Recent developments in supporting adolescent and young adult siblings of cancer patients.

abstract：PURPOSE OF REVIEW:Temsirolimus (Torisel) is a mammalian target of rapamycin (mTOR) inhibitor approved for the treatment of relapsed/refractory mantle cell lymphoma (MCL). The recommended dosage in this indication (175 mg once weekly for 3 weeks and then 75 mg once weekly as maintenance) is higher than that for renal ce...

journal_title：Current opinion in oncology

authors： Bouabdallah K,Ribrag V,Terriou L,Soria JC,Delarue R

更新日期：2013-03-01 00:00:00

abstract：:Renal cell carcinoma remains a challenge for oncologists, with only 20% of patients being cured by surgical removal of the involved kidney and a handful of patients with advanced disease being cured by surgery, immunotherapy, or both. Although advances in early detection, recognition of high-risk groups, and chemother...

journal_title：Current opinion in oncology

authors： Savage PD

更新日期：1994-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite significant improvements in the treatment of Burkitt lymphoma, outcomes of adults are generally inferior to those of children. This review summarizes the most recent developments in the management of Burkitt lymphoma and leukemia in adults. RECENT FINDINGS:Current regimens have largely been d...

journal_title：Current opinion in oncology

authors： Kasamon YL,Swinnen LJ

更新日期：2004-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Mantle cell lymphoma is an aggressive non-Hodgkin's lymphoma characterized by the t(11;14) chromosomal translocation and overexpression of cyclin D1. Constituting approximately 5 to 8% of all non-Hodgkin's lymphomas, it carries the poorest prognosis among non-Hodgkin's lymphoma subtypes. Standard and ...

journal_title：Current opinion in oncology

authors： Williams ME,Densmore JJ

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:We aimed to summarize the recent reflections and collaborative initiatives pertaining to the definition of more appropriate eligibility criteria in cancer clinical trials. RECENT FINDINGS:There is an intrinsic tension between two opposite purposes when it comes to defining eligibility criteria: on th...

journal_title：Current opinion in oncology

authors： Penel N,Lebellec L,Vanseymortier M

更新日期：2018-09-01 00:00:00

abstract：:The interferons are complex proteins that have been widely tested as therapy for neoplastic diseases. Interferon (IFN)-alpha has been the most extensively studied in melanoma. It produces responses in about 16% of metastatic melanomas, about one third of which are complete. It has been combined with chemotherapy and b...

journal_title：Current opinion in oncology

authors： Agarwala SS,Kirkwood JM

更新日期：1996-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Molecular genetic alterations characterize the development of human cancer. Recent advances in molecular genetic technology and the success of the human genome project have empowered investigators with new tools in dissecting the cancer genome for discovery of new cancer-associated genes. The purpose ...

journal_title：Current opinion in oncology

authors： Shih IeM,Wang TL

更新日期：2005-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The accumulation of somatic mutations is the major driving force for tumorigenesis. These mutations uniquely differentiate tumor cells from their normal counterparts. Mutations within tumor cells and mutant DNA released by tumor cells into blood, lymph, stool, tissues and other bodily compartments can...

journal_title：Current opinion in oncology

authors： Diehl F,Diaz LA Jr

更新日期：2007-01-01 00:00:00

abstract：:Lymphomas include a vast number of pathologic conditions in which the search for new active drugs follows different routes. Hodgkin's disease and high-grade non-Hodgkin's lymphoma are very sensitive to chemotherapy, responding well to existing regimens; the inability to cure seems to be caused by acquired drug resista...

journal_title：Current opinion in oncology

authors： Straneo M,Gianni L

更新日期：1994-09-01 00:00:00

abstract：:Despite its appeal, lung cancer screening has been found to be of little value at this time. However, use of monoclonal antibodies to detect cancer cells in the sputum may prove to be of value in high-risk subjects. Once a cancer is diagnosed, anatomic staging by the International TNM Staging System has shown its effe...

