The type II transforming growth factor-beta receptor as a tumor-suppressor gene.

Abstract:

:Recent work has shown that: 1) loss of transforming growth factor-beta response is associated with malignant progression, 2) maintenance of autocrine negative transforming growth factor-beta activity is a key impediment to malignant progression, and 3) the major mechanism for loss of RII expression in replication error-positive colorectal cancer patients is mutation of the poly A tract of the transforming growth factor-beta receptor type II (RII) gene resulting in the generation of a premature STOP codon. Major issues for the role of RII in cancer are identified as the determination of the penetrance of mechanisms of RII loss in non-replication error tumors and other types of malignancies in addition to colon cancer. Analysis of mechanism of RII loss may prove to have clinical use in defining the clinical course of subset of different types of malignancies and, in addition, it may result in the identification of new therapeutic targets and approaches for some subsets of cancers.

journal_name

Curr Opin Oncol

authors

Brattain MG,Markowitz SD,Willson JK

doi

10.1097/00001622-199601000-00009

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

49-53

issue

1

eissn

1040-8746

issn

1531-703X

journal_volume

8

pub_type

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