Mitogen-activating protein kinase pathway alterations in Langerhans cell histiocytosis.

abstract：:Cutaneous malignant melanoma and its precursors were the general subjects of the National Institutes of Health Consensus Conference held in January 1992. Particular emphasis was placed on the diagnosis of early melanoma, especially melanoma in situ, and the controversies surrounding dysplastic nevi. Recent studies of ...

journal_title：Current opinion in oncology

authors： Barnhill RL

更新日期：1993-03-01 00:00:00

abstract：:Thyroid cancers are still the most common endocrine cancers. They are dominated by well-differentiated carcinomas, including papillary carcinoma, follicular carcinoma, and medullary thyroid carcinoma. Diagnosis is based on fine-needle aspiration cytologic examination. Recently, reverse transcription polymerase chain r...

journal_title：Current opinion in oncology

authors： Bi J,Lu B

更新日期：2000-01-01 00:00:00

abstract：:Advances in the understanding of the cellular and molecular derangements involved in the initiation and progression of multiple myeloma are beginning to be translated into novel therapeutic approaches. The myeloma stem cell has been under intense scrutiny regarding its normal B-cell counterpart. Oncogenes, tumor-suppr...

journal_title：Current opinion in oncology

authors： Varterasian ML

更新日期：1999-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The current status of postoperative adjuvant therapy for nonsmall cell lung cancer (NSCLC) is reviewed. RECENT FINDINGS:Cisplatin-based postoperative chemotherapy is a current standard of care for patients with stage II-III NSCLC who underwent complete resection. However, its benefit is limited. In t...

journal_title：Current opinion in oncology

authors： Mitsudomi T,Soh J

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To evaluate the current literature for processes of care and outcomes of multimodal therapies for muscle-invasive urothelial carcinoma of the bladder. RECENT FINDINGS:Treatments for high-risk bladder cancer remain an active area of investigation. Despite evidence of the benefits, the use of chemother...

journal_title：Current opinion in oncology

authors： Keegan KA,Resnick MJ,Clark PE

更新日期：2012-05-01 00:00:00

abstract：:Some of the most dramatic advances in the treatment of cancer have used the immune system in combination with conventional or transplantation chemotherapy. Adoptive immunotherapy has been used for relapses after allogeneic bone marrow transplantation, and it has been particularly effective for chronic myeloid leukemia...

journal_title：Current opinion in oncology

authors： Ballen K,Stewart FM

更新日期：1997-11-01 00:00:00

abstract：PURPOSE OF REVIEW:In the present review, we discuss the possible role of the unfolded protein response (UPR) in the acquisition of tumor cell characteristics and in the prognosis of cancer outcome, which could assist and contribute to the development of more promising therapeutic strategies. RECENT FINDINGS:Accumulati...

journal_title：Current opinion in oncology

authors： Galmiche A,Sauzay C,Chevet E,Pluquet O

更新日期：2017-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Mantle cell lymphoma is an aggressive non-Hodgkin's lymphoma characterized by the t(11;14) chromosomal translocation and overexpression of cyclin D1. Constituting approximately 5 to 8% of all non-Hodgkin's lymphomas, it carries the poorest prognosis among non-Hodgkin's lymphoma subtypes. Standard and ...

journal_title：Current opinion in oncology

authors： Williams ME,Densmore JJ

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Current treatment modalities provide limited improvement in the natural course of lung cancer, and prognosis remains poor. Lung cancer is a malignancy with great molecular heterogeneity. The complexity of the signalling process leading to cancer cell proliferation and to the neoplastic phenotype suppo...

journal_title：Current opinion in oncology

authors： Cascone T,Gridelli C,Ciardiello F

更新日期：2007-03-01 00:00:00

abstract：:Graft-versus-host disease (GVHD) continues to be a major obstacle to the success of allogeneic bone marrow transplantation. Furthermore, several clinical strategies being employed at this time in the field of bone marrow transplantation have had an impact on GVHD. In addition to the usual division of topics such as pa...

journal_title：Current opinion in oncology

authors： Marcellus DC,Vogelsang GB

更新日期：1997-03-01 00:00:00

abstract：:Chemopreventive strategies hold substantial promise for reducing the incidence of colorectal cancer, the second leading cause of cancer-related mortality in the United States. This review focuses on recent advances in the identification of molecular targets and novel strategies for chemopreventive intervention. Many c...

journal_title：Current opinion in oncology

authors： Clapper ML,Chang WC,Meropol NJ

更新日期：2001-07-01 00:00:00

abstract：:Work in the field of molecular neuro-oncology has evolved from a purely descriptive catalogue of regional mutations to the implication of specific genes in the malignant process. Reverse genetic strategies have resulted in the cloning of the neurofibromatosis-1 and neurofibromatosis-2 genes, the molecular physiology o...

journal_title：Current opinion in oncology

authors： Mikkelsen T

更新日期：1994-05-01 00:00:00

abstract：:A better understanding of the immunobiology after transplantation and of the available recombinant cytokines that enhance hematopoietic reconstitution following autologous and allogeneic bone marrow transplantation is likely to result in safer application of bone marrow transplantation. Residual tumor cells escaping c...

journal_title：Current opinion in oncology

authors： Slavin S,Nagler A

更新日期：1991-04-01 00:00:00

abstract：:Disease-free survival for patients with small sarcomas of bone has been impressively improved with the use of intensive combination chemotherapy and safe local control with surgery or radiation. The ability of monoclonal antibodies to recognize different antigens has allowed new insights into the histogenesis and has ...

