p53, stem cell biology and childhood blastomas.

abstract：:Malignant melanoma is a tumor that offers unique possibilities for approaches to targeted therapy by virtue of the pigment biosynthesis pathway. Such approaches may seek to use the incorporation of toxic intermediates or to use the natural transcriptional control of genes coding for enzymes involved in melanin formati...

journal_title：Current opinion in oncology

authors： Hart IR,Vile RG

更新日期：1994-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Early trials of high-dose therapy with autologous stem cell transplantation in mantle cell lymphoma were discouraging, with no clear survival advantage attributable to the procedure. Most early series were plagued by small numbers, retrospective designs, and short follow-up. Also, until recently, allo...

journal_title：Current opinion in oncology

authors： Jacobsen E,Freedman A

更新日期：2004-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will discuss the most recent literature regarding frontline therapy, treatment of patients not eligible for intensive chemotherapy, and novel agents for relapsed/refractory patients with mantle cell lymphoma (MCL). RECENT FINDINGS:Longer follow-up of previously studied intensive regimens ...

journal_title：Current opinion in oncology

authors： Rivera-Rodriguez N,Cabanillas F

更新日期：2013-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Advances in the health system and medical sciences are continuously pushing the barrier of life-expectancy. As a consequence, humans are being increasingly afflicted by age-associated diseases, such as cancer. The challenge now lies in understanding the mechanisms underlying ageing in order to reduce ...

journal_title：Current opinion in oncology

authors： Pereira B,Ferreira MG

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The concept of palliative care is becoming increasingly important in the management of glioma patients. However, the right time for implementation, as well as the individual degree of integration of palliative care aspects, are still a matter of debate. This review updates recent evidence of palliativ...

journal_title：Current opinion in oncology

authors： Oberndorfer S,Hutterer M

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Management of the epithelial ovarian cancer (EOC) remains a therapeutic challenge, with continued poor overall survival (OS). Given low chemotherapy response rates for recurrent disease and short survival times, new treatment options with improved therapeutic indices for targeting cancer's vulnerabili...

journal_title：Current opinion in oncology

authors： Ratner ES,Sartorelli AC,Lin ZP

更新日期：2012-09-01 00:00:00

abstract：:Controversy exists over the role that environmental estrogens, such as pesticides or polychlorinated biphenyls (PCBs), might play as risk factors for breast cancer. Several laboratory studies have suggested that these chemicals function as weak estrogens, binding to the estrogen receptor and inducing various measures ...

journal_title：Current opinion in oncology

authors： Davidson NE

更新日期：1998-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDLs) are one of the more frequent mesenchymal neoplasms and are characterized by specific chromosome aberrations: supernumerary chromosome or giant marker chromosome or both. Extra copies of known oncogenes such as MDM2, CDK4, SAS, HMGA...

journal_title：Current opinion in oncology

authors： Arrigoni G,Doglioni C

更新日期：2004-07-01 00:00:00

abstract：:A better understanding of the immunobiology after transplantation and of the available recombinant cytokines that enhance hematopoietic reconstitution following autologous and allogeneic bone marrow transplantation is likely to result in safer application of bone marrow transplantation. Residual tumor cells escaping c...

journal_title：Current opinion in oncology

authors： Slavin S,Nagler A

更新日期：1991-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Mantle cell lymphoma is an aggressive non-Hodgkin's lymphoma characterized by the t(11;14) chromosomal translocation and overexpression of cyclin D1. Constituting approximately 5 to 8% of all non-Hodgkin's lymphomas, it carries the poorest prognosis among non-Hodgkin's lymphoma subtypes. Standard and ...

journal_title：Current opinion in oncology

authors： Williams ME,Densmore JJ

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The remarkable progress witnessed over the past few years in the diagnosis, prognosis, and therapy of chronic lymphocytic leukemia has profoundly changed the clinical approach to this disease. This review focuses on the most recent advances in the diagnostic and prognostic examination of patients with...

journal_title：Current opinion in oncology

authors： Gentile M,Mauro FR,Guarini A,Foà R

更新日期：2005-11-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we highlight key recent insights into hematopoiesis and hematological malignancies through the application of novel single-cell approaches. We particularly focus on biological insights made through the study of stem/progenitors cells in myeloid malignancy at single-cell resolution. RE...

journal_title：Current opinion in oncology

authors： Brierley CK,Mead AJ

更新日期：2020-03-01 00:00:00

abstract：:In testicular cancer epidemiology, the increasing recognition that germinal epithelial atrophy is the final common pathway in the development of this tumor has developed along with reports that elevated follicule-stimulating hormone levels at the time of diagnosis of first tumor correlate with risk of developing a sec...

journal_title：Current opinion in oncology

authors： Oliver RT

更新日期：1991-06-01 00:00:00

abstract：:New clinical and epidemiologic studies provide information about the possible causes of human leukemia. Evidence for a viral etiology continues to appear, and the relationship between myelodysplastic syndrome and the leukemias is now linked through molecular genetic studies. Molecular mechanisms of leukemogenesis are ...

journal_title：Current opinion in oncology

authors： Vogel VG,Fisher RE

更新日期：1993-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The effect of psychotherapy on the survival of cancer patients has been debated for the past 20 years, mainly due to contradictory findings in the studies published so far. Several reviews have been published, almost all of which criticize the methods used in the studies. In 2007, three replication st...

