Systemic therapy for gynecologic cancer.

abstract：PURPOSE OF REVIEW:Oral mucositis remains a frequent debilitating toxicity associated with drug and radiation regimens used to treat cancer. This review highlights the recent understanding of the biological basis, risk factors for, and management for oral mucositis. RECENT FINDINGS:Prevalence and incidence data for muc...

journal_title：Current opinion in oncology

authors： Villa A,Sonis ST

更新日期：2015-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The mesenchymal-epidermal transition (c-MET) receptor tyrosine kinase has a central role in the cancer cell's survival. MET and its ligand, hepatocyte growth factor (HGF), have recently been identified as promising targets in solid tumors, including nonsmall-cell lung cancer (NSCLC). RECENT FINDINGS:...

journal_title：Current opinion in oncology

authors： Landi L,Minuti G,D'Incecco A,Cappuzzo F

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Malignant brain tumors have a very poor prognosis and the natural history of disease is very short, usually less than 1 year. Brain tumor patients often present peculiar symptoms of disease that require appropriate supportive treatment, namely, peritumoral brain edema, venous thromboembolism, seizures...

journal_title：Current opinion in oncology

authors： Pace A,Metro G,Fabi A

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Significant advances have been made in the treatment of younger patients with acute myeloid leukemia over the past 3 decades, but prognosis in the elderly has remained dismal, with median survival times of only a few months. Although a small percentage of older patients may be cured by standard chemot...

journal_title：Current opinion in oncology

authors： Amadori S,Del Principe MI,Venditti A

更新日期：2014-11-01 00:00:00

abstract：:The bcr-abl fusion protein is present in the vast majority of cases of chronic myelogenous leukemia, and the deregulated tyrosine kinase activity of this protein is essential for leukemic transformation. Thus, bcr-abl is an ideal target for pharmacologic inhibition. In preclinical studies, ST1571 (formerly CGP57148B),...

journal_title：Current opinion in oncology

authors： O'Dwyer ME,Druker BJ

更新日期：2000-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Neoplasms of the endocrine pancreas, commonly referenced as pancreatic islet cell tumors, are rare, often well differentiated endocrine neoplasms, whose biology remains poorly characterized. This article reviews the current clinical management of pancreatic islet cell tumors and describes the molecula...

journal_title：Current opinion in oncology

authors： House MG,Schulick RD

更新日期：2006-01-01 00:00:00

abstract：:A review of the recent literature about liver cancers shows the increasing role of hepatitis C as a risk factor for the development of hepatocellular carcinoma. A new discussion has arisen with regard to the association between the use of oral contraceptives and hepatocellular carcinoma. Patients at risk for developin...

journal_title：Current opinion in oncology

authors： Weimann A,Oldhafer KJ,Pichlmayr R

更新日期：1995-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Vandetanib is a small molecule tyrosine kinase inhibitor that has been recently approved as an 'orphan drug' for the treatment of patients with unresectable, locally advanced, or metastatic medullary thyroid cancer (MTC). RECENT FINDINGS:MTC is a neuroendocrine malignancy frequently associated with m...

journal_title：Current opinion in oncology

authors： Campbell MJ,Seib CD,Gosnell J

更新日期：2013-01-01 00:00:00

abstract：:Thyroid cancers are still the most common endocrine cancers. They are dominated by well-differentiated carcinomas, including papillary carcinoma, follicular carcinoma, and medullary thyroid carcinoma. Diagnosis is based on fine-needle aspiration cytologic examination. Recently, reverse transcription polymerase chain r...

journal_title：Current opinion in oncology

authors： Bi J,Lu B

更新日期：2000-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Molecular genetic alterations characterize the development of human cancer. Recent advances in molecular genetic technology and the success of the human genome project have empowered investigators with new tools in dissecting the cancer genome for discovery of new cancer-associated genes. The purpose ...

