Abstract:
PURPOSE OF REVIEW:To describe the state-of-the-art of the surgical management of stage IIIA-N2 nonsmall cell lung cancer. RECENT FINDINGS:When completely resected, occult N2 found at thoracotomy, skip metastases, and single-level N2 in selected locations are reported to portend acceptable survival rates. Conversely, preoperatively proven ipsilateral mediastinal nodal involvement requires a multidisciplinary approach on the basis of neoadjuvant chemotherapy or chemoradiation. In these patients, complete resection of the primary tumor remains among the strongest prognosticators of survival. When technically feasible, radical mediastinal lymphadenectomy could be of added value. Given the demonstrated increase in postoperative morbidity and mortality, pneumonectomy should be avoided when possible, whereas lobectomy and parenchymal sparing resections should be favored if compatible with the resection of the original extent of the primary on tumor-free margins. SUMMARY:Only selected patients with N2 disease may benefit from primary surgery. The impact of postoperative morbidity after induction treatment is still being evaluated. In this setting, differences in treatment sequence and combination (chemotherapy alone or chemoradiation) may influence postsurgical outcome. Patients' selection revolves around the modern concepts of oncologic operability and surgical resectability intended as assessment of survival benefit and ability to completely resect all residual tumor after neoadjuvant therapy.
journal_name
Curr Opin Oncoljournal_title
Current opinion in oncologyauthors
Rocco Gdoi
10.1097/CCO.0b013e3283210476subject
Has Abstractpub_date
2009-03-01 00:00:00pages
105-9issue
2eissn
1040-8746issn
1531-703Xpii
00001622-200903000-00004journal_volume
21pub_type
杂志文章,评审abstract::Myelodysplasia or myelodysplastic syndromes represent a heterogeneous group of bone marrow disorders characterized by dysmaturation, cytopenias, and a propensity for leukemic transformation. Although universally adopted, the French-American-British classification still has several limitations and an inability to categ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199401000-00005
更新日期:1994-01-01 00:00:00
abstract::In testicular cancer epidemiology, the increasing recognition that germinal epithelial atrophy is the final common pathway in the development of this tumor has developed along with reports that elevated follicule-stimulating hormone levels at the time of diagnosis of first tumor correlate with risk of developing a sec...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:
更新日期:1991-06-01 00:00:00
abstract::Cutaneous T-cell lymphoma, which usually presents as mycosis fungoides or Sézary syndrome, remains a mostly incurable, yet highly treatable group of diseases. The myriad of active therapies continues to grow, and new insights into the mechanism of systemic and topical therapies are being elucidated. Multimodality trea...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199309000-00007
更新日期:1993-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Loss of cell growth control is not sufficient to explain why tumours form as the immune system recognizes many malignant cells and keeps them in check. The local inflammatory microenvironment is a pivotal factor in tumour formation, as tumour-associated inflammation actively suppresses antitumour immu...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000035
更新日期:2014-01-01 00:00:00
abstract::Biologic approaches to lymphoma treatment are now a practical reality rather than a vaguely perceived hope for the future. Interferon alfa seems to have been established as a life-extending therapy for selected patients with follicular lymphoma. Humanized anti-CD20 monoclonal antibody (rituximab) has an authentic 50% ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199909000-00005
更新日期:1999-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this review is to describe the major steps leading to the immunosuppressive tumor microenvironment and to summarize some of the new immunotherapies that interfere with these mechanisms. RECENT FINDINGS:Immunotherapy has improved the outcome of relapsed/metastatic head and neck squamous cel...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000623
更新日期:2020-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Most patients affected by lung cancer are treated with chemotherapy, and hence are at risk of myelosuppression. Hematopoietic growth factors have a relevant role in this setting, as they can improve quality of life, reduce the rate of chemotherapy-induced complications and allow the administration of ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000268
更新日期:2016-03-01 00:00:00
abstract::Bisphosphonates inhibit osteoclast-mediated bone resorption in metastatic bone disease. A wealth of preclinical data have begun to shed light on the complex mechanisms by which bisphosphonates inhibit bone resorption and interfere with the formation and growth of bone metastases. Nitrogen-containing bisphosphonates in...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200211000-00004
更新日期:2002-11-01 00:00:00
abstract::The bcr-abl fusion protein is present in the vast majority of cases of chronic myelogenous leukemia, and the deregulated tyrosine kinase activity of this protein is essential for leukemic transformation. Thus, bcr-abl is an ideal target for pharmacologic inhibition. In preclinical studies, ST1571 (formerly CGP57148B),...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200011000-00013
更新日期:2000-11-01 00:00:00
abstract::Several epithelial tumors display epidermal growth factor receptor (EGFR) overexpression (with or without EGFR gene amplification) that is often associated with increased production of EGFR ligands. This permits the activation of endogenous tumor EGFR via autocrine mechanisms, resulting in cellular proliferation and t...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200111000-00012
更新日期:2001-11-01 00:00:00
abstract:PURPOSE OF REVIEW:This paper reviews the advances in surgery in head and neck cancer patients. RECENT FINDINGS:Sentinel node biopsy is a promising diagnostic technique to detect occult lymph node metastases, especially in oral carcinomas. Fludeoxyglucose-PET seems to be useful in detecting recurrent (laryngeal) carcin...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e3283380009
更新日期:2010-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The remarkable progress witnessed over the past few years in the diagnosis, prognosis, and therapy of chronic lymphocytic leukemia has profoundly changed the clinical approach to this disease. This review focuses on the most recent advances in the diagnostic and prognostic examination of patients with...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/01.cco.0000181403.75460.c7
更新日期:2005-11-01 00:00:00
abstract:KEY POINTS:(1) Surgery is the standard primary treatment for early stage endometrial cancer, with local adjuvant therapies such as pelvic radiotherapy and vaginal brachytherapy most often used in patients with high risk of recurrence. (2) There are currently very few well designed studies evaluating local therapies in ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/01.cco.0000284643.94948.44
