Abstract：
OBJECTIVES:To determine if the number of involved anatomic areas can modify the standard risk groups in pediatric Hodgkin's lymphoma, identifying children who would benefit from a reduction in treatment intensity. METHODS:Retrospective study evaluating age, sex, histology, Ann-Arbor stage, presence of B symptoms, number of involved anatomic areas, risk grouping (favorable vs. unfavorable), and laboratory exams. All patients received doxorubicin-containing chemotherapy. Patients in complete remission for 5 years or longer were evaluated as for late effects. RESULTS:Sixty-nine patients (2-18 years) were included, 68% belonged to the unfavorable risk group. Overall survival and event-free survival were 94 and 87%, respectively. Late effects were screened in 46 cases. Advanced stage and > or = four involved anatomic areas had negative impact on event-free survival, while only the number of involved anatomic areas retained statistical significance when using Cox analysis (hazard ratio = 6.4, 95%CI = 1.08-38.33; p = 0.04). Risk groups were adjusted by number of involved anatomic areas (< four/> or = four involved anatomic areas), with a significant reallocation of patients (p = 0.008). Of the 30 patients with late effects, 21 were in the original unfavorable risk group and 14 (66.6%) could have been reallocated to the favorable risk group based on the number of involved anatomic areas. CONCLUSIONS:If re-stratification had been applied, a considerable number of children would have received less intensive treatment and, consequently, could have had lower chances of late effects. A prospective study could define if adjustment of risk group by number of involved anatomic areas would have any impact on survival rates.
journal_name
J Pediatr (Rio J)journal_title
Jornal de pediatriaauthors
Morais A,Barros MH,Hassan R,Morais VL,Muniz MTdoi
10.2223/JPED.1891subject
Has Abstractpub_date
2009-05-01 00:00:00pages
236-42issue
3eissn
0021-7557issn
1678-4782journal_volume
85pub_type
杂志文章abstract：OBJECTIVE:To observe the intensity of the inflammatory reaction caused by urine on the intestinal wall of rats. METHODS:Experimental model, using 20 Wistar rats divided into two groups. All the animals were submitted to abdominal puncture at the right inferior quadrant, twice daily for five days. In Group I (control g...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.1113
更新日期：2003-11-01 00:00:00
abstract：OBJECTIVE:To evaluate the presence of insulin resistance and its association with other metabolic abnormalities in obese children and adolescents. METHODS:Retrospective study of 220 children and adolescents aged 5-14 years. Anthropometric measurements were performed (weight, height, and waist circumference) and clinic...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2014.03.005
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:To assess the carotid intima-media thickness and factors associated with cardiovascular disease in children and adolescents with chronic kidney disease. MATERIAL AND METHODS:Observational, cross-sectional study carried out at the Universidade Federal de São Paulo (chronic kidney disease outpatient clinics) w...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2018.06.010
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:A review article was carried out, addressing the clinical and epidemiological characteristics of immune system deficiencies, which are associated with or predispose to recurrent infectious processes, autoimmune diseases, auto inflammatory diseases, or neoplasms, and which are classified as inborn errors of im...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.1016/j.jped.2020.10.009
更新日期：2020-11-22 00:00:00
abstract：:The purpose of the authors in this article was to evaluate the effects of supplementing maternal milk with two different caloric formulas on the growth of premature newborns until they reached 40 weeks of post-conceptional age. Seventy premature infants weighing < 1750g at birth were randomized: 35 adequate for gestat...
