Opposing effects of SWI/SNF and Mi-2/NuRD chromatin remodeling complexes on epigenetic reprogramming by EBF and Pax5.

abstract：:The recent discovery of small molecules targeting the cytochrome bc 1 :aa 3 in Mycobacterium tuberculosis triggered interest in the terminal respiratory oxidases for antituberculosis drug development. The mycobacterial cytochrome...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kalia NP,Hasenoehrl EJ,Ab Rahman NB,Koh VH,Ang MLT,Sajorda DR,Hards K,Grüber G,Alonso S,Cook GM,Berney M,Pethe K

更新日期：2017-07-11 00:00:00

abstract：:Migration of organisms (or cells) is typically an adaptive response to spatiotemporal variation in resources that requires individuals to detect and respond to long-range and noisy environmental gradients. Many organisms, from wildebeest to bacteria, migrate en masse in a process that can involve a vast number of indi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guttal V,Couzin ID

更新日期：2010-09-14 00:00:00

abstract：:The periaqueductal gray (PAG) and amygdala are known to be important for defensive responses, and many contemporary fear-conditioning models present the PAG as downstream of the amygdala, directing the appropriate behavior (i.e., freezing or fleeing). However, empirical studies of this circuitry are inconsistent and w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim EJ,Horovitz O,Pellman BA,Tan LM,Li Q,Richter-Levin G,Kim JJ

更新日期：2013-09-03 00:00:00

abstract：:We demonstrate the successful fabrication on CaF2 substrates of FeSe(1-x)Tex films with 0 ≤ x ≤ 1, including the region of 0.1 ≤ x ≤ 0.4, which is well known to be the "phase-separation region," via pulsed laser deposition that is a thermodynamically nonequilibrium method. In the resulting films, we observe a giant en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Imai Y,Sawada Y,Nabeshima F,Maeda A

更新日期：2015-02-17 00:00:00

abstract：:Major changes in the mRNA population of murine liver occur after administration of bacterial lipopolysaccharide, an agent that causes increases in the concentrations of acute-phase serum proteins. The mRNA for one of these, serum amyloid A, is increased at least 500-fold compared to the normal level. It becomes one of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morrow JF,Stearman RS,Peltzman CG,Potter DA

更新日期：1981-08-01 00:00:00

abstract：:We isolated erythroleukemic cell lines arrested at different levels of the erythroid differentiation pathway. One cell line (CB5), established from mice infected with the helper-independent Friend murine leukemia virus (F-MuLV), exhibited properties similar to those of the normal erythroid progenitor burst-forming cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shibuya T,Mak TW

更新日期：1983-06-01 00:00:00

abstract：:Superoxide dismutases (SODs; superoxide: superoxide oxidoreductase, EC 1.15.1.1) play a key role in protection against oxygen radicals, and SOD gene expression is highly induced during environmental stress. To determine the conditions of SOD induction, the promoter of the cytosolic copper/zinc SOD (Cu/ZnSODcyt) gene w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hérouart D,Van Montagu M,Inzé D

更新日期：1993-04-01 00:00:00

abstract：:Previous work has demonstrated a role for the E2F1 gene product in signaling apoptosis, both as a result of the deregulation of the Rb/E2F pathway as well as in response to DNA damage. We now show that the ability of cells to suppress the apoptotic potential of E2F1, as might occur during the course of normal cellular...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hallstrom TC,Nevins JR

更新日期：2003-09-16 00:00:00

abstract：:A mitochondrial gene from Saccharomyces cerevisiae encoding a hydrophobic membrane protein, subunit 8 of the F0/F1-type mitochondrial ATPase complex, has been functionally replaced by an artificial nuclear gene specifying an imported version of this protein. The experiments reported here utilized a multicopy expressio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nagley P,Farrell LB,Gearing DP,Nero D,Meltzer S,Devenish RJ

更新日期：1988-04-01 00:00:00

abstract：:Previous reports have shown that γδ T cells are important for the elimination of malaria parasites in humans and mice. However, how γδ T cells are involved in protective immunity against blood-stage malaria remains unknown. We infected γδ T-cell-deficient (TCRδ-KO) mice and control wild-type mice with Plasmodium bergh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inoue S,Niikura M,Takeo S,Mineo S,Kawakami Y,Uchida A,Kamiya S,Kobayashi F

