Human phagocytes have multiple lipid A-binding sites.

abstract：:The Burkholderia cepacia epidemic strain marker (BCESM) is a useful epidemiological marker for virulent B. cenocepacia strains that infect patients with cystic fibrosis. However, there was no evidence that the original marker, identified by random amplified polymorphic DNA fingerprinting, contributed to pathogenicity....

journal_title：Infection and immunity

authors： Baldwin A,Sokol PA,Parkhill J,Mahenthiralingam E

更新日期：2004-03-01 00:00:00

abstract：:Experimental infection of mice with a virulent strain of Mycobacterium avium leads to a slowly progressive disease, which we have previously shown culminates in loss of gamma interferon (IFN-gamma) production by T lymphocytes and death of the animals approximately 40 weeks after infection. Here we investigated the cha...

journal_title：Infection and immunity

authors： Mannering SI,Cheers C

更新日期：2002-01-01 00:00:00

abstract：:The var gene-encoded Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family is responsible for antigenic variation and sequestration of infected erythrocytes during malaria. We have previously grouped the 60 PfEMP1 variants of P. falciparum clone 3D7 into groups A and B/A (category A) and groups B, B/C, ...

journal_title：Infection and immunity

authors： Joergensen L,Turner L,Magistrado P,Dahlbäck MA,Vestergaard LS,Lusingu JP,Lemnge M,Salanti A,Theander TG,Jensen AT

更新日期：2006-12-01 00:00:00

abstract：:Escherichia coli containing the K1 capsule is the leading cause of gram-negative meningitis, but the pathogenesis of this disease is not completely understood. Recent microarray experiments in which we compared the gene expression profile of E. coli K1 associated with human brain microvascular endothelial cells (HBMEC...

journal_title：Infection and immunity

authors： Parthasarathy G,Yao Y,Kim KS

更新日期：2007-06-01 00:00:00

abstract：:Human gamma delta T cells are known to respond at high frequencies to pathogenic mycobacteria. Here we show that opportunistic strains of mycobacteria share with pathogenic mycobacteria the ability to trigger at high frequencies human V gamma 9V delta 2 T-cell-receptor-positive T lymphocytes. Stimulating ligands were ...

journal_title：Infection and immunity

authors： Häcker G,Kromer S,Heeg K,Ivanyi J,Wagner H,Pfeffer K

更新日期：1992-07-01 00:00:00

abstract：:Antioxidants are protective against septic shock in animal models. Recently, free radical scavengers have been found to inhibit the activation of the NF-kappa B protein in a number of cell lines. This transcriptional regulatory protein binds to the promoters of the proinflammatory cytokines tumor necrosis factor, inte...

journal_title：Infection and immunity

authors： Kelly KA,Hill MR,Youkhana K,Wanker F,Gimble JM

更新日期：1994-08-01 00:00:00

abstract：:Little data are available regarding L-form phagocyte interactions. Due to difficulty with more conventional methods, a serum-free technique of surface phagocytosis employing cellulose ester micropore filters, fluorochrome staining, and reflecting fluorescence microscopy was developed. Intracellular localization of L-f...

journal_title：Infection and immunity

authors： Harwick HJ,Barajas L,Montgomerie JZ,Kalmanson GM,Guze LB

更新日期：1972-06-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF) is thought to play a major role in the pathogenesis of septic shock. Anti-TNF antibody was preadministered in low-dose endotoxin lethality models in which BALB/c mice were challenged with small amounts of lipopolysaccharide following their sensitization with either carrageenan (CAR) o...

journal_title：Infection and immunity

authors： Franks AK,Kujawa KI,Yaffe LJ

更新日期：1991-08-01 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) is a prominent, food-borne cause of diarrhea, bloody diarrhea, and the hemolytic uremic syndrome in industrialized countries. Most strains of EHEC carry the locus for enterocyte effacement (LEE) pathogenicity island, but a proportion of isolates from patients with severe disea...

journal_title：Infection and immunity

authors： Leyton DL,Sloan J,Hill RE,Doughty S,Hartland EL

更新日期：2003-11-01 00:00:00

abstract：:Zoonotic infections caused by Salmonella enterica serovar Typhimurium pose a constant threat to consumer health, with the pig being a particularly major source of multidrug-resistant isolates. Vaccination, as a promising approach to reduce colonization and shedding, has been scarcely used, as it interferes with curren...

journal_title：Infection and immunity

authors： Selke M,Meens J,Springer S,Frank R,Gerlach GF

更新日期：2007-05-01 00:00:00

abstract：:Q fever is a zoonotic disease of worldwide significance caused by the obligate intracellular bacterium Coxiella burnetii. Humans with Q fever may experience an acute flu-like illness and pneumonia and/or chronic hepatitis or endocarditis. Various markers demonstrate significant phylogenetic separation between and clus...

