Abstract:
PURPOSE OF REVIEW:Crizotinib now is accepted as the standard first-line treatment of ALK-rearranged lung adenocarcinomas. To overcome the problem of crizotinib resistance, second-generation ALK inhibitors are in development. The aim of this review is to give an overview on the mechanisms behind crizotinib resistance and on the preclinical background and clinical development of these compounds. RECENT FINDINGS:Based on phase I/II data, ceritinib has gained accelerated FDA approval for the treatment of crizotinib-resistant ALK-rearranged lung cancer. The clinical development of alectinib has already reached phase III. With AP26113, ASP3026, TSR-011, X-396 and different heat shock protein 90 inhibitors, several other compounds led to promising early trial results. The toxicity profile of these drugs seems manageable, although side-effects still require attention and optimized supportive care. SUMMARY:Second-generation ALK inhibitors have arrived as part of our daily clinical practice. Challenges for the future will be to find the optimal place for these new drugs within the treatment algorithms. To reach this goal, careful trial design with special emphasis on genetically defined, homogeneous patient populations is imperative.
journal_name
Curr Opin Oncoljournal_title
Current opinion in oncologyauthors
Pall Gdoi
10.1097/CCO.0000000000000165subject
Has Abstractpub_date
2015-03-01 00:00:00pages
118-24issue
2eissn
1040-8746issn
1531-703Xjournal_volume
27pub_type
杂志文章,评审abstract::The biologic and clinical heterogeneity of lymphomas represents the major obstacle to their diagnosis. Because histologic analysis, which is the initial diagnostic approach, has been demonstrated to be insufficient in the definition of certain types of lymphomas, molecular and immunologic techniques have been increasi...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199609000-00002
更新日期:1996-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The mesenchymal-epidermal transition (c-MET) receptor tyrosine kinase has a central role in the cancer cell's survival. MET and its ligand, hepatocyte growth factor (HGF), have recently been identified as promising targets in solid tumors, including nonsmall-cell lung cancer (NSCLC). RECENT FINDINGS:...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e32835daf37
更新日期:2013-03-01 00:00:00
abstract::The treatment options for patients with recurrent head and neck malignancies arising in a previously irradiated field are limited. Surgical salvage is feasible in a minority of patients. The majority are referred for palliative chemotherapy with no realistic chance for cure. Data are accumulating to support reirradiat...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200205000-00013
更新日期:2002-05-01 00:00:00
abstract::There is an emerging consensus on the importance of identifying non-Hodgkin's lymphoma patients with different prognoses so that these patients can be optimally treated and the relative benefits of different therapeutic approaches can be adequately assessed. This review of recent publications on prognostic factors in ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199210000-00007
更新日期:1992-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Overexpression of the Bcl-2 oncoprotein is noted in various malignant disorders. In patients with hematologic malignancies, increased production of the Bcl-2 oncoprotein is associated with chemotherapy resistance, aggressive clinical course, and poor survival. Bcl-2 is an important molecular target. D...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/01.cco.0000142074.67968.eb
更新日期:2004-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Small-cell carcinomas of the gynecologic tract are aggressive malignancies that can be misdiagnosed or inappropriately managed. This review provides a summary of current literature that will help the clinician to correctly diagnose and treat patients with small-cell carcinomas of the cervix, ovary, ut...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e3283565ed6
更新日期:2012-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize recent developments and controversies in the diagnosis and management of nonmuscle invasive bladder cancer (NMIBC). RECENT FINDINGS:The majority of incident bladder cancer diagnoses are noninvasive. The mainstay of diagnosis remains cystoscopy and transurethral resection, with enhanced o...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000067
更新日期:2014-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Vandetanib is a small molecule tyrosine kinase inhibitor that has been recently approved as an 'orphan drug' for the treatment of patients with unresectable, locally advanced, or metastatic medullary thyroid cancer (MTC). RECENT FINDINGS:MTC is a neuroendocrine malignancy frequently associated with m...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e32835a42b9
更新日期:2013-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Current treatment modalities provide limited improvement in the natural course of lung cancer, and prognosis remains poor. Lung cancer is a malignancy with great molecular heterogeneity. The complexity of the signalling process leading to cancer cell proliferation and to the neoplastic phenotype suppo...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e328011beec
更新日期:2007-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Biobanking has been identified as a key area for development in order to accelerate the discovery and development of new drugs. This review describes the recent advances in the field of biobanking and biospecimen research, with special reference to tumour banks which are the biobanks of primary intere...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e32834161b8
更新日期:2011-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Gallbladder carcinoma (GBC), classified as a biliary tract cancer (BTC) along with intrahepatic and extrahepatic cholangiocarcinomas, is a rare disease in Western countries, but a highly prevalent disease in Chile, other countries in Latin America, India and Japan. It commonly presents at an advanced ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e3283620fd8
更新日期:2013-07-01 00:00:00
abstract::Since 1977, when it was first demonstrated that a small number of patients with refractory leukemia could be cured by bone marrow transplantation, there has been an international effort to increase the proportion of patients cured. This article reviews recent developments in the treatment of adult leukemia with partic...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:
更新日期:1995-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The possibility of complete recovery for a lung cancer patient depends on very early diagnosis, as it allows total surgical resection. Screening for this cancer in a high-risk population can be performed using a radiological approach, but this holds a certain number of limitations. Liquid biopsy could...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000343
