Reclassifying endometrial carcinomas with a combined morphological and molecular approach.

abstract：PURPOSE OF REVIEW:The possibility of complete recovery for a lung cancer patient depends on very early diagnosis, as it allows total surgical resection. Screening for this cancer in a high-risk population can be performed using a radiological approach, but this holds a certain number of limitations. Liquid biopsy could...

journal_title：Current opinion in oncology

authors： Hofman P

更新日期：2017-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on the current concepts relating to the use of radiation therapy in the care of surgical patients with retroperitoneal sarcoma. Radiation therapy for retroperitoneal sarcoma patients is complex because it requires decisions on not only the timing of administration, but also the tec...

journal_title：Current opinion in oncology

authors： Pawlik TM,Ahuja N,Herman JM

更新日期：2007-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Melanoma is the third most common metastatic brain tumor in the United States and is a major cause of morbidity and mortality. The development of more effective therapies for melanoma brain metastases is a major unmet clinical need and is summarized in this review. RECENT FINDINGS:Management strategi...

journal_title：Current opinion in oncology

authors： Tarhini AA,Agarwala SS

更新日期：2004-03-01 00:00:00

abstract：PURPOSE OF REVIEW:T-cell lymphomas (TCL) represent a particularly poor prognosis subgroup of lymphomas. The goal of this review is to provide emerging information on one agent demonstrating activity in these challenging diseases. Pralatrexate is a novel antifolate designed to have high affinity for the reduced folate c...

journal_title：Current opinion in oncology

authors： O'Connor OA

更新日期：2006-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Several epidemiologic studies have enhanced our understanding of the impact of respiratory viruses on bone marrow transplant recipients. RECENT FINDINGS:Respiratory viral infections occur frequently following stem cell transplantation but present atypically. Many patients have asymptomatic infections...

journal_title：Current opinion in oncology

authors： Ison MG

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The most common mechanism of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is acquisition of the T790M gatekeeper mutation. Third-generation EGFR TKIs irreversibly inhibit EGFR mutants (EGFRm), especially T790M, while sparing wild-type EGFR. There are several ...

journal_title：Current opinion in oncology

authors： Sun JM,Park K

更新日期：2017-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Myelodysplastic syndromes (MDSs) are rare disorders in children, showing peculiar clinical manifestations and biological features. This review will summarize biological, genetic and clinical features of childhood MDS and will provide an update of the algorithm of treatment of the different disease var...

journal_title：Current opinion in oncology

authors： Galaverna F,Ruggeri A,Locatelli F

更新日期：2018-11-01 00:00:00

abstract：:The bcr-abl fusion protein is present in the vast majority of cases of chronic myelogenous leukemia, and the deregulated tyrosine kinase activity of this protein is essential for leukemic transformation. Thus, bcr-abl is an ideal target for pharmacologic inhibition. In preclinical studies, ST1571 (formerly CGP57148B),...

journal_title：Current opinion in oncology

authors： O'Dwyer ME,Druker BJ

更新日期：2000-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Mycosis fungoides and Sézary syndrome arise from malignant T cells that reside in skin, and subsequently are capable of circulating between skin, lymph nodes, and blood. The pathophysiologic mechanisms that cause and result in different behaviors of the skin-homing-malignant T cells in different stage...

journal_title：Current opinion in oncology

authors： Rubio Gonzalez B,Zain J,Rosen ST,Querfeld C

更新日期：2016-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Sub-Saharan Africa has the largest population of people living with AIDS in the world, with Nigeria having the third largest after South Africa and India. With the advent of treatment programs, more people in Nigeria are now living with the virus but are at increased risk of cancer similar to the expe...

journal_title：Current opinion in oncology

authors： Akinwande O,Ogundiran T,Akarolo-Anthony S,Mamadu I,Dakum P,Blattner W,Adebamowo C

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Small bowel adenocarcinoma (SBA) is a rare cancer with a poor prognosis and little information to guide its management. In recent years, improved diagnostic imaging and an increase in reported experience with use of chemotherapy may alter the way we manage SBA. This review will summarize recent advanc...

journal_title：Current opinion in oncology

authors： Speranza G,Doroshow JH,Kummar S

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Oral mucositis remains a frequent debilitating toxicity associated with drug and radiation regimens used to treat cancer. This review highlights the recent understanding of the biological basis, risk factors for, and management for oral mucositis. RECENT FINDINGS:Prevalence and incidence data for muc...

journal_title：Current opinion in oncology

authors： Villa A,Sonis ST

更新日期：2015-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Management of the epithelial ovarian cancer (EOC) remains a therapeutic challenge, with continued poor overall survival (OS). Given low chemotherapy response rates for recurrent disease and short survival times, new treatment options with improved therapeutic indices for targeting cancer's vulnerabili...

journal_title：Current opinion in oncology

authors： Ratner ES,Sartorelli AC,Lin ZP

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The worldwide incidence of melanoma and nonmelanoma skin cancers is increasing alarmingly. The development of new techniques such as dermoscopy leads to a consequent progress in skin cancers screening. The purpose of this review is to highlight recent advances in dermoscopy, reviewing primary research...

journal_title：Current opinion in oncology

authors： Massone C,Di Stefani A,Soyer HP

更新日期：2005-03-01 00:00:00

abstract：:The use of highly sensitive and specific assays to detect residual disease in patients with acute leukemia should provide a basis for optimizing therapy and maximizing each patient's chance of cure. Strategies for detecting residual disease are based on biologic properties that allow acute leukemia cells to be disting...

