology

    pub_type: 杂志文章,评审


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  • Adoptive immunotherapy.

    abstract::Some of the most dramatic advances in the treatment of cancer have used the immune system in combination with conventional or transplantation chemotherapy. Adoptive immunotherapy has been used for relapses after allogeneic bone marrow transplantation, and it has been particularly effective for chronic myeloid leukemia...

    journal_title:Current opinion in oncology

    pub_type: 杂志文章,评审


    authors: Ballen K,Stewart FM

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  • p53, stem cell biology and childhood blastomas.

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    journal_title:Current opinion in oncology

    pub_type: 杂志文章,评审


    authors: Oh L,Hafsi H,Hainaut P,Ariffin H

    更新日期:2019-03-01 00:00:00

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    journal_title:Current opinion in oncology

    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


    authors: Cutler C,Antin JH

    更新日期:2006-03-01 00:00:00

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    abstract::The currently used staging system in melanoma has not been significantly modified since 1988. While this four-stage system effectively stratifies patients into prognostic groups, additional discriminating criteria have been reported that is not presently incorporated in the staging system. The following additions and ...

    journal_title:Current opinion in oncology

    pub_type: 杂志文章,评审


    authors: Ross M

    更新日期:1998-03-01 00:00:00

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    journal_title:Current opinion in oncology

    pub_type: 杂志文章,评审


    authors: Rini BI,Rathmell WK,Godley P

    更新日期:2008-05-01 00:00:00

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    abstract:PURPOSE OF REVIEW:Overexpression of the Bcl-2 oncoprotein is noted in various malignant disorders. In patients with hematologic malignancies, increased production of the Bcl-2 oncoprotein is associated with chemotherapy resistance, aggressive clinical course, and poor survival. Bcl-2 is an important molecular target. D...

    journal_title:Current opinion in oncology

    pub_type: 杂志文章,评审


    authors: Chanan-Khan A

    更新日期:2004-11-01 00:00:00

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    abstract::The pathogenesis of prostate cancer reflects complex interactions among environmental and genetic factors. Recent advances suggest molecular mechanisms that may explain geographic and ethnic variations in prostate cancer incidence, and understanding of molecular disease progression is advancing rapidly. Clinically, th...

    journal_title:Current opinion in oncology

    pub_type: 杂志文章,评审


    authors: Small EJ,Reese DM

    更新日期:2000-05-01 00:00:00

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    abstract:PURPOSE OF REVIEW:To review the state-of-the-art and new developments in the management of patients with brain metastases. RECENT FINDINGS:Treatment decisions are based on prognostic factors to maximize neurologic function and survival, while avoiding unnecessary therapies. Whole-brain radiotherapy (WBRT) is the treat...

    journal_title:Current opinion in oncology

    pub_type: 杂志文章,评审


    authors: Soffietti R,Rudà R,Trevisan E

    更新日期:2008-11-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Gill CM,Brastianos PK

    更新日期:2019-11-01 00:00:00

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    journal_title:Current opinion in oncology

    pub_type: 杂志文章,评审


    authors: Michallet AS,Coiffier B,Salles G

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    journal_title:Current opinion in oncology

    pub_type: 杂志文章,评审


    authors: Brewster A,Helzlsouer K

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    authors: Pace A,Metro G,Fabi A

    更新日期:2010-11-01 00:00:00

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    journal_title:Current opinion in oncology

    pub_type: 杂志文章,评审


    authors: Schreckenberger C,Kaufmann AM

    更新日期:2004-09-01 00:00:00

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    journal_title:Current opinion in oncology

    pub_type: 杂志文章,评审


    authors: Arcangeli S,Mestermann K,Weber J,Bonini C,Casucci M,Hudecek M

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    journal_title:Current opinion in oncology

    pub_type: 杂志文章,收录出版,评审


    authors: House MG,Schulick RD

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    journal_title:Current opinion in oncology

    pub_type: 杂志文章


    authors: DeVita VT Jr

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  • On mitochondrial metabolism in tumor biology.

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    journal_title:Current opinion in oncology

    pub_type: 杂志文章,评审


    authors: Shoshan M

    更新日期:2017-01-01 00:00:00

  • Treatment of adult acute leukemia.

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    journal_title:Current opinion in oncology

    pub_type: 杂志文章,评审


    authors: Büchner T

    更新日期:1997-01-01 00:00:00