Pathology and prognostic factors.

abstract：PURPOSE OF REVIEW:To describe recent advances in the diagnosis and treatment of paraneoplastic neurological syndromes (PNS). RECENT FINDINGS:PNS are rare complications of cancer caused by an immune cross-reaction between antigens expressed by tumor cells and neurons. The target of the immune attack can be an intracell...

journal_title：Current opinion in oncology

authors： Berzero G,Psimaras D

更新日期：2018-11-01 00:00:00

abstract：PURPOSE OF REVIEW:(18)F-fluoro-2-deoxy-D-glucose PET-computed tomography (CT) has a major clinical impact in oncology not only for diagnostics but also for staging, response assessment, and relapse detection. However, several other PET tracers are needed for a more complete molecular characterization of cancers which h...

journal_title：Current opinion in oncology

authors： Garcia C,Gebhart G,Flamen P

更新日期：2012-11-01 00:00:00

abstract：PURPOSE OF REVIEW:In the 1990s, cancer patients were described as poor candidates for ICU admission on the basis of high mortality rates and management costs. Over the last decade, however, advances in the management of malignancies and organ failures have led to substantial increases in survival. This review discusses...

journal_title：Current opinion in oncology

authors： Darmon M,Azoulay E

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we highlight key recent insights into hematopoiesis and hematological malignancies through the application of novel single-cell approaches. We particularly focus on biological insights made through the study of stem/progenitors cells in myeloid malignancy at single-cell resolution. RE...

journal_title：Current opinion in oncology

authors： Brierley CK,Mead AJ

更新日期：2020-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the current knowledge about the biology and clinical management of adult desmoid tumors. RECENT FINDINGS:In the past decade, we have learned that desmoid tumors are driven by alterations of the Wnt/APC/β-catenin pathway, sporadic desmoid tumors are associated with somatic mutations of CT...

journal_title：Current opinion in oncology

authors： Penel N,Chibon F,Salas S

更新日期：2017-07-01 00:00:00

abstract：:Collaborative study groups have invested considerable effort in the last decade in defining the role of allogeneic and autologous bone marrow transplantation as consolidation treatment for first remission of acute myeloid leukemia in younger patients. These efforts have been able, more precisely, to quantitate the deg...

journal_title：Current opinion in oncology

authors： Burnett AK,Kell J

更新日期：2000-03-01 00:00:00

abstract：:Serial analysis of gene expression has been widely used to characterize gene expression patterns associated with tumor formation. These studies resulted in the identification of tumor-specific markers, transcriptional pathways, or therapeutic targets. In this review, recent applications and developments of serial anal...

journal_title：Current opinion in oncology

authors： Hermeking H

更新日期：2003-01-01 00:00:00

abstract：:Breast cancer remains a worldwide public health concern despite the fact that mortality rates have been declining in some countries as a result of improvements in adjuvant therapy and screening for breast cancer. In the prevention arena, advances in our understanding of the effects of tamoxifen have led to the investi...

journal_title：Current opinion in oncology

authors： Brewster A,Helzlsouer K

更新日期：2001-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Sub-Saharan Africa has the largest population of people living with AIDS in the world, with Nigeria having the third largest after South Africa and India. With the advent of treatment programs, more people in Nigeria are now living with the virus but are at increased risk of cancer similar to the expe...

journal_title：Current opinion in oncology

authors： Akinwande O,Ogundiran T,Akarolo-Anthony S,Mamadu I,Dakum P,Blattner W,Adebamowo C

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to highlight the most important developments in the diagnosis, prevention, and management of prostate cancer reported in the past year that have been published in the medical literature. RECENT FINDINGS:Recent research has yielded important insights into the effects of l...

journal_title：Current opinion in oncology

authors： Ryan CJ,Small EJ

更新日期：2004-05-01 00:00:00

abstract：:Prophylactic platelet transfusion can prevent spontaneous hemorrhage in thrombocytopenic cancer patients undergoing intensive treatment, but it is limited by the development of platelet alloimmunization. Exclusive use of leukocyte-depleted blood products delays or prevents the development of platelet alloimmunization ...