journal_title：Current opinion in oncology

authors： Shih IeM,Wang TL

更新日期：2005-01-01 00:00:00

abstract：:Oligodeoxynucleotides have been proposed as both in vitro and in vivo inhibitors of gene expression because of the specificity of Watson-Crick base pair hybridization. Phosphodiester oligodeoxynucleotides (normal DNA) cannot be used as drugs because they are nuclease sensitive. Significant efforts have been made to st...

journal_title：Current opinion in oncology

authors： Stein CA,Narayanan R

更新日期：1994-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Advances in the health system and medical sciences are continuously pushing the barrier of life-expectancy. As a consequence, humans are being increasingly afflicted by age-associated diseases, such as cancer. The challenge now lies in understanding the mechanisms underlying ageing in order to reduce ...

journal_title：Current opinion in oncology

authors： Pereira B,Ferreira MG

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) constitute a diverse group of neoplasms arising from the diffuse neuroendocrine cell system. During the last 2 years a new classification system, the WHO 2010, has come into clinical practice together with Tumor Nodes Metastases (TNM) staging and...

journal_title：Current opinion in oncology

authors： Oberg K

更新日期：2012-07-01 00:00:00

abstract：:Recent work has shown that: 1) loss of transforming growth factor-beta response is associated with malignant progression, 2) maintenance of autocrine negative transforming growth factor-beta activity is a key impediment to malignant progression, and 3) the major mechanism for loss of RII expression in replication erro...

journal_title：Current opinion in oncology

authors： Brattain MG,Markowitz SD,Willson JK

更新日期：1996-01-01 00:00:00

abstract：:Obstruction of the superior vena cava is seldom a true emergency and should not be treated without an adequate tissue diagnosis. For patients who are poor operative risks for invasive procedures, percutaneous biopsies of mediastinal masses under ultrasound guidance have resulted in a high diagnostic yield. Superior ve...

journal_title：Current opinion in oncology

authors： Shepherd FA

更新日期：1995-03-01 00:00:00

abstract：PURPOSE OF REVIEW:A small percentage of gliomas are caused by inheritance in cancer syndromes but there is also a general familial aggregation of glioma. Recently, low penetrant genes associated with glioma risk have been identified. RECENT FINDINGS:Seven independent chromosomal loci have robustly been associated with...

journal_title：Current opinion in oncology

authors： Melin B

更新日期：2011-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Multiple myeloma is a common hematological malignancy arising in the bone marrow. Bone lesions were initially depicted with conventional radiography, although recently F-FDG PET/CT and MRI are recognized as having a clear role in the initial workup and in the evaluation of therapy response. RECENT FI...

journal_title：Current opinion in oncology

authors： Martí-Bonmatí L,Ramirez-Fuentes C,Alberich-Bayarri Á,Ruiz-Llorca C

更新日期：2015-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Human immunodeficiency virus infection is associated with an increased risk of non-Hodgkin lymphoma. Even with a decrease in AIDS-defining illnesses after the advent of highly active antiretroviral therapy, HIV-associated non-Hodgkin lymphoma remains an important problem. RECENT FINDINGS:Low CD4+ T-l...

journal_title：Current opinion in oncology

authors： Behler CM,Kaplan LD

更新日期：2006-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Concept of refractory coeliac disease (RCD) emerged in the past decade and refers to persistence of malnutrition and intestinal villous atrophy for more than 1 year strict gluten-free diet in coeliac patients. Diagnosis of this condition remains difficult and conditions treatment and follow-up. RECEN...

journal_title：Current opinion in oncology

authors： Malamut G,Cellier C

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Small-cell carcinomas of the gynecologic tract are aggressive malignancies that can be misdiagnosed or inappropriately managed. This review provides a summary of current literature that will help the clinician to correctly diagnose and treat patients with small-cell carcinomas of the cervix, ovary, ut...

