Supportive care in neurooncology.

abstract：:Tamoxifen as adjuvant systemic treatment after first isolated locoregional recurrence of breast cancer has been shown to decrease the subsequent locoregional relapse rate, but it affects neither distant metastases nor survival. In metastatic disease, tamoxifen has not improved response when added to ablation of ovaria...

journal_title：Current opinion in oncology

authors： Rubens RD

更新日期：1995-11-01 00:00:00

abstract：:Enormous progress has been made in the last several years in delineating signal transduction pathways associated with cell proliferation and apoptosis. The components of these pathways, which include both oncogenes and tumor suppressors, may provide viable targets for therapeutic intervention for the treatment of canc...

journal_title：Current opinion in oncology

authors： Huang PS,Heimbrook DC

更新日期：1997-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review presents an overview of recent developments in research examining coping with the effects of cancer treatment on sexuality. RECENT FINDINGS:A search was conducted using PubMed and Web of Knowledge to find papers published or in press in 2010. Papers examining coping efforts, effects of ca...

journal_title：Current opinion in oncology

authors： Reese JB

更新日期：2011-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Primary central nervous system lymphoma (PCNSL) is a rare tumor, and its optimal management is a matter of controversy. Recent developments of collaborative groups devoted to PCNSL have allowed to conduct randomized trials addressing important issues. In addition, genome wide analysis provided new ins...

journal_title：Current opinion in oncology

authors： Hottinger AF,Alentorn A,Hoang-Xuan K

更新日期：2015-11-01 00:00:00

abstract：:The clinical staging of bone tumors, even rare ones, has been much improved with the availability of better imaging techniques. Once diagnosis of a rare bone tumor has been made, close consultation between clinician, radiologist, and pathologist is essential for optimal treatment. Recent advances in the staging proced...

journal_title：Current opinion in oncology

authors： Dirix LY,Van Oosterom AT

更新日期：1991-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe recent advances in the diagnosis and treatment of paraneoplastic neurological syndromes (PNS). RECENT FINDINGS:PNS are rare complications of cancer caused by an immune cross-reaction between antigens expressed by tumor cells and neurons. The target of the immune attack can be an intracell...

journal_title：Current opinion in oncology

authors： Berzero G,Psimaras D

更新日期：2018-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Neoplasms of the endocrine pancreas, commonly referenced as pancreatic islet cell tumors, are rare, often well differentiated endocrine neoplasms, whose biology remains poorly characterized. This article reviews the current clinical management of pancreatic islet cell tumors and describes the molecula...

journal_title：Current opinion in oncology

authors： House MG,Schulick RD

更新日期：2006-01-01 00:00:00

abstract：:With the widespread diffusion of stereotactic radiosurgical procedures, GKR treatments have gained considerable momentum as a major therapeutic option for patients harboring primary or metastatic brain tumors. Present results in high grade gliomas indicate a potential palliative role of this technique. The overall low...

journal_title：Current opinion in oncology

authors： Gerosa M,Nicolato A,Foroni R

更新日期：2003-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite remarkable advances in the treatment of non-Hodgkin's lymphoma of all histologic subtypes, nervous system involvement remains a dire complication associated with a rapid decline in quality of life, few good treatment options, and a short overall survival. In fact, these advances in treatment m...

journal_title：Current opinion in oncology

authors： Lim HY,Thiel E,Glantz MJ

更新日期：2008-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Currently, endometrial carcinoma diagnosis is based on morphology, often supplemented by immunohistochemistry. However, especially with high-grade endometrial carcinomas, there is considerable interobserver variability in diagnosis calling into question the value of morphology in stratifying these tum...

journal_title：Current opinion in oncology

authors： Carlson J,McCluggage WG

更新日期：2019-09-01 00:00:00

abstract：:The prophylactic or pre-emptive approach should help to restrict use of antibiotics and lead to better management of infection. It is clear that if effective pre-emptive therapy is available (be it as prophylaxis), the empiric additions of other agents should be taken into account and tailored accordingly. On the othe...

journal_title：Current opinion in oncology

authors： Klastersky J

更新日期：1996-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The rising incidence of oropharyngeal squamous cell carcinoma (OPSCC), in large part as a result of the human papillomavirus (HPV), has driven a movement for the change in the management strategies. Renewed interest in minimally invasive approaches of endoscopic head and neck surgery led to introducti...

journal_title：Current opinion in oncology

authors： Dias FL,Walder F,Leonhardt FD

更新日期：2017-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Childhood blastomas, unlike adult cancers, originate from developing organs in which molecular and cellular features exhibit differentiation arrest and embryonic characteristics. Conventional cancer therapies, which rely on the generalized cytotoxic effect on rapidly dividing cells, may damage delicat...

journal_title：Current opinion in oncology

authors： Oh L,Hafsi H,Hainaut P,Ariffin H

更新日期：2019-03-01 00:00:00

abstract：:The identification of new active agents for the treatment of squamous carcinoma of the head and neck remains a high priority for clinical investigators. For the past several years a number of investigational drugs have demonstrated activity in patients with recurrent or metastatic disease. Included are the following a...

journal_title：Current opinion in oncology

authors： Murphy BA

更新日期：1996-05-01 00:00:00

abstract：:Obstruction of the superior vena cava is seldom a true emergency and should not be treated without an adequate tissue diagnosis. For patients who are poor operative risks for invasive procedures, percutaneous biopsies of mediastinal masses under ultrasound guidance have resulted in a high diagnostic yield. Superior ve...