journal_title：Current opinion in oncology

authors： Wallerstein R Jr,Deisseroth AB

更新日期：1991-08-01 00:00:00

abstract：PURPOSE OF REVIEW:In the present review, we summarize the recent developments in the management of germ cell tumors (GCTs). RECENT FINDINGS:Treatment-related acute and late-onset toxicity remains a key challenge in the management of GCTs, with recent evidence showing that the adverse health outcomes of etoposide and c...

journal_title：Current opinion in oncology

authors： Chahoud J,Zhang M,Shah A,Lin SH,Pisters LL,Tu SM

更新日期：2018-05-01 00:00:00

abstract：:The biologic and clinical heterogeneity of lymphomas represents the major obstacle to their diagnosis. Because histologic analysis, which is the initial diagnostic approach, has been demonstrated to be insufficient in the definition of certain types of lymphomas, molecular and immunologic techniques have been increasi...

journal_title：Current opinion in oncology

authors： Veronese ML,Schichman SA,Croce CM

更新日期：1996-09-01 00:00:00

abstract：:Mucosal injury due to ionizing radiation or cytotoxic agents begins with damage to stem cells in the basal epithelium, progresses as these cells are depleted, and is complicated by inflammation and superimposed infection. Suppression of oral and pharyngeal infection, cytokine stimulation of neutrophils, and protection...

journal_title：Current opinion in oncology

authors： Marks JE

更新日期：1997-05-01 00:00:00

abstract：:Recent publications dealing with the pathology of squamous carcinomas of the head and neck have been critically reviewed with particular reference to potential prognostic factors and improved methods for identifying nodal metastases. The topics covered include cytophotometry and proliferative patterns, molecular biolo...

journal_title：Current opinion in oncology

authors： Carter RL

更新日期：1993-05-01 00:00:00

abstract：PURPOSE OF REVIEW:A number of clinical trials are currently testing chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered T cells for the treatment of haematologic malignancies and selected solid tumours, and CD19-CAR-T cells have produced impressive clinical responses in B-cell malignancies. Here, we su...

journal_title：Current opinion in oncology

authors： Arcangeli S,Mestermann K,Weber J,Bonini C,Casucci M,Hudecek M

更新日期：2020-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review is to describe the major steps leading to the immunosuppressive tumor microenvironment and to summarize some of the new immunotherapies that interfere with these mechanisms. RECENT FINDINGS:Immunotherapy has improved the outcome of relapsed/metastatic head and neck squamous cel...

journal_title：Current opinion in oncology

authors： Merlano MC,Denaro N,Garrone O

更新日期：2020-05-01 00:00:00

abstract：:The appearance of skin lesions in patients with occult or obvious malignancy may be of extreme value in the detection and management of cancer because the skin is readily accessible to examination and biopsy. Examination of the skin of our patients can provide important insights into underlying malignant processes or ...

journal_title：Current opinion in oncology

authors： Sabir S,James WD,Schuchter LM

更新日期：1999-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews the potential benefit of maintenance therapy for patients with follicular lymphoma. RECENT FINDINGS:Follicular lymphoma, despite substantial improvements in survival, is usually incurable. Several randomized studies have shown that the combination of anti-CD20 and chemotherapy ca...

journal_title：Current opinion in oncology

authors： Michallet AS,Coiffier B,Salles G

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the state-of-the-art and new developments in the management of patients with brain metastases. RECENT FINDINGS:Treatment decisions are based on prognostic factors to maximize neurologic function and survival, while avoiding unnecessary therapies. Whole-brain radiotherapy (WBRT) is the treat...

