Abstract:
:The cancer patient often presents with fever and pulmonary infiltrates, in particular during the course of chemotherapy or after bone marrow transplantation. In these conditions, specific diagnoses are mainly related to an infective cause, but noninfectious processes, malignant or not, are also found alone or in combination with infection. Identification of the pulmonary process can be achieved by bronchoscopic techniques, including bronchoalveolar lavage (BAL) and transbronchial biopsy (TBB). BAL may help identify opportunistic organisms but also bacterial pneumonia, provided quantitative cultures are performed, and TBB has been shown to increase the diagnostic yield of BAL. These two procedures should then be combined, provided there is no contraindication.
journal_name
Curr Opin Oncoljournal_title
Current opinion in oncologyauthors
Ninane Vdoi
10.1097/00001622-200107000-00005keywords:
subject
Has Abstractpub_date
2001-07-01 00:00:00pages
236-41issue
4eissn
1040-8746issn
1531-703Xjournal_volume
13pub_type
杂志文章abstract::Despite its appeal, lung cancer screening has been found to be of little value at this time. However, use of monoclonal antibodies to detect cancer cells in the sputum may prove to be of value in high-risk subjects. Once a cancer is diagnosed, anatomic staging by the International TNM Staging System has shown its effe...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199104000-00010
更新日期:1991-04-01 00:00:00
abstract:PURPOSE OF REVIEW:This review summarizes recent studies on applications of molecular markers such as chromosome 1p/19q codeletion and MGMT status in the treatment of glioma. RECENT FINDINGS:Prospective trials confirmed that 1p/19q codeletion represents a strong and independent favourable prognostic factor in anaplasti...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e3282f075f3
更新日期:2007-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Small bowel adenocarcinoma (SBA) is a rare cancer with a poor prognosis and little information to guide its management. In recent years, improved diagnostic imaging and an increase in reported experience with use of chemotherapy may alter the way we manage SBA. This review will summarize recent advanc...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e32833a86fe
更新日期:2010-07-01 00:00:00
abstract:PURPOSE OF REVIEW:This paper reviews the advances in surgery in head and neck cancer patients. RECENT FINDINGS:Sentinel node biopsy is a promising diagnostic technique to detect occult lymph node metastases, especially in oral carcinomas. Fludeoxyglucose-PET seems to be useful in detecting recurrent (laryngeal) carcin...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e3283380009
更新日期:2010-05-01 00:00:00
abstract::Twenty-three years after it was observed that successful treatment of Hodgkin's disease was associated with risk of a second malignancy related to treatment, the literature is maturing. Early reports of leukemia risk rising and falling between 5 and 10 years after treatment continue to be supported. The real problem i...
journal_title:Current opinion in oncology
pub_type: 杂志文章
doi:10.1097/00001622-199709050-00006
更新日期:1997-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Chronic graft-versus-host disease is an important cause of late morbidity and mortality after allogeneic stem cell transplantation. With the renewed interest in its pathophysiology and treatment, this review discusses recent clinical and laboratory advances in this disease. Advances in pathophysiology...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/01.cco.0000208784.07195.84
更新日期:2006-03-01 00:00:00
abstract::The clinical staging of bone tumors, even rare ones, has been much improved with the availability of better imaging techniques. Once diagnosis of a rare bone tumor has been made, close consultation between clinician, radiologist, and pathologist is essential for optimal treatment. Recent advances in the staging proced...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:
更新日期:1991-08-01 00:00:00
abstract::The appearance of skin lesions in patients with occult or obvious malignancy may be of extreme value in the detection and management of cancer because the skin is readily accessible to examination and biopsy. Examination of the skin of our patients can provide important insights into underlying malignant processes or ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199903000-00011
更新日期:1999-03-01 00:00:00
abstract::Despite continuing advances in the molecular characterization of the events promoting metastasis, no significant impact has been made on therapy or survival rates for patients with advanced tumors. Over the past 12 months there has been a general consolidation of the emerging evidence indicating that tumor spread is r...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:
更新日期:1993-01-01 00:00:00
abstract:PURPOSE OF REVIEW:As the number and uses for targeted therapies such as epidermal growth factor receptor inhibitors (EGFRIs) increase, so does the need to recognize and treat the dermatologic side-effects of these agents. Although agents such as gefitinib, erlotinib, cetuximab, lapatinib, and panitumumab have less syst...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e3283474063
更新日期:2011-07-01 00:00:00
abstract:PURPOSE OF REVIEW:PremRNA alternative splicing is more a rule than an exception as it affects more than 90% of multiexons genes and plays a key role in proteome diversity. Here, we discuss some recent studies published in the extensively growing field linking RNA splicing and cancer. RECENT FINDINGS:These last years, ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000254
更新日期:2016-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Imatinib has exceptional activity in controlling gastrointestinal stromal tumor (GIST) due to inhibition of the constitutively active conformation of KIT and platelet-derived growth factor-alpha (PDGFRA), which is commonly seen in this tumor. This review explores the current available data on the corr...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e32833a6b8e
更新日期:2010-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Most patients affected by lung cancer are treated with chemotherapy, and hence are at risk of myelosuppression. Hematopoietic growth factors have a relevant role in this setting, as they can improve quality of life, reduce the rate of chemotherapy-induced complications and allow the administration of ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000268
更新日期:2016-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Malignant brain tumors have a very poor prognosis and the natural history of disease is very short, usually less than 1 year. Brain tumor patients often present peculiar symptoms of disease that require appropriate supportive treatment, namely, peritumoral brain edema, venous thromboembolism, seizures...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e32833e078c
