An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes.

abstract：:Hatchlings of the painted turtle (Chrysemys picta marginata) are unique as the only reptile and highest vertebrate life form known to tolerate the natural freezing of extracellular body fluids during winter hibernation. Turtles survived frequent exposures to temperatures as low as -6 degrees C to -8 degrees C in their...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Storey KB,Storey JM,Brooks SP,Churchill TA,Brooks RJ

更新日期：1988-11-01 00:00:00

abstract：:GTP hydrolysis by elongation factor Tu (EF-Tu), a translational GTPase that delivers aminoacyl-tRNAs to the ribosome, plays a crucial role in decoding and translational fidelity. The basic reaction mechanism and the way the ribosome contributes to catalysis are a matter of debate. Here we use mutational analysis in co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maracci C,Peske F,Dannies E,Pohl C,Rodnina MV

更新日期：2014-10-07 00:00:00

abstract：:Two mutants of Balb/c 3T3 cells defective in adhesiveness to substratum have been isolated. After exposure to a mutagen a cell population was treated with prostaglandin E1 and methylisobutylxanthine to elevate the cells 3':5'-cyclic AMP levels and adhesion to the substratum; then, loosley adherent cells were harvested...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pouysségur JM,Pastan I

更新日期：1976-02-01 00:00:00

abstract：:Practicing a motor skill triggers a process of memory consolidation that continues for hours after practice has ended, and becomes manifest in an improved skill at later testing. We used a sequential motor task (finger-to-thumb opposition task) to show that, in humans, the formation of motor skill memories essentially...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fischer S,Hallschmid M,Elsner AL,Born J

更新日期：2002-09-03 00:00:00

abstract：:Hybridoma technology was used for preparation of murine monoclonal antibodies of high titer against bone-Gla protein and osteonectin. A procedure of immunization and hybridization similar to that already described [Katzmann, J.A., Nesheim, M.E., Hibbard, L.S. & Mann, K.G. (1981) Proc. Natl. Acad. Sci. USA 78, 162-166;...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stenner DD,Romberg RW,Tracy RP,Katzmann JA,Riggs BL,Mann KG

更新日期：1984-05-01 00:00:00

abstract：:A model is presented for age-specific selection on the genotypes in a population. Each genotype is assigned a life table that specifies the viability and fecundity of its age classes. Breeding and reproduction occur at regular intervals, and generations overlap. Examples were generated on a digital computer. Gene freq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson WW,King CE

更新日期：1970-07-01 00:00:00

abstract：:Reactive oxygen species (ROS) mediate abscisic acid (ABA) signaling in guard cells. To dissect guard cell ABA-ROS signaling genetically, a cell type-specific functional genomics approach was used to identify 2 MAPK genes, MPK9 and MPK12, which are preferentially and highly expressed in guard cells. To provide genetic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jammes F,Song C,Shin D,Munemasa S,Takeda K,Gu D,Cho D,Lee S,Giordo R,Sritubtim S,Leonhardt N,Ellis BE,Murata Y,Kwak JM

更新日期：2009-12-01 00:00:00

abstract：:I describe the self-splicing of an RNA that consists of exon sequences flanked by group II intron sequences. I find that this RNA undergoes accurate splicing in vitro, yielding an excised exon circle. This splicing reaction involves the joining of the 5' splice site at the end of an exon to the 3' splice site at the b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jarrell KA

更新日期：1993-09-15 00:00:00

abstract：:Stabilization of neuronal activity by homeostatic control systems is fundamental for proper functioning of neural circuits. Failure in neuronal homeostasis has been hypothesized to underlie common pathophysiological mechanisms in a variety of brain disorders. However, the key molecules regulating homeostasis in centra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vertkin I,Styr B,Slomowitz E,Ofir N,Shapira I,Berner D,Fedorova T,Laviv T,Barak-Broner N,Greitzer-Antes D,Gassmann M,Bettler B,Lotan I,Slutsky I

更新日期：2015-06-23 00:00:00

abstract：:The protooncogene c-fps/fes is a single vertebrate locus homologous to both the fps transforming gene of Fujinami avian sarcoma virus and the fes transforming gene of two feline sarcoma virus isolates. The human c-fps/fes locus has been previously cloned and characterized. We report that a recombinant gene in which 3'...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sodroski JG,Goh WC,Haseltine WA