更新日期:2007-09-01 00:00:00
abstract::Kaposi sarcoma (KS), an unusual tumor of vascular origin, was one of the first recognized manifestations of AIDS. In the past few years, it has become clear that human herpesvirus-8 (HHV-8) is critical to the development of KS in the setting of immunosuppression, such as that seen with HIV infection. Other genetic and...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200003000-00013
更新日期:2000-03-01 00:00:00
abstract::This paper covers the outcome of previously conducted clinical trials on chemotherapy for malignant pleural mesothelioma and presents data from recent phase II and phase III trials. In contrast to conventional cytotoxic drugs, which have barely produced response rates exceeding 30%, recently introduced chemotherapeuti...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200303000-00006
更新日期:2003-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Several epidemiologic studies have enhanced our understanding of the impact of respiratory viruses on bone marrow transplant recipients. RECENT FINDINGS:Respiratory viral infections occur frequently following stem cell transplantation but present atypically. Many patients have asymptomatic infections...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e328324bc1c
更新日期:2009-03-01 00:00:00
abstract::Family history plays an important role in breast, ovarian, and colorectal cancers. The increasing availability of genetic testing has forced women with these malignancies and their physicians to confront new questions regarding screening and prevention. This review highlights the screening for and prevention of breast...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200009000-00019
更新日期:2000-09-01 00:00:00
abstract::The prophylactic or pre-emptive approach should help to restrict use of antibiotics and lead to better management of infection. It is clear that if effective pre-emptive therapy is available (be it as prophylaxis), the empiric additions of other agents should be taken into account and tailored accordingly. On the othe...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199607000-00002
更新日期:1996-07-01 00:00:00
abstract::During the past year there have been a number of important advances in the area of systemic therapy for breast cancer. Combined chemoendocrine therapy has been shown to be more effective than tamoxifen alone in the adjuvant therapy of node-negative estrogen receptor-positive breast cancer. Preliminary results of a ran...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199811000-00007
更新日期:1998-11-01 00:00:00
abstract:PURPOSE OF REVIEW:The phosphoinositide 3-kinases are lipid kinases that are activated in response to external factors. They regulate a number of intracellular signaling pathways involved in cell motility, metabolism, survival, and growth. This review summarizes the current knowledge about specific contributions of Clas...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e3282f3111e
更新日期:2008-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this article will be to review neuroendocrine tumours (NETs) of the gynaecological tract. NETs are generally considered to be uncommon and primary tumours in the gynaecological tract on arrival rare or very rare. It is important to distinguish true primary tumours from metastatic as the...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000321
更新日期:2016-09-01 00:00:00
abstract::Oligodeoxynucleotides have been proposed as both in vitro and in vivo inhibitors of gene expression because of the specificity of Watson-Crick base pair hybridization. Phosphodiester oligodeoxynucleotides (normal DNA) cannot be used as drugs because they are nuclease sensitive. Significant efforts have been made to st...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199411000-00010
更新日期:1994-11-01 00:00:00
abstract:PURPOSE OF REVIEW:The objective of the sentinel lymph node procedure in breast cancer is to perform an accurate axillary staging and provide good local control, while sparing the patients the morbidity of an axillary lymph node dissection. Since its routine clinical use, questions were raised concerning the implication...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/01.cco.0000183542.63675.66
更新日期:2005-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To evaluate the current literature for processes of care and outcomes of multimodal therapies for muscle-invasive urothelial carcinoma of the bladder. RECENT FINDINGS:Treatments for high-risk bladder cancer remain an active area of investigation. Despite evidence of the benefits, the use of chemother...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e3283510587
更新日期:2012-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Human immunodeficiency virus infection is associated with an increased risk of non-Hodgkin lymphoma. Even with a decrease in AIDS-defining illnesses after the advent of highly active antiretroviral therapy, HIV-associated non-Hodgkin lymphoma remains an important problem. RECENT FINDINGS:Low CD4+ T-l...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/01.cco.0000239881.16216.05
更新日期:2006-09-01 00:00:00
abstract::Carcinoma of the uterine corpus is the most common malignancy in the female pelvis. Surgical resection and staging are now the accepted approach to therapy, with excellent survival compared with other gynecologic malignancies. Several controversies exist, however, regarding optimal surgical management. Some of these c...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200209000-00007
更新日期:2002-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The concept of palliative care is becoming increasingly important in the management of glioma patients. However, the right time for implementation, as well as the individual degree of integration of palliative care aspects, are still a matter of debate. This review updates recent evidence of palliativ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000584
更新日期:2019-11-01 00:00:00
abstract::The interferons are complex proteins that have been widely tested as therapy for neoplastic diseases. Interferon (IFN)-alpha has been the most extensively studied in melanoma. It produces responses in about 16% of metastatic melanomas, about one third of which are complete. It has been combined with chemotherapy and b...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199603000-00015
更新日期:1996-03-01 00:00:00
abstract::The preclinical and clinical investigations of therapeutic approaches to melanoma have progressed significantly in the past year. This article reviews recently published information relevant to preclinical studies of the biologic function of stromal tissue, growth factors (and receptors), interferons, cytokines, and a...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199204000-00020
更新日期:1992-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Myelodysplastic syndromes (MDSs) are rare disorders in children, showing peculiar clinical manifestations and biological features. This review will summarize biological, genetic and clinical features of childhood MDS and will provide an update of the algorithm of treatment of the different disease var...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000488
更新日期:2018-11-01 00:00:00