Abstract:
PURPOSE OF REVIEW:Gastrointestinal stromal tumour patients with exon 9 KIT mutations have a worse outcome, but progression-free survival is improved by treatment with imatinib 800 mg daily. This review looks at the evidence and asks whether this should be standard treatment from diagnosis. RECENT FINDINGS:The phase III trial in advanced gastrointestinal stromal tumour, EORTC 62005, demonstrated increased progression-free survival for imatinib 800 mg daily versus 400 mg. Mutational analysis showed the benefit was primarily due to patients with exon 9 mutations. A meta-analysis has confirmed this finding. Patients who progress on standard dose imatinib may also experience disease stabilization. The significance of this in relation to data on pharmacokinetics and secondary mutations will be discussed. SUMMARY:Mutational analysis of KIT and PDGFRA should ideally be performed in all patients with advanced gastrointestinal stromal tumour. Patients with mutations in exon 9 of KIT should be considered for treatment with imatinib 800 mg daily, but current data do not indicate whether there is a survival advantage for immediate treatment at 800 mg. There still appears to be a role for the higher dose in patients progressing after an initial response to the standard dose therapy.
journal_name
Curr Opin Oncoljournal_title
Current opinion in oncologyauthors
Judson Idoi
10.1097/CCO.0b013e328302ed96subject
Has Abstractpub_date
2008-07-01 00:00:00pages
433-7issue
4eissn
1040-8746issn
1531-703Xpii
00001622-200807000-00015journal_volume
20pub_type
杂志文章,评审abstract::The search for effective adjuvant therapy for melanoma has resulted in the testing of a remarkably broad spectrum of therapeutic agents. Until recently, there was little evidence to suggest a benefit for any adjuvant therapy. The demonstration of activity for adjuvant high-dose interferon alfa in a cooperative group t...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199703000-00015
更新日期:1997-03-01 00:00:00
abstract::A review of the recent literature about liver cancers shows the increasing role of hepatitis C as a risk factor for the development of hepatocellular carcinoma. A new discussion has arisen with regard to the association between the use of oral contraceptives and hepatocellular carcinoma. Patients at risk for developin...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199507000-00017
更新日期:1995-07-01 00:00:00
abstract::The management of tumors arising from or, by extension, involving the skull base is complex due to the density and sensitivity of nearby neurovascular structures, the proximity of these structures to the relatively contaminated spaces of the paranasal sinuses or ear and mastoid, the varied pathologic entities encounte...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199505000-00002
更新日期:1995-05-01 00:00:00
abstract:PURPOSE OF REVIEW:To review recent observations that describe changes in the likelihood of invasive fungal infections, shifts in types of fungal pathogens, and altered manifestations of fungal syndromes after hematopoietic cell transplantation and explore how changes in transplant practices are influencing these epidem...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/01.cco.0000152975.65477.7c
更新日期:2005-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Tumor stroma is composed of many cellular subtypes, of which the most abundant are fibroblasts, macrophages and endothelial cells. During the process of tissue injury, these three cellular subtypes must coordinate their activity to efficiently contribute to tissue regeneration. In tumor, this mechanis...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000420
更新日期:2018-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The possibility of complete recovery for a lung cancer patient depends on very early diagnosis, as it allows total surgical resection. Screening for this cancer in a high-risk population can be performed using a radiological approach, but this holds a certain number of limitations. Liquid biopsy could...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000343
更新日期:2017-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The p53 tumor suppressor is a master regulator of antitumor defenses through its control of growth arrest, senescence and apoptosis. In recent years, p53 regulation was found to extend to a variety of biological processes including autophagy, fertility, metabolism and immune responses. Here, we focus ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e32835b6386
更新日期:2013-01-01 00:00:00
abstract::Renal cell carcinoma remains a devastating disease known for insidious onset, with patients often having advanced incurable disease at the time of diagnosis. Biologic therapy with IL-2 offers a chance for prolonged remission for a minority of patients, but its toxicities preclude most patients from ever receiving it. ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199505000-00013
更新日期:1995-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Concept of refractory coeliac disease (RCD) emerged in the past decade and refers to persistence of malnutrition and intestinal villous atrophy for more than 1 year strict gluten-free diet in coeliac patients. Diagnosis of this condition remains difficult and conditions treatment and follow-up. RECEN...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/01.cco.0000432526.47228.b6
更新日期:2013-09-01 00:00:00
abstract::Seroepidemiologic studies show that Kaposi's sarcoma herpesvirus (KSHV) is more prevalent in those populations at higher risk to develop Kaposi's sarcoma (KS). Anti-KSHV antibody titer is also higher in those who develop KS. KSHV is a sexually transmitted disease among homosexual men, but other routes of transmission ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199809000-00007
更新日期:1998-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Despite remarkable advances in the treatment of non-Hodgkin's lymphoma of all histologic subtypes, nervous system involvement remains a dire complication associated with a rapid decline in quality of life, few good treatment options, and a short overall survival. In fact, these advances in treatment m...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e32830b829e
更新日期:2008-09-01 00:00:00
abstract::Less than 1% of all cancers are present in the thyroid, yet thyroid nodules are found in 4 to 10% of the adult population. Because thyroid nodules are relatively common, the diagnostic dilemma is to distinguish between a more common benign nodule, which usually does not require specific treatment, and a malignant nodu...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200201000-00009
更新日期:2002-01-01 00:00:00
abstract::Recent work has shown that: 1) loss of transforming growth factor-beta response is associated with malignant progression, 2) maintenance of autocrine negative transforming growth factor-beta activity is a key impediment to malignant progression, and 3) the major mechanism for loss of RII expression in replication erro...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199601000-00009
更新日期:1996-01-01 00:00:00
