Palliative care in glioma management.

abstract：:Bisphosphonates inhibit osteoclast-mediated bone resorption in metastatic bone disease. A wealth of preclinical data have begun to shed light on the complex mechanisms by which bisphosphonates inhibit bone resorption and interfere with the formation and growth of bone metastases. Nitrogen-containing bisphosphonates in...

journal_title：Current opinion in oncology

authors： Green JR

更新日期：2002-11-01 00:00:00

abstract：:A better understanding of the immunobiology after transplantation and of the available recombinant cytokines that enhance hematopoietic reconstitution following autologous and allogeneic bone marrow transplantation is likely to result in safer application of bone marrow transplantation. Residual tumor cells escaping c...

journal_title：Current opinion in oncology

authors： Slavin S,Nagler A

更新日期：1991-04-01 00:00:00

abstract：:The development of new chemotherapeutic agents for cancer treatment is pursued with the hope of finding compounds with novel chemical characteristics, unique mechanisms of action, and with improved therapeutic indexes. Seven novel agents at different stages of clinical development have been selected for review. D1694 ...

journal_title：Current opinion in oncology

authors： Erlichman C

更新日期：1991-12-01 00:00:00

abstract：:The preclinical and clinical investigations of therapeutic approaches to melanoma have progressed significantly in the past year. This article reviews recently published information relevant to preclinical studies of the biologic function of stromal tissue, growth factors (and receptors), interferons, cytokines, and a...

journal_title：Current opinion in oncology

authors： Kirkwood JM

更新日期：1992-04-01 00:00:00

abstract：:Contrary to the case with bacterial infections, progress in the diagnosis and treatment of invasive mycoses in cancer patients has been unsatisfactory. Amphotericin B deoxycholate has remained the drug of choice for severe invasive fungal infections for nearly 40 years. However, its infusion-related side effects, as w...

journal_title：Current opinion in oncology

authors： Martino P,Girmenia C

更新日期：1997-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent Food and Drug Administration (FDA) approval of five new immune checkpoint inhibitors for the treatment of metastatic urothelial cancer represents the first major treatment breakthrough for this disease since the introduction of combination chemotherapy over 30 years ago. This review examines th...

journal_title：Current opinion in oncology

authors： Tabayoyong W,Gao J

更新日期：2018-05-01 00:00:00

abstract：:In testicular cancer epidemiology, the increasing recognition that germinal epithelial atrophy is the final common pathway in the development of this tumor has developed along with reports that elevated follicule-stimulating hormone levels at the time of diagnosis of first tumor correlate with risk of developing a sec...

journal_title：Current opinion in oncology

authors： Oliver RT

更新日期：1991-06-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights the most important developments in the biology and treatment of Merkel cell carcinoma published in the medical literature over the past year. RECENT FINDINGS:Adjuvant radiotherapy to the primary site with or without coverage of the nodal region is recommended in most older seri...

journal_title：Current opinion in oncology

authors： Tai P

更新日期：2008-03-01 00:00:00

abstract：:Obstruction of the superior vena cava is seldom a true emergency and should not be treated without an adequate tissue diagnosis. For patients who are poor operative risks for invasive procedures, percutaneous biopsies of mediastinal masses under ultrasound guidance have resulted in a high diagnostic yield. Superior ve...

journal_title：Current opinion in oncology

authors： Shepherd FA

更新日期：1995-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Malignant brain tumors have a very poor prognosis and the natural history of disease is very short, usually less than 1 year. Brain tumor patients often present peculiar symptoms of disease that require appropriate supportive treatment, namely, peritumoral brain edema, venous thromboembolism, seizures...

journal_title：Current opinion in oncology

authors： Pace A,Metro G,Fabi A

更新日期：2010-11-01 00:00:00

abstract：:The currently used staging system in melanoma has not been significantly modified since 1988. While this four-stage system effectively stratifies patients into prognostic groups, additional discriminating criteria have been reported that is not presently incorporated in the staging system. The following additions and ...

journal_title：Current opinion in oncology

authors： Ross M

更新日期：1998-03-01 00:00:00

abstract：:Palliative (terminal) care is now recognized worldwide as an important, multidisciplinary aspect of the continuing care of patients with incurable cancer. Symptom control and quality-of-life are of the essence. Various treatment methods are available, and radiotherapy and chemotherapy (used appropriately) are importan...

journal_title：Current opinion in oncology

authors： Hancock BW,Ahmedzai S,Clark D

更新日期：1993-07-01 00:00:00

abstract：:Advances in the understanding of the cellular and molecular derangements involved in the initiation and progression of multiple myeloma are beginning to be translated into novel therapeutic approaches. The myeloma stem cell has been under intense scrutiny regarding its normal B-cell counterpart. Oncogenes, tumor-suppr...

journal_title：Current opinion in oncology

authors： Varterasian ML

更新日期：1999-01-01 00:00:00

abstract：:Phosphatases are regulatory enzymes that antagonize the action of kinases within the cell. An understanding of the contribution of kinases to cancer has emerged during the past two decades; however, our understanding of phosphatases in cancer has lagged behind. Currently, three phosphatases have been implicated in the...

journal_title：Current opinion in oncology

authors： Parsons R

更新日期：1998-01-01 00:00:00

abstract：KEY POINTS:(1) Surgery is the standard primary treatment for early stage endometrial cancer, with local adjuvant therapies such as pelvic radiotherapy and vaginal brachytherapy most often used in patients with high risk of recurrence. (2) There are currently very few well designed studies evaluating local therapies in ...

