Bone marrow transplantation for chronic myelogenous leukemia.

abstract：PURPOSE OF REVIEW:Human immunodeficiency virus infection is associated with an increased risk of non-Hodgkin lymphoma. Even with a decrease in AIDS-defining illnesses after the advent of highly active antiretroviral therapy, HIV-associated non-Hodgkin lymphoma remains an important problem. RECENT FINDINGS:Low CD4+ T-l...

journal_title：Current opinion in oncology

authors： Behler CM,Kaplan LD

更新日期：2006-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Gallbladder carcinoma (GBC), classified as a biliary tract cancer (BTC) along with intrahepatic and extrahepatic cholangiocarcinomas, is a rare disease in Western countries, but a highly prevalent disease in Chile, other countries in Latin America, India and Japan. It commonly presents at an advanced ...

journal_title：Current opinion in oncology

authors： McNamara MG,Metran-Nascente C,Knox JJ

更新日期：2013-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Small bowel adenocarcinoma (SBA) is a rare cancer with a poor prognosis and little information to guide its management. In recent years, improved diagnostic imaging and an increase in reported experience with use of chemotherapy may alter the way we manage SBA. This review will summarize recent advanc...

journal_title：Current opinion in oncology

authors： Speranza G,Doroshow JH,Kummar S

更新日期：2010-07-01 00:00:00

abstract：:Although early clinical gene therapy trials for recurrent central nervous system neoplasms showed the proof-of-principle, they did not fulfill the high expectations suggested by the preclinical experimental data. Insufficient distribution of vectors in human brain tumors and very low transduction efficiency require th...

journal_title：Current opinion in oncology

authors： Weyerbrock A,Oldfield EH

更新日期：1999-05-01 00:00:00

abstract：PURPOSE OF REVIEW:(18)F-fluoro-2-deoxy-D-glucose PET-computed tomography (CT) has a major clinical impact in oncology not only for diagnostics but also for staging, response assessment, and relapse detection. However, several other PET tracers are needed for a more complete molecular characterization of cancers which h...

journal_title：Current opinion in oncology

authors： Garcia C,Gebhart G,Flamen P

更新日期：2012-11-01 00:00:00

abstract：:This review highlights recent advances in understanding the mode of action of retinoids at the level of molecular and cellular biology in relation to the new clinical results achieved with retinoids in various malignancies. All-trans-retinoic acid has been established in the clinic as a first-line differentiation ther...

journal_title：Current opinion in oncology

authors： Holdener EE,Bollag W

更新日期：1993-11-01 00:00:00

abstract：:Recent efforts have been directed at identifying and characterizing candidate tumor suppressor genes and the activities of oncogenes in primary brain tumors. The p53 gene mapping to region p13 of chromosome 17 has several characteristics as a tumor suppressor gene. The wild-type p53 protein, which is a transcriptional...

journal_title：Current opinion in oncology

authors： Steck PA,Saya H

更新日期：1991-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this study is to update the reader on advances in postpubertal male germ cell tumours (GCTs) over the last 18 months. RECENT FINDINGS:Single nucleotide polymorphisms, including in four sex-determination genes, have been identified as additional genetic susceptibility loci to testicular...

journal_title：Current opinion in oncology

authors： Feldman DR

更新日期：2015-05-01 00:00:00

abstract：PURPOSE OF REVIEW:We aimed to summarize the recent reflections and collaborative initiatives pertaining to the definition of more appropriate eligibility criteria in cancer clinical trials. RECENT FINDINGS:There is an intrinsic tension between two opposite purposes when it comes to defining eligibility criteria: on th...

journal_title：Current opinion in oncology

authors： Penel N,Lebellec L,Vanseymortier M

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Cutaneous squamous cell carcinoma (cSCC) is a highly prevalent malignancy frequently occurring on body surfaces chronically exposed to ultraviolet radiation. While a large majority of tumors remain localized to the skin and immediate subcutaneous tissue and are cured with surgical excision, a small su...

journal_title：Current opinion in oncology

authors： Mulvaney PM,Schmults CD

更新日期：2020-03-01 00:00:00

abstract：:The bcr-abl fusion protein is present in the vast majority of cases of chronic myelogenous leukemia, and the deregulated tyrosine kinase activity of this protein is essential for leukemic transformation. Thus, bcr-abl is an ideal target for pharmacologic inhibition. In preclinical studies, ST1571 (formerly CGP57148B),...

journal_title：Current opinion in oncology

authors： O'Dwyer ME,Druker BJ

更新日期：2000-11-01 00:00:00

abstract：:Disease-free survival for patients with small sarcomas of bone has been impressively improved with the use of intensive combination chemotherapy and safe local control with surgery or radiation. The ability of monoclonal antibodies to recognize different antigens has allowed new insights into the histogenesis and has ...

journal_title：Current opinion in oncology

authors： Jürgens HF

更新日期：1994-07-01 00:00:00

abstract：:Breast cancer is a leading women's health issue. Continued advances in understanding the temporal sequencing of relevant exposures promises to shed light on the continuum of breast carcinogenesis. Oral contraceptive use and the transient increase in risk following childbirth are exposures that affect the near-term ris...

journal_title：Current opinion in oncology

authors： Alberg AJ,Helzlsouer KJ

更新日期：1997-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Preclinical and clinical developments in germ cell tumors over the past year are summarized. RECENT FINDINGS:Attenuations in the rising incidence of testicular germ cell tumors are beginning to be observed in certain European populations. Additional data on predisposing factors related to race, estro...

journal_title：Current opinion in oncology

authors： Bridges B,Hussain A

更新日期：2007-05-01 00:00:00

abstract：:Tyrosine kinase (type 1) growth factor receptors include the erbB family. These cell surface receptors were discovered in the context of cellular transformation and have subsequently been found to be overexpressed in many types of human cancer. Cumulative evidence suggests that upregulation of the most well-characteri...

