Abstract:
PURPOSE OF REVIEW:Therapy of malignant melanoma recently experienced remarkable advances with the introduction of two treatment regimens, gene mutation-based therapies with signaling pathway inhibitors (kinase inhibitors) and treatments with immune modulators. Both strategies prolong patients' survival but still have specific limitations, demanding the identification of additional genetic and immunological biomarkers as predictors of treatment response and prognosis. New developments in that field are summarized in this review. RECENT FINDINGS:Activating oncogene mutations are important melanoma biomarkers. They predict responsiveness to kinase inhibitor therapies and have therapy independent prognostic relevance. Epigenetic alterations (DNA methylation, chromatin remodeling, and noncoding RNA) in melanoma are emerging as potentially valuable biomarkers. With the successful introduction of immunotherapies for melanoma, interest in immunological biomarkers has grown. Tumor-reactive cytotoxic T cells from patients' peripheral blood were recently proposed to predict prognosis and response to immunotherapy. A superior immune profile assessment could be achieved by combining a detailed characterization of a tumor's immune cell infiltrate with its (immune) gene signature. SUMMARY:Genetic melanoma markers have already become clinically relevant. We expect both their role and that of immunological biomarkers to increase significantly in the next few years, enabling personalized therapy with optimal treatment selection for individual tumors.
journal_name
Curr Opin Oncoljournal_title
Current opinion in oncologyauthors
Griewank KG,Ugurel S,Schadendorf D,Paschen Adoi
10.1097/CCO.0b013e32835dafdfsubject
Has Abstractpub_date
2013-03-01 00:00:00pages
145-51issue
2eissn
1040-8746issn
1531-703Xjournal_volume
25pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:To present the model of the Supportive Care in Cancer Unit (SCCU) of the National Cancer Institute (NCI) of Milan. RECENT FINDINGS:In the last few years, there has been a debate on different models of integration of palliative care in oncology, on early palliative care, supportive care, supportive an...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e328352eabc
更新日期:2012-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Imatinib has exceptional activity in controlling gastrointestinal stromal tumor (GIST) due to inhibition of the constitutively active conformation of KIT and platelet-derived growth factor-alpha (PDGFRA), which is commonly seen in this tumor. This review explores the current available data on the corr...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e32833a6b8e
更新日期:2010-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Langerhans cell histiocytosis (LCH) is a rare disorder characterized by the infiltration of involved tissues by specialized dendritic cells. The demonstration of the constant activation of the mitogen-activated protein kinase (MAPK) pathway in LCH lesions has been a breakthrough in the understanding o...
journal_title:Current opinion in oncology
pub_type: 杂志文章
doi:10.1097/CCO.0000000000000707
更新日期:2020-12-09 00:00:00
abstract:PURPOSE OF REVIEW:The possibility of complete recovery for a lung cancer patient depends on very early diagnosis, as it allows total surgical resection. Screening for this cancer in a high-risk population can be performed using a radiological approach, but this holds a certain number of limitations. Liquid biopsy could...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000343
更新日期:2017-01-01 00:00:00
abstract::There is an emerging consensus on the importance of identifying non-Hodgkin's lymphoma patients with different prognoses so that these patients can be optimally treated and the relative benefits of different therapeutic approaches can be adequately assessed. This review of recent publications on prognostic factors in ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199210000-00007
更新日期:1992-10-01 00:00:00
abstract:PURPOSE OF REVIEW:This review highlights the most important developments in the biology and treatment of Merkel cell carcinoma published in the medical literature over the past year. RECENT FINDINGS:Adjuvant radiotherapy to the primary site with or without coverage of the nodal region is recommended in most older seri...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e3282f46d5d
更新日期:2008-03-01 00:00:00
abstract::Tamoxifen as adjuvant systemic treatment after first isolated locoregional recurrence of breast cancer has been shown to decrease the subsequent locoregional relapse rate, but it affects neither distant metastases nor survival. In metastatic disease, tamoxifen has not improved response when added to ablation of ovaria...
