Abstract:
:Recent work has shown that: 1) loss of transforming growth factor-beta response is associated with malignant progression, 2) maintenance of autocrine negative transforming growth factor-beta activity is a key impediment to malignant progression, and 3) the major mechanism for loss of RII expression in replication error-positive colorectal cancer patients is mutation of the poly A tract of the transforming growth factor-beta receptor type II (RII) gene resulting in the generation of a premature STOP codon. Major issues for the role of RII in cancer are identified as the determination of the penetrance of mechanisms of RII loss in non-replication error tumors and other types of malignancies in addition to colon cancer. Analysis of mechanism of RII loss may prove to have clinical use in defining the clinical course of subset of different types of malignancies and, in addition, it may result in the identification of new therapeutic targets and approaches for some subsets of cancers.
journal_name
Curr Opin Oncoljournal_title
Current opinion in oncologyauthors
Brattain MG,Markowitz SD,Willson JKdoi
10.1097/00001622-199601000-00009subject
Has Abstractpub_date
1996-01-01 00:00:00pages
49-53issue
1eissn
1040-8746issn
1531-703Xjournal_volume
8pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:To provide examples of mitochondria-specific metabolic events that influence tumor cell biology, and of metabolism-related mitochondrial biomarkers and therapeutic targets in cancer cells. RECENT FINDINGS:Cancer cell mitochondria are rewired to optimally serve the cancer cell under various conditions...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000336
更新日期:2017-01-01 00:00:00
abstract::Despite its appeal, lung cancer screening has been found to be of little value at this time. However, use of monoclonal antibodies to detect cancer cells in the sputum may prove to be of value in high-risk subjects. Once a cancer is diagnosed, anatomic staging by the International TNM Staging System has shown its effe...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199104000-00010
更新日期:1991-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Mantle cell lymphoma is an aggressive non-Hodgkin's lymphoma characterized by the t(11;14) chromosomal translocation and overexpression of cyclin D1. Constituting approximately 5 to 8% of all non-Hodgkin's lymphomas, it carries the poorest prognosis among non-Hodgkin's lymphoma subtypes. Standard and ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/01.cco.0000174039.69656.2b
更新日期:2005-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Ovarian germ cell tumours are rare, but curable at all stages of disease. This review gives an outline of the main controversies regarding the management of this disease. RECENT FINDINGS:Pelvic malignancies are very rare during pregnancy, which should avoid the need for radical surgery or termination...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/01.cco.0000239891.44031.38
更新日期:2006-09-01 00:00:00
abstract::The management of tumors arising from or, by extension, involving the skull base is complex due to the density and sensitivity of nearby neurovascular structures, the proximity of these structures to the relatively contaminated spaces of the paranasal sinuses or ear and mastoid, the varied pathologic entities encounte...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199505000-00002
更新日期:1995-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The last decade has seen a paradigm change in that tumor stroma contributes to malignant tumor progression in a manner comparable to genetic and epigenetic changes within cancer cells. This review summarizes recent novel insights into how inflammatory conditions stimulate the formation and expansion o...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e32831bed7e
更新日期:2009-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The objective of the sentinel lymph node procedure in breast cancer is to perform an accurate axillary staging and provide good local control, while sparing the patients the morbidity of an axillary lymph node dissection. Since its routine clinical use, questions were raised concerning the implication...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/01.cco.0000183542.63675.66
更新日期:2005-11-01 00:00:00
abstract::Myelodysplasia or myelodysplastic syndromes represent a heterogeneous group of bone marrow disorders characterized by dysmaturation, cytopenias, and a propensity for leukemic transformation. Although universally adopted, the French-American-British classification still has several limitations and an inability to categ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199401000-00005
更新日期:1994-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Several epidemiologic studies have enhanced our understanding of the impact of respiratory viruses on bone marrow transplant recipients. RECENT FINDINGS:Respiratory viral infections occur frequently following stem cell transplantation but present atypically. Many patients have asymptomatic infections...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e328324bc1c
更新日期:2009-03-01 00:00:00
abstract::Approximately 1 in 10 US women will be diagnosed with breast cancer in her lifetime. With such a high incidence, breast cancer is a serious health concern for all American women. Within the past year, clues about the function of genes associated with breast cancer have been garnered, and novel genes that may contribut...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200011000-00002
更新日期:2000-11-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews the recent advancements and refinements of the sentinel lymph node (SLN) biopsy technique in breast cancer. RECENT FINDINGS:Data from four randomized controlled trials conclusively demonstrate that SLN biopsy is associated with less arm morbidity and better quality of life than a...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e328315ef1d
更新日期:2008-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Most patients affected by lung cancer are treated with chemotherapy, and hence are at risk of myelosuppression. Hematopoietic growth factors have a relevant role in this setting, as they can improve quality of life, reduce the rate of chemotherapy-induced complications and allow the administration of ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000268
更新日期:2016-03-01 00:00:00
abstract::Obstruction of the superior vena cava is seldom a true emergency and should not be treated without an adequate tissue diagnosis. For patients who are poor operative risks for invasive procedures, percutaneous biopsies of mediastinal masses under ultrasound guidance have resulted in a high diagnostic yield. Superior ve...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199503000-00010
更新日期:1995-03-01 00:00:00
