Abstract:
PURPOSE:To assess the association between exogenous oestrogen exposure, female reproductive factors and the long-term incidence of cataract. METHODS:People aged 49+ years living in a defined geographic region were invited to participate in this prospective population-based survey. Of 2072 women (83% of those eligible) who were examined during 1992-1994 at baseline, around 75% of survivors were re-examined at 5- and 10-year follow-up visits. Lens photographs were assessed using the Wisconsin Cataract Grading System by masked graders. An interviewer-administered questionnaire was used at each visit to collect information on female reproductive factors and the use of the oral contraceptive pill and postmenopausal hormone replacement therapy. RESULTS:After adjusting for age, smoking, socioeconomic status, steroid use, hypertension and diabetes, ever having used the oral contraceptive pill had a mild protective effect against incident cortical cataract (odds ratio 0.70, 95% confidence interval 0.50-0.98). However, hormone replacement therapy, age at menarche, age at menopause, duration of exposure to endogenous oestrogen, parity and type of menopause were not found to have significant associations with the incidence of any type of cataract or cataract surgery. CONCLUSION:Apart from a weak protective association of oral contraceptive pill use and the development of cortical cataract, we found no significant longitudinal associations between exogenous oestrogen exposure, female reproductive factors and the long-term incidence of cataract in this older population-based cohort.
journal_name
Acta Ophthalmoljournal_title
Acta ophthalmologicaauthors
Kanthan GL,Wang JJ,Burlutsky G,Rochtchina E,Cumming RG,Mitchell Pdoi
10.1111/j.1755-3768.2009.01565.xsubject
Has Abstractpub_date
2010-11-01 00:00:00pages
773-8issue
7eissn
1755-375Xissn
1755-3768pii
AOS1565journal_volume
88pub_type
杂志文章abstract:PURPOSE:To determine the molecular genetic cause in previously unreported probands with optic atrophy from the United Kingdom, Czech Republic and Canada. METHODS:OPA1 coding regions and flanking intronic sequences were screened by direct sequencing in 82 probands referred with a diagnosis of bilateral optic atrophy. D...
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journal_title:Acta ophthalmologica
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更新日期:2014-12-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
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journal_title:Acta ophthalmologica
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2008.01184.x
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更新日期:2015-06-01 00:00:00
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doi:10.1111/j.1755-3768.2008.01210.x
更新日期:2008-08-01 00:00:00
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journal_title:Acta ophthalmologica
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doi:10.1111/aos.12136
更新日期:2013-11-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1755-3768.2009.01809.x
更新日期:2011-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-02 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1755-3768.2012.02505.x
更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1755-3768.2009.01752.x
更新日期:2011-09-01 00:00:00
abstract:PURPOSE:To analyse intraocular cytokine levels and prevalence of intraocular antiretinal antibodies (ARAs) in patients with retinitis pigmentosa (RP), age-related macular degeneration (AMD), glaucoma and cataract, and correlate the results to clinical manifestations. METHODS:We collected intraocular fluid samples from...
journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.13899
更新日期:2019-03-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/j.1600-0420.2007.01105.x
更新日期:2008-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1755-3768.2011.02267.x
更新日期:2012-05-01 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
doi:10.1111/aos.14499
更新日期:2020-07-13 00:00:00
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journal_title:Acta ophthalmologica
pub_type: 杂志文章
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更新日期:2019-12-06 00:00:00