Cutaneous T-cell lymphomas.

abstract：:Although early clinical gene therapy trials for recurrent central nervous system neoplasms showed the proof-of-principle, they did not fulfill the high expectations suggested by the preclinical experimental data. Insufficient distribution of vectors in human brain tumors and very low transduction efficiency require th...

journal_title：Current opinion in oncology

authors： Weyerbrock A,Oldfield EH

更新日期：1999-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Multiple myeloma is a common hematological malignancy arising in the bone marrow. Bone lesions were initially depicted with conventional radiography, although recently F-FDG PET/CT and MRI are recognized as having a clear role in the initial workup and in the evaluation of therapy response. RECENT FI...

journal_title：Current opinion in oncology

authors： Martí-Bonmatí L,Ramirez-Fuentes C,Alberich-Bayarri Á,Ruiz-Llorca C

更新日期：2015-11-01 00:00:00

abstract：:The rising rate of germ cell cancer of the testis over the past decade has been demonstrated to be occurring predominantly in the younger age group (15 to 19 years) in association with earlier onset of puberty and earlier onset of regular sexual activity. Chemicals and viruses, with their atrophogenic effect, remain t...

journal_title：Current opinion in oncology

authors： Oliver RT

更新日期：1996-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past 20 years, tremendous strides have been made to decrease treatment-related morbidity and mortality following allogeneic transplant, including management of acute and chronic lung injury. Within this context, three distinct entities are recognized, idiopathic pneumonia syndrome (IPS), bron...

journal_title：Current opinion in oncology

authors： Yanik G,Kitko C

更新日期：2013-03-01 00:00:00

abstract：:The currently used staging system in melanoma has not been significantly modified since 1988. While this four-stage system effectively stratifies patients into prognostic groups, additional discriminating criteria have been reported that is not presently incorporated in the staging system. The following additions and ...

journal_title：Current opinion in oncology

authors： Ross M

更新日期：1998-03-01 00:00:00

abstract：:Infection with the human immunodeficiency virus-1 is associated with a marked increase in the incidence of Kaposi's sarcoma. Recent studies suggest that the risk of Kaposi's sarcoma in human immunodeficiency virus infection is increased with oral-fecal contact and that a sexually transmitted agent possibly related to ...

journal_title：Current opinion in oncology

authors： Miles SA

更新日期：1992-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Imatinib has exceptional activity in controlling gastrointestinal stromal tumor (GIST) due to inhibition of the constitutively active conformation of KIT and platelet-derived growth factor-alpha (PDGFRA), which is commonly seen in this tumor. This review explores the current available data on the corr...

journal_title：Current opinion in oncology

authors： Marrari A,Trent JC,George S

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:AIDS-related malignancies are an ongoing cause of mortality in individuals with HIV infection. In the HIV-negative setting, high-dose chemotherapy or stem cell transplantation is an option for patients with hematologic malignancies. Prior to the advent of effective HIV therapy, stem cell transplantati...

journal_title：Current opinion in oncology

authors： Krishnan A,Forman SJ

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Biobanking has been identified as a key area for development in order to accelerate the discovery and development of new drugs. This review describes the recent advances in the field of biobanking and biospecimen research, with special reference to tumour banks which are the biobanks of primary intere...

journal_title：Current opinion in oncology

authors： Hewitt RE

更新日期：2011-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the 2008-2009 literature on pediatric genitourinary tumors and highlight the most significant publications. RECENT FINDINGS:New techniques such as gene expression profiling, PET, nephron-sparing surgery, and stem cell transplantation are being incorporated into contemporary treatments for p...

journal_title：Current opinion in oncology

authors： McLean TW,Buckley KS

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize major recent findings on the biology of human herpesvirus-8, i.e. Kaposi's sarcoma-associated herpesvirus, and the implications of these findings for Kaposi's sarcoma treatment. RECENT FINDINGS:Although reduced in incidence in developed countries since the introduction of highly active a...

journal_title：Current opinion in oncology

authors： Dittmer DP,Krown SE

更新日期：2007-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Relapse has become the leading cause of death following allogeneic hematopoietic stem cell transplantation (HSCT). Despite improved understanding of the biology that underlies the graft-versus-leukemia/tumor effect the relapse rate did not decrease over the past 20 years. In general, prognosis is poor...

journal_title：Current opinion in oncology

authors： Kröger N

更新日期：2011-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Tumor stroma is composed of many cellular subtypes, of which the most abundant are fibroblasts, macrophages and endothelial cells. During the process of tissue injury, these three cellular subtypes must coordinate their activity to efficiently contribute to tissue regeneration. In tumor, this mechanis...

journal_title：Current opinion in oncology

authors： Ronca R,Van Ginderachter JA,Turtoi A

更新日期：2018-01-01 00:00:00

abstract：:The prognosis of pediatric low-grade gliomas is relatively favorable, but residual or unresectable tumors remain a challenge. Conventional radiation therapy is effective but may be associated with unacceptable sequelae in young children. Chemotherapy can delay the need for radiation therapy in young children; however,...

journal_title：Current opinion in oncology

authors： Schmandt SM,Packer RJ

更新日期：2000-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To present the model of the Supportive Care in Cancer Unit (SCCU) of the National Cancer Institute (NCI) of Milan. RECENT FINDINGS:In the last few years, there has been a debate on different models of integration of palliative care in oncology, on early palliative care, supportive care, supportive an...

journal_title：Current opinion in oncology

authors： Ida RC,Adelaide PM,Stefania B

更新日期：2012-07-01 00:00:00

abstract：:Recent papers dealing with the effect of biologic response modifiers on the therapeutic activity of anticancer drugs are reviewed. Preclinical findings indicate that both interferons and tumor necrosis factor-alpha are able to synergize with different cytotoxic drugs in increasing both tumor cytotoxicity or cytostasis...