journal_title：Current opinion in oncology

authors： Baer MR

更新日期：1998-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the state-of-the-art and new developments in the management of patients with brain metastases. RECENT FINDINGS:Treatment decisions are based on prognostic factors to maximize neurologic function and survival, while avoiding unnecessary therapies. Whole-brain radiotherapy (WBRT) is the treat...

journal_title：Current opinion in oncology

authors： Soffietti R,Rudà R,Trevisan E

更新日期：2008-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The rising incidence of oropharyngeal squamous cell carcinoma (OPSCC), in large part as a result of the human papillomavirus (HPV), has driven a movement for the change in the management strategies. Renewed interest in minimally invasive approaches of endoscopic head and neck surgery led to introducti...

journal_title：Current opinion in oncology

authors： Dias FL,Walder F,Leonhardt FD

更新日期：2017-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The review aims at comprehensively discussing our current knowledge on bone metastases incidence in non-small cell lung cancer (NSCLC), their related complications as well as clinical impact in patients suffering from advanced disease. RECENT FINDINGS:After evoking the use of zoledronic acid as the e...

journal_title：Current opinion in oncology

authors： Peters S,Meylan E

更新日期：2013-03-01 00:00:00

abstract：:This review presents some of the articles published over the past year pertaining to the etiology, epidemiology, risk and prognostic factors, screening, and imaging techniques of gynecologic cancer. The most significant advances in this period were made in the area of the genetics of gynecologic cancers and the factor...

journal_title：Current opinion in oncology

authors： Leung Y,DePetrillo AD

更新日期：1993-09-01 00:00:00

abstract：:Over the past year, a number of important papers have appeared in the medical literature dealing with the chemotherapeutic management of gynecologic cancers. Among these papers, several studies have again demonstrated the superiority of platinum-based chemotherapy regimens for ovarian cancer compared with non-platinum...

journal_title：Current opinion in oncology

authors： Markman M

更新日期：1992-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Neoplasms of the endocrine pancreas, commonly referenced as pancreatic islet cell tumors, are rare, often well differentiated endocrine neoplasms, whose biology remains poorly characterized. This article reviews the current clinical management of pancreatic islet cell tumors and describes the molecula...

journal_title：Current opinion in oncology

authors： House MG,Schulick RD

更新日期：2006-01-01 00:00:00

abstract：:Human immunodeficiency virus (HIV)-1 infection is associated with increased frequency of Kaposi's sarcoma and high-grade B-cell lymphoma. Several other cancers in HIV-1-infected individuals have been reported, although without statistically significant increase in their respective occurrences. Although HIV-1 does not ...

journal_title：Current opinion in oncology

authors： Gill PS

更新日期：1991-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss the recent developments of multimodal treatment for patients with local advanced rectal cancer, including incorporation of new chemotherapeutic and targeted agents, and the optimal sequence and timing of treatment components. RECENT FINDINGS:Five randomized trials have been completed to de...

journal_title：Current opinion in oncology

authors： Rödel C,Hofheinz R,Liersch T

更新日期：2012-07-01 00:00:00

abstract：:The development of non-myeloablative and reduced-intensity conditioning regimens has enabled older or medically infirm patients with myeloid malignancies to be treated with allogeneic hematopoietic cell transplantation (HCT). The regimens are sufficiently immunosuppressive to allow engraftment of allogeneic cells and ...

journal_title：Current opinion in oncology

authors： Storb R

更新日期：2009-06-01 00:00:00

abstract：:Breast cancer remains a worldwide public health concern despite the fact that mortality rates have been declining in some countries as a result of improvements in adjuvant therapy and screening for breast cancer. In the prevention arena, advances in our understanding of the effects of tamoxifen have led to the investi...

journal_title：Current opinion in oncology

authors： Brewster A,Helzlsouer K

更新日期：2001-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on the surgical management of soft tissue sarcomas of the hands and the feet. With recent advances in limb salvage surgery and radiotherapy delivery, local control of soft tissue sarcoma in the extremity has become optimized, and the associated functional results of this treatment ...

journal_title：Current opinion in oncology

authors： Ferguson PC

更新日期：2005-07-01 00:00:00

abstract：:Malignant melanoma is a tumor that offers unique possibilities for approaches to targeted therapy by virtue of the pigment biosynthesis pathway. Such approaches may seek to use the incorporation of toxic intermediates or to use the natural transcriptional control of genes coding for enzymes involved in melanin formati...

journal_title：Current opinion in oncology

authors： Hart IR,Vile RG

更新日期：1994-03-01 00:00:00

abstract：:Many new modalities and increasing data have become available in the treatment of brain tumors. We will review the growing experience with newer treatment modalities such as brachytherapy, radiosurgery, hyperthermia, and photodynamic therapy. ...

journal_title：Current opinion in oncology

authors： Bahary JP,Larson DA

更新日期：1992-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Differentiated thyroid cancer (DTC), with a rapidly increasing incidence is the most common endocrine malignancy, but with generally favorable survival. Total thyroidectomy with 'therapeutic' cervical lymph node dissection for involved lymph nodes is the standard of care. A more controversial topic is...

journal_title：Current opinion in oncology

authors： Carling T,Long WD 3rd,Udelsman R

更新日期：2010-01-01 00:00:00

abstract：:Kaposi sarcoma (KS), an unusual tumor of vascular origin, was one of the first recognized manifestations of AIDS. In the past few years, it has become clear that human herpesvirus-8 (HHV-8) is critical to the development of KS in the setting of immunosuppression, such as that seen with HIV infection. Other genetic and...

journal_title：Current opinion in oncology

authors： Mitsuyasu RT

更新日期：2000-03-01 00:00:00