Abstract：
OBJECTIVE:A review article was carried out, addressing the clinical and epidemiological characteristics of immune system deficiencies, which are associated with or predispose to recurrent infectious processes, autoimmune diseases, auto inflammatory diseases, or neoplasms, and which are classified as inborn errors of immunity (IEI) and secondary immunodeficiencies (SID). Emphasis was placed on the classification of the main signs and symptoms for each organ and system, which will serve as warning signs, to guide the pediatrician in the investigation of the main IEI. In addition, the main secondary changes in the immune system triggered by infections (with emphasis on COVID-19), drugs, chronic diseases, metabolic and nutritional disorders were identified. SOURCES OF DATA:This review included articles published in the last five years and that were identified in the MEDLINE platform (PubMed). SUMMARY OF FINDINGS:The recurrence of infectious processes, associated with the severity of the condition and/or unusual profile of the infectious agent, always related to the age range of symptom onset, are the most important findings for suspected diagnosis. CONCLUSIONS:Considering this scenario, immunity disorders should be part of the investigation carried out by the general pediatrician, whether they are the innate errors of immunity (primary immunodeficiencies) or secondary immunodeficiencies, so that the diagnosis is attained as early as possible and therapeutic measures are implemented, reducing the morbidity and mortality of these patients.
journal_name
J Pediatr (Rio J)journal_title
Jornal de pediatriaauthors
Barreto ICDP,Barreto BAP,Cavalcante EGDN,Condino Neto Adoi
10.1016/j.jped.2020.10.009subject
Has Abstractpub_date
2020-11-22 00:00:00eissn
0021-7557issn
1678-4782pii
S0021-7557(20)30226-6pub_type
杂志文章,评审abstract：OBJECTIVES:The purpose of this study was to investigate what effect the ingestion of sardines, rich in omega-3 series polyunsaturated fatty acids, has on the composition of breastmilk. METHODS:This was a prospective study of 31 nursing mothers under observation at the Hospital Guilherme Alvaro. Each was given 2 kg of ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1439
更新日期：2006-01-01 00:00:00
abstract：:In order to better understand the natural history of chronic functional constipation, a questionnaire was applied to 163 children and infants, before beginning standardized treatment. Median age (range) at start was 3 mo(0-108 mo) but age at arrival at the Pediatric Gastroenterology Unit was 53 mo(2-146 mo). In 62.4% ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.688
更新日期：1994-09-01 00:00:00
abstract：OBJECTIVE:Total bilirubin is beneficial for protecting cardiovascular diseases in adults. The authors aimed to investigate the association of total bilirubin, red blood cell, and hemoglobin levels with the prevalence of high blood pressure in children and adolescents. METHODS:A total of 3776 students (aged from 6 to 1...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2017.07.018
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:To find evidence of the symptoms of anxiety/depression in children with developmental coordination disorder as compared to their typically developing peers at both the group and individual level, and to identify how many different tools are used to measure anxiety and/or depression. METHODS:Electronic search...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2019.03.002
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVES:To assess the prevalence of congenital hypothyroidism and the ability of various neonatal thyroid-stimulating hormone (TSHneo) cutoff values to detect this disease. METHODS:This cohort study was based on the retrospective collection of information available from the Reference Service for Newborn Screening d...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2016.07.006
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVE:This study reviews clinical features, evolution, comorbidity and suicidal behavior in childhood and adolescence depression. Its objective is to provide clear information on this common, severe and not very easily recognized pathology. SOURCES:Literature searches were performed through Medline (1991-2000), wi...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：OBJECTIVE:To evaluate compliance in children with acute lymphoblastic leukemia. METHOD:Compliance was assessed through specific interviews. RESULTS:A total of 73 patients who had concluded the maintenance phase of chemotherapy were enrolled on the study. Eighty-one percent of the interviews were conducted with the pa...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：