journal_title：Infection and immunity

authors： Russell-Lodrigue KE,Andoh M,Poels MW,Shive HR,Weeks BR,Zhang GQ,Tersteeg C,Masegi T,Hotta A,Yamaguchi T,Fukushi H,Hirai K,McMurray DN,Samuel JE

更新日期：2009-12-01 00:00:00

abstract：:Herein we characterized various genetic markers and the biological behavior of a natural recombinant strain of Toxoplasma gondii (P-Br). From nine genetic markers analyzed, three (B1, ROP1, and SAG1) and three (cS10-A6, GRA6, and SAG3) markers belong to parasites from the type I and type III lineages, respectively. Th...

journal_title：Infection and immunity

authors： Fux B,Rodrigues CV,Portela RW,Silva NM,Su C,Sibley D,Vitor RW,Gazzinelli RT

更新日期：2003-11-01 00:00:00

abstract：:Protection against colibacillosis in neonatal piglets was obtained by immunization of pregnant dams with procholeragenoid. Procholeragenoid is a stable high-molecular-weight aggregate of cholera toxin formed during the heating of cholera toxin. Procholeragenoid retained approximately 1% of the toxicity of native toxin...

journal_title：Infection and immunity

authors： Fürer E,Cryz SJ Jr,Dorner F,Nicolet J,Wanner M,Germanier R

更新日期：1982-03-01 00:00:00

abstract：:Vibrio parahaemolyticus, a gram-negative marine bacterium, is an important pathogen causing food-borne gastroenteritis or septicemia. Recent genome sequencing of the RIMD2210633 strain (a Kanagawa phenomenon-positive clinical isolate of serotype O3:K6) revealed that the strain has two sets of gene clusters that encode...

journal_title：Infection and immunity

authors： Ono T,Park KS,Ueta M,Iida T,Honda T

更新日期：2006-02-01 00:00:00

abstract：:CD8+ T cells are essential for protection against mycobacteria, as is clearly demonstrated by the fatal outcome of experimental infection of beta-2 microglobulin knockout mice. However, the mechanisms and antigens (Ags) leading to CD8+ T-cell activation and regulation have been poorly characterized. Here we show that,...

journal_title：Infection and immunity

authors： Denis O,Lozes E,Huygen K

更新日期：1997-02-01 00:00:00

abstract：:While gamma/delta T cells are involved in host defense and immunopathology in a variety of infectious diseases, their precise role is not yet clearly defined. In the absence of gamma/delta T cells, mice die after infection with a dose of Listeria monocytogenes that is not lethal in immunologically intact animals. Morb...

journal_title：Infection and immunity

authors： Skeen MJ,Rix EP,Freeman MM,Ziegler HK

更新日期：2001-12-01 00:00:00

abstract：:Adhesion of Trichomonas vaginalis is believed to be dependent on four adhesion proteins, which are thought to bind to vaginal epithelial cells in a specific manner with a ligand-receptor type of interaction. However, the specific receptors on the host cell have not yet been identified. In this work, the ability of the...

journal_title：Infection and immunity

authors： Addis MF,Rappelli P,Fiori PL

更新日期：2000-07-01 00:00:00

abstract：:The role of type 1 pili in promoting bladder colonization was examined by constructing two mutant strains of a clinical Escherichia coli isolate. One mutant was isogenic to the parental strain save for a lesion in a gene required for pilus receptor binding; the other mutant was isogenic save for a lesion in the gene e...

journal_title：Infection and immunity

authors： Keith BR,Maurer L,Spears PA,Orndorff PE

更新日期：1986-09-01 00:00:00

abstract：:The goal of this study was to determine the roles of eosinophils and neutrophils in innate and adaptive protective immunity to larval Strongyloides stercoralis in mice. The experimental approach used was to treat mice with an anti-CCR3 monoclonal antibody to eliminate eosinophils or to use CXCR2-/- mice, which have a ...

journal_title：Infection and immunity

authors： Galioto AM,Hess JA,Nolan TJ,Schad GA,Lee JJ,Abraham D

更新日期：2006-10-01 00:00:00

abstract：:Toll-like receptors (TLRs) are a group of highly conserved molecules that initiate the innate immune response to pathogens by recognizing structural motifs expressed by microbes. We have identified a novel TLR, TLR15, by bioinformatic analysis of the chicken genome, which is distinct from any known vertebrate TLR and ...

journal_title：Infection and immunity

authors： Higgs R,Cormican P,Cahalane S,Allan B,Lloyd AT,Meade K,James T,Lynn DJ,Babiuk LA,O'farrelly C

更新日期：2006-03-01 00:00:00

abstract：:Thirty percent of Streptococcus pneumoniae isolates contain pilus islet 1, coding for a pilus composed of the backbone subunit RrgB and two ancillary proteins, RrgA and RrgC. RrgA is the major determinant of in vitro adhesion associated with pilus 1, is protective in vivo in mouse models, and exists in two variants (c...