journal_title：Current opinion in oncology

authors： Soffietti R,Rudà R,Trevisan E

更新日期：2008-11-01 00:00:00

abstract：:The development of non-myeloablative and reduced-intensity conditioning regimens has enabled older or medically infirm patients with myeloid malignancies to be treated with allogeneic hematopoietic cell transplantation (HCT). The regimens are sufficiently immunosuppressive to allow engraftment of allogeneic cells and ...

journal_title：Current opinion in oncology

authors： Storb R

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Evaluate the recent literature about the relation of clinical infection and colorectal cancer in terms of diagnosis of an occult infection and possible impact on oncological outcome and review the possible role of the gut microbiota in the role of colorectal cancer oncogenesis. RECENT FINDINGS:Data p...

journal_title：Current opinion in oncology

authors： Massaut E,Hendlisz B,Klastersky JA

更新日期：2019-07-01 00:00:00

abstract：KEY POINTS:(1) Surgery is the standard primary treatment for early stage endometrial cancer, with local adjuvant therapies such as pelvic radiotherapy and vaginal brachytherapy most often used in patients with high risk of recurrence. (2) There are currently very few well designed studies evaluating local therapies in ...

journal_title：Current opinion in oncology

authors： Deeks E

更新日期：2007-09-01 00:00:00

abstract：PURPOSE OF REVIEW:In the present review, we discuss the possible role of the unfolded protein response (UPR) in the acquisition of tumor cell characteristics and in the prognosis of cancer outcome, which could assist and contribute to the development of more promising therapeutic strategies. RECENT FINDINGS:Accumulati...

journal_title：Current opinion in oncology

authors： Galmiche A,Sauzay C,Chevet E,Pluquet O

更新日期：2017-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To review recent observations that describe changes in the likelihood of invasive fungal infections, shifts in types of fungal pathogens, and altered manifestations of fungal syndromes after hematopoietic cell transplantation and explore how changes in transplant practices are influencing these epidem...

journal_title：Current opinion in oncology

authors： Wingard JR

更新日期：2005-03-01 00:00:00

abstract：:Approximately 1 in 10 US women will be diagnosed with breast cancer in her lifetime. With such a high incidence, breast cancer is a serious health concern for all American women. Within the past year, clues about the function of genes associated with breast cancer have been garnered, and novel genes that may contribut...

journal_title：Current opinion in oncology

authors： Unger MA,Weber BL

更新日期：2000-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Langerhans cell histiocytosis (LCH) is a rare disorder characterized by the infiltration of involved tissues by specialized dendritic cells. The demonstration of the constant activation of the mitogen-activated protein kinase (MAPK) pathway in LCH lesions has been a breakthrough in the understanding o...

journal_title：Current opinion in oncology

authors： Jouenne F,Benattia A,Tazi A

更新日期：2020-12-09 00:00:00

abstract：PURPOSE OF REVIEW:Vandetanib is a small molecule tyrosine kinase inhibitor that has been recently approved as an 'orphan drug' for the treatment of patients with unresectable, locally advanced, or metastatic medullary thyroid cancer (MTC). RECENT FINDINGS:MTC is a neuroendocrine malignancy frequently associated with m...

journal_title：Current opinion in oncology

authors： Campbell MJ,Seib CD,Gosnell J

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The recent contributions to renal cell carcinoma in the fields of molecular biology and the expanded use of molecularly targeted agents will be reviewed. This study is intended to update prognostic and therapeutic decision-making data and provide perspective on advances in understanding the molecular ...

journal_title：Current opinion in oncology

authors： Rini BI,Rathmell WK,Godley P

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Mycosis fungoides and Sézary syndrome arise from malignant T cells that reside in skin, and subsequently are capable of circulating between skin, lymph nodes, and blood. The pathophysiologic mechanisms that cause and result in different behaviors of the skin-homing-malignant T cells in different stage...

journal_title：Current opinion in oncology

authors： Rubio Gonzalez B,Zain J,Rosen ST,Querfeld C

更新日期：2016-01-01 00:00:00