Testicular cancer.

abstract：PURPOSE OF REVIEW:Avoiding immune destruction is one emerging hallmark of cancer, including glioblastoma. The number of immunotherapy approaches to fight glioblastoma is growing. Here, we review the recent progress in four main areas: dendritic cell immunotherapy, peptide vaccination, chimeric antigen receptors and imm...

journal_title：Current opinion in oncology

authors： Finocchiaro G,Pellegatta S

更新日期：2014-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights the most important developments in the biology and treatment of Merkel cell carcinoma published in the medical literature over the past year. RECENT FINDINGS:Adjuvant radiotherapy to the primary site with or without coverage of the nodal region is recommended in most older seri...

journal_title：Current opinion in oncology

authors： Tai P

更新日期：2008-03-01 00:00:00

abstract：:Renal cell carcinoma remains a challenge for oncologists, with only 20% of patients being cured by surgical removal of the involved kidney and a handful of patients with advanced disease being cured by surgery, immunotherapy, or both. Although advances in early detection, recognition of high-risk groups, and chemother...

journal_title：Current opinion in oncology

authors： Savage PD

更新日期：1994-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Biobanking has been identified as a key area for development in order to accelerate the discovery and development of new drugs. This review describes the recent advances in the field of biobanking and biospecimen research, with special reference to tumour banks which are the biobanks of primary intere...

journal_title：Current opinion in oncology

authors： Hewitt RE

更新日期：2011-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDLs) are one of the more frequent mesenchymal neoplasms and are characterized by specific chromosome aberrations: supernumerary chromosome or giant marker chromosome or both. Extra copies of known oncogenes such as MDM2, CDK4, SAS, HMGA...

journal_title：Current opinion in oncology

authors： Arrigoni G,Doglioni C

更新日期：2004-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The advent of immunotherapy significantly improved clinical outcomes in cancer patients, although immune checkpoint blockade (ICB) still lack of efficacy in a consistent proportion of treated patients. The purpose of this article is to review the most innovative and clinically promising ICB-based comb...

journal_title：Current opinion in oncology

authors： Fucà G,de Braud F,Di Nicola M

更新日期：2018-09-01 00:00:00

abstract：:Graft-versus-host disease (GVHD) continues to be a major obstacle to the success of allogeneic bone marrow transplantation. Furthermore, several clinical strategies being employed at this time in the field of bone marrow transplantation have had an impact on GVHD. In addition to the usual division of topics such as pa...

journal_title：Current opinion in oncology

authors： Marcellus DC,Vogelsang GB

更新日期：1997-03-01 00:00:00

abstract：:The clinical staging of bone tumors, even rare ones, has been much improved with the availability of better imaging techniques. Once diagnosis of a rare bone tumor has been made, close consultation between clinician, radiologist, and pathologist is essential for optimal treatment. Recent advances in the staging proced...

journal_title：Current opinion in oncology

authors： Dirix LY,Van Oosterom AT

更新日期：1991-08-01 00:00:00

abstract：:Prophylactic platelet transfusion can prevent spontaneous hemorrhage in thrombocytopenic cancer patients undergoing intensive treatment, but it is limited by the development of platelet alloimmunization. Exclusive use of leukocyte-depleted blood products delays or prevents the development of platelet alloimmunization ...

journal_title：Current opinion in oncology

authors： Wallerstein R Jr,Deisseroth AB

更新日期：1991-08-01 00:00:00

abstract：:Bisphosphonates inhibit osteoclast-mediated bone resorption in metastatic bone disease. A wealth of preclinical data have begun to shed light on the complex mechanisms by which bisphosphonates inhibit bone resorption and interfere with the formation and growth of bone metastases. Nitrogen-containing bisphosphonates in...

journal_title：Current opinion in oncology

authors： Green JR

更新日期：2002-11-01 00:00:00

abstract：:In the past decade, the discovery of tumor antigens recognized by T cells has revolutionized the tumor vaccine field. The appreciation that peptides are bound to and restricted by major histocompatibility class I and II molecules for immune recognition has encouraged a number of early-phase clinical trials of peptide ...

journal_title：Current opinion in oncology

authors： Weber JS,Aparicio A

更新日期：2001-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Advances in the health system and medical sciences are continuously pushing the barrier of life-expectancy. As a consequence, humans are being increasingly afflicted by age-associated diseases, such as cancer. The challenge now lies in understanding the mechanisms underlying ageing in order to reduce ...

journal_title：Current opinion in oncology

authors： Pereira B,Ferreira MG

更新日期：2013-01-01 00:00:00

abstract：:Infection with the human immunodeficiency virus-1 is associated with a marked increase in the incidence of Kaposi's sarcoma. Recent studies suggest that the risk of Kaposi's sarcoma in human immunodeficiency virus infection is increased with oral-fecal contact and that a sexually transmitted agent possibly related to ...

journal_title：Current opinion in oncology

authors： Miles SA

更新日期：1992-10-01 00:00:00

abstract：PURPOSE OF REVIEW:In the 1990s, cancer patients were described as poor candidates for ICU admission on the basis of high mortality rates and management costs. Over the last decade, however, advances in the management of malignancies and organ failures have led to substantial increases in survival. This review discusses...

journal_title：Current opinion in oncology

authors： Darmon M,Azoulay E

更新日期：2009-07-01 00:00:00

abstract：:The prognosis of pediatric low-grade gliomas is relatively favorable, but residual or unresectable tumors remain a challenge. Conventional radiation therapy is effective but may be associated with unacceptable sequelae in young children. Chemotherapy can delay the need for radiation therapy in young children; however,...

