Prophylaxis and treatment of dermatologic adverse events from epidermal growth factor receptor inhibitors.

abstract：PURPOSE OF REVIEW:The psychosocial needs of adolescent and young adult (AYA) siblings of cancer patients are easily overlooked. Accordingly, the evidence base informing short and long-term outcomes for these young people is sparse. This review provides an overview of recent research highlighting the experiences, unmet ...

journal_title：Current opinion in oncology

authors： Patterson P,Medlow S,McDonald FE

更新日期：2015-07-01 00:00:00

abstract：:Recent efforts have been directed at identifying and characterizing candidate tumor suppressor genes and the activities of oncogenes in primary brain tumors. The p53 gene mapping to region p13 of chromosome 17 has several characteristics as a tumor suppressor gene. The wild-type p53 protein, which is a transcriptional...

journal_title：Current opinion in oncology

authors： Steck PA,Saya H

更新日期：1991-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The current status of postoperative adjuvant therapy for nonsmall cell lung cancer (NSCLC) is reviewed. RECENT FINDINGS:Cisplatin-based postoperative chemotherapy is a current standard of care for patients with stage II-III NSCLC who underwent complete resection. However, its benefit is limited. In t...

journal_title：Current opinion in oncology

authors： Mitsudomi T,Soh J

更新日期：2021-01-01 00:00:00

abstract：:Biologic approaches to lymphoma treatment are now a practical reality rather than a vaguely perceived hope for the future. Interferon alfa seems to have been established as a life-extending therapy for selected patients with follicular lymphoma. Humanized anti-CD20 monoclonal antibody (rituximab) has an authentic 50% ...

journal_title：Current opinion in oncology

authors： Bendandi M,Longo DL

更新日期：1999-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the state-of-the-art of the surgical management of stage IIIA-N2 nonsmall cell lung cancer. RECENT FINDINGS:When completely resected, occult N2 found at thoracotomy, skip metastases, and single-level N2 in selected locations are reported to portend acceptable survival rates. Conversely, p...

journal_title：Current opinion in oncology

authors： Rocco G

更新日期：2009-03-01 00:00:00

abstract：:Recent publications dealing with the pathology of squamous carcinomas of the head and neck have been critically reviewed with particular reference to potential prognostic factors and improved methods for identifying nodal metastases. The topics covered include cytophotometry and proliferative patterns, molecular biolo...

journal_title：Current opinion in oncology

authors： Carter RL

更新日期：1993-05-01 00:00:00

abstract：PURPOSE OF REVIEW:In the past few years, the advent of PARP inhibitors has been a revolution in the management of ovarian cancer. Patients harboring somatic or germ line BRCA1/2 mutations exhibit different clinical and treatment response behavior. The BRCA gene is involved in repairing DNA repair via homologous recombi...

journal_title：Current opinion in oncology

authors： Vanacker H,Romeo C,Ray-Coquard I

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The treatment of HIV infection has been transformed by the introduction of highly active antiretroviral therapy. For patients who respond and can tolerate lifelong therapy, HIV infection may become a chronic disease requiring long-term ambulatory care follow-up. The current management of antiretrovira...

journal_title：Current opinion in oncology

authors： Kalkut G

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The rising incidence of oropharyngeal squamous cell carcinoma (OPSCC), in large part as a result of the human papillomavirus (HPV), has driven a movement for the change in the management strategies. Renewed interest in minimally invasive approaches of endoscopic head and neck surgery led to introducti...

journal_title：Current opinion in oncology

authors： Dias FL,Walder F,Leonhardt FD

更新日期：2017-05-01 00:00:00

abstract：:Despite its appeal, lung cancer screening has been found to be of little value at this time. However, use of monoclonal antibodies to detect cancer cells in the sputum may prove to be of value in high-risk subjects. Once a cancer is diagnosed, anatomic staging by the International TNM Staging System has shown its effe...

journal_title：Current opinion in oncology

authors： Shields TW

更新日期：1991-04-01 00:00:00

abstract：:The biologic and clinical heterogeneity of lymphomas represents the major obstacle to their diagnosis. Because histologic analysis, which is the initial diagnostic approach, has been demonstrated to be insufficient in the definition of certain types of lymphomas, molecular and immunologic techniques have been increasi...

journal_title：Current opinion in oncology

authors： Veronese ML,Schichman SA,Croce CM

更新日期：1996-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe recent advances in the diagnosis and treatment of paraneoplastic neurological syndromes (PNS). RECENT FINDINGS:PNS are rare complications of cancer caused by an immune cross-reaction between antigens expressed by tumor cells and neurons. The target of the immune attack can be an intracell...

journal_title：Current opinion in oncology

authors： Berzero G,Psimaras D

更新日期：2018-11-01 00:00:00

abstract：PURPOSE OF REVIEW:AIDS-related malignancies are an ongoing cause of mortality in individuals with HIV infection. In the HIV-negative setting, high-dose chemotherapy or stem cell transplantation is an option for patients with hematologic malignancies. Prior to the advent of effective HIV therapy, stem cell transplantati...

journal_title：Current opinion in oncology

authors： Krishnan A,Forman SJ

更新日期：2010-09-01 00:00:00

abstract：:Over the past decade, high-dose chemotherapy followed by autologous bone marrow support (ABMS) has been employed with increasing frequency to treat patients with a variety of solid tumors. This paper explores the rationale and relevant clinical data for the use of this approach to treat patients with breast and ovaria...

journal_title：Current opinion in oncology

authors： Shpall EJ,Jones RB,Bearman S

更新日期：1994-03-01 00:00:00

abstract：:The pathogenesis of prostate cancer reflects complex interactions among environmental and genetic factors. Recent advances suggest molecular mechanisms that may explain geographic and ethnic variations in prostate cancer incidence, and understanding of molecular disease progression is advancing rapidly. Clinically, th...