更新日期：2005-05-01 00:00:00
abstract：OBJECTIVE:To correlate different methods of body composition assessment in overweight or obese schoolchildren, using deuterium oxide (D2O) dilution as a reference. METHODS:Percentage of total body water (%TBW), fat free mass (%FFM), and body fat (%BF) were assessed by D2O and tetrapolar electrical bioimpedance analysi...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2015.03.007
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVE:To describe the current scientific knowledge on the effects of physical exercise on the growth of children and adolescents since intrauterine life. SOURCE OF DATA:A search was carried out in the Medline, Embase, Scielo, and Cochrane databases of studies published from 1990 to 2018. The authors included studi...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.1016/j.jped.2018.11.003
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:To evaluate retinol concentration in colostrum samples collected with a 24 hour interval. METHOD:Colostrum was collected from 24 recently-delivered mothers at two points in time, 0 hours (T0) and 24 hours later (T24), and a pooled sample of colostrum from T0 and T24 was also analyzed. Fat content was determi...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1646
更新日期：2007-07-01 00:00:00
abstract：OBJECTIVE:To observe the behavior of the plotted vectors on the RXc (R - resistance - and Xc - reactance corrected for body height/length) graph through bioelectrical impedance analysis (BIVA) and phase angle (PA) values in stable premature infants, considering the hypothesis that preterm infants present vector behavio...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2016.04.005
更新日期：2012-05-01 00:00:00
abstract：OBJECTIVE:To describe the linear growth and growth velocity of preterm infants born small for gestational age according to variables such as weight, length and head circumference, from birth to three months of corrected age. METHODS:Prospective study of one hundred preterm infants born small for gestational age from 2...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：
更新日期：2002-05-01 00:00:00
abstract：OBJECTIVES:To assess adequacy of vitamin C intake in HIV-infected children and adolescents; to evaluate serum levels of vitamin C and indicators of oxidative stress; to compare with the uninfected group; to correlate serum vitamin C with oxidative stress and associate them according to the reference values. METHODS:Co...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.2141
更新日期：2011-11-01 00:00:00
abstract：OBJECTIVE:To evaluate the safety, tolerability and potential therapeutic effects of gastrin-releasing peptide in three children with autistic spectrum disorder. METHODS:Case series study with the intravenous administration of gastrin-releasing peptide in the dose of 160pmol/kg for four consecutive days. To evaluate th...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2015.08.012
更新日期：2016-05-01 00:00:00
abstract：OBJECTIVE:to investigate the pulmonary response to exercise of non-morbidly obese adolescents, considering the gender. METHODS:a prospective cross-sectional study was conducted with 92 adolescents (47 obese and 45 eutrophic), divided in four groups according to obesity and gender. Anthropometric parameters, pulmonary ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2013.08.005
更新日期：2014-05-01 00:00:00
abstract：OBJECTIVE:Our aim was to determine whether endogenous mononuclear leukocyte DNA strand is a target of phototherapy. METHODS:The study included 65 term infants aged between 3-10 days that had been exposed to intensive (n = 23) or conventional (n = 23) phototherapy for at least 48 hours due to neonatal jaundice, and a c...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1765
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVE:To compare the use of intravenous vs. oral antibiotic therapy. METHODS:All febrile neutropenic patients younger than 18 years old with low risk of complications and receiving chemotherapy were selected. The study was conducted from 2002 to 2005 at the Pediatric Oncology Unit of Hospital de Clínicas de Porto ...
