Status of bcr-abl tyrosine kinase inhibitors in chronic myelogenous leukemia.

abstract：:The biologic and clinical heterogeneity of lymphomas represents the major obstacle to their diagnosis. Because histologic analysis, which is the initial diagnostic approach, has been demonstrated to be insufficient in the definition of certain types of lymphomas, molecular and immunologic techniques have been increasi...

journal_title：Current opinion in oncology

authors： Veronese ML,Schichman SA,Croce CM

更新日期：1996-09-01 00:00:00

abstract：PURPOSE OF REVIEW:In the past few years, the advent of PARP inhibitors has been a revolution in the management of ovarian cancer. Patients harboring somatic or germ line BRCA1/2 mutations exhibit different clinical and treatment response behavior. The BRCA gene is involved in repairing DNA repair via homologous recombi...

journal_title：Current opinion in oncology

authors： Vanacker H,Romeo C,Ray-Coquard I

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:A small percentage of gliomas are caused by inheritance in cancer syndromes but there is also a general familial aggregation of glioma. Recently, low penetrant genes associated with glioma risk have been identified. RECENT FINDINGS:Seven independent chromosomal loci have robustly been associated with...

journal_title：Current opinion in oncology

authors： Melin B

更新日期：2011-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the state-of-the-art of the surgical management of stage IIIA-N2 nonsmall cell lung cancer. RECENT FINDINGS:When completely resected, occult N2 found at thoracotomy, skip metastases, and single-level N2 in selected locations are reported to portend acceptable survival rates. Conversely, p...

journal_title：Current opinion in oncology

authors： Rocco G

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Ovarian germ cell tumours are rare, but curable at all stages of disease. This review gives an outline of the main controversies regarding the management of this disease. RECENT FINDINGS:Pelvic malignancies are very rare during pregnancy, which should avoid the need for radical surgery or termination...

journal_title：Current opinion in oncology

authors： Patterson DM,Rustin GJ

更新日期：2006-09-01 00:00:00

abstract：:Mantle cell lymphoma is a distinct subtype and accounts for approximately 5 to 10% of non-Hodgkin lymphomas. The malignant cells express pan B-cell markers, including CD19, CD20 and CD22, and the T-cell marker CD5, whereas CD10 and CD23 expression are usually absent. By cytogenetic analysis, the t(11;14)(q13;q32) tran...

journal_title：Current opinion in oncology

authors： Leonard JP,Schattner EJ,Coleman M

更新日期：2001-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights the most important developments in the biology and treatment of Merkel cell carcinoma published in the medical literature over the past year. RECENT FINDINGS:Adjuvant radiotherapy to the primary site with or without coverage of the nodal region is recommended in most older seri...

journal_title：Current opinion in oncology

authors： Tai P

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Human immunodeficiency virus infection is associated with an increased risk of non-Hodgkin lymphoma. Even with a decrease in AIDS-defining illnesses after the advent of highly active antiretroviral therapy, HIV-associated non-Hodgkin lymphoma remains an important problem. RECENT FINDINGS:Low CD4+ T-l...

journal_title：Current opinion in oncology

authors： Behler CM,Kaplan LD

更新日期：2006-09-01 00:00:00

abstract：:Both paclitaxel and docetaxel have shown activity when used as a single agent in patients with squamous cell carcinoma of the head and neck (SCCHN). Combinations of both drugs with platinum derivatives and antimetabolites have been tested in patient populations with encouraging results, but some have exhibited conside...

journal_title：Current opinion in oncology

authors： Schrijvers D,Vermorken JB

更新日期：1998-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize major recent findings on the biology of human herpesvirus-8, i.e. Kaposi's sarcoma-associated herpesvirus, and the implications of these findings for Kaposi's sarcoma treatment. RECENT FINDINGS:Although reduced in incidence in developed countries since the introduction of highly active a...

journal_title：Current opinion in oncology

authors： Dittmer DP,Krown SE

更新日期：2007-09-01 00:00:00

abstract：:Contrary to the case with bacterial infections, progress in the diagnosis and treatment of invasive mycoses in cancer patients has been unsatisfactory. Amphotericin B deoxycholate has remained the drug of choice for severe invasive fungal infections for nearly 40 years. However, its infusion-related side effects, as w...

journal_title：Current opinion in oncology

authors： Martino P,Girmenia C

更新日期：1997-07-01 00:00:00

abstract：:In this review, recent advances in the clinical therapy of osteosarcoma, including results from the European Osteosarcoma Intergroup trial demonstrating the efficacy of a short intensive two drug protocol are discussed as well the evolving role of ifosfamide. Biologically, the area of interest on chromosome 3q, which ...

journal_title：Current opinion in oncology

authors： Himelstein BP

更新日期：1998-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Salivary gland malignancies are a rare and heterogeneous group of tumors with considerable variability in their natural history. Historically they have been treated with surgery and radiation therapy. It is only recently that there has been any growth in our understanding of these diseases and their m...

journal_title：Current opinion in oncology

authors： Adelstein DJ,Rodriguez CP

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The most common mechanism of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is acquisition of the T790M gatekeeper mutation. Third-generation EGFR TKIs irreversibly inhibit EGFR mutants (EGFRm), especially T790M, while sparing wild-type EGFR. There are several ...

journal_title：Current opinion in oncology

authors： Sun JM,Park K

更新日期：2017-03-01 00:00:00

abstract：:Phosphatases are regulatory enzymes that antagonize the action of kinases within the cell. An understanding of the contribution of kinases to cancer has emerged during the past two decades; however, our understanding of phosphatases in cancer has lagged behind. Currently, three phosphatases have been implicated in the...