abstract:PURPOSE OF REVIEW:A number of clinical trials are currently testing chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered T cells for the treatment of haematologic malignancies and selected solid tumours, and CD19-CAR-T cells have produced impressive clinical responses in B-cell malignancies. Here, we su...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000664
更新日期:2020-09-01 00:00:00
abstract::Over the past year, a number of important papers have appeared in the medical literature dealing with the chemotherapeutic management of gynecologic cancers. Among these papers, several studies have again demonstrated the superiority of platinum-based chemotherapy regimens for ovarian cancer compared with non-platinum...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199210000-00019
更新日期:1992-10-01 00:00:00
abstract:PURPOSE OF REVIEW:We aimed to summarize the recent reflections and collaborative initiatives pertaining to the definition of more appropriate eligibility criteria in cancer clinical trials. RECENT FINDINGS:There is an intrinsic tension between two opposite purposes when it comes to defining eligibility criteria: on th...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000470
更新日期:2018-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDLs) are one of the more frequent mesenchymal neoplasms and are characterized by specific chromosome aberrations: supernumerary chromosome or giant marker chromosome or both. Extra copies of known oncogenes such as MDM2, CDK4, SAS, HMGA...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/01.cco.0000127878.85125.53
更新日期:2004-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The management of febrile neutropenia has evolved significantly with the development of risk stratification and recognition of the efficacy of oral antibiotics in low-risk patients. There remains uncertainty concerning the need for hospitalization and role of early hospital discharge. We review recent...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e3281214436
更新日期:2007-07-01 00:00:00
abstract:PURPOSE OF REVIEW:We summarize the concept of a locally advanced basal cell carcinoma (laBCC) and present the current consensus definition. We also review the key pieces of primary research undertaken in the past year and how these affect the use of smoothened inhibitors in a clinical setting. RECENT FINDINGS:Medium t...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000259
更新日期:2016-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The advent of immunotherapy significantly improved clinical outcomes in cancer patients, although immune checkpoint blockade (ICB) still lack of efficacy in a consistent proportion of treated patients. The purpose of this article is to review the most innovative and clinically promising ICB-based comb...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000466
更新日期:2018-09-01 00:00:00
abstract::Graft-versus-host disease (GVHD) continues to be a major obstacle to the success of allogeneic bone marrow transplantation. Furthermore, several clinical strategies being employed at this time in the field of bone marrow transplantation have had an impact on GVHD. In addition to the usual division of topics such as pa...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199703000-00005
更新日期:1997-03-01 00:00:00
abstract::In the past decade, the discovery of tumor antigens recognized by T cells has revolutionized the tumor vaccine field. The appreciation that peptides are bound to and restricted by major histocompatibility class I and II molecules for immune recognition has encouraged a number of early-phase clinical trials of peptide ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200103000-00007
更新日期:2001-03-01 00:00:00
abstract:PURPOSE OF REVIEW:This article reviews the most recent developments and implications in regard to isocitrate dehydrogenase mutations in chondrosarcoma, a disease in which currently available systemic therapies have proven inefficacious, with an emphasis on how disruption in normal cellular metabolism plays a role in on...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000092
更新日期:2014-07-01 00:00:00
abstract::A better understanding of the immunobiology after transplantation and of the available recombinant cytokines that enhance hematopoietic reconstitution following autologous and allogeneic bone marrow transplantation is likely to result in safer application of bone marrow transplantation. Residual tumor cells escaping c...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199104000-00005
更新日期:1991-04-01 00:00:00
abstract:PURPOSE OF REVIEW:To discuss the recent developments of multimodal treatment for patients with local advanced rectal cancer, including incorporation of new chemotherapeutic and targeted agents, and the optimal sequence and timing of treatment components. RECENT FINDINGS:Five randomized trials have been completed to de...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e328352ea02
更新日期:2012-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Salivary gland malignancies are a rare and heterogeneous group of tumors with considerable variability in their natural history. Historically they have been treated with surgery and radiation therapy. It is only recently that there has been any growth in our understanding of these diseases and their m...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e328344f59c
更新日期:2011-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Early trials of high-dose therapy with autologous stem cell transplantation in mantle cell lymphoma were discouraging, with no clear survival advantage attributable to the procedure. Most early series were plagued by small numbers, retrospective designs, and short follow-up. Also, until recently, allo...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200403000-00004
更新日期:2004-03-01 00:00:00
abstract::The correct use of tumor markers in patients with gynecological cancers can make an impact on management of the disease. Their value in screening for ovarian cancer cannot be recommended outside trials. Increased levels of various markers give prognostic information that could alter therapy for patients with early ova...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199609000-00015
更新日期:1996-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe recent advances in the diagnosis and treatment of paraneoplastic neurological syndromes (PNS). RECENT FINDINGS:PNS are rare complications of cancer caused by an immune cross-reaction between antigens expressed by tumor cells and neurons. The target of the immune attack can be an intracell...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000479
更新日期:2018-11-01 00:00:00
abstract::Chronic myelogenous leukemia (CML) is a hematologic malignancy characterized by an initial chronic phase of expanded clonal myelopoiesis followed by inevitable progression to accelerated phase and finally to fatal blast crisis. Although interferon therapy results in hematologic control of disease in most patients and ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199803000-00003
更新日期:1998-03-01 00:00:00