journal_title：Current opinion in oncology

authors： Parmiani G,Rivoltini L

更新日期：1991-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Most patients affected by lung cancer are treated with chemotherapy, and hence are at risk of myelosuppression. Hematopoietic growth factors have a relevant role in this setting, as they can improve quality of life, reduce the rate of chemotherapy-induced complications and allow the administration of ...

journal_title：Current opinion in oncology

authors： Genova C,Rijavec E,Grossi F

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Retroperitoneal sarcoma (RPS) is a rare disease, and until recently, its natural history and outcome were poorly understood. Recently, collaborations between individual centers have led to an unprecedented collection of retrospective and prospective data and successful recruitment to the first randomi...

journal_title：Current opinion in oncology

authors： van Houdt WJ,Raut CP,Bonvalot S,Swallow CJ,Haas R,Gronchi A

更新日期：2019-07-01 00:00:00

abstract：PURPOSE OF REVIEW:For several decades, hematopoietic cell transplantation (HCT) has been considered the standard curative therapy for many patients with hematological malignancies. In addition to the cytotoxic effects of the chemotherapy and radiation used in the conditioning regimen, the benefits of HCT are derived fr...

journal_title：Current opinion in oncology

authors： Ghosh A,Politikos I,Perales MA

更新日期：2017-11-01 00:00:00

abstract：:The development of non-myeloablative and reduced-intensity conditioning regimens has enabled older or medically infirm patients with myeloid malignancies to be treated with allogeneic hematopoietic cell transplantation (HCT). The regimens are sufficiently immunosuppressive to allow engraftment of allogeneic cells and ...

journal_title：Current opinion in oncology

authors： Storb R

更新日期：2009-06-01 00:00:00

abstract：:A better understanding of the immunobiology after transplantation and of the available recombinant cytokines that enhance hematopoietic reconstitution following autologous and allogeneic bone marrow transplantation is likely to result in safer application of bone marrow transplantation. Residual tumor cells escaping c...

journal_title：Current opinion in oncology

authors： Slavin S,Nagler A

更新日期：1991-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Gallbladder carcinoma (GBC), classified as a biliary tract cancer (BTC) along with intrahepatic and extrahepatic cholangiocarcinomas, is a rare disease in Western countries, but a highly prevalent disease in Chile, other countries in Latin America, India and Japan. It commonly presents at an advanced ...

journal_title：Current opinion in oncology

authors： McNamara MG,Metran-Nascente C,Knox JJ

更新日期：2013-07-01 00:00:00

abstract：KEY POINTS:(1) Surgery is the standard primary treatment for early stage endometrial cancer, with local adjuvant therapies such as pelvic radiotherapy and vaginal brachytherapy most often used in patients with high risk of recurrence. (2) There are currently very few well designed studies evaluating local therapies in ...

journal_title：Current opinion in oncology

authors： Deeks E

更新日期：2007-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Although outcomes for patients with follicular lymphoma have improved with chemoimmunotherapy, the disease remains incurable. There is a wide variation in survival, and although the Follicular Lymphoma International Prognostic Index helps to risk-stratify patients, there is a need for robust biomarker...

journal_title：Current opinion in oncology

authors： Gribben JG

更新日期：2010-09-01 00:00:00

abstract：:During the past year there have been a number of important advances in the area of systemic therapy for breast cancer. Combined chemoendocrine therapy has been shown to be more effective than tamoxifen alone in the adjuvant therapy of node-negative estrogen receptor-positive breast cancer. Preliminary results of a ran...

journal_title：Current opinion in oncology

authors： Dees EC,Kennedy MJ

更新日期：1998-11-01 00:00:00

abstract：:Despite continuing advances in the molecular characterization of the events promoting metastasis, no significant impact has been made on therapy or survival rates for patients with advanced tumors. Over the past 12 months there has been a general consolidation of the emerging evidence indicating that tumor spread is r...

journal_title：Current opinion in oncology

authors： Dorudi S,Hart IR

更新日期：1993-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Immunotherapy of HPV-induced premalignant anogenital lesions and cervical cancer has made impressive progress. HPV as causative agent is targeted by prophylactic and therapeutic vaccination strategies. Preclinical and clinical studies have shown induction of natural and/or vaccine-induced immune respo...

journal_title：Current opinion in oncology

authors： Schreckenberger C,Kaufmann AM

更新日期：2004-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review presents an overview of recent developments in research examining coping with the effects of cancer treatment on sexuality. RECENT FINDINGS:A search was conducted using PubMed and Web of Knowledge to find papers published or in press in 2010. Papers examining coping efforts, effects of ca...

journal_title：Current opinion in oncology

authors： Reese JB

更新日期：2011-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent developments and controversies in the diagnosis and management of nonmuscle invasive bladder cancer (NMIBC). RECENT FINDINGS:The majority of incident bladder cancer diagnoses are noninvasive. The mainstay of diagnosis remains cystoscopy and transurethral resection, with enhanced o...

journal_title：Current opinion in oncology

authors： Bassett JC,Eifler JB,Resnick MJ,Clark PE

更新日期：2014-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The most common mechanism of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is acquisition of the T790M gatekeeper mutation. Third-generation EGFR TKIs irreversibly inhibit EGFR mutants (EGFRm), especially T790M, while sparing wild-type EGFR. There are several ...

journal_title：Current opinion in oncology

authors： Sun JM,Park K

更新日期：2017-03-01 00:00:00