Apply innovative technologies to explore cancer genome.

abstract：PURPOSE OF REVIEW:Sub-Saharan Africa has the largest population of people living with AIDS in the world, with Nigeria having the third largest after South Africa and India. With the advent of treatment programs, more people in Nigeria are now living with the virus but are at increased risk of cancer similar to the expe...

journal_title：Current opinion in oncology

authors： Akinwande O,Ogundiran T,Akarolo-Anthony S,Mamadu I,Dakum P,Blattner W,Adebamowo C

更新日期：2009-09-01 00:00:00

abstract：:Less than 1% of all cancers are present in the thyroid, yet thyroid nodules are found in 4 to 10% of the adult population. Because thyroid nodules are relatively common, the diagnostic dilemma is to distinguish between a more common benign nodule, which usually does not require specific treatment, and a malignant nodu...

journal_title：Current opinion in oncology

authors： Weiss RE,Lado-Abeal J

更新日期：2002-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The lateral neck compartment is the second most frequent target region for metastatic papillary thyroid cancer (PTC) and medullary thyroid cancer (MTC). Lateral lymph node metastases are associated with locoregional recurrence and, when they involve either side of the neck, with mediastinal and distan...

journal_title：Current opinion in oncology

authors： Dralle H,Machens A

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an overview of recent updates in understanding the mechanisms by which glioblastoma cells interact with their cellular and molecular partners within the microenvironment. RECENT FINDINGS:We have now a better knowledge of the cell populations involved in Glioblastoma (GBM) invasio...

journal_title：Current opinion in oncology

authors： Chouleur T,Tremblay ML,Bikfalvi A

更新日期：2020-11-01 00:00:00

abstract：PURPOSE OF REVIEW:An overview of many of the preclinical and clinical developments in germ cell tumors over the past year is presented. RECENT FINDINGS:Recent epidemiologic studies show changes in the ethnic incidence of germ cell tumors; in particular, African-Americans have seen an increase. Additionally, risk facto...

journal_title：Current opinion in oncology

authors： Bridges B,Hussain A

更新日期：2006-05-01 00:00:00

abstract：:Despite its appeal, lung cancer screening has been found to be of little value at this time. However, use of monoclonal antibodies to detect cancer cells in the sputum may prove to be of value in high-risk subjects. Once a cancer is diagnosed, anatomic staging by the International TNM Staging System has shown its effe...

journal_title：Current opinion in oncology

authors： Shields TW

更新日期：1991-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine the most recent changes in published guidelines by various organizations for the treatment of patients with differentiated thyroid cancer. This document provides a comparison of recommendations for common topics currently found in available thyroid cancer care guidelines. RECENT FINDINGS:R...

journal_title：Current opinion in oncology

authors： Miller BS,Doherty GM

更新日期：2011-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Neoplasms of the endocrine pancreas, commonly referenced as pancreatic islet cell tumors, are rare, often well differentiated endocrine neoplasms, whose biology remains poorly characterized. This article reviews the current clinical management of pancreatic islet cell tumors and describes the molecula...

journal_title：Current opinion in oncology

authors： House MG,Schulick RD

更新日期：2006-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Concept of refractory coeliac disease (RCD) emerged in the past decade and refers to persistence of malnutrition and intestinal villous atrophy for more than 1 year strict gluten-free diet in coeliac patients. Diagnosis of this condition remains difficult and conditions treatment and follow-up. RECEN...

journal_title：Current opinion in oncology

authors： Malamut G,Cellier C

更新日期：2013-09-01 00:00:00

abstract：:Breast cancer remains a worldwide public health concern despite the fact that mortality rates have been declining in some countries as a result of improvements in adjuvant therapy and screening for breast cancer. In the prevention arena, advances in our understanding of the effects of tamoxifen have led to the investi...

journal_title：Current opinion in oncology

authors： Brewster A,Helzlsouer K

更新日期：2001-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this article will be to review neuroendocrine tumours (NETs) of the gynaecological tract. NETs are generally considered to be uncommon and primary tumours in the gynaecological tract on arrival rare or very rare. It is important to distinguish true primary tumours from metastatic as the...

journal_title：Current opinion in oncology

authors： Reed NS

更新日期：2016-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Childhood blastomas, unlike adult cancers, originate from developing organs in which molecular and cellular features exhibit differentiation arrest and embryonic characteristics. Conventional cancer therapies, which rely on the generalized cytotoxic effect on rapidly dividing cells, may damage delicat...

journal_title：Current opinion in oncology

authors： Oh L,Hafsi H,Hainaut P,Ariffin H

更新日期：2019-03-01 00:00:00

abstract：PURPOSE OF REVIEW:We summarize the concept of a locally advanced basal cell carcinoma (laBCC) and present the current consensus definition. We also review the key pieces of primary research undertaken in the past year and how these affect the use of smoothened inhibitors in a clinical setting. RECENT FINDINGS:Medium t...

journal_title：Current opinion in oncology

authors： Khoo AB,Ali FR,Lear JT

更新日期：2016-03-01 00:00:00

abstract：:Recent work has shown that: 1) loss of transforming growth factor-beta response is associated with malignant progression, 2) maintenance of autocrine negative transforming growth factor-beta activity is a key impediment to malignant progression, and 3) the major mechanism for loss of RII expression in replication erro...

journal_title：Current opinion in oncology

authors： Brattain MG,Markowitz SD,Willson JK

更新日期：1996-01-01 00:00:00

abstract：:Both paclitaxel and docetaxel have shown activity when used as a single agent in patients with squamous cell carcinoma of the head and neck (SCCHN). Combinations of both drugs with platinum derivatives and antimetabolites have been tested in patient populations with encouraging results, but some have exhibited conside...

