Neuroendocrine tumors of the diffuse neuroendocrine system.

abstract：:Phosphatases are regulatory enzymes that antagonize the action of kinases within the cell. An understanding of the contribution of kinases to cancer has emerged during the past two decades; however, our understanding of phosphatases in cancer has lagged behind. Currently, three phosphatases have been implicated in the...

journal_title：Current opinion in oncology

authors： Parsons R

更新日期：1998-01-01 00:00:00

abstract：:Mucosal injury due to ionizing radiation or cytotoxic agents begins with damage to stem cells in the basal epithelium, progresses as these cells are depleted, and is complicated by inflammation and superimposed infection. Suppression of oral and pharyngeal infection, cytokine stimulation of neutrophils, and protection...

journal_title：Current opinion in oncology

authors： Marks JE

更新日期：1997-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To highlight the most recent advances in the imaging of gliomas with a focus on high-grade gliomas. In the last several years, MRI and PET imaging of the brain have moved beyond anatomic imaging and are now capable of probing different aspects of tumor biology and response to treatment. These new tech...

journal_title：Current opinion in oncology

authors： Gerstner ER,Batchelor TT

更新日期：2010-11-01 00:00:00

abstract：:Although variation in diet may account for approximately one third of the variation in cancer incidence worldwide, epidemiologic studies have proven to be a blunt instrument for identifying causal relationships between intakes of specific food constituents and cancer risk at specific sites. Diets rich in fruits and ve...

journal_title：Current opinion in oncology

authors： Mathers JC,Burn J

更新日期：1999-09-01 00:00:00

abstract：:Paraendocrine syndromes are the remote effects of cancer that result from ectopic hormonal production. Recent investigations have concentrated in five areas that include the evaluation of diagnostic studies, the recognition of rare cases, the contribution of secondary hormones, the clinical distinctions of ectopic syn...

journal_title：Current opinion in oncology

authors： Pierce ST

更新日期：1993-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine the most recent changes in published guidelines by various organizations for the treatment of patients with differentiated thyroid cancer. This document provides a comparison of recommendations for common topics currently found in available thyroid cancer care guidelines. RECENT FINDINGS:R...

journal_title：Current opinion in oncology

authors： Miller BS,Doherty GM

更新日期：2011-01-01 00:00:00

abstract：:Thyroid cancers are still the most common endocrine cancers. They are dominated by well-differentiated carcinomas, including papillary carcinoma, follicular carcinoma, and medullary thyroid carcinoma. Diagnosis is based on fine-needle aspiration cytologic examination. Recently, reverse transcription polymerase chain r...

journal_title：Current opinion in oncology

authors： Bi J,Lu B

更新日期：2000-01-01 00:00:00

abstract：:Seroepidemiologic studies show that Kaposi's sarcoma herpesvirus (KSHV) is more prevalent in those populations at higher risk to develop Kaposi's sarcoma (KS). Anti-KSHV antibody titer is also higher in those who develop KS. KSHV is a sexually transmitted disease among homosexual men, but other routes of transmission ...

journal_title：Current opinion in oncology

authors： Whitby D,Boshoff C

更新日期：1998-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this article will be to review neuroendocrine tumours (NETs) of the gynaecological tract. NETs are generally considered to be uncommon and primary tumours in the gynaecological tract on arrival rare or very rare. It is important to distinguish true primary tumours from metastatic as the...

journal_title：Current opinion in oncology

authors： Reed NS

更新日期：2016-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Preclinical and clinical developments in germ cell tumors over the past year are summarized. RECENT FINDINGS:Attenuations in the rising incidence of testicular germ cell tumors are beginning to be observed in certain European populations. Additional data on predisposing factors related to race, estro...

journal_title：Current opinion in oncology

authors： Bridges B,Hussain A

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This paper reviews the advances in surgery in head and neck cancer patients. RECENT FINDINGS:Sentinel node biopsy is a promising diagnostic technique to detect occult lymph node metastases, especially in oral carcinomas. Fludeoxyglucose-PET seems to be useful in detecting recurrent (laryngeal) carcin...

journal_title：Current opinion in oncology

authors： de Bree R,Leemans CR

更新日期：2010-05-01 00:00:00

abstract：:It is generally accepted that patients with chronic myelogenous leukemia in chronic phase under the age of 50 years who have HLA-identical siblings, should be offered bone marrow transplantation within the first year of diagnosis. The projected disease-free survival for these patients is 70% to 80% at 4 years, and mos...

journal_title：Current opinion in oncology

authors： Goldman JM

更新日期：1992-04-01 00:00:00

abstract：:The appearance of skin lesions in patients with occult or obvious malignancy may be of extreme value in the detection and management of cancer because the skin is readily accessible to examination and biopsy. Examination of the skin of our patients can provide important insights into underlying malignant processes or ...

journal_title：Current opinion in oncology

authors： Sabir S,James WD,Schuchter LM

更新日期：1999-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Significant advances have been made in the treatment of younger patients with acute myeloid leukemia over the past 3 decades, but prognosis in the elderly has remained dismal, with median survival times of only a few months. Although a small percentage of older patients may be cured by standard chemot...

journal_title：Current opinion in oncology

authors： Amadori S,Del Principe MI,Venditti A

更新日期：2014-11-01 00:00:00

abstract：:The identification of new active agents for the treatment of squamous carcinoma of the head and neck remains a high priority for clinical investigators. For the past several years a number of investigational drugs have demonstrated activity in patients with recurrent or metastatic disease. Included are the following a...