journal_title：Current opinion in oncology

authors： Shields TW

更新日期：1991-04-01 00:00:00

abstract：:Over the past year, several research areas have been noteworthy. This article discusses several reports on psychiatric morbidity and psychological factors of breast cancer, quality-of-life issues related to breast cancer treatment, and psychological factors in breast cancer screening. An area of increasing interest in...

journal_title：Current opinion in oncology

authors： Stefanek ME

更新日期：1992-12-01 00:00:00

abstract：:Controversy exists over the role that environmental estrogens, such as pesticides or polychlorinated biphenyls (PCBs), might play as risk factors for breast cancer. Several laboratory studies have suggested that these chemicals function as weak estrogens, binding to the estrogen receptor and inducing various measures ...

journal_title：Current opinion in oncology

authors： Davidson NE

更新日期：1998-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on the current concepts relating to the use of radiation therapy in the care of surgical patients with retroperitoneal sarcoma. Radiation therapy for retroperitoneal sarcoma patients is complex because it requires decisions on not only the timing of administration, but also the tec...

journal_title：Current opinion in oncology

authors： Pawlik TM,Ahuja N,Herman JM

更新日期：2007-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an overview of recent updates in understanding the mechanisms by which glioblastoma cells interact with their cellular and molecular partners within the microenvironment. RECENT FINDINGS:We have now a better knowledge of the cell populations involved in Glioblastoma (GBM) invasio...

journal_title：Current opinion in oncology

authors： Chouleur T,Tremblay ML,Bikfalvi A

更新日期：2020-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review presents the analysis of recently published studies about the benefit from granulocyte-colony stimulating factors (G-CSF) in older cancer patients receiving chemotherapy. RECENT FINDINGS:During the last years, no major study aiming to confirm the clinical benefit of G-CSF prophylaxis in o...

journal_title：Current opinion in oncology

authors： Klastersky JA,Dal Lago L,Lalami Y

更新日期：2020-07-01 00:00:00

abstract：:Thyroid cancers are still the most common endocrine cancers. They are dominated by well-differentiated carcinomas, including papillary carcinoma, follicular carcinoma, and medullary thyroid carcinoma. Diagnosis is based on fine-needle aspiration cytologic examination. Recently, reverse transcription polymerase chain r...

journal_title：Current opinion in oncology

authors： Bi J,Lu B

更新日期：2000-01-01 00:00:00

abstract：:New data continue to refine our knowledge of systemic therapy for breast cancer. These include the third Oxford Overview on adjuvant systemic therapy, a small advantage of anthracycline regimens over CMF (cyclophosphamide, methotrexate, and 5-fluorouracil), and renewed interest in the "classic CMF" regimen. Primary ch...

journal_title：Current opinion in oncology

authors： Wolff AC

更新日期：1999-11-01 00:00:00

abstract：PURPOSE OF REVIEW:(18)F-fluoro-2-deoxy-D-glucose PET-computed tomography (CT) has a major clinical impact in oncology not only for diagnostics but also for staging, response assessment, and relapse detection. However, several other PET tracers are needed for a more complete molecular characterization of cancers which h...

journal_title：Current opinion in oncology

authors： Garcia C,Gebhart G,Flamen P

更新日期：2012-11-01 00:00:00

abstract：:Perioperative brachytherapy results in a better local control rate than surgery alone for extremity soft tissue sarcoma. Brachytherapy enables the delivery of a high radiation dose to a limited volume of tissue, allows the reduction of radiation treatment time, enables direct visualization of the tumor bed and surroun...

journal_title：Current opinion in oncology

authors： Ballo MT,Lee AK

更新日期：2003-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize major recent findings on the biology of human herpesvirus-8, i.e. Kaposi's sarcoma-associated herpesvirus, and the implications of these findings for Kaposi's sarcoma treatment. RECENT FINDINGS:Although reduced in incidence in developed countries since the introduction of highly active a...