journal_title：Infection and immunity

authors： Moschioni M,Emolo C,Biagini M,Maccari S,Pansegrau W,Donati C,Hilleringmann M,Ferlenghi I,Ruggiero P,Sinisi A,Pizza M,Norais N,Barocchi MA,Masignani V

更新日期：2010-12-01 00:00:00

abstract：:Previous studies have reported that human vascular endothelial cells lack the membrane-bound lipopolysaccharide (LPS) receptor, CD14 (mCD14). By optimizing assay conditions, including the selection of anti-CD14 monoclonal antibody, we now demonstrate that human umbilical vein endothelial cells (HUVEC) express CD14 on ...

journal_title：Infection and immunity

authors： Jersmann HP,Hii CS,Hodge GL,Ferrante A

更新日期：2001-01-01 00:00:00

abstract：:This study was designed to evaluate the immunogenicity and the protective efficacy of a divalent fusion DNA vaccine encoding both the Brucella abortus L7/L12 protein (ribosomal protein) and Omp16 protein (outer membrane lipoprotein), designated pcDNA3.1-L7/L12-Omp16. Intramuscular injection of this divalent DNA vaccin...

journal_title：Infection and immunity

authors： Luo D,Ni B,Li P,Shi W,Zhang S,Han Y,Mao L,He Y,Wu Y,Wang X

更新日期：2006-05-01 00:00:00

abstract：:Outer membrane protein F (porin) was purified by extraction from polyacrylamide gels of cell envelope proteins of the Pseudomonas aeruginosa PAO1 strain. Rats were immunized intramuscularly with 25 micrograms of protein F on days 1 and 14 and then challenged on day 28 via intratracheal inoculation of bacterium-contain...

journal_title：Infection and immunity

authors： Gilleland HE Jr,Gilleland LB,Matthews-Greer JM

更新日期：1988-05-01 00:00:00

abstract：:Proteins from human polymorphonuclear leukocyte granules were extracted with 0.2 M acetate, pH 4.0, and fractionated by Sephadex G-100 column chromatography. The fractions demonstrated selective bactericidal action against a deep rough cell wall mutant of Escherichia coli O111:B4 with rough lipopolysacharide and cell ...

journal_title：Infection and immunity

authors： Modrzakowski MC,Cooney MH,Martin LE,Spitznagel JK

更新日期：1979-03-01 00:00:00

abstract：:Adult volunteers received a booster dose (4 x 10(8) CFU) of attenuated Vibrio cholerae CVD 103-HgR oral vaccine 15 or 24 months after primary immunization. The immune response was modest, presumably due to rapid clearance of the vaccine strain by a primed immune system. ...

journal_title：Infection and immunity

authors： Cryz SJ Jr,Levine MM,Losonsky G,Kaper JB,Althaus B

更新日期：1992-09-01 00:00:00

abstract：:Infection with Mycobacterium avium subsp. paratuberculosis is associated with high levels of morbidity, decreased production, and early culling in dairy cattle. Clinical symptoms of Johne's disease include persistent diarrhea, inappetence, and resultant weight loss due to chronic inflammation of the small intestine. A...

journal_title：Infection and immunity

authors： Aho AD,McNulty AM,Coussens PM

更新日期：2003-11-01 00:00:00

abstract：:The population structure of the Bacillus cereus group (52 strains of B. anthracis, B. cereus, and B. thuringiensis) was investigated by sequencing seven gene fragments (rpoB, gyrB, pycA, mdh, mbl, mutS, and plcR). Most of the strains were classifiable into two large subgroups in six housekeeping gene trees but not in ...

journal_title：Infection and immunity

authors： Ko KS,Kim JW,Kim JM,Kim W,Chung SI,Kim IJ,Kook YH

更新日期：2004-09-01 00:00:00

abstract：:The T-cell-stimulating activity of staphylococcal enterotoxin B (SEB) is an important factor in the pathogenesis of certain staphylococcal diseases. To investigate the immunologically active domains of the SEB molecule, we have produced truncated fragments of recombinant SEB by C-terminal and N-terminal deletions. The...

journal_title：Infection and immunity

authors： Metzroth B,Marx T,Linnig M,Fleischer B

更新日期：1993-06-01 00:00:00

abstract：:Neutrophil extracellular traps (NETs) are produced by neutrophils as an innate immune defense mechanism to trap and kill microbial pathogens. NETs are comprised of ejected chromatin that forms a lattice structure enmeshed with numerous antimicrobial proteins. In addition to forming the structural backbone of NETs, ext...

journal_title：Infection and immunity

authors： Wilton M,Halverson TWR,Charron-Mazenod L,Parkins MD,Lewenza S

更新日期：2018-08-22 00:00:00