journal_title：Current opinion in oncology

authors： Lango MN,Shin DM,Grandis JR

更新日期：2001-05-01 00:00:00

abstract：:Pleural effusions are a common development in patients with cancer. The optimal means of control are not defined, but systemic treatment is often effective in patients with drug-sensitive tumors. Local treatments advocated in the management of malignant pleural effusions differ in the means of drainage, the length of ...

journal_title：Current opinion in oncology

authors： Tattersall M

更新日期：1992-08-01 00:00:00

abstract：:Contrary to the case with bacterial infections, progress in the diagnosis and treatment of invasive mycoses in cancer patients has been unsatisfactory. Amphotericin B deoxycholate has remained the drug of choice for severe invasive fungal infections for nearly 40 years. However, its infusion-related side effects, as w...

journal_title：Current opinion in oncology

authors： Martino P,Girmenia C

更新日期：1997-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past 20 years, tremendous strides have been made to decrease treatment-related morbidity and mortality following allogeneic transplant, including management of acute and chronic lung injury. Within this context, three distinct entities are recognized, idiopathic pneumonia syndrome (IPS), bron...

journal_title：Current opinion in oncology

authors： Yanik G,Kitko C

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:T-cell lymphomas (TCL) represent a particularly poor prognosis subgroup of lymphomas. The goal of this review is to provide emerging information on one agent demonstrating activity in these challenging diseases. Pralatrexate is a novel antifolate designed to have high affinity for the reduced folate c...

journal_title：Current opinion in oncology

authors： O'Connor OA

更新日期：2006-11-01 00:00:00

abstract：:The behavior of renal cell carcinoma remains one of the most unpredictable of the genitourinary neoplasms. Once this disease has spread beyond the confines of the kidney, it is extremely difficult to control. This year, emphasis has focused on the characteristic cytogenetic and chromosomal changes that are seen in thi...

journal_title：Current opinion in oncology

authors： Reese JH

更新日期：1992-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Most patients affected by lung cancer are treated with chemotherapy, and hence are at risk of myelosuppression. Hematopoietic growth factors have a relevant role in this setting, as they can improve quality of life, reduce the rate of chemotherapy-induced complications and allow the administration of ...

journal_title：Current opinion in oncology

authors： Genova C,Rijavec E,Grossi F

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the 2008-2009 literature on pediatric genitourinary tumors and highlight the most significant publications. RECENT FINDINGS:New techniques such as gene expression profiling, PET, nephron-sparing surgery, and stem cell transplantation are being incorporated into contemporary treatments for p...

journal_title：Current opinion in oncology

authors： McLean TW,Buckley KS

更新日期：2010-05-01 00:00:00

abstract：:The prognosis of pediatric low-grade gliomas is relatively favorable, but residual or unresectable tumors remain a challenge. Conventional radiation therapy is effective but may be associated with unacceptable sequelae in young children. Chemotherapy can delay the need for radiation therapy in young children; however,...

journal_title：Current opinion in oncology

authors： Schmandt SM,Packer RJ

更新日期：2000-05-01 00:00:00

abstract：:The identification of new active agents for the treatment of squamous carcinoma of the head and neck remains a high priority for clinical investigators. For the past several years a number of investigational drugs have demonstrated activity in patients with recurrent or metastatic disease. Included are the following a...

journal_title：Current opinion in oncology

authors： Murphy BA

更新日期：1996-05-01 00:00:00

abstract：:The prophylactic or pre-emptive approach should help to restrict use of antibiotics and lead to better management of infection. It is clear that if effective pre-emptive therapy is available (be it as prophylaxis), the empiric additions of other agents should be taken into account and tailored accordingly. On the othe...

journal_title：Current opinion in oncology

authors： Klastersky J

更新日期：1996-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To review recent observations that describe changes in the likelihood of invasive fungal infections, shifts in types of fungal pathogens, and altered manifestations of fungal syndromes after hematopoietic cell transplantation and explore how changes in transplant practices are influencing these epidem...

journal_title：Current opinion in oncology

authors： Wingard JR

更新日期：2005-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on the surgical management of soft tissue sarcomas of the hands and the feet. With recent advances in limb salvage surgery and radiotherapy delivery, local control of soft tissue sarcoma in the extremity has become optimized, and the associated functional results of this treatment ...

journal_title：Current opinion in oncology

authors： Ferguson PC

更新日期：2005-07-01 00:00:00

abstract：:Recent studies are refining the treatment approaches of radiation therapy and combination chemotherapy in Hodgkin's disease. In early-stage disease, attempts are being made to lessen the toxicity of treatment while maintaining excellent results. Optimal results are achieved in advanced disease with combined radiation ...

journal_title：Current opinion in oncology

authors： Straus DJ

更新日期：1993-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The management of febrile neutropenia has evolved significantly with the development of risk stratification and recognition of the efficacy of oral antibiotics in low-risk patients. There remains uncertainty concerning the need for hospitalization and role of early hospital discharge. We review recent...

journal_title：Current opinion in oncology

authors： Innes H,Marshall E

更新日期：2007-07-01 00:00:00

abstract：:Prophylactic platelet transfusion can prevent spontaneous hemorrhage in thrombocytopenic cancer patients undergoing intensive treatment, but it is limited by the development of platelet alloimmunization. Exclusive use of leukocyte-depleted blood products delays or prevents the development of platelet alloimmunization ...

journal_title：Current opinion in oncology

authors： Wallerstein R Jr,Deisseroth AB

更新日期：1991-08-01 00:00:00