journal_title:Current opinion in oncology
pub_type: 临床试验,杂志文章,评审
doi:10.1097/00001622-199511000-00008
更新日期:1995-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the 2008-2009 literature on pediatric genitourinary tumors and highlight the most significant publications. RECENT FINDINGS:New techniques such as gene expression profiling, PET, nephron-sparing surgery, and stem cell transplantation are being incorporated into contemporary treatments for p...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e32833841a1
更新日期:2010-05-01 00:00:00
abstract::Biologic approaches to lymphoma treatment are now a practical reality rather than a vaguely perceived hope for the future. Interferon alfa seems to have been established as a life-extending therapy for selected patients with follicular lymphoma. Humanized anti-CD20 monoclonal antibody (rituximab) has an authentic 50% ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199909000-00005
更新日期:1999-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to highlight the most important developments in the diagnosis, prevention, and management of prostate cancer reported in the past year that have been published in the medical literature. RECENT FINDINGS:Recent research has yielded important insights into the effects of l...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200405000-00009
更新日期:2004-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Mycosis fungoides and Sézary syndrome arise from malignant T cells that reside in skin, and subsequently are capable of circulating between skin, lymph nodes, and blood. The pathophysiologic mechanisms that cause and result in different behaviors of the skin-homing-malignant T cells in different stage...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000243
更新日期:2016-01-01 00:00:00
abstract:PURPOSE OF REVIEW:For several decades, hematopoietic cell transplantation (HCT) has been considered the standard curative therapy for many patients with hematological malignancies. In addition to the cytotoxic effects of the chemotherapy and radiation used in the conditioning regimen, the benefits of HCT are derived fr...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000408
更新日期:2017-11-01 00:00:00
abstract::Graft-versus-host disease (GVHD) continues to be a major obstacle to the success of allogeneic bone marrow transplantation. Furthermore, several clinical strategies being employed at this time in the field of bone marrow transplantation have had an impact on GVHD. In addition to the usual division of topics such as pa...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199703000-00005
更新日期:1997-03-01 00:00:00
abstract::The incidence and variety of solid tumors reported among human immunodeficiency virus (HIV)-infected individuals are increasing. Among the most common of these tumors are anogenital malignant and premalignant tumors associated with human papillomavirus infection. Cervical intraepithelial neoplasia is one such human pa...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199110000-00012
更新日期:1991-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Immunotherapy of HPV-induced premalignant anogenital lesions and cervical cancer has made impressive progress. HPV as causative agent is targeted by prophylactic and therapeutic vaccination strategies. Preclinical and clinical studies have shown induction of natural and/or vaccine-induced immune respo...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200409000-00013
更新日期:2004-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Human immunodeficiency virus infection is associated with an increased risk of non-Hodgkin lymphoma. Even with a decrease in AIDS-defining illnesses after the advent of highly active antiretroviral therapy, HIV-associated non-Hodgkin lymphoma remains an important problem. RECENT FINDINGS:Low CD4+ T-l...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/01.cco.0000239881.16216.05
更新日期:2006-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The management of febrile neutropenia has evolved significantly with the development of risk stratification and recognition of the efficacy of oral antibiotics in low-risk patients. There remains uncertainty concerning the need for hospitalization and role of early hospital discharge. We review recent...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e3281214436
更新日期:2007-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Concept of refractory coeliac disease (RCD) emerged in the past decade and refers to persistence of malnutrition and intestinal villous atrophy for more than 1 year strict gluten-free diet in coeliac patients. Diagnosis of this condition remains difficult and conditions treatment and follow-up. RECEN...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/01.cco.0000432526.47228.b6
更新日期:2013-09-01 00:00:00
abstract::During the past year there have been a number of important advances in the area of systemic therapy for breast cancer. Combined chemoendocrine therapy has been shown to be more effective than tamoxifen alone in the adjuvant therapy of node-negative estrogen receptor-positive breast cancer. Preliminary results of a ran...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199811000-00007
更新日期:1998-11-01 00:00:00
abstract::Although variation in diet may account for approximately one third of the variation in cancer incidence worldwide, epidemiologic studies have proven to be a blunt instrument for identifying causal relationships between intakes of specific food constituents and cancer risk at specific sites. Diets rich in fruits and ve...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199909000-00015
更新日期:1999-09-01 00:00:00
abstract::The preclinical and clinical investigations of therapeutic approaches to melanoma have progressed significantly in the past year. This article reviews recently published information relevant to preclinical studies of the biologic function of stromal tissue, growth factors (and receptors), interferons, cytokines, and a...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199204000-00020
更新日期:1992-04-01 00:00:00
abstract::The correct use of tumor markers in patients with gynecological cancers can make an impact on management of the disease. Their value in screening for ovarian cancer cannot be recommended outside trials. Increased levels of various markers give prognostic information that could alter therapy for patients with early ova...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199609000-00015
更新日期:1996-09-01 00:00:00
abstract::Recent publications dealing with the pathology of squamous carcinomas of the head and neck have been critically reviewed with particular reference to potential prognostic factors and improved methods for identifying nodal metastases. The topics covered include cytophotometry and proliferative patterns, molecular biolo...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199305000-00009
更新日期:1993-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Increasing attention is being given to personalized medicine in oncology, where therapies are tailored to the particular characteristics of the individual cancer patient. In recent years, there has been greater focus on prostate-specific membrane antigen (PSMA) in prostate cancer (PCa) as a target for...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000277
更新日期:2016-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The remarkable progress witnessed over the past few years in the diagnosis, prognosis, and therapy of chronic lymphocytic leukemia has profoundly changed the clinical approach to this disease. This review focuses on the most recent advances in the diagnostic and prognostic examination of patients with...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/01.cco.0000181403.75460.c7
更新日期:2005-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize recent developments and controversies in the diagnosis and management of nonmuscle invasive bladder cancer (NMIBC). RECENT FINDINGS:The majority of incident bladder cancer diagnoses are noninvasive. The mainstay of diagnosis remains cystoscopy and transurethral resection, with enhanced o...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000067
更新日期:2014-05-01 00:00:00
abstract::The currently used staging system in melanoma has not been significantly modified since 1988. While this four-stage system effectively stratifies patients into prognostic groups, additional discriminating criteria have been reported that is not presently incorporated in the staging system. The following additions and ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199803000-00013
更新日期:1998-03-01 00:00:00
abstract::The treatment options for patients with recurrent head and neck malignancies arising in a previously irradiated field are limited. Surgical salvage is feasible in a minority of patients. The majority are referred for palliative chemotherapy with no realistic chance for cure. Data are accumulating to support reirradiat...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200205000-00013
更新日期:2002-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Melanoma is the third most common metastatic brain tumor in the United States and is a major cause of morbidity and mortality. The development of more effective therapies for melanoma brain metastases is a major unmet clinical need and is summarized in this review. RECENT FINDINGS:Management strategi...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200403000-00014
更新日期:2004-03-01 00:00:00
abstract::The development of new chemotherapeutic agents for cancer treatment is pursued with the hope of finding compounds with novel chemical characteristics, unique mechanisms of action, and with improved therapeutic indexes. Seven novel agents at different stages of clinical development have been selected for review. D1694 ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199112000-00011
更新日期:1991-12-01 00:00:00