New insights in risk stratification of differentiated thyroid cancer.

abstract：PURPOSE OF REVIEW:PremRNA alternative splicing is more a rule than an exception as it affects more than 90% of multiexons genes and plays a key role in proteome diversity. Here, we discuss some recent studies published in the extensively growing field linking RNA splicing and cancer. RECENT FINDINGS:These last years, ...

journal_title：Current opinion in oncology

authors： Abou Faycal C,Gazzeri S,Eymin B

更新日期：2016-01-01 00:00:00

abstract：:Renal cell carcinoma remains a challenge for oncologists, with only 20% of patients being cured by surgical removal of the involved kidney and a handful of patients with advanced disease being cured by surgery, immunotherapy, or both. Although advances in early detection, recognition of high-risk groups, and chemother...

journal_title：Current opinion in oncology

authors： Savage PD

更新日期：1994-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Preclinical and clinical developments in germ cell tumors over the past year are summarized. RECENT FINDINGS:Attenuations in the rising incidence of testicular germ cell tumors are beginning to be observed in certain European populations. Additional data on predisposing factors related to race, estro...

journal_title：Current opinion in oncology

authors： Bridges B,Hussain A

更新日期：2007-05-01 00:00:00

abstract：:Over the past decade, high-dose chemotherapy followed by autologous bone marrow support (ABMS) has been employed with increasing frequency to treat patients with a variety of solid tumors. This paper explores the rationale and relevant clinical data for the use of this approach to treat patients with breast and ovaria...

journal_title：Current opinion in oncology

authors： Shpall EJ,Jones RB,Bearman S

更新日期：1994-03-01 00:00:00

abstract：:Despite its appeal, lung cancer screening has been found to be of little value at this time. However, use of monoclonal antibodies to detect cancer cells in the sputum may prove to be of value in high-risk subjects. Once a cancer is diagnosed, anatomic staging by the International TNM Staging System has shown its effe...

journal_title：Current opinion in oncology

authors： Shields TW

更新日期：1991-04-01 00:00:00

abstract：:Perioperative brachytherapy results in a better local control rate than surgery alone for extremity soft tissue sarcoma. Brachytherapy enables the delivery of a high radiation dose to a limited volume of tissue, allows the reduction of radiation treatment time, enables direct visualization of the tumor bed and surroun...

journal_title：Current opinion in oncology

authors： Ballo MT,Lee AK

更新日期：2003-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Retroperitoneal sarcoma (RPS) is a rare disease, and until recently, its natural history and outcome were poorly understood. Recently, collaborations between individual centers have led to an unprecedented collection of retrospective and prospective data and successful recruitment to the first randomi...

journal_title：Current opinion in oncology

authors： van Houdt WJ,Raut CP,Bonvalot S,Swallow CJ,Haas R,Gronchi A

更新日期：2019-07-01 00:00:00

abstract：:The publication of the proceedings of Fourth Workshop on Carcinoma in situ was an impressive leap in our understanding of the interaction between prenatal and postpubertal factors in the development of germ cell cancer as well as increased insight into the molecular events that are involved in the development of these...

journal_title：Current opinion in oncology

authors： Oliver RT

更新日期：1999-05-01 00:00:00

abstract：:The past decade has been marked by an explosion of knowledge regarding the dysregulation of cancer at the molecular level. It has become apparent that oncogenes, tumor suppressor genes, and other ancillary molecules interact in complex pathways that govern cellular homeostasis. We review three molecular events that ha...

journal_title：Current opinion in oncology

authors： Dome JS,Look AT

更新日期：1999-01-01 00:00:00

abstract：:The preclinical and clinical investigations of therapeutic approaches to melanoma have progressed significantly in the past year. This article reviews recently published information relevant to preclinical studies of the biologic function of stromal tissue, growth factors (and receptors), interferons, cytokines, and a...

journal_title：Current opinion in oncology

authors： Kirkwood JM

更新日期：1992-04-01 00:00:00

abstract：PURPOSE OF REVIEW:The recent contributions to renal cell carcinoma in the fields of molecular biology and the expanded use of molecularly targeted agents will be reviewed. This study is intended to update prognostic and therapeutic decision-making data and provide perspective on advances in understanding the molecular ...

journal_title：Current opinion in oncology

authors： Rini BI,Rathmell WK,Godley P

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide examples of mitochondria-specific metabolic events that influence tumor cell biology, and of metabolism-related mitochondrial biomarkers and therapeutic targets in cancer cells. RECENT FINDINGS:Cancer cell mitochondria are rewired to optimally serve the cancer cell under various conditions...

journal_title：Current opinion in oncology

authors： Shoshan M

更新日期：2017-01-01 00:00:00

abstract：:Bisphosphonates inhibit osteoclast-mediated bone resorption in metastatic bone disease. A wealth of preclinical data have begun to shed light on the complex mechanisms by which bisphosphonates inhibit bone resorption and interfere with the formation and growth of bone metastases. Nitrogen-containing bisphosphonates in...

journal_title：Current opinion in oncology

authors： Green JR

更新日期：2002-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Crizotinib now is accepted as the standard first-line treatment of ALK-rearranged lung adenocarcinomas. To overcome the problem of crizotinib resistance, second-generation ALK inhibitors are in development. The aim of this review is to give an overview on the mechanisms behind crizotinib resistance an...

journal_title：Current opinion in oncology

authors： Pall G

更新日期：2015-03-01 00:00:00

abstract：:During the past year there have been a number of important advances in the area of systemic therapy for breast cancer. Combined chemoendocrine therapy has been shown to be more effective than tamoxifen alone in the adjuvant therapy of node-negative estrogen receptor-positive breast cancer. Preliminary results of a ran...