journal_title：Current opinion in oncology

authors： Small EJ,Reese DM

更新日期：2000-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Ovarian germ cell tumours are rare, but curable at all stages of disease. This review gives an outline of the main controversies regarding the management of this disease. RECENT FINDINGS:Pelvic malignancies are very rare during pregnancy, which should avoid the need for radical surgery or termination...

journal_title：Current opinion in oncology

authors： Patterson DM,Rustin GJ

更新日期：2006-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review is to describe the major steps leading to the immunosuppressive tumor microenvironment and to summarize some of the new immunotherapies that interfere with these mechanisms. RECENT FINDINGS:Immunotherapy has improved the outcome of relapsed/metastatic head and neck squamous cel...

journal_title：Current opinion in oncology

authors： Merlano MC,Denaro N,Garrone O

更新日期：2020-05-01 00:00:00

abstract：:Recent work has shown that: 1) loss of transforming growth factor-beta response is associated with malignant progression, 2) maintenance of autocrine negative transforming growth factor-beta activity is a key impediment to malignant progression, and 3) the major mechanism for loss of RII expression in replication erro...

journal_title：Current opinion in oncology

authors： Brattain MG,Markowitz SD,Willson JK

更新日期：1996-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Melanoma has proven resistant to most available chemotherapy and immunotherapy. Despite a range of different biochemical targets, most agents kill cancer cells by induction of apoptosis. RECENT FINDINGS:Investigation of this process has provided insights into the resistance mechanisms in cancer cells...

journal_title：Current opinion in oncology

authors： Hersey P

更新日期：2006-03-01 00:00:00

abstract：:The appearance of skin lesions in patients with occult or obvious malignancy may be of extreme value in the detection and management of cancer because the skin is readily accessible to examination and biopsy. Examination of the skin of our patients can provide important insights into underlying malignant processes or ...

journal_title：Current opinion in oncology

authors： Sabir S,James WD,Schuchter LM

更新日期：1999-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of the review is to delineate novel approaches for biology-based treatment in advanced gastric cancer. We reviewed the latest translational and clinical research articles and congress presentations. RECENT FINDINGS:A new molecular classification of gastric cancer based on histology, genet...

journal_title：Current opinion in oncology

authors： Obermannová R,Lordick F

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Loss of cell growth control is not sufficient to explain why tumours form as the immune system recognizes many malignant cells and keeps them in check. The local inflammatory microenvironment is a pivotal factor in tumour formation, as tumour-associated inflammation actively suppresses antitumour immu...

journal_title：Current opinion in oncology

authors： Huang L,Mellor AL

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The mesenchymal-epidermal transition (c-MET) receptor tyrosine kinase has a central role in the cancer cell's survival. MET and its ligand, hepatocyte growth factor (HGF), have recently been identified as promising targets in solid tumors, including nonsmall-cell lung cancer (NSCLC). RECENT FINDINGS:...

journal_title：Current opinion in oncology

authors： Landi L,Minuti G,D'Incecco A,Cappuzzo F

更新日期：2013-03-01 00:00:00

abstract：:Many new modalities and increasing data have become available in the treatment of brain tumors. We will review the growing experience with newer treatment modalities such as brachytherapy, radiosurgery, hyperthermia, and photodynamic therapy. ...

journal_title：Current opinion in oncology

authors： Bahary JP,Larson DA

更新日期：1992-06-01 00:00:00

abstract：:Collaborative study groups have invested considerable effort in the last decade in defining the role of allogeneic and autologous bone marrow transplantation as consolidation treatment for first remission of acute myeloid leukemia in younger patients. These efforts have been able, more precisely, to quantitate the deg...

journal_title：Current opinion in oncology

authors： Burnett AK,Kell J

更新日期：2000-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Evaluate the recent literature about the relation of clinical infection and colorectal cancer in terms of diagnosis of an occult infection and possible impact on oncological outcome and review the possible role of the gut microbiota in the role of colorectal cancer oncogenesis. RECENT FINDINGS:Data p...

journal_title：Current opinion in oncology

authors： Massaut E,Hendlisz B,Klastersky JA

更新日期：2019-07-01 00:00:00

abstract：:With the widespread diffusion of stereotactic radiosurgical procedures, GKR treatments have gained considerable momentum as a major therapeutic option for patients harboring primary or metastatic brain tumors. Present results in high grade gliomas indicate a potential palliative role of this technique. The overall low...

journal_title：Current opinion in oncology

authors： Gerosa M,Nicolato A,Foroni R

更新日期：2003-05-01 00:00:00

abstract：:Although variation in diet may account for approximately one third of the variation in cancer incidence worldwide, epidemiologic studies have proven to be a blunt instrument for identifying causal relationships between intakes of specific food constituents and cancer risk at specific sites. Diets rich in fruits and ve...

journal_title：Current opinion in oncology

authors： Mathers JC,Burn J

更新日期：1999-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Therapy of malignant melanoma recently experienced remarkable advances with the introduction of two treatment regimens, gene mutation-based therapies with signaling pathway inhibitors (kinase inhibitors) and treatments with immune modulators. Both strategies prolong patients' survival but still have s...

journal_title：Current opinion in oncology

authors： Griewank KG,Ugurel S,Schadendorf D,Paschen A

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews the potential benefit of maintenance therapy for patients with follicular lymphoma. RECENT FINDINGS:Follicular lymphoma, despite substantial improvements in survival, is usually incurable. Several randomized studies have shown that the combination of anti-CD20 and chemotherapy ca...

journal_title：Current opinion in oncology

authors： Michallet AS,Coiffier B,Salles G

更新日期：2011-09-01 00:00:00