更新日期：2012-07-24 00:00:00

abstract：:In response to environmental stresses, the mammalian serine threonine kinases PERK, GCN2, HRI, and PKR phosphorylate the regulatory serine 51 of the eukaryotic translation initiation factor 2α (eIF2α) to inhibit global protein synthesis. Plasmodium, the protozoan that causes malaria, expresses three eIF2α kinases: IK1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang M,Mishra S,Sakthivel R,Rojas M,Ranjan R,Sullivan WJ Jr,Fontoura BM,Ménard R,Dever TE,Nussenzweig V

更新日期：2012-03-06 00:00:00

abstract：:Activated macrophages are described as classically activated or M1 type and alternatively activated or M2 type, depending on their response to proinflammatory stimuli and the expression of genetic markers including iNOS, arginase1, Ym1, and Fizz1. Here we report that Akt kinases differentially contribute to macrophage...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arranz A,Doxaki C,Vergadi E,Martinez de la Torre Y,Vaporidi K,Lagoudaki ED,Ieronymaki E,Androulidaki A,Venihaki M,Margioris AN,Stathopoulos EN,Tsichlis PN,Tsatsanis C

更新日期：2012-06-12 00:00:00

abstract：:The x-ray crystal structures of the sulfide oxidase antibody 28B4 and of antibody 28B4 complexed with hapten have been solved at 2.2-angstrom and 1.9-angstrom resolution, respectively. To our knowledge, these structures are the highest resolution catalytic antibody structures to date and provide insight into the molec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsieh-Wilson LC,Schultz PG,Stevens RC

更新日期：1996-05-28 00:00:00

abstract：:Our main goal is to analyze the geometric and spectral properties of the Picard modular group with Gaussian integer entries acting on the two-dimensional complex hyperbolic space. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Francsics G,Lax PD

更新日期：2006-07-25 00:00:00

abstract：:The three-dimensional structures of RNA enzymes form catalytic centers that include specific substrate binding sites. High-resolution determination of these and other RNA structures is essential for a detailed understanding of the function of RNA in biological systems. The crystal structures of only a few RNA molecule...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doudna JA,Grosshans C,Gooding A,Kundrot CE

更新日期：1993-08-15 00:00:00

abstract：:Type beta transforming growth factor (TGF-beta) activity was found in conditioned medium harvested from fetal rat and neonatal mouse calvariae by using the anchorage-independent growth of normal rat kidney fibroblasts as an indicator system. Calvariae incubated with parathyroid hormone, 1,25-dihydroxyvitamin D3, and i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pfeilschifter J,Mundy GR

更新日期：1987-04-01 00:00:00

abstract：:The intracellular localization of phytochrome was seen in dark-grown oat (Avena sativa L., cv. Garry) and rice (Oryza sativa L., cv. unknown) shoots after various light treatments using an indirect peroxidase-antiperoxidase antibody labeling method. Phytochrome is generally distributed throughout the cytoplasm in cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mackenzie JM Jr,Coleman RA,Briggs WR,Pratt LH

更新日期：1975-03-01 00:00:00

abstract：:In mitosis, chromosome, cytoskeleton, and organelle dynamics must be coordinated for successful cell division. Here, we present evidence for a role for Arf1, a small GTPase associated with the Golgi apparatus, in the orchestration of mitotic Golgi breakdown, chromosome segregation, and cytokinesis. We show that early ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Altan-Bonnet N,Phair RD,Polishchuk RS,Weigert R,Lippincott-Schwartz J

更新日期：2003-11-11 00:00:00

abstract：:A major challenge in DNA microarray analysis is to effectively dissociate actual gene expression values from experimental noise. We report here a detailed noise analysis for oligonuleotide-based microarray experiments involving reverse transcription, generation of labeled cRNA (target) through in vitro transcription, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tu Y,Stolovitzky G,Klein U

更新日期：2002-10-29 00:00:00

abstract：:The atmospheric and deep sea reservoirs of carbon dioxide are linked via physical, chemical, and biological processes. The last of these include photosynthesis, particle settling, and organic matter remineralization, and are collectively termed the "biological carbon pump." Herein, we present results from a 13-y (1992...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karl DM,Church MJ,Dore JE,Letelier RM,Mahaffey C