abstract::The prognosis of pediatric low-grade gliomas is relatively favorable, but residual or unresectable tumors remain a challenge. Conventional radiation therapy is effective but may be associated with unacceptable sequelae in young children. Chemotherapy can delay the need for radiation therapy in young children; however,...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200005000-00002
更新日期:2000-05-01 00:00:00
abstract::Malignant melanoma is a tumor that offers unique possibilities for approaches to targeted therapy by virtue of the pigment biosynthesis pathway. Such approaches may seek to use the incorporation of toxic intermediates or to use the natural transcriptional control of genes coding for enzymes involved in melanin formati...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199403000-00016
更新日期:1994-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this article will be to review neuroendocrine tumours (NETs) of the gynaecological tract. NETs are generally considered to be uncommon and primary tumours in the gynaecological tract on arrival rare or very rare. It is important to distinguish true primary tumours from metastatic as the...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000321
更新日期:2016-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe the state-of-the-art of the surgical management of stage IIIA-N2 nonsmall cell lung cancer. RECENT FINDINGS:When completely resected, occult N2 found at thoracotomy, skip metastases, and single-level N2 in selected locations are reported to portend acceptable survival rates. Conversely, p...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e3283210476
更新日期:2009-03-01 00:00:00
abstract::Pleural effusions are a common development in patients with cancer. The optimal means of control are not defined, but systemic treatment is often effective in patients with drug-sensitive tumors. Local treatments advocated in the management of malignant pleural effusions differ in the means of drainage, the length of ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199208000-00007
更新日期:1992-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Childhood blastomas, unlike adult cancers, originate from developing organs in which molecular and cellular features exhibit differentiation arrest and embryonic characteristics. Conventional cancer therapies, which rely on the generalized cytotoxic effect on rapidly dividing cells, may damage delicat...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000504
更新日期:2019-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Human immunodeficiency virus infection is associated with an increased risk of non-Hodgkin lymphoma. Even with a decrease in AIDS-defining illnesses after the advent of highly active antiretroviral therapy, HIV-associated non-Hodgkin lymphoma remains an important problem. RECENT FINDINGS:Low CD4+ T-l...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/01.cco.0000239881.16216.05
更新日期:2006-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Preclinical and clinical developments in germ cell tumors over the past year are summarized. RECENT FINDINGS:Attenuations in the rising incidence of testicular germ cell tumors are beginning to be observed in certain European populations. Additional data on predisposing factors related to race, estro...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e3280ad43df
更新日期:2007-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The possibility of complete recovery for a lung cancer patient depends on very early diagnosis, as it allows total surgical resection. Screening for this cancer in a high-risk population can be performed using a radiological approach, but this holds a certain number of limitations. Liquid biopsy could...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000343
更新日期:2017-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Oral mucositis remains a frequent debilitating toxicity associated with drug and radiation regimens used to treat cancer. This review highlights the recent understanding of the biological basis, risk factors for, and management for oral mucositis. RECENT FINDINGS:Prevalence and incidence data for muc...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000180
更新日期:2015-05-01 00:00:00
abstract::The behavior of renal cell carcinoma remains one of the most unpredictable of the genitourinary neoplasms. Once this disease has spread beyond the confines of the kidney, it is extremely difficult to control. This year, emphasis has focused on the characteristic cytogenetic and chromosomal changes that are seen in thi...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199206000-00002
更新日期:1992-06-01 00:00:00
abstract::Over the past year, several research areas have been noteworthy. This article discusses decision making related to breast cancer treatment, the effects of treatment on measures of psychological distress, and studies related to quality-of-life among breast cancer patients. In addition, an area of continued interest inv...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199311000-00008
更新日期:1993-11-01 00:00:00
abstract::The biologic and clinical heterogeneity of lymphomas represents the major obstacle to their diagnosis. Because histologic analysis, which is the initial diagnostic approach, has been demonstrated to be insufficient in the definition of certain types of lymphomas, molecular and immunologic techniques have been increasi...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199609000-00002
更新日期:1996-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Relapse has become the leading cause of death following allogeneic hematopoietic stem cell transplantation (HSCT). Despite improved understanding of the biology that underlies the graft-versus-leukemia/tumor effect the relapse rate did not decrease over the past 20 years. In general, prognosis is poor...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e328342c6c8
更新日期:2011-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To discuss the recent developments of multimodal treatment for patients with local advanced rectal cancer, including incorporation of new chemotherapeutic and targeted agents, and the optimal sequence and timing of treatment components. RECENT FINDINGS:Five randomized trials have been completed to de...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e328352ea02
更新日期:2012-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Chemotherapy is a cornerstone treatment in patients with early breast cancer. Although some cancer cell-related predictors are emerging, the indications of chemotherapy and the choice of chemotherapy regimen are not individualized enough, emphasizing the need for new predictors. This review will summa...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e32833fb384
更新日期:2010-11-01 00:00:00
abstract::The development of new chemotherapeutic agents for cancer treatment is pursued with the hope of finding compounds with novel chemical characteristics, unique mechanisms of action, and with improved therapeutic indexes. Seven novel agents at different stages of clinical development have been selected for review. D1694 ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199112000-00011
更新日期:1991-12-01 00:00:00