journal_title：Jornal de pediatria
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.2223/jped.607
更新日期：1996-05-01 00:00:00
abstract：OBJECTIVES:To describe the prevalence of and factors associated with overweight in children under 4 years of age in Feira de Santana, state of Bahia, Brazil. METHODS:Cross-sectional study nested within a birth cohort of 793 children born in Feira de Santana, Brazil. Independent variables were related to infant charact...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.2009
更新日期：2010-07-01 00:00:00
abstract：OBJECTIVE:To report the results of open challenge tests performed in children fed with cow's milk-free diet. DESCRIPTION:Cross-sectional study evaluating cow's milk open challenge performed under supervision in a hospital setting during 2.5 hours and ambulatory follow-up for 30 days when no immediate reaction occurred...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1967
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVE:to determine, by Doppler-echocardiography, the frequency of cardiac diastolic dysfunction in asymptomatic and clinically stable pediatric patients with vertical infection by the human immunodeficiency virus (HIV), from the cardiovascular viewpoint. METHODS:this was an observational, prospective, and cross-se...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2014.01.004
更新日期：2014-07-01 00:00:00
abstract：:OBJECTIVE: This paper examines the main causes of mortality among adolescents ages 10 to 19 in the city of Rio de Janeiro with a focus on mortality prevention. METHODS: Mortality data from 1981 to 1995 were taken from the Mortality Information System of the Brazilian Ministry of Health. Age and sex specific mortality ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.325
更新日期：1999-09-01 00:00:00
abstract：OBJECTIVE:To assess the prevalence of metabolic syndrome-like symptoms in a population of preterm infants with very low birth weight (<1500g) at 2 years of corrected age and identify the occurrence of associated risk factors. METHODS:Cross-sectional study during a five-year period, including preterm infants born with ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2018.02.009
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:To analyze the implementation of a protocol proposed by the Brazilian National Health Surveillance Agency (Agência Nacional de Vigilância Sanitária - ANVISA) to improve sepsis diagnosis in very low birth weight newborns. METHODS:This was a prospective study that evaluated the implementation of a protocol inv...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2013.01.009
更新日期：2013-09-01 00:00:00
abstract：OBJECTIVE:To assess the evolution of nutritional status in children admitted to the Teaching Hospital of Universidade Federal de Alagoas. METHODS:A retrospective study was performed on 52 children (0-10 yrs) whose length of hospital stay exceeded 10 days (from February to July/2001). We compared their nutritional stat...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.905
更新日期：2002-11-01 00:00:00
abstract：OBJECTIVE:To describe the increased risk of acquiring infectious diseases associated with out-of-home childcare and the effectiveness of measures for the control and prevention of diseases transmission at daycare and preschool education centers. SOURCES:A review of literature in the MEDLINE, LILACS and Cochrane Librar...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.2223/JPED.1649
更新日期：2007-07-01 00:00:00
abstract：OBJECTIVE:To analyze acute splenic sequestration (ASS) in children with sickle cell anemia diagnosed through a newborn screening program in the state of Minas Gerais, Brazil, and followed up at the hematology center in the city of Belo Horizonte, Minas Gerais, Brazil. METHODS:Retrospective cohort of 255 children with ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1885
更新日期：2009-03-01 00:00:00
abstract：OBJECTIVE:Exposure to sunlight in childhood is often more intense than in adults. Literature data unequivocally show the association between this social behavior and the risk for developing malignant melanoma and non-melanoma skin cancer, even in adulthood. Furthermore, skin photoaging begins already in childhood throu...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.2223/jped.2194
更新日期：2012-05-01 00:00:00
abstract：OBJECTIVE:To determine the prevalence of celiac disease and to describe the histological alterations, clinical manifestations, and conditions associated with a group of first-degree relatives of celiac disease patients in the municipality of Recife, Northeast Brazil. METHOD:The study was conducted in outpatient clinic...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.2013
更新日期：2010-07-01 00:00:00
abstract：:Immediate skin test reactions are the hallmark of atopic diseases. EMLA (eutectic mixture of local anesthetics) is a local anesthetic that reduces the pain and apprehension for skin testing. We studied EMLA effects on the skin prick test with allergen and histamine. Reactions were evaluated by means of wheal and flare...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.613
更新日期：1996-07-01 00:00:00