更新日期：1984-05-01 00:00:00

abstract：:On April 20, 2010, the Deepwater Horizon (DWH) blowout occurred, releasing more oil than any accidental spill in history. Oil release continued for 87 d and much of the oil and gas remained in, or returned to, the deep sea. A coral community significantly impacted by the spill was discovered in late 2010 at 1,370 m de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fisher CR,Hsing PY,Kaiser CL,Yoerger DR,Roberts HH,Shedd WW,Cordes EE,Shank TM,Berlet SP,Saunders MG,Larcom EA,Brooks JM

更新日期：2014-08-12 00:00:00

abstract：:Point mutations in vascular smooth muscle α-actin (SM α-actin), encoded by the gene ACTA2, are the most prevalent cause of familial thoracic aortic aneurysms and dissections (TAAD). Here, we provide the first molecular characterization, to our knowledge, of the effect of the R258C mutation in SM α-actin, expressed wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu H,Fagnant PM,Bookwalter CS,Joel P,Trybus KM

更新日期：2015-08-04 00:00:00

abstract：:Bitemporal injections of puromycin that primarily affect the hippocampal-entorhinal area induce amnesia of aversive maze-learning in mice for 3 days after training but are ineffective 6 or more days after training. At these later times, additional puromycin sites covering widespread forebrain areas are necessary to in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flexner JB,Flexner LB,Church AC,Rainbow TC,Brunswick DJ

更新日期：1985-11-01 00:00:00

abstract：:In Drosophila, P-element transposition causes mutagenesis and genome instability during hybrid dysgenesis. The P-element 31-bp terminal inverted repeats (TIRs) contain sequences essential for transposase cleavage and have been implicated in DNA repair via protein-DNA interactions with cellular proteins. The identity a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Francis MJ,Roche S,Cho MJ,Beall E,Min B,Panganiban RP,Rio DC

更新日期：2016-11-15 00:00:00

abstract：:I describe some recent observations of large-scale structure in the galaxy distribution. The best constraints come from two-dimensional galaxy surveys and studies of angular correlation functions. Results from galaxy redshift surveys are much less precise but are consistent with the angular correlations, provided the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Efstathiou G

更新日期：1993-06-01 00:00:00

abstract：:Observing the structure and regeneration of the myelin sheath in peripheral nerves following injury and during repair would help in understanding the pathogenesis and treatment of neurological diseases caused by an abnormal myelin sheath. In the present study, transmission electron microscopy, immunofluorescence stain...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu B,Xin W,Tan JR,Zhu RP,Li T,Wang D,Kan SS,Xiong DK,Li HH,Zhang MM,Sun HH,Wagstaff W,Zhou C,Wang ZJ,Zhang YG,He TC

更新日期：2019-10-29 00:00:00

abstract：:A 38-base-pair region required for normal CYC1 mRNA 3' end formation in Saccharomyces cerevisiae was shown to be necessary for the termination of transcription in vivo by examining the stability of CEN3 plasmids. CEN3 plasmids were stably maintained during vegetative growth, unless a GAL1 transcript impinged on the CE...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Russo P,Sherman F

更新日期：1989-11-01 00:00:00

abstract：:Splenic cells from one BALB/c mouse and one C57/BL mouse, immunized with purified rat liver glucocorticoid receptor (GR), were fused with the mouse myeloma cell line Sp 2/0-Ag 14. Screening for production of anti-GR-antibodies by the hybridomas was carried out with an enzyme-linked immunosorbent assay, using partially...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okret S,Wikström AC,Wrange O,Andersson B,Gustafsson JA

更新日期：1984-03-01 00:00:00

abstract：:Elevated expression of the marORAB multiple antibiotic-resistance operon enhances the resistance of Escherichia coli to various medically significant antibiotics. Transcription of the operon is repressed in vivo by the marR-encoded protein, MarR, and derepressed by salicylate and certain antibiotics. The possibility t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martin RG,Rosner JL

更新日期：1995-06-06 00:00:00

abstract：:Although peroxisome proliferator-activated receptor gamma (PPARgamma) agonists such as thiazolidinediones (TZDs) are widely used to treat type 2 diabetes, how its activation in individual tissues contributes to TZD's therapeutic action remains controversial. As TZDs are known to have receptor-independent effects, we s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugii S,Olson P,Sears DD,Saberi M,Atkins AR,Barish GD,Hong SH,Castro GL,Yin YQ,Nelson MC,Hsiao G,Greaves DR,Downes M,Yu RT,Olefsky JM,Evans RM