journal_title：Current opinion in oncology

authors： Murphy BA

更新日期：1996-05-01 00:00:00

abstract：:Over the past year, several research areas have been noteworthy. This article discusses several reports on psychiatric morbidity and psychological factors of breast cancer, quality-of-life issues related to breast cancer treatment, and psychological factors in breast cancer screening. An area of increasing interest in...

journal_title：Current opinion in oncology

authors： Stefanek ME

更新日期：1992-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic graft-versus-host disease is an important cause of late morbidity and mortality after allogeneic stem cell transplantation. With the renewed interest in its pathophysiology and treatment, this review discusses recent clinical and laboratory advances in this disease. Advances in pathophysiology...

journal_title：Current opinion in oncology

authors： Cutler C,Antin JH

更新日期：2006-03-01 00:00:00

abstract：:The incidence and variety of solid tumors reported among human immunodeficiency virus (HIV)-infected individuals are increasing. Among the most common of these tumors are anogenital malignant and premalignant tumors associated with human papillomavirus infection. Cervical intraepithelial neoplasia is one such human pa...

journal_title：Current opinion in oncology

authors： Palefsky JM

更新日期：1991-10-01 00:00:00

abstract：:Chronic myelogenous leukemia (CML) is a hematologic malignancy characterized by an initial chronic phase of expanded clonal myelopoiesis followed by inevitable progression to accelerated phase and finally to fatal blast crisis. Although interferon therapy results in hematologic control of disease in most patients and ...

journal_title：Current opinion in oncology

authors： Enright H,McGlave P

更新日期：1998-03-01 00:00:00

abstract：:Human immunodeficiency virus (HIV)-1 infection is associated with increased frequency of Kaposi's sarcoma and high-grade B-cell lymphoma. Several other cancers in HIV-1-infected individuals have been reported, although without statistically significant increase in their respective occurrences. Although HIV-1 does not ...

journal_title：Current opinion in oncology

authors： Gill PS

更新日期：1991-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To evaluate the application of narrative within medical practice. Illness like cancer constitutes a biographical disruption that occurs several times during the disease, from diagnosis to complications and treatments. This review analyzes the interest of narrative ethics in medicine with a focus on ca...

journal_title：Current opinion in oncology

authors： Lossignol D

更新日期：2014-07-01 00:00:00

abstract：:Serial analysis of gene expression has been widely used to characterize gene expression patterns associated with tumor formation. These studies resulted in the identification of tumor-specific markers, transcriptional pathways, or therapeutic targets. In this review, recent applications and developments of serial anal...

journal_title：Current opinion in oncology

authors： Hermeking H

更新日期：2003-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Biobanking has been identified as a key area for development in order to accelerate the discovery and development of new drugs. This review describes the recent advances in the field of biobanking and biospecimen research, with special reference to tumour banks which are the biobanks of primary intere...

journal_title：Current opinion in oncology

authors： Hewitt RE

更新日期：2011-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Imatinib has exceptional activity in controlling gastrointestinal stromal tumor (GIST) due to inhibition of the constitutively active conformation of KIT and platelet-derived growth factor-alpha (PDGFRA), which is commonly seen in this tumor. This review explores the current available data on the corr...

journal_title：Current opinion in oncology

authors： Marrari A,Trent JC,George S

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The recent contributions to renal cell carcinoma in the fields of molecular biology and the expanded use of molecularly targeted agents will be reviewed. This study is intended to update prognostic and therapeutic decision-making data and provide perspective on advances in understanding the molecular ...

journal_title：Current opinion in oncology

authors： Rini BI,Rathmell WK,Godley P

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of the review is to delineate novel approaches for biology-based treatment in advanced gastric cancer. We reviewed the latest translational and clinical research articles and congress presentations. RECENT FINDINGS:A new molecular classification of gastric cancer based on histology, genet...

journal_title：Current opinion in oncology

authors： Obermannová R,Lordick F

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:In the present review, we summarize the recent developments in the management of germ cell tumors (GCTs). RECENT FINDINGS:Treatment-related acute and late-onset toxicity remains a key challenge in the management of GCTs, with recent evidence showing that the adverse health outcomes of etoposide and c...

journal_title：Current opinion in oncology

authors： Chahoud J,Zhang M,Shah A,Lin SH,Pisters LL,Tu SM

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Tumor stroma is composed of many cellular subtypes, of which the most abundant are fibroblasts, macrophages and endothelial cells. During the process of tissue injury, these three cellular subtypes must coordinate their activity to efficiently contribute to tissue regeneration. In tumor, this mechanis...

journal_title：Current opinion in oncology

authors： Ronca R,Van Ginderachter JA,Turtoi A

更新日期：2018-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize major recent findings on the biology of human herpesvirus-8, i.e. Kaposi's sarcoma-associated herpesvirus, and the implications of these findings for Kaposi's sarcoma treatment. RECENT FINDINGS:Although reduced in incidence in developed countries since the introduction of highly active a...

journal_title：Current opinion in oncology

authors： Dittmer DP,Krown SE

更新日期：2007-09-01 00:00:00

abstract：:The pathogenesis of prostate cancer reflects complex interactions among environmental and genetic factors. Recent advances suggest molecular mechanisms that may explain geographic and ethnic variations in prostate cancer incidence, and understanding of molecular disease progression is advancing rapidly. Clinically, th...

journal_title：Current opinion in oncology

authors： Small EJ,Reese DM

更新日期：2000-05-01 00:00:00