更新日期:2010-11-01 00:00:00
abstract::Biologic approaches to lymphoma treatment are now a practical reality rather than a vaguely perceived hope for the future. Interferon alfa seems to have been established as a life-extending therapy for selected patients with follicular lymphoma. Humanized anti-CD20 monoclonal antibody (rituximab) has an authentic 50% ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199909000-00005
更新日期:1999-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The phosphoinositide 3-kinases are lipid kinases that are activated in response to external factors. They regulate a number of intracellular signaling pathways involved in cell motility, metabolism, survival, and growth. This review summarizes the current knowledge about specific contributions of Clas...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e3282f3111e
更新日期:2008-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The psychosocial needs of adolescent and young adult (AYA) siblings of cancer patients are easily overlooked. Accordingly, the evidence base informing short and long-term outcomes for these young people is sparse. This review provides an overview of recent research highlighting the experiences, unmet ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000194
更新日期:2015-07-01 00:00:00
abstract::Over the past year, a number of important papers have appeared in the medical literature dealing with the chemotherapeutic management of gynecologic cancers. Among these papers, several studies have again demonstrated the superiority of platinum-based chemotherapy regimens for ovarian cancer compared with non-platinum...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199210000-00019
更新日期:1992-10-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide examples of mitochondria-specific metabolic events that influence tumor cell biology, and of metabolism-related mitochondrial biomarkers and therapeutic targets in cancer cells. RECENT FINDINGS:Cancer cell mitochondria are rewired to optimally serve the cancer cell under various conditions...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000336
更新日期:2017-01-01 00:00:00
abstract::Advances in the understanding of the cellular and molecular derangements involved in the initiation and progression of multiple myeloma are beginning to be translated into novel therapeutic approaches. The myeloma stem cell has been under intense scrutiny regarding its normal B-cell counterpart. Oncogenes, tumor-suppr...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199901000-00002
更新日期:1999-01-01 00:00:00
abstract::Bladder cancer is a common and chemotherapy-responsive tumor, related to tobacco smoking, environmental arsenic exposure, industrial dye exposure, and parasitic schistosomiasis exposure. Both reduction of carcinogen exposure and chemoprevention, possibly with cyclooxygenase 2 inhibitors, should reduce the incidence. T...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200205000-00003
更新日期:2002-05-01 00:00:00
abstract::Phosphatases are regulatory enzymes that antagonize the action of kinases within the cell. An understanding of the contribution of kinases to cancer has emerged during the past two decades; however, our understanding of phosphatases in cancer has lagged behind. Currently, three phosphatases have been implicated in the...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199801000-00014
更新日期:1998-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent discoveries have demonstrated that ovarian cancer is actually composed of multiple separate diseases. Clear cell cancer is an important example. This review will describe the unique biology of clear cell carcinoma, its novel molecular features, and the recent translation of this into new therap...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e328363e0c7
更新日期:2013-09-01 00:00:00
abstract::Pleural effusions are a common development in patients with cancer. The optimal means of control are not defined, but systemic treatment is often effective in patients with drug-sensitive tumors. Local treatments advocated in the management of malignant pleural effusions differ in the means of drainage, the length of ...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199208000-00007
更新日期:1992-08-01 00:00:00
abstract:PURPOSE OF REVIEW:Ovarian germ cell tumours are rare, but curable at all stages of disease. This review gives an outline of the main controversies regarding the management of this disease. RECENT FINDINGS:Pelvic malignancies are very rare during pregnancy, which should avoid the need for radical surgery or termination...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/01.cco.0000239891.44031.38
更新日期:2006-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Retroperitoneal sarcoma (RPS) is a rare disease, and until recently, its natural history and outcome were poorly understood. Recently, collaborations between individual centers have led to an unprecedented collection of retrospective and prospective data and successful recruitment to the first randomi...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000535
更新日期:2019-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize major recent findings on the biology of human herpesvirus-8, i.e. Kaposi's sarcoma-associated herpesvirus, and the implications of these findings for Kaposi's sarcoma treatment. RECENT FINDINGS:Although reduced in incidence in developed countries since the introduction of highly active a...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e3281eb8ea7
更新日期:2007-09-01 00:00:00
abstract::Over the past year, several research areas have been noteworthy. This article discusses decision making related to breast cancer treatment, the effects of treatment on measures of psychological distress, and studies related to quality-of-life among breast cancer patients. In addition, an area of continued interest inv...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199311000-00008
更新日期:1993-11-01 00:00:00
abstract::The rising rate of germ cell cancer of the testis over the past decade has been demonstrated to be occurring predominantly in the younger age group (15 to 19 years) in association with earlier onset of puberty and earlier onset of regular sexual activity. Chemicals and viruses, with their atrophogenic effect, remain t...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-199605000-00015
更新日期:1996-05-01 00:00:00
abstract::Cutaneous malignant melanoma and its precursors were the general subjects of the National Institutes of Health Consensus Conference held in January 1992. Particular emphasis was placed on the diagnosis of early melanoma, especially melanoma in situ, and the controversies surrounding dysplastic nevi. Recent studies of ...
journal_title:Current opinion in oncology
pub_type: 共识发展会议,杂志文章,评审
doi:10.1097/00001622-199303000-00016
更新日期:1993-03-01 00:00:00