journal_title：Current opinion in oncology

authors： Dittmer DP,Krown SE

更新日期：2007-09-01 00:00:00

abstract：:Although variation in diet may account for approximately one third of the variation in cancer incidence worldwide, epidemiologic studies have proven to be a blunt instrument for identifying causal relationships between intakes of specific food constituents and cancer risk at specific sites. Diets rich in fruits and ve...

journal_title：Current opinion in oncology

authors： Mathers JC,Burn J

更新日期：1999-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Imatinib has exceptional activity in controlling gastrointestinal stromal tumor (GIST) due to inhibition of the constitutively active conformation of KIT and platelet-derived growth factor-alpha (PDGFRA), which is commonly seen in this tumor. This review explores the current available data on the corr...

journal_title：Current opinion in oncology

authors： Marrari A,Trent JC,George S

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:In the 1990s, cancer patients were described as poor candidates for ICU admission on the basis of high mortality rates and management costs. Over the last decade, however, advances in the management of malignancies and organ failures have led to substantial increases in survival. This review discusses...

journal_title：Current opinion in oncology

authors： Darmon M,Azoulay E

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The rising incidence of oropharyngeal squamous cell carcinoma (OPSCC), in large part as a result of the human papillomavirus (HPV), has driven a movement for the change in the management strategies. Renewed interest in minimally invasive approaches of endoscopic head and neck surgery led to introducti...

journal_title：Current opinion in oncology

authors： Dias FL,Walder F,Leonhardt FD

更新日期：2017-05-01 00:00:00

abstract：:Collaborative study groups have invested considerable effort in the last decade in defining the role of allogeneic and autologous bone marrow transplantation as consolidation treatment for first remission of acute myeloid leukemia in younger patients. These efforts have been able, more precisely, to quantitate the deg...

journal_title：Current opinion in oncology

authors： Burnett AK,Kell J

更新日期：2000-03-01 00:00:00

abstract：:Biologic approaches to lymphoma treatment are now a practical reality rather than a vaguely perceived hope for the future. Interferon alfa seems to have been established as a life-extending therapy for selected patients with follicular lymphoma. Humanized anti-CD20 monoclonal antibody (rituximab) has an authentic 50% ...

journal_title：Current opinion in oncology

authors： Bendandi M,Longo DL

更新日期：1999-09-01 00:00:00

abstract：:The use of highly sensitive and specific assays to detect residual disease in patients with acute leukemia should provide a basis for optimizing therapy and maximizing each patient's chance of cure. Strategies for detecting residual disease are based on biologic properties that allow acute leukemia cells to be disting...

journal_title：Current opinion in oncology

authors： Baer MR

更新日期：1998-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Tumor stroma is composed of many cellular subtypes, of which the most abundant are fibroblasts, macrophages and endothelial cells. During the process of tissue injury, these three cellular subtypes must coordinate their activity to efficiently contribute to tissue regeneration. In tumor, this mechanis...

journal_title：Current opinion in oncology

authors： Ronca R,Van Ginderachter JA,Turtoi A

更新日期：2018-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The possibility of complete recovery for a lung cancer patient depends on very early diagnosis, as it allows total surgical resection. Screening for this cancer in a high-risk population can be performed using a radiological approach, but this holds a certain number of limitations. Liquid biopsy could...

journal_title：Current opinion in oncology

authors： Hofman P

更新日期：2017-01-01 00:00:00

abstract：:Cutaneous T-cell lymphoma, which usually presents as mycosis fungoides or Sézary syndrome, remains a mostly incurable, yet highly treatable group of diseases. The myriad of active therapies continues to grow, and new insights into the mechanism of systemic and topical therapies are being elucidated. Multimodality trea...

journal_title：Current opinion in oncology

authors： Kaplan EH,Leslie WT

更新日期：1993-09-01 00:00:00