Abstract:
:High-dose melphalan chemotherapy and autologous peripheral blood stem cell transplantation has been shown to result in durable hematologic response and prolonged overall survival in systemic AL amyloidosis. In this retrospective study, we evaluated clinical and hematologic responses in 69 patients with predominant liver involvement who were treated with high-dose intravenous melphalan and autologous stem cell transplantation from 1998 to 2006. Nine patients (13%) died from treatment-related mortality, similar to patients without hepatic involvement. The overall survival was 81% at one year and 61% at five years, by Kaplan-Meier estimates. A hematologic complete response was achieved by 53% (31/58) of patients at one year. A hepatic response occurred in 57% (33/58) at one year after high-dose intravenous melphalan and autologous stem cell transplantation and 63% (19/30) at two years after high-dose intravenous melphalan and autologous stem cell transplantation. In conclusion, hepatic disease improves in almost 2/3 patients treated with high-dose intravenous melphalan and autologous stem cell transplantation who have a complete or partial hematologic response to treatment.
journal_name
Haematologicajournal_title
Haematologicaauthors
Girnius S,Seldin DC,Skinner M,Finn KT,Quillen K,Doros G,Sanchorawala Vdoi
10.3324/haematol.2008.001925subject
Has Abstractpub_date
2009-07-01 00:00:00pages
1029-32issue
7eissn
0390-6078issn
1592-8721pii
haematol.2008.001925journal_volume
94pub_type
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