journal_title：Current opinion in oncology

authors： Deeks E

更新日期：2007-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide examples of mitochondria-specific metabolic events that influence tumor cell biology, and of metabolism-related mitochondrial biomarkers and therapeutic targets in cancer cells. RECENT FINDINGS:Cancer cell mitochondria are rewired to optimally serve the cancer cell under various conditions...

journal_title：Current opinion in oncology

authors： Shoshan M

更新日期：2017-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Tumor stroma is composed of many cellular subtypes, of which the most abundant are fibroblasts, macrophages and endothelial cells. During the process of tissue injury, these three cellular subtypes must coordinate their activity to efficiently contribute to tissue regeneration. In tumor, this mechanis...

journal_title：Current opinion in oncology

authors： Ronca R,Van Ginderachter JA,Turtoi A

更新日期：2018-01-01 00:00:00

abstract：:Recent papers dealing with the effect of biologic response modifiers on the therapeutic activity of anticancer drugs are reviewed. Preclinical findings indicate that both interferons and tumor necrosis factor-alpha are able to synergize with different cytotoxic drugs in increasing both tumor cytotoxicity or cytostasis...

journal_title：Current opinion in oncology

authors： Parmiani G,Rivoltini L

更新日期：1991-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To present the model of the Supportive Care in Cancer Unit (SCCU) of the National Cancer Institute (NCI) of Milan. RECENT FINDINGS:In the last few years, there has been a debate on different models of integration of palliative care in oncology, on early palliative care, supportive care, supportive an...

journal_title：Current opinion in oncology

authors： Ida RC,Adelaide PM,Stefania B

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Advances in the health system and medical sciences are continuously pushing the barrier of life-expectancy. As a consequence, humans are being increasingly afflicted by age-associated diseases, such as cancer. The challenge now lies in understanding the mechanisms underlying ageing in order to reduce ...

journal_title：Current opinion in oncology

authors： Pereira B,Ferreira MG

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Myxoid/round cell liposarcoma (MRCL) represents about 10% of all soft-tissue sarcomas. Therapeutic options for this subgroup of tumours are limited, essentially doxorubicin-based regimens and trabectedin. Recently, the mammalian target of rapamycin (mTOR) pathway has been identified as a therapeutic t...

journal_title：Current opinion in oncology

authors： Sanfilippo R,Dei Tos AP,Casali PG

更新日期：2013-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent developments and controversies in the diagnosis and management of nonmuscle invasive bladder cancer (NMIBC). RECENT FINDINGS:The majority of incident bladder cancer diagnoses are noninvasive. The mainstay of diagnosis remains cystoscopy and transurethral resection, with enhanced o...

journal_title：Current opinion in oncology

authors： Bassett JC,Eifler JB,Resnick MJ,Clark PE

更新日期：2014-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To evaluate the application of narrative within medical practice. Illness like cancer constitutes a biographical disruption that occurs several times during the disease, from diagnosis to complications and treatments. This review analyzes the interest of narrative ethics in medicine with a focus on ca...

journal_title：Current opinion in oncology

authors： Lossignol D

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To review recent observations that describe changes in the likelihood of invasive fungal infections, shifts in types of fungal pathogens, and altered manifestations of fungal syndromes after hematopoietic cell transplantation and explore how changes in transplant practices are influencing these epidem...

journal_title：Current opinion in oncology

authors： Wingard JR

更新日期：2005-03-01 00:00:00

abstract：:The interferons are complex proteins that have been widely tested as therapy for neoplastic diseases. Interferon (IFN)-alpha has been the most extensively studied in melanoma. It produces responses in about 16% of metastatic melanomas, about one third of which are complete. It has been combined with chemotherapy and b...

journal_title：Current opinion in oncology

authors： Agarwala SS,Kirkwood JM

更新日期：1996-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Salivary gland malignancies are a rare and heterogeneous group of tumors with considerable variability in their natural history. Historically they have been treated with surgery and radiation therapy. It is only recently that there has been any growth in our understanding of these diseases and their m...

journal_title：Current opinion in oncology

authors： Adelstein DJ,Rodriguez CP

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDLs) are one of the more frequent mesenchymal neoplasms and are characterized by specific chromosome aberrations: supernumerary chromosome or giant marker chromosome or both. Extra copies of known oncogenes such as MDM2, CDK4, SAS, HMGA...

journal_title：Current opinion in oncology

authors： Arrigoni G,Doglioni C

更新日期：2004-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Increasing attention is being given to personalized medicine in oncology, where therapies are tailored to the particular characteristics of the individual cancer patient. In recent years, there has been greater focus on prostate-specific membrane antigen (PSMA) in prostate cancer (PCa) as a target for...

journal_title：Current opinion in oncology

authors： Bouchelouche K,Choyke PL

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The mesenchymal-epidermal transition (c-MET) receptor tyrosine kinase has a central role in the cancer cell's survival. MET and its ligand, hepatocyte growth factor (HGF), have recently been identified as promising targets in solid tumors, including nonsmall-cell lung cancer (NSCLC). RECENT FINDINGS:...

journal_title：Current opinion in oncology

authors： Landi L,Minuti G,D'Incecco A,Cappuzzo F

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Prevention of infectious complications of chemotherapy-induced granulocytopenia is a major issue in preventive medicine, as febrile neutropenia is still associated with an overall 10% mortality and extensive morbidity and cost. RECENT FINDINGS:The prescription of granulocyte colony-stimulating factor...

journal_title：Current opinion in oncology

authors： Klastersky J,Awada A,Aoun M,Paesmans M

更新日期：2009-07-01 00:00:00