journal_title：Current opinion in oncology

authors： Cohen JG,Chan JK,Kapp DS

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Childhood blastomas, unlike adult cancers, originate from developing organs in which molecular and cellular features exhibit differentiation arrest and embryonic characteristics. Conventional cancer therapies, which rely on the generalized cytotoxic effect on rapidly dividing cells, may damage delicat...

journal_title：Current opinion in oncology

authors： Oh L,Hafsi H,Hainaut P,Ariffin H

更新日期：2019-03-01 00:00:00

abstract：:Seroepidemiologic studies show that Kaposi's sarcoma herpesvirus (KSHV) is more prevalent in those populations at higher risk to develop Kaposi's sarcoma (KS). Anti-KSHV antibody titer is also higher in those who develop KS. KSHV is a sexually transmitted disease among homosexual men, but other routes of transmission ...

journal_title：Current opinion in oncology

authors： Whitby D,Boshoff C

更新日期：1998-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The review aims at comprehensively discussing our current knowledge on bone metastases incidence in non-small cell lung cancer (NSCLC), their related complications as well as clinical impact in patients suffering from advanced disease. RECENT FINDINGS:After evoking the use of zoledronic acid as the e...

journal_title：Current opinion in oncology

authors： Peters S,Meylan E

更新日期：2013-03-01 00:00:00

abstract：:It is generally accepted that patients with chronic myelogenous leukemia in chronic phase under the age of 50 years who have HLA-identical siblings, should be offered bone marrow transplantation within the first year of diagnosis. The projected disease-free survival for these patients is 70% to 80% at 4 years, and mos...

journal_title：Current opinion in oncology

authors： Goldman JM

更新日期：1992-04-01 00:00:00

abstract：:Controversy exists over the role that environmental estrogens, such as pesticides or polychlorinated biphenyls (PCBs), might play as risk factors for breast cancer. Several laboratory studies have suggested that these chemicals function as weak estrogens, binding to the estrogen receptor and inducing various measures ...

journal_title：Current opinion in oncology

authors： Davidson NE

更新日期：1998-09-01 00:00:00

abstract：PURPOSE OF REVIEW:More therapeutic options are needed for bone and soft tissue sarcomas, especially for patients with metastatic disease. Recent randomized clinical trials conducted in colon, breast and lung cancer have shown the anti-vascular endothelial growth factor agent, bevacizumab, alone or in combination with c...

journal_title：Current opinion in oncology

authors： Balasubramanian L,Evens AM

更新日期：2006-07-01 00:00:00

abstract：:This paper covers the outcome of previously conducted clinical trials on chemotherapy for malignant pleural mesothelioma and presents data from recent phase II and phase III trials. In contrast to conventional cytotoxic drugs, which have barely produced response rates exceeding 30%, recently introduced chemotherapeuti...

journal_title：Current opinion in oncology

authors： Tomek S,Manegold C

更新日期：2003-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Numerous staging and scoring systems exist for differentiated thyroid cancer (DTC), but all harbor limitations. This has prompted investigation for new factors with prognostic implications for DTC. RECENT FINDINGS:Several new factors that may be involved in DTC risk stratification have emerged, such ...

journal_title：Current opinion in oncology

authors： Papaleontiou M,Haymart MR

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Imatinib has exceptional activity in controlling gastrointestinal stromal tumor (GIST) due to inhibition of the constitutively active conformation of KIT and platelet-derived growth factor-alpha (PDGFRA), which is commonly seen in this tumor. This review explores the current available data on the corr...

journal_title：Current opinion in oncology

authors： Marrari A,Trent JC,George S

更新日期：2010-07-01 00:00:00

abstract：:Chronic myelogenous leukemia (CML) is a hematologic malignancy characterized by an initial chronic phase of expanded clonal myelopoiesis followed by inevitable progression to accelerated phase and finally to fatal blast crisis. Although interferon therapy results in hematologic control of disease in most patients and ...

journal_title：Current opinion in oncology

authors： Enright H,McGlave P

更新日期：1998-03-01 00:00:00