更新日期:2017-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Oral mucositis remains a frequent debilitating toxicity associated with drug and radiation regimens used to treat cancer. This review highlights the recent understanding of the biological basis, risk factors for, and management for oral mucositis. RECENT FINDINGS:Prevalence and incidence data for muc...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000180
更新日期:2015-05-01 00:00:00
abstract::Family history plays an important role in breast, ovarian, and colorectal cancers. The increasing availability of genetic testing has forced women with these malignancies and their physicians to confront new questions regarding screening and prevention. This review highlights the screening for and prevention of breast...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200009000-00019
更新日期:2000-09-01 00:00:00
abstract::Breast cancer remains a worldwide public health concern despite the fact that mortality rates have been declining in some countries as a result of improvements in adjuvant therapy and screening for breast cancer. In the prevention arena, advances in our understanding of the effects of tamoxifen have led to the investi...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200111000-00002
更新日期:2001-11-01 00:00:00
abstract::Despite continuing advances in the molecular characterization of the events promoting metastasis, no significant impact has been made on therapy or survival rates for patients with advanced tumors. Over the past 12 months there has been a general consolidation of the emerging evidence indicating that tumor spread is r...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:
更新日期:1993-01-01 00:00:00
abstract:PURPOSE OF REVIEW:We aimed to summarize the recent reflections and collaborative initiatives pertaining to the definition of more appropriate eligibility criteria in cancer clinical trials. RECENT FINDINGS:There is an intrinsic tension between two opposite purposes when it comes to defining eligibility criteria: on th...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000470
更新日期:2018-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Tumor stroma is composed of many cellular subtypes, of which the most abundant are fibroblasts, macrophages and endothelial cells. During the process of tissue injury, these three cellular subtypes must coordinate their activity to efficiently contribute to tissue regeneration. In tumor, this mechanis...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000420
更新日期:2018-01-01 00:00:00
abstract::Carcinoma of the uterine corpus is the most common malignancy in the female pelvis. Surgical resection and staging are now the accepted approach to therapy, with excellent survival compared with other gynecologic malignancies. Several controversies exist, however, regarding optimal surgical management. Some of these c...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200209000-00007
更新日期:2002-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Small bowel adenocarcinoma (SBA) is a rare cancer with a poor prognosis and little information to guide its management. In recent years, improved diagnostic imaging and an increase in reported experience with use of chemotherapy may alter the way we manage SBA. This review will summarize recent advanc...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e32833a86fe
更新日期:2010-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The current status of postoperative adjuvant therapy for nonsmall cell lung cancer (NSCLC) is reviewed. RECENT FINDINGS:Cisplatin-based postoperative chemotherapy is a current standard of care for patients with stage II-III NSCLC who underwent complete resection. However, its benefit is limited. In t...
journal_title:Current opinion in oncology
pub_type: 杂志文章
doi:10.1097/CCO.0000000000000702
更新日期:2021-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To examine the most recent changes in published guidelines by various organizations for the treatment of patients with differentiated thyroid cancer. This document provides a comparison of recommendations for common topics currently found in available thyroid cancer care guidelines. RECENT FINDINGS:R...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e32833fc9c4
更新日期:2011-01-01 00:00:00
abstract::Enormous progress has been made in the last several years in delineating signal transduction pathways associated with cell proliferation and apoptosis. The components of these pathways, which include both oncogenes and tumor suppressors, may provide viable targets for therapeutic intervention for the treatment of canc...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199701000-00015
更新日期:1997-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Neuroendocrine tumors (previously referred to as carcinoids) are ill-understood, enigmatic malignancies that, although slow-growing compared with adenocarcinomas, can behave aggressively. In 2004, they comprised 1.25% of all malignancies; their incidence is increasing by approximately 6% per year. The...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e3282f1c595
更新日期:2008-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Currently, endometrial carcinoma diagnosis is based on morphology, often supplemented by immunohistochemistry. However, especially with high-grade endometrial carcinomas, there is considerable interobserver variability in diagnosis calling into question the value of morphology in stratifying these tum...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000560
更新日期:2019-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Despite significant improvements in the treatment of Burkitt lymphoma, outcomes of adults are generally inferior to those of children. This review summarizes the most recent developments in the management of Burkitt lymphoma and leukemia in adults. RECENT FINDINGS:Current regimens have largely been d...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200409000-00003
更新日期:2004-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To review recent observations that describe changes in the likelihood of invasive fungal infections, shifts in types of fungal pathogens, and altered manifestations of fungal syndromes after hematopoietic cell transplantation and explore how changes in transplant practices are influencing these epidem...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/01.cco.0000152975.65477.7c
更新日期:2005-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The last decade has seen a paradigm change in that tumor stroma contributes to malignant tumor progression in a manner comparable to genetic and epigenetic changes within cancer cells. This review summarizes recent novel insights into how inflammatory conditions stimulate the formation and expansion o...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e32831bed7e
更新日期:2009-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize the current knowledge about the biology and clinical management of adult desmoid tumors. RECENT FINDINGS:In the past decade, we have learned that desmoid tumors are driven by alterations of the Wnt/APC/β-catenin pathway, sporadic desmoid tumors are associated with somatic mutations of CT...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000374
更新日期:2017-07-01 00:00:00