journal_title：Current opinion in oncology

authors： Shepherd FA

更新日期：1995-03-01 00:00:00

abstract：PURPOSE OF REVIEW:PremRNA alternative splicing is more a rule than an exception as it affects more than 90% of multiexons genes and plays a key role in proteome diversity. Here, we discuss some recent studies published in the extensively growing field linking RNA splicing and cancer. RECENT FINDINGS:These last years, ...

journal_title：Current opinion in oncology

authors： Abou Faycal C,Gazzeri S,Eymin B

更新日期：2016-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Increasing attention is being given to personalized medicine in oncology, where therapies are tailored to the particular characteristics of the individual cancer patient. In recent years, there has been greater focus on prostate-specific membrane antigen (PSMA) in prostate cancer (PCa) as a target for...

journal_title：Current opinion in oncology

authors： Bouchelouche K,Choyke PL

更新日期：2016-05-01 00:00:00

abstract：:Over the past decade, high-dose chemotherapy followed by autologous bone marrow support (ABMS) has been employed with increasing frequency to treat patients with a variety of solid tumors. This paper explores the rationale and relevant clinical data for the use of this approach to treat patients with breast and ovaria...

journal_title：Current opinion in oncology

authors： Shpall EJ,Jones RB,Bearman S

更新日期：1994-03-01 00:00:00

abstract：:Infection with HIV is associated with an increased risk of systemic and primary central nervous system non-Hodgkin's lymphoma. Patients with systemic non-Hodgkin's lymphoma usually present with high- or intermediate-grade histology and extranodal dissemination. Although the prognosis for such patients is poor, some pa...

journal_title：Current opinion in oncology

authors： Sparano JA

更新日期：1995-09-01 00:00:00

abstract：:The appearance of skin lesions in patients with occult or obvious malignancy may be of extreme value in the detection and management of cancer because the skin is readily accessible to examination and biopsy. Examination of the skin of our patients can provide important insights into underlying malignant processes or ...

journal_title：Current opinion in oncology

authors： Sabir S,James WD,Schuchter LM

更新日期：1999-03-01 00:00:00

abstract：:In testicular cancer epidemiology, the increasing recognition that germinal epithelial atrophy is the final common pathway in the development of this tumor has developed along with reports that elevated follicule-stimulating hormone levels at the time of diagnosis of first tumor correlate with risk of developing a sec...

journal_title：Current opinion in oncology

authors： Oliver RT

更新日期：1991-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent Food and Drug Administration (FDA) approval of five new immune checkpoint inhibitors for the treatment of metastatic urothelial cancer represents the first major treatment breakthrough for this disease since the introduction of combination chemotherapy over 30 years ago. This review examines th...

journal_title：Current opinion in oncology

authors： Tabayoyong W,Gao J

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Melanoma has proven resistant to most available chemotherapy and immunotherapy. Despite a range of different biochemical targets, most agents kill cancer cells by induction of apoptosis. RECENT FINDINGS:Investigation of this process has provided insights into the resistance mechanisms in cancer cells...

journal_title：Current opinion in oncology

authors： Hersey P

更新日期：2006-03-01 00:00:00

abstract：:The currently used staging system in melanoma has not been significantly modified since 1988. While this four-stage system effectively stratifies patients into prognostic groups, additional discriminating criteria have been reported that is not presently incorporated in the staging system. The following additions and ...

journal_title：Current opinion in oncology

authors： Ross M

更新日期：1998-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Knowledge of the pathophysiology of Kaposi sarcoma continues to expand and influence our therapeutic approaches. This review summarizes developments within the last 18 to 24 months. RECENT FINDINGS:Pieces of the puzzle as they relate to viral factors-both human herpes virus 8 (HHV-8) and human immuno...

journal_title：Current opinion in oncology

authors： Noy A

更新日期：2003-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Significant advances have been made in the treatment of younger patients with acute myeloid leukemia over the past 3 decades, but prognosis in the elderly has remained dismal, with median survival times of only a few months. Although a small percentage of older patients may be cured by standard chemot...

journal_title：Current opinion in oncology

authors： Amadori S,Del Principe MI,Venditti A

更新日期：2014-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The p53 tumor suppressor is a master regulator of antitumor defenses through its control of growth arrest, senescence and apoptosis. In recent years, p53 regulation was found to extend to a variety of biological processes including autophagy, fertility, metabolism and immune responses. Here, we focus ...

journal_title：Current opinion in oncology

authors： Menendez D,Shatz M,Resnick MA

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the state-of-the-art and new developments in the management of patients with brain metastases. RECENT FINDINGS:Treatment decisions are based on prognostic factors to maximize neurologic function and survival, while avoiding unnecessary therapies. Whole-brain radiotherapy (WBRT) is the treat...

journal_title：Current opinion in oncology

authors： Soffietti R,Rudà R,Trevisan E

更新日期：2008-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent developments and controversies in the diagnosis and management of nonmuscle invasive bladder cancer (NMIBC). RECENT FINDINGS:The majority of incident bladder cancer diagnoses are noninvasive. The mainstay of diagnosis remains cystoscopy and transurethral resection, with enhanced o...

journal_title：Current opinion in oncology

authors： Bassett JC,Eifler JB,Resnick MJ,Clark PE

更新日期：2014-05-01 00:00:00

abstract：:Recent publications dealing with the pathology of squamous carcinomas of the head and neck have been critically reviewed with particular reference to potential prognostic factors and improved methods for identifying nodal metastases. The topics covered include cytophotometry and proliferative patterns, molecular biolo...

journal_title：Current opinion in oncology

authors： Carter RL

更新日期：1993-05-01 00:00:00