journal_title：Current opinion in oncology

authors： Parsons R

更新日期：1998-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To highlight the most recent advances in the imaging of gliomas with a focus on high-grade gliomas. In the last several years, MRI and PET imaging of the brain have moved beyond anatomic imaging and are now capable of probing different aspects of tumor biology and response to treatment. These new tech...

journal_title：Current opinion in oncology

authors： Gerstner ER,Batchelor TT

更新日期：2010-11-01 00:00:00

abstract：:The incidence and variety of solid tumors reported among human immunodeficiency virus (HIV)-infected individuals are increasing. Among the most common of these tumors are anogenital malignant and premalignant tumors associated with human papillomavirus infection. Cervical intraepithelial neoplasia is one such human pa...

journal_title：Current opinion in oncology

authors： Palefsky JM

更新日期：1991-10-01 00:00:00

abstract：:A better understanding of the immunobiology after transplantation and of the available recombinant cytokines that enhance hematopoietic reconstitution following autologous and allogeneic bone marrow transplantation is likely to result in safer application of bone marrow transplantation. Residual tumor cells escaping c...

journal_title：Current opinion in oncology

authors： Slavin S,Nagler A

更新日期：1991-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite remarkable advances in the treatment of non-Hodgkin's lymphoma of all histologic subtypes, nervous system involvement remains a dire complication associated with a rapid decline in quality of life, few good treatment options, and a short overall survival. In fact, these advances in treatment m...

journal_title：Current opinion in oncology

authors： Lim HY,Thiel E,Glantz MJ

更新日期：2008-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Currently, endometrial carcinoma diagnosis is based on morphology, often supplemented by immunohistochemistry. However, especially with high-grade endometrial carcinomas, there is considerable interobserver variability in diagnosis calling into question the value of morphology in stratifying these tum...

journal_title：Current opinion in oncology

authors： Carlson J,McCluggage WG

更新日期：2019-09-01 00:00:00

abstract：:The development of new chemotherapeutic agents for cancer treatment is pursued with the hope of finding compounds with novel chemical characteristics, unique mechanisms of action, and with improved therapeutic indexes. Seven novel agents at different stages of clinical development have been selected for review. D1694 ...

journal_title：Current opinion in oncology

authors： Erlichman C

更新日期：1991-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The p53 tumor suppressor is a master regulator of antitumor defenses through its control of growth arrest, senescence and apoptosis. In recent years, p53 regulation was found to extend to a variety of biological processes including autophagy, fertility, metabolism and immune responses. Here, we focus ...

journal_title：Current opinion in oncology

authors： Menendez D,Shatz M,Resnick MA

更新日期：2013-01-01 00:00:00

abstract：:The currently used staging system in melanoma has not been significantly modified since 1988. While this four-stage system effectively stratifies patients into prognostic groups, additional discriminating criteria have been reported that is not presently incorporated in the staging system. The following additions and ...

journal_title：Current opinion in oncology

authors： Ross M

更新日期：1998-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe how to better identify frail multiple myeloma patients and to treat them appropriately. RECENT FINDINGS:Proteasome inhibitors, such as bortezomib, carfilzomib, and ixazomib, and immunomodulatory agents (IMiDs), such as thalidomide, lenalidomide, and pomalidomide, have significantly improv...

journal_title：Current opinion in oncology

authors： Zweegman S,Engelhardt M,Larocca A,EHA SWG on ‘Aging and Hematology’.

更新日期：2017-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The effect of psychotherapy on the survival of cancer patients has been debated for the past 20 years, mainly due to contradictory findings in the studies published so far. Several reviews have been published, almost all of which criticize the methods used in the studies. In 2007, three replication st...

journal_title：Current opinion in oncology

authors： Boesen EH,Johansen C

更新日期：2008-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Although outcomes for patients with follicular lymphoma have improved with chemoimmunotherapy, the disease remains incurable. There is a wide variation in survival, and although the Follicular Lymphoma International Prognostic Index helps to risk-stratify patients, there is a need for robust biomarker...

journal_title：Current opinion in oncology

authors： Gribben JG

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The remarkable progress witnessed over the past few years in the diagnosis, prognosis, and therapy of chronic lymphocytic leukemia has profoundly changed the clinical approach to this disease. This review focuses on the most recent advances in the diagnostic and prognostic examination of patients with...

journal_title：Current opinion in oncology

authors： Gentile M,Mauro FR,Guarini A,Foà R

更新日期：2005-11-01 00:00:00

abstract：:Approximately 1 in 10 US women will be diagnosed with breast cancer in her lifetime. With such a high incidence, breast cancer is a serious health concern for all American women. Within the past year, clues about the function of genes associated with breast cancer have been garnered, and novel genes that may contribut...

journal_title：Current opinion in oncology

authors： Unger MA,Weber BL

更新日期：2000-11-01 00:00:00

abstract：:Enormous progress has been made in the last several years in delineating signal transduction pathways associated with cell proliferation and apoptosis. The components of these pathways, which include both oncogenes and tumor suppressors, may provide viable targets for therapeutic intervention for the treatment of canc...

journal_title：Current opinion in oncology

authors： Huang PS,Heimbrook DC

更新日期：1997-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Immune checkpoint inhibitors have demonstrated remarkable efficacy with durable responses in the treatment of various malignancies. This new class of therapeutic agents is associated with a toxicity profile that differs from conventional cytotoxic therapy. The present review is focused on one of these...

journal_title：Current opinion in oncology

authors： Tabchi S,Messier C,Blais N

更新日期：2016-07-01 00:00:00