journal_title：Current opinion in oncology

authors： Boesen EH,Johansen C

更新日期：2008-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the current knowledge about the biology and clinical management of adult desmoid tumors. RECENT FINDINGS:In the past decade, we have learned that desmoid tumors are driven by alterations of the Wnt/APC/β-catenin pathway, sporadic desmoid tumors are associated with somatic mutations of CT...

journal_title：Current opinion in oncology

authors： Penel N,Chibon F,Salas S

更新日期：2017-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize major recent findings on the biology of human herpesvirus-8, i.e. Kaposi's sarcoma-associated herpesvirus, and the implications of these findings for Kaposi's sarcoma treatment. RECENT FINDINGS:Although reduced in incidence in developed countries since the introduction of highly active a...

journal_title：Current opinion in oncology

authors： Dittmer DP,Krown SE

更新日期：2007-09-01 00:00:00

abstract：:Obstruction of the superior vena cava is seldom a true emergency and should not be treated without an adequate tissue diagnosis. For patients who are poor operative risks for invasive procedures, percutaneous biopsies of mediastinal masses under ultrasound guidance have resulted in a high diagnostic yield. Superior ve...

journal_title：Current opinion in oncology

authors： Shepherd FA

更新日期：1995-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The recent contributions to renal cell carcinoma in the fields of molecular biology and the expanded use of molecularly targeted agents will be reviewed. This study is intended to update prognostic and therapeutic decision-making data and provide perspective on advances in understanding the molecular ...

journal_title：Current opinion in oncology

authors： Rini BI,Rathmell WK,Godley P

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The management of febrile neutropenia has evolved significantly with the development of risk stratification and recognition of the efficacy of oral antibiotics in low-risk patients. There remains uncertainty concerning the need for hospitalization and role of early hospital discharge. We review recent...

journal_title：Current opinion in oncology

authors： Innes H,Marshall E

更新日期：2007-07-01 00:00:00

abstract：:Disease-free survival for patients with small sarcomas of bone has been impressively improved with the use of intensive combination chemotherapy and safe local control with surgery or radiation. The ability of monoclonal antibodies to recognize different antigens has allowed new insights into the histogenesis and has ...

journal_title：Current opinion in oncology

authors： Jürgens HF

更新日期：1994-07-01 00:00:00

abstract：:The incidence of lung cancer continues to rise. The need and demand for more effective treatment to improve survival and palliate symptoms increases at a great rate. The most recent evidence for the use of chemotherapy in the palliative setting is summarized in this review of the literature from the last few years. It...

journal_title：Current opinion in oncology

authors： Medley L,Cullen M

更新日期：2002-07-01 00:00:00

abstract：:During the past year there have been a number of important advances in the area of systemic therapy for breast cancer. Combined chemoendocrine therapy has been shown to be more effective than tamoxifen alone in the adjuvant therapy of node-negative estrogen receptor-positive breast cancer. Preliminary results of a ran...

journal_title：Current opinion in oncology

authors： Dees EC,Kennedy MJ

更新日期：1998-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Current treatment modalities provide limited improvement in the natural course of lung cancer, and prognosis remains poor. Lung cancer is a malignancy with great molecular heterogeneity. The complexity of the signalling process leading to cancer cell proliferation and to the neoplastic phenotype suppo...

journal_title：Current opinion in oncology

authors： Cascone T,Gridelli C,Ciardiello F

更新日期：2007-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Tumor stroma is composed of many cellular subtypes, of which the most abundant are fibroblasts, macrophages and endothelial cells. During the process of tissue injury, these three cellular subtypes must coordinate their activity to efficiently contribute to tissue regeneration. In tumor, this mechanis...

journal_title：Current opinion in oncology

authors： Ronca R,Van Ginderachter JA,Turtoi A

更新日期：2018-01-01 00:00:00

abstract：:Collaborative study groups have invested considerable effort in the last decade in defining the role of allogeneic and autologous bone marrow transplantation as consolidation treatment for first remission of acute myeloid leukemia in younger patients. These efforts have been able, more precisely, to quantitate the deg...

journal_title：Current opinion in oncology

authors： Burnett AK,Kell J

更新日期：2000-03-01 00:00:00

abstract：PURPOSE OF REVIEW:An overview of many of the preclinical and clinical developments in germ cell tumors over the past year is presented. RECENT FINDINGS:Recent epidemiologic studies show changes in the ethnic incidence of germ cell tumors; in particular, African-Americans have seen an increase. Additionally, risk facto...

journal_title：Current opinion in oncology

authors： Bridges B,Hussain A

更新日期：2006-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this study is to update the reader on advances in postpubertal male germ cell tumours (GCTs) over the last 18 months. RECENT FINDINGS:Single nucleotide polymorphisms, including in four sex-determination genes, have been identified as additional genetic susceptibility loci to testicular...

journal_title：Current opinion in oncology

authors： Feldman DR

更新日期：2015-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Cutaneous squamous cell carcinoma (cSCC) is a highly prevalent malignancy frequently occurring on body surfaces chronically exposed to ultraviolet radiation. While a large majority of tumors remain localized to the skin and immediate subcutaneous tissue and are cured with surgical excision, a small su...

journal_title：Current opinion in oncology

authors： Mulvaney PM,Schmults CD

更新日期：2020-03-01 00:00:00

abstract：:In this review, recent advances in the clinical therapy of osteosarcoma, including results from the European Osteosarcoma Intergroup trial demonstrating the efficacy of a short intensive two drug protocol are discussed as well the evolving role of ifosfamide. Biologically, the area of interest on chromosome 3q, which ...

journal_title：Current opinion in oncology

authors： Himelstein BP

更新日期：1998-07-01 00:00:00