更新日期：2012-02-07 00:00:00

abstract：:In the mammalian retina, extensive processing of spatiotemporal and chromatic information occurs. One key principle in signal transfer through the retina is parallel processing. Two of these parallel pathways are the ON- and OFF-channels transmitting light and dark signals. This dual system is created in the outer ple...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hack I,Peichl L,Brandstätter JH

更新日期：1999-11-23 00:00:00

abstract：:Secretion of extracellular polymeric substances (EPSs) by growing bacteria is an integral part of forming biofilm-like structures. In such dense systems, mechanical interactions among the structural components can be expected to significantly contribute to morphological properties. Here, we use a particle-based modeli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ghosh P,Mondal J,Ben-Jacob E,Levine H

更新日期：2015-04-28 00:00:00

abstract：:Infectious RNA transcripts were generated from full-length cDNA clones of the tobacco etch potyvirus genome containing an insertion of the bacterial beta-glucuronidase (GUS) gene between the polyprotein-coding sequences for the N-terminal 35-kDa proteinase and the helper component-proteinase. The recombinant virus was...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dolja VV,McBride HJ,Carrington JC

更新日期：1992-11-01 00:00:00

abstract：:We have identified a protein present only in erythroid cells that binds to two adjacent sites within an enhancer region of the chicken beta-globin locus. Mutation of the sites, so that binding by the factor can no longer be detected in vitro, leads to a loss of enhancing ability, assayed by transient expression in pri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Evans T,Reitman M,Felsenfeld G

更新日期：1988-08-01 00:00:00

abstract：:BACE1 is the rate-limiting enzyme for amyloid-β peptides (Aβ) generation, a key event in the pathogenesis of Alzheimer's disease (AD). By an unknown mechanism, levels of BACE1 and a BACE1 mRNA-stabilizing antisense RNA (BACE1-AS) are elevated in the brains of AD patients, implicating that dysregulation of BACE1 expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bahn G,Park JS,Yun UJ,Lee YJ,Choi Y,Park JS,Baek SH,Choi BY,Cho YS,Kim HK,Han J,Sul JH,Baik SH,Lim J,Wakabayashi N,Bae SH,Han JW,Arumugam TV,Mattson MP,Jo DG

更新日期：2019-06-18 00:00:00

abstract：:The most common monogenic cause of small-vessel disease leading to ischemic stroke and vascular dementia is the neurodegenerative syndrome cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), which is associated with mutations in the Notch 3 receptor. CADASIL pathology ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arboleda-Velasquez JF,Manent J,Lee JH,Tikka S,Ospina C,Vanderburg CR,Frosch MP,Rodríguez-Falcón M,Villen J,Gygi S,Lopera F,Kalimo H,Moskowitz MA,Ayata C,Louvi A,Artavanis-Tsakonas S

更新日期：2011-05-24 00:00:00

abstract：:Maintenance of genome stability is essential for the accurate propagation of genetic information and cell growth and survival. Organisms have therefore developed efficient strategies to prevent DNA lesions and rearrangements. Much of the information concerning these strategies has been obtained through the study of ba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maréchal A,Parent JS,Véronneau-Lafortune F,Joyeux A,Lang BF,Brisson N

更新日期：2009-08-25 00:00:00

abstract：:Id2 is a natural inhibitor of the basic helix-loop-helix transcription factors and the retinoblastoma tumor suppressor protein. Active Id2 prevents differentiation and promotes cell-cycle progression and tumorigenesis in the nervous system. A key event that regulates Id2 activity during differentiation is translocatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lasorella A,Iavarone A

更新日期：2006-03-28 00:00:00

abstract：:Fusions with the bacterial gene for chloramphenicol acetyltransferase followed by P-element-mediated germ-line transformation in Drosophila have permitted localization of the DNA sequence that confers a high degree of developmental specificity on a pair of silkmoth eggshell (chorion) genes. The short, 272-base-pair, 5...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitsialis SA,Spoerel N,Leviten M,Kafatos FC

更新日期：1987-11-01 00:00:00

abstract：:Usher syndrome type 1 (USH1) patients suffer from sensorineuronal deafness, vestibular dysfunction, and visual impairment. Several genetic loci have been linked to USH1, and four of the relevant genes have been identified. They encode the unconventional myosin VIIa, the PDZ-domain protein harmonin, and the putative ad...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Siemens J,Kazmierczak P,Reynolds A,Sticker M,Littlewood-Evans A,Müller U

更新日期：2002-11-12 00:00:00