journal_title：Current opinion in oncology

authors： Dees EC,Kennedy MJ

更新日期：1998-11-01 00:00:00

abstract：:Diarrhea is a common event in the clinical history of cancer patients. It can be caused by the presence of tumor or it can be a side effect of treatment. The latter problem is occurring more often because new drugs (CPT-11) or drug combinations (fluorouracil plus interferon or leucovorin) have diarrhea as the dose-lim...

journal_title：Current opinion in oncology

authors： Cascinu S

更新日期：1995-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Advances in the health system and medical sciences are continuously pushing the barrier of life-expectancy. As a consequence, humans are being increasingly afflicted by age-associated diseases, such as cancer. The challenge now lies in understanding the mechanisms underlying ageing in order to reduce ...

journal_title：Current opinion in oncology

authors： Pereira B,Ferreira MG

更新日期：2013-01-01 00:00:00

abstract：:The biologic and clinical heterogeneity of lymphomas represents the major obstacle to their diagnosis. Because histologic analysis, which is the initial diagnostic approach, has been demonstrated to be insufficient in the definition of certain types of lymphomas, molecular and immunologic techniques have been increasi...

journal_title：Current opinion in oncology

authors： Veronese ML,Schichman SA,Croce CM

更新日期：1996-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The review aims at comprehensively discussing our current knowledge on bone metastases incidence in non-small cell lung cancer (NSCLC), their related complications as well as clinical impact in patients suffering from advanced disease. RECENT FINDINGS:After evoking the use of zoledronic acid as the e...

journal_title：Current opinion in oncology

authors： Peters S,Meylan E

更新日期：2013-03-01 00:00:00

abstract：:The management of tumors arising from or, by extension, involving the skull base is complex due to the density and sensitivity of nearby neurovascular structures, the proximity of these structures to the relatively contaminated spaces of the paranasal sinuses or ear and mastoid, the varied pathologic entities encounte...

journal_title：Current opinion in oncology

authors： DeMonte F

更新日期：1995-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Vandetanib is a small molecule tyrosine kinase inhibitor that has been recently approved as an 'orphan drug' for the treatment of patients with unresectable, locally advanced, or metastatic medullary thyroid cancer (MTC). RECENT FINDINGS:MTC is a neuroendocrine malignancy frequently associated with m...

journal_title：Current opinion in oncology

authors： Campbell MJ,Seib CD,Gosnell J

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Increasing attention is being given to personalized medicine in oncology, where therapies are tailored to the particular characteristics of the individual cancer patient. In recent years, there has been greater focus on prostate-specific membrane antigen (PSMA) in prostate cancer (PCa) as a target for...

journal_title：Current opinion in oncology

authors： Bouchelouche K,Choyke PL

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The most common mechanism of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is acquisition of the T790M gatekeeper mutation. Third-generation EGFR TKIs irreversibly inhibit EGFR mutants (EGFRm), especially T790M, while sparing wild-type EGFR. There are several ...

journal_title：Current opinion in oncology

authors： Sun JM,Park K

更新日期：2017-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the state-of-the-art of the surgical management of stage IIIA-N2 nonsmall cell lung cancer. RECENT FINDINGS:When completely resected, occult N2 found at thoracotomy, skip metastases, and single-level N2 in selected locations are reported to portend acceptable survival rates. Conversely, p...

journal_title：Current opinion in oncology

authors： Rocco G

更新日期：2009-03-01 00:00:00

abstract：:Oligodeoxynucleotides have been proposed as both in vitro and in vivo inhibitors of gene expression because of the specificity of Watson-Crick base pair hybridization. Phosphodiester oligodeoxynucleotides (normal DNA) cannot be used as drugs because they are nuclease sensitive. Significant efforts have been made to st...

journal_title：Current opinion in oncology

authors： Stein CA,Narayanan R

更新日期：1994-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Mantle cell lymphoma is an aggressive non-Hodgkin's lymphoma characterized by the t(11;14) chromosomal translocation and overexpression of cyclin D1. Constituting approximately 5 to 8% of all non-Hodgkin's lymphomas, it carries the poorest prognosis among non-Hodgkin's lymphoma subtypes. Standard and ...

journal_title：Current opinion in oncology

authors： Williams ME,Densmore JJ

更新日期：2005-09-01 00:00:00

abstract：:In testicular cancer epidemiology, the increasing recognition that germinal epithelial atrophy is the final common pathway in the development of this tumor has developed along with reports that elevated follicule-stimulating hormone levels at the time of diagnosis of first tumor correlate with risk of developing a sec...

journal_title：Current opinion in oncology

authors： Oliver RT

更新日期：1991-06-01 00:00:00

abstract：:The identification of new active agents for the treatment of squamous carcinoma of the head and neck remains a high priority for clinical investigators. For the past several years a number of investigational drugs have demonstrated activity in patients with recurrent or metastatic disease. Included are the following a...

journal_title：Current opinion in oncology

authors： Murphy BA

更新日期：1996-05-01 00:00:00

abstract：:Over the past year, several research areas have been noteworthy. This article discusses decision making related to breast cancer treatment, the effects of treatment on measures of psychological distress, and studies related to quality-of-life among breast cancer patients. In addition, an area of continued interest inv...

journal_title：Current opinion in oncology

authors： Stefanek ME

更新日期：1993-11-01 00:00:00

abstract：:Chronotherapy consists in the administration of medicines according to biological rhythms. Further insight into the mechanisms of the circadian system has led to adapting the delivery of cancer chemotherapy to rhythms in drug metabolism or cell proliferation. The pharmacology of anticancer agents has long been known t...

journal_title：Current opinion in oncology

authors： Lévi F

更新日期：1996-07-01 00:00:00