journal_title：Current opinion in oncology

authors： Schmandt SM,Packer RJ

更新日期：2000-05-01 00:00:00

abstract：PURPOSE OF REVIEW:We summarize the concept of a locally advanced basal cell carcinoma (laBCC) and present the current consensus definition. We also review the key pieces of primary research undertaken in the past year and how these affect the use of smoothened inhibitors in a clinical setting. RECENT FINDINGS:Medium t...

journal_title：Current opinion in oncology

authors： Khoo AB,Ali FR,Lear JT

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:In the present review, we summarize the recent developments in the management of germ cell tumors (GCTs). RECENT FINDINGS:Treatment-related acute and late-onset toxicity remains a key challenge in the management of GCTs, with recent evidence showing that the adverse health outcomes of etoposide and c...

journal_title：Current opinion in oncology

authors： Chahoud J,Zhang M,Shah A,Lin SH,Pisters LL,Tu SM

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:AIDS-related malignancies are an ongoing cause of mortality in individuals with HIV infection. In the HIV-negative setting, high-dose chemotherapy or stem cell transplantation is an option for patients with hematologic malignancies. Prior to the advent of effective HIV therapy, stem cell transplantati...

journal_title：Current opinion in oncology

authors： Krishnan A,Forman SJ

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF REVIEW:As the number and uses for targeted therapies such as epidermal growth factor receptor inhibitors (EGFRIs) increase, so does the need to recognize and treat the dermatologic side-effects of these agents. Although agents such as gefitinib, erlotinib, cetuximab, lapatinib, and panitumumab have less syst...

journal_title：Current opinion in oncology

authors： Wu PA,Balagula Y,Lacouture ME,Anadkat MJ

更新日期：2011-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Early trials of high-dose therapy with autologous stem cell transplantation in mantle cell lymphoma were discouraging, with no clear survival advantage attributable to the procedure. Most early series were plagued by small numbers, retrospective designs, and short follow-up. Also, until recently, allo...

journal_title：Current opinion in oncology

authors： Jacobsen E,Freedman A

更新日期：2004-03-01 00:00:00

abstract：:Recent studies are refining the treatment approaches of radiation therapy and combination chemotherapy in Hodgkin's disease. In early-stage disease, attempts are being made to lessen the toxicity of treatment while maintaining excellent results. Optimal results are achieved in advanced disease with combined radiation ...

journal_title：Current opinion in oncology

authors： Straus DJ

更新日期：1993-09-01 00:00:00

abstract：:The preclinical and clinical investigations of therapeutic approaches to melanoma have progressed significantly in the past year. This article reviews recently published information relevant to preclinical studies of the biologic function of stromal tissue, growth factors (and receptors), interferons, cytokines, and a...

journal_title：Current opinion in oncology

authors： Kirkwood JM

更新日期：1992-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to update knowledge on therapy-related myeloid neoplasms (t-MN), taking into account the new 2008 WHO classification, new genome-wide approaches for the definition of susceptibility towards t-MN and the introduction of new more aggressive treatments in cancer patients. R...

journal_title：Current opinion in oncology

authors： Leone G,Fianchi L,Voso MT

更新日期：2011-11-01 00:00:00

abstract：:Controversy exists over the role that environmental estrogens, such as pesticides or polychlorinated biphenyls (PCBs), might play as risk factors for breast cancer. Several laboratory studies have suggested that these chemicals function as weak estrogens, binding to the estrogen receptor and inducing various measures ...

journal_title：Current opinion in oncology

authors： Davidson NE

更新日期：1998-09-01 00:00:00

abstract：PURPOSE OF REVIEW:We used two examples of genes, TP53 and EGFR, which are somatically altered by intragenic mutations in common cancer types to illustrate how somatic mutations have followed very different routes to clinical applications. RECENT FINDINGS:TP53 somatic mutations are frequent in many cancers. Their progn...

journal_title：Current opinion in oncology

authors： Olivier M,Taniere P

更新日期：2011-01-01 00:00:00

abstract：:The appearance of skin lesions in patients with occult or obvious malignancy may be of extreme value in the detection and management of cancer because the skin is readily accessible to examination and biopsy. Examination of the skin of our patients can provide important insights into underlying malignant processes or ...

journal_title：Current opinion in oncology

authors： Sabir S,James WD,Schuchter LM

更新日期：1999-03-01 00:00:00

abstract：:The development of new chemotherapeutic agents for cancer treatment is pursued with the hope of finding compounds with novel chemical characteristics, unique mechanisms of action, and with improved therapeutic indexes. Seven novel agents at different stages of clinical development have been selected for review. D1694 ...

journal_title：Current opinion in oncology

authors： Erlichman C

更新日期：1991-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The current status of postoperative adjuvant therapy for nonsmall cell lung cancer (NSCLC) is reviewed. RECENT FINDINGS:Cisplatin-based postoperative chemotherapy is a current standard of care for patients with stage II-III NSCLC who underwent complete resection. However, its benefit is limited. In t...

journal_title：Current opinion in oncology

authors： Mitsudomi T,Soh J

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Mantle cell lymphoma is an aggressive non-Hodgkin's lymphoma characterized by the t(11;14) chromosomal translocation and overexpression of cyclin D1. Constituting approximately 5 to 8% of all non-Hodgkin's lymphomas, it carries the poorest prognosis among non-Hodgkin's lymphoma subtypes. Standard and ...

journal_title：Current opinion in oncology

authors： Williams ME,Densmore JJ

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Loss of cell growth control is not sufficient to explain why tumours form as the immune system recognizes many malignant cells and keeps them in check. The local inflammatory microenvironment is a pivotal factor in tumour formation, as tumour-associated inflammation actively suppresses antitumour immu...

journal_title：Current opinion in oncology

authors： Huang L,Mellor AL

更新日期：2014-01-01 00:00:00