更新日期：2009-12-29 00:00:00

abstract：:DNA replication intermediates in human melanoma cells have been investigated by using the drug aphidicolin, which inhibits DNA polymerase alpha. In untreated cells, Okazaki fragments and 10-kilobase (kb) DNA intermediates are formed. In aphidicolin-treated cells, the replication fork is stopped and there is no formati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lönn U,Lönn S

更新日期：1983-07-01 00:00:00

abstract：:Two-phase random textures abound in a host of contexts, including porous and composite media, ecological structures, biological media, and astrophysical structures. Questions surrounding the spatial structure of such textures continue to pose many theoretical challenges. For example, can two-point correlation function...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiao Y,Stillinger FH,Torquato S

更新日期：2009-10-20 00:00:00

abstract：:Chemokines and their receptors direct leukocyte migration among blood, lymph and tissues. Evidence has recently accumulated that, besides their chemotactic functions, chemokine receptors are highly versatile players that fine tune immune responses. During human T cell activation by antigen-presenting cells, the chemok...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Contento RL,Molon B,Boularan C,Pozzan T,Manes S,Marullo S,Viola A

更新日期：2008-07-22 00:00:00

abstract：:P2X receptors for ATP have a wide range of physiological roles and comprise a structurally distinct family of ligand-gated trimeric ion channels. The crystal structure of a P2X4 receptor, in combination with mutagenesis studies, has provided a model of the intersubunit ATP-binding sites and identified an extracellular...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roberts JA,Allsopp RC,El Ajouz S,Vial C,Schmid R,Young MT,Evans RJ

更新日期：2012-03-20 00:00:00

abstract：:Understanding the factors that shape macroevolutionary patterns in functional traits is a central goal of evolutionary biology. Alternative strategies of sexual reproduction (inbreeding vs. outcrossing) have divergent effects on population genetic structure and could thereby broadly influence trait evolution. However,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Campbell SA,Kessler A

更新日期：2013-03-05 00:00:00

abstract：:Adipose triglyceride lipase (ATGL) initiates intracellular triglyceride (TG) catabolism. In humans, ATGL deficiency causes neutral lipid storage disease with myopathy (NLSDM) characterized by a systemic TG accumulation. Mice with a genetic deletion of ATGL (AKO) also accumulate TG in many tissues. However, neither NLS...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schreiber R,Hofer P,Taschler U,Voshol PJ,Rechberger GN,Kotzbeck P,Jaeger D,Preiss-Landl K,Lord CC,Brown JM,Haemmerle G,Zimmermann R,Vidal-Puig A,Zechner R

更新日期：2015-11-10 00:00:00

abstract：:Class I gene products D, L, and R encoded by the D region of the H-2q haplotype were isolated by sequential immunoprecipitation from Nonidet P-40 extracts of B10.AKM murine spleen cells. Primary structural comparisons of these molecules were made by tryptic peptide map analyses and radiochemical amino acid sequence de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lillehoj EP,Hansen TH,Sachs DH,Coligan JE

更新日期：1984-04-01 00:00:00

abstract：:Cystic fibrosis (CF) is an autosomal recessive disorder, the most common lethal genetic disease in Caucasians. Respiratory disease is the major cause of morbidity and mortality. Indeed, 95% of CF patients die of respiratory failure. Pseudomonas aeruginosa, an opportunistic pathogen, chronically infects the lungs of ov...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li JD,Feng W,Gallup M,Kim JH,Gum J,Kim Y,Basbaum C

更新日期：1998-05-12 00:00:00

abstract：:In this study we examine how the introduction of a reference lottery with nonrandom outcomes alters the way in which choices among pairs of lotteries are made, even if it does not alter the choices. We use different domains (some of the lotteries produce gains, other losses) and different contexts (one member of the p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dickhaut J,McCabe K,Nagode JC,Rustichini A,Smith K,Pardo JV

更新日期：2003-03-18 00:00:00

abstract：:Saccharomyces cerevisiae Hop2 and Mnd1 are abundant meiosisspecific chromosomal proteins, and mutations in the corresponding genes lead to defects in meiotic recombination and in homologous chromosome interactions during mid-prophase. Analysis of various double mutants suggests that HOP2, MND1, and DMC1 act in the sam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YK,Leng CH,Olivares H,Lee MH,Chang YC,Kung WM,Ti SC,Lo YH,Wang AH,Chang CS,Bishop DK,Hsueh YP,Wang TF

更新日期：2004-07-20 00:00:00