Abstract:
PURPOSE OF REVIEW:The purpose of this review is to highlight recent studies on mammalian sirtuins that coordinately regulate cellular metabolic homeostasis upon fasting and to summarize the beneficial effects of fasting on carcinogenesis and cancer therapy. RECENT FINDINGS:Recent studies have demonstrated that fasting may protect normal cells and mice from the metabolic conditions that are harmful as well as decrease the incidence of carcinogenesis. Fasting could also slow the tumor growth and augment the efficacy of certain systemic agents/chemotherapy drugs in various cancers. The mechanism behind this proposed idea may be due to, at least in some part, the metabolic regulation by Sirtuin family proteins whose functions are involved in specific aspects of longevity, stress response and metabolism. Sirtuins, particularly SIRT1 and SIRT3, can be activated by fasting and further exhibit their effects in insulin response, antioxidant defense, and glycolysis. Therefore, sirtuins may have anticancer effects by shifting metabolism to a less proliferative cell phenotype as well as less prone to oxidative stress attack. SUMMARY:The in-depth understanding of the essential role of sirtuins in fasting process may have significant implications in developing a new metabolic diagram of cancer prevention or treatment.
journal_name
Curr Opin Oncoljournal_title
Current opinion in oncologyauthors
Zhu Y,Yan Y,Gius DR,Vassilopoulos Adoi
10.1097/01.cco.0000432527.49984.a3subject
Has Abstractpub_date
2013-11-01 00:00:00pages
630-6issue
6eissn
1040-8746issn
1531-703Xjournal_volume
25pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:To review recent observations that describe changes in the likelihood of invasive fungal infections, shifts in types of fungal pathogens, and altered manifestations of fungal syndromes after hematopoietic cell transplantation and explore how changes in transplant practices are influencing these epidem...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
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abstract::Controversy exists over the role that environmental estrogens, such as pesticides or polychlorinated biphenyls (PCBs), might play as risk factors for breast cancer. Several laboratory studies have suggested that these chemicals function as weak estrogens, binding to the estrogen receptor and inducing various measures ...
journal_title:Current opinion in oncology
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journal_title:Current opinion in oncology
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journal_title:Current opinion in oncology
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journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
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journal_title:Current opinion in oncology
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journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
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journal_title:Current opinion in oncology
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更新日期:2011-03-01 00:00:00
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journal_title:Current opinion in oncology
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journal_title:Current opinion in oncology
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journal_title:Current opinion in oncology
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journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
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journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0b013e3282f1c595
更新日期:2008-01-01 00:00:00
abstract::Less than 1% of all cancers are present in the thyroid, yet thyroid nodules are found in 4 to 10% of the adult population. Because thyroid nodules are relatively common, the diagnostic dilemma is to distinguish between a more common benign nodule, which usually does not require specific treatment, and a malignant nodu...
journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/00001622-200201000-00009
更新日期:2002-01-01 00:00:00
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journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
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更新日期:1997-03-01 00:00:00
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journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:10.1097/CCO.0000000000000277
更新日期:2016-05-01 00:00:00
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journal_title:Current opinion in oncology
pub_type: 杂志文章
doi:10.1097/00001622-199709050-00006
更新日期:1997-09-01 00:00:00
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journal_title:Current opinion in oncology
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更新日期:2002-11-01 00:00:00
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journal_title:Current opinion in oncology
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journal_title:Current opinion in oncology
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journal_title:Current opinion in oncology
pub_type: 杂志文章,评审
doi:
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journal_title:Current opinion in oncology
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更新日期:2004-05-01 00:00:00
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journal_title:Current opinion in oncology
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journal_title:Current opinion in oncology
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更新日期:2010-01-01 00:00:00
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journal_title:Current opinion in oncology
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更新日期:2006-03-01 00:00:00
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journal_title:Current opinion in oncology
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journal_title:Current opinion in oncology
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更新日期:2014-11-01 00:00:00