journal_title：Current opinion in oncology

authors： Schrijvers D,Vermorken JB

更新日期：1998-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to update knowledge on therapy-related myeloid neoplasms (t-MN), taking into account the new 2008 WHO classification, new genome-wide approaches for the definition of susceptibility towards t-MN and the introduction of new more aggressive treatments in cancer patients. R...

journal_title：Current opinion in oncology

authors： Leone G,Fianchi L,Voso MT

更新日期：2011-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Malignant brain tumors have a very poor prognosis and the natural history of disease is very short, usually less than 1 year. Brain tumor patients often present peculiar symptoms of disease that require appropriate supportive treatment, namely, peritumoral brain edema, venous thromboembolism, seizures...

journal_title：Current opinion in oncology

authors： Pace A,Metro G,Fabi A

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Current treatment modalities provide limited improvement in the natural course of lung cancer, and prognosis remains poor. Lung cancer is a malignancy with great molecular heterogeneity. The complexity of the signalling process leading to cancer cell proliferation and to the neoplastic phenotype suppo...

journal_title：Current opinion in oncology

authors： Cascone T,Gridelli C,Ciardiello F

更新日期：2007-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Sarcomas are a diverse group of rare solid tumors with limited treatment options for patients with advanced, inoperable disease. Cabozantinib is a tyrosine kinase inhibitor currently approved for advanced renal cell, hepatocellular, and medullary thyroid carcinoma. Cabozantinib has potent activity aga...

journal_title：Current opinion in oncology

authors： Schöffski P,Blay JY,Ray-Coquard I

更新日期：2020-07-01 00:00:00

abstract：:Although early clinical gene therapy trials for recurrent central nervous system neoplasms showed the proof-of-principle, they did not fulfill the high expectations suggested by the preclinical experimental data. Insufficient distribution of vectors in human brain tumors and very low transduction efficiency require th...

journal_title：Current opinion in oncology

authors： Weyerbrock A,Oldfield EH

更新日期：1999-05-01 00:00:00

abstract：:Breast cancer is a leading women's health issue. Continued advances in understanding the temporal sequencing of relevant exposures promises to shed light on the continuum of breast carcinogenesis. Oral contraceptive use and the transient increase in risk following childbirth are exposures that affect the near-term ris...

journal_title：Current opinion in oncology

authors： Alberg AJ,Helzlsouer KJ

更新日期：1997-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Gastrointestinal stromal tumour patients with exon 9 KIT mutations have a worse outcome, but progression-free survival is improved by treatment with imatinib 800 mg daily. This review looks at the evidence and asks whether this should be standard treatment from diagnosis. RECENT FINDINGS:The phase II...

journal_title：Current opinion in oncology

authors： Judson I

更新日期：2008-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Imatinib has exceptional activity in controlling gastrointestinal stromal tumor (GIST) due to inhibition of the constitutively active conformation of KIT and platelet-derived growth factor-alpha (PDGFRA), which is commonly seen in this tumor. This review explores the current available data on the corr...

journal_title：Current opinion in oncology

authors： Marrari A,Trent JC,George S

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The last decade has seen a paradigm change in that tumor stroma contributes to malignant tumor progression in a manner comparable to genetic and epigenetic changes within cancer cells. This review summarizes recent novel insights into how inflammatory conditions stimulate the formation and expansion o...

journal_title：Current opinion in oncology

authors： Zumsteg A,Christofori G

更新日期：2009-01-01 00:00:00

abstract：:The rising rate of germ cell cancer of the testis over the past decade has been demonstrated to be occurring predominantly in the younger age group (15 to 19 years) in association with earlier onset of puberty and earlier onset of regular sexual activity. Chemicals and viruses, with their atrophogenic effect, remain t...

journal_title：Current opinion in oncology

authors： Oliver RT

更新日期：1996-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Salivary gland malignancies are a rare and heterogeneous group of tumors with considerable variability in their natural history. Historically they have been treated with surgery and radiation therapy. It is only recently that there has been any growth in our understanding of these diseases and their m...

journal_title：Current opinion in oncology

authors： Adelstein DJ,Rodriguez CP

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The management of febrile neutropenia has evolved significantly with the development of risk stratification and recognition of the efficacy of oral antibiotics in low-risk patients. There remains uncertainty concerning the need for hospitalization and role of early hospital discharge. We review recent...

journal_title：Current opinion in oncology

authors： Innes H,Marshall E

更新日期：2007-07-01 00:00:00

abstract：:The correct use of tumor markers in patients with gynecological cancers can make an impact on management of the disease. Their value in screening for ovarian cancer cannot be recommended outside trials. Increased levels of various markers give prognostic information that could alter therapy for patients with early ova...

journal_title：Current opinion in oncology

authors： Rustin GJ

更新日期：1996-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Small bowel adenocarcinoma (SBA) is a rare cancer with a poor prognosis and little information to guide its management. In recent years, improved diagnostic imaging and an increase in reported experience with use of chemotherapy may alter the way we manage SBA. This review will summarize recent advanc...

journal_title：Current opinion in oncology

authors： Speranza G,Doroshow JH,Kummar S

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:AIDS-related malignancies are an ongoing cause of mortality in individuals with HIV infection. In the HIV-negative setting, high-dose chemotherapy or stem cell transplantation is an option for patients with hematologic malignancies. Prior to the advent of effective HIV therapy, stem cell transplantati...

journal_title：Current opinion in oncology

authors： Krishnan A,Forman SJ

更新日期：2010-09-01 00:00:00