abstract：OBJECTIVES:To guide the diagnostic and therapeutic management of severe forms of food allergy. DATA SOURCES:Search in the Medline database using the terms "severe food allergy," "anaphylaxis and food allergy," "generalized urticaria and food allergy," and "food protein-induced enterocolitis syndrome" in the last ten y...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.1016/j.jped.2017.06.021
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to investigate the effect of different ergonomic desk designs and pencil grip patterns on handwriting performance in children with hemiplegic cerebral palsy and healthy children. METHODS:Twenty-six children with left hemiplegic cerebral palsy and 32 typically developing children wer...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1914
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVE:To verify the concurrent validity and interobserver reliability of the Alberta Infant Motor Scale (AIMS) in premature infants followed-up at the outpatient clinic of Instituto Fernandes Figueira, Fundação Oswaldo Cruz (IFF/Fiocruz), in Rio de Janeiro, Brazil. METHODS:A total of 88 premature infants were enro...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1836
更新日期：2008-09-01 00:00:00
abstract：OBJECTIVES:To identify the prevalence of iron deficiency in the population studied, as well as verifying if such deprivation is associated with vitamin A deficiency. METHODS:One hundred seventy-nine children, > or = 24 months and < 72 months of age, with no diarrhea and/or fever at collection were studied. Vitamin A d...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：
更新日期：2005-03-01 00:00:00
abstract：:Phototherapy is a common procedure in the neonatal period. However there is great controversy in the literature about when and at which serum bilirubin levels phototherapy and exchange transfusion should be indicated. The aim of this paper is to review the literature and to suggest guidelines to help pediatricians in ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.776
更新日期：1995-07-01 00:00:00
abstract：:OBJECTIVE: To determine the prevalence of rotavirus in the etiology of acute diarrhea in children from Natal city, RN, Brazil and investigate the existence or not of a seasonal distribution of this pathogen in our environment.METHODS: Fecal samples from 1,903 children (boys and girls) with ages ranging from 1 month to...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.6
更新日期：2000-07-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to identify the causes of congenital microcephaly in Rio Grande do Sul, a state in southern Brazil, where no ZIKV outbreak was detected, from December 2015 to December 2016, which was the period when ZIKV infection was at its peak in northeast Brazil. METHODS:This was a cross-sectio...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2018.05.013
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:This study of Terena Indian children less than 10 years old was undertaken in order to compare weight and height in 1995 and 2002 and to evaluate anemia prevalence in 2002. METHODS:This was a cross-sectional study of the Limão Verde and Córrego Seco tribes, located in Aquidauana, Mato Gosso do Sul, Brazil. T...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1389
更新日期：2005-09-01 00:00:00
abstract：OBJECTIVE:To describe the characteristics of macrophage activation syndrome associated with juvenile idiopathic arthritis. DESCRIPTION:This is a retrospective study involving 462 patients with juvenile idiopathic arthritis. Seven (1.5%) of those patients suffered from systemic onset juvenile idiopathic arthritis and d...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：
更新日期：2004-11-01 00:00:00
abstract：OBJECTIVE:to investigate the pulmonary response to exercise of non-morbidly obese adolescents, considering the gender. METHODS:a prospective cross-sectional study was conducted with 92 adolescents (47 obese and 45 eutrophic), divided in four groups according to obesity and gender. Anthropometric parameters, pulmonary ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2013.08.005
更新日期：2014-05-01 00:00:00
abstract：:OBJECTIVE: The aim of this article is to review and update the knowledge about sleep disorders in childhood. SOURCES: Normal sleep ontogenesis and therapeutics for the most prevalent sleep disorders were reviewed. The text was based on classical articles and books and on Medline (publications from 2000 and 2001) using...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.852
更新日期：2002-07-01 00:00:00
abstract：OBJECTIVE:To present the characteristics of pediatric patients with chronic and irreversible diseases submitted to palliative extubation. METHOD:This is a descriptive analysis of a series of patients admitted to a public pediatric hospital, with chronic and irreversible diseases, permanently dependent on ventilatory s...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2019.07.005
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVE:to assess the epidemiological and genetic factors associated with severity of acute viral bronchiolitis (AVB) by respiratory syncytial virus (RSV). DATA SOURCE:the key words "bronchiolitis", "risk factor", "genetics" and "respiratory syncytial virus", and all combinations among them were used to perform a se...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.1016/j.jped.2013.02.022
更新日期：2013-11-01 00:00:00