journal_title：Jornal de pediatria
pub_type： 杂志文章,随机对照试验
doi：10.2223/JPED.1956
更新日期：2009-11-01 00:00:00
abstract：OBJECTIVE:To present a wide-ranging review of the literature on broncopulmonary dysplasia, covering new definitions, pathophysiology, prevention, treatment, prognosis and progression. SOURCES OF DATA:The most relevant articles published on the subject since it was first described in 1967 were selected from MEDLINE sea...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：
更新日期：2005-03-01 00:00:00
abstract：:OBJECTIVE: Neonatal tetanus is an infection with high mortality, constituting a problem in underdeveloped countries, where there is faulty prenatal attendance. In spite of this and of the decreasing incidence of the disease in the state of Rio Grande do Sul, we report a case of neonatal tetanus identified in 1997. MET...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.80
更新日期：2000-09-01 00:00:00
abstract：:OBJECTIVE: Evaluation of epidemiological, clinical and laboratory features of Plasmodium vivax malaria in children and adolescents. METHODS: This study was carried out in the Malaria Program of the Evandro Chagas Institute (Belém, Pará), from January 1995 to November 1996. 100 children and adolescents with the diagnos...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.295
更新日期：1999-05-01 00:00:00
abstract：OBJECTIVE:Report the incidence, epidemiology, clinical features, death, and vaccination status of patients with whooping cough and perform genotypic characterization of isolates of B. pertussis identified in the state of Paraná, during January 2007 to December 2013. METHODS:Cross-sectional study including 1,209 patien...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2014.09.004
更新日期：2015-07-01 00:00:00
abstract：:OBJECTIVES: Air pollution has been a significant worldwide problem with repercussions in the respiratory tract, along the years. The main objectives of this review are to present results from studies on the harmful effects of allergens as well as of pollutants over the respiratory tract.METHOD: Published studies were ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.481
更新日期：1998-07-01 00:00:00
abstract：OBJECTIVE:To describe the clinical and demographic characteristics of non-Hodgkin's lymphoma patients diagnosed at the Pediatric Oncology Unit at the Instituto Materno-Infantil Professor Fernando Figueira (IMIP) over a 9-year period, and also to describe their survival rates and possible associations between the surviv...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1726
更新日期：2007-11-01 00:00:00
abstract：OBJECTIVE:To describe the antimicrobial activity of β-defensin-2 produced in the mammary gland and secreted in human breast milk. METHODS:The peptide production was performed by DNA cloning. β-defensin-2 levels were quantified in 61 colostrum samples and 39 mature milk samples from healthy donors, by an indirect enzym...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.1016/j.jped.2014.05.006
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVE:To review the literature on the effects of parental divorce over the psychological maladjustment and physical health problems in children of divorced parents, thus contributing to the integration of existing scientific knowledge based on the biopsychosocial model of the impact of divorce on children's physica...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.2223/JPED.1925
更新日期：2009-09-01 00:00:00
abstract：OBJECTIVE:To assess the evolution of nutritional status in children admitted to the Teaching Hospital of Universidade Federal de Alagoas. METHODS:A retrospective study was performed on 52 children (0-10 yrs) whose length of hospital stay exceeded 10 days (from February to July/2001). We compared their nutritional stat...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/jped.905
更新日期：2002-11-01 00:00:00
abstract：OBJECTIVE:To assess pulmonary function in children and adolescents subjected to correction of rheumatic valve disease in order to quantify changes caused by factors inherent to surgery and rheumatic heart disease. METHODS:This was a longitudinal and quantitative intervention study, undertaken at a children's hospital ...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.1462
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVE:To analyze the available evidence regarding the efficacy of interventions on parents whose children were aged 2-5 years to promote parental competence and skills for children's healthy lifestyles. SOURCE:Articles published in English and Spanish, available at PubMed, Psycinfo, CINAHL, Web of Science, Eric, a...
journal_title：Jornal de pediatria
pub_type： 杂志文章,评审
doi：10.1016/j.jped.2017.07.019
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:To assess the health-related quality of life (HRQoL) of children surviving to pediatric intensive care discharge. METHODS:A prospective evaluation of HRQoL at admission and 6 months later was carried out with children aged 6 years or more, admitted to three tertiary pediatric intensive care units (PICUs) fro...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：10.2223/JPED.2151
更新日期：2012-01-01 00:00:00
abstract：:OBJECTIVE: To verify the effects of malnutrition and nutritional rehabilitation regarding seizure threshold, body weight and brain weight in rats. METHODS: Pregnant Wistar rats and their pups were used. Part of the rat pups were submitted to a malnutrition protocol and the rest served as nourished controls. At P15, ma...
journal_title：Jornal de pediatria
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