journal_title：Current opinion in oncology

authors： Jürgens HF

更新日期：1994-07-01 00:00:00

abstract：:Although variation in diet may account for approximately one third of the variation in cancer incidence worldwide, epidemiologic studies have proven to be a blunt instrument for identifying causal relationships between intakes of specific food constituents and cancer risk at specific sites. Diets rich in fruits and ve...

journal_title：Current opinion in oncology

authors： Mathers JC,Burn J

更新日期：1999-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) constitute a diverse group of neoplasms arising from the diffuse neuroendocrine cell system. During the last 2 years a new classification system, the WHO 2010, has come into clinical practice together with Tumor Nodes Metastases (TNM) staging and...

journal_title：Current opinion in oncology

authors： Oberg K

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews the potential benefit of maintenance therapy for patients with follicular lymphoma. RECENT FINDINGS:Follicular lymphoma, despite substantial improvements in survival, is usually incurable. Several randomized studies have shown that the combination of anti-CD20 and chemotherapy ca...

journal_title：Current opinion in oncology

authors： Michallet AS,Coiffier B,Salles G

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Molecular genetic alterations characterize the development of human cancer. Recent advances in molecular genetic technology and the success of the human genome project have empowered investigators with new tools in dissecting the cancer genome for discovery of new cancer-associated genes. The purpose ...

journal_title：Current opinion in oncology

authors： Shih IeM,Wang TL

更新日期：2005-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to highlight the most important developments in the diagnosis, prevention, and management of prostate cancer reported in the past year that have been published in the medical literature. RECENT FINDINGS:Recent research has yielded important insights into the effects of l...

journal_title：Current opinion in oncology

authors： Ryan CJ,Small EJ

更新日期：2004-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review presents an overview of recent developments in research examining coping with the effects of cancer treatment on sexuality. RECENT FINDINGS:A search was conducted using PubMed and Web of Knowledge to find papers published or in press in 2010. Papers examining coping efforts, effects of ca...

journal_title：Current opinion in oncology

authors： Reese JB

更新日期：2011-07-01 00:00:00

abstract：:The preclinical and clinical investigations of therapeutic approaches to melanoma have progressed significantly in the past year. This article reviews recently published information relevant to preclinical studies of the biologic function of stromal tissue, growth factors (and receptors), interferons, cytokines, and a...

journal_title：Current opinion in oncology

authors： Kirkwood JM

更新日期：1992-04-01 00:00:00

abstract：:The rising rate of germ cell cancer of the testis over the past decade has been demonstrated to be occurring predominantly in the younger age group (15 to 19 years) in association with earlier onset of puberty and earlier onset of regular sexual activity. Chemicals and viruses, with their atrophogenic effect, remain t...

journal_title：Current opinion in oncology

authors： Oliver RT

更新日期：1996-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The mutational landscape in lung adenocarcinoma (LADC) is broadly recognized, particularly regarding the presence of the epidermal growth factor receptor (EGFR) mutation in non-smokers. However, even in the EGFR canonical-mutant LADC, other accompanying alterations surface which may have a major impac...

journal_title：Current opinion in oncology

authors： Rosell R,Karachaliou N,Arrieta O

更新日期：2020-01-01 00:00:00

abstract：:Our understanding of the pathogenesis and management of squamous cell carcinoma of the anal canal has undergone profound change over the last 30 years. Epidemiologic studies have demonstrated that infection with human papillomavirus is most likely responsible for the majority of cases. Primary treatment with concomita...

journal_title：Current opinion in oncology

authors： Ryan DP,Mayer RJ

更新日期：2000-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The effect of psychotherapy on the survival of cancer patients has been debated for the past 20 years, mainly due to contradictory findings in the studies published so far. Several reviews have been published, almost all of which criticize the methods used in the studies. In 2007, three replication st...

journal_title：Current opinion in oncology

authors： Boesen EH,Johansen C

更新日期：2008-07-01 00:00:00

abstract：:Lymphomas include a vast number of pathologic conditions in which the search for new active drugs follows different routes. Hodgkin's disease and high-grade non-Hodgkin's lymphoma are very sensitive to chemotherapy, responding well to existing regimens; the inability to cure seems to be caused by acquired drug resista...

journal_title：Current opinion in oncology

authors： Straneo M,Gianni L

更新日期：1994-09-01 00:00:00

abstract：PURPOSE OF REVIEW:A small percentage of gliomas are caused by inheritance in cancer syndromes but there is also a general familial aggregation of glioma. Recently, low penetrant genes associated with glioma risk have been identified. RECENT FINDINGS:Seven independent chromosomal loci have robustly been associated with...

journal_title：Current opinion in oncology

authors： Melin B

更新日期：2011-11-01 00:00:00

abstract：:Twenty-three years after it was observed that successful treatment of Hodgkin's disease was associated with risk of a second malignancy related to treatment, the literature is maturing. Early reports of leukemia risk rising and falling between 5 and 10 years after treatment continue to be supported. The real problem i...

journal_title：Current opinion in oncology

authors： DeVita VT Jr

更新日期：1997-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the current knowledge about the biology and clinical management of adult desmoid tumors. RECENT FINDINGS:In the past decade, we have learned that desmoid tumors are driven by alterations of the Wnt/APC/β-catenin pathway, sporadic desmoid tumors are associated with somatic mutations of CT...

journal_title：Current opinion in oncology

authors： Penel N,Chibon F,Salas S

更新日期：2017-07-01 00:00:00

abstract：:The treatment options for patients with recurrent head and neck malignancies arising in a previously irradiated field are limited. Surgical salvage is feasible in a minority of patients. The majority are referred for palliative chemotherapy with no realistic chance for cure. Data are accumulating to support reirradiat...

journal_title：Current opinion in oncology

authors： Garofalo MC,Haraf DJ

更新日期：2002-05-01 00:00:00