Absence of hisT-mediated tRNA pseudouridylation results in a uracil requirement that interferes with Escherichia coli K-12 cell division.

Abstract:

:We show that hisT function is required for normal growth of Escherichia coli K-12, since a lack of hisT-mediated pseudouridine tRNA modification causes a uracil requirement that interferes with cell division. We also show that hisT transcription is positively growth rate regulated in exponentially growing bacteria and is induced during the transition from exponential to stationary growth phase.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Tsui HC,Arps PJ,Connolly DM,Winkler ME

doi

10.1128/jb.173.22.7395-7400.1991

subject

Has Abstract

pub_date

1991-11-01 00:00:00

pages

7395-400

issue

22

eissn

0021-9193

issn

1098-5530

journal_volume

173

pub_type

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