Facing the challenges of Cu, Fe and Zn homeostasis in plants.

Abstract:

:Plants have recently moved into the spotlight owing to the growing realization that the world needs solutions to energy and food production that are sustainable and environmentally sound. Iron, copper and zinc are essential for plant growth and development, yet the same properties that make these transition metals indispensable can also make them deadly in excess. Iron and copper are most often used for their redox properties, whereas zinc is primarily used for its ability to act as a Lewis acid. Here we review recent advances in the field of metal homeostasis and integrate the findings on uptake and transport of these three metals.

journal_name

Nat Chem Biol

journal_title

Nature chemical biology

authors

Palmer CM,Guerinot ML

doi

10.1038/nchembio.166

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

333-40

issue

5

eissn

1552-4450

issn

1552-4469

pii

nchembio.166

journal_volume

5

pub_type

杂志文章,评审
  • Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

    abstract::Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were active in i...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/nchembio.215

    authors: Yuan J,Johnson RL,Huang R,Wichterman J,Jiang H,Hayton K,Fidock DA,Wellems TE,Inglese J,Austin CP,Su XZ

    更新日期:2009-10-01 00:00:00

  • Functional mining of transporters using synthetic selections.

    abstract::Only 25% of bacterial membrane transporters have functional annotation owing to the difficulty of experimental study and of accurate prediction of their function. Here we report a sequence-independent method for high-throughput mining of novel transporters. The method is based on ligand-responsive biosensor systems th...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/nchembio.2189

    authors: Genee HJ,Bali AP,Petersen SD,Siedler S,Bonde MT,Gronenberg LS,Kristensen M,Harrison SJ,Sommer MO

    更新日期:2016-12-01 00:00:00

  • A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis.

    abstract::Inorganic nitrite (NO(2)(-)) is emerging as a regulator of physiological functions and tissue responses to ischemia, whereas the more stable nitrate anion (NO(3)(-)) is generally considered to be biologically inert. Bacteria express nitrate reductases that produce nitrite, but mammals lack these specific enzymes. Here...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/nchembio.92

    authors: Jansson EA,Huang L,Malkey R,Govoni M,Nihlén C,Olsson A,Stensdotter M,Petersson J,Holm L,Weitzberg E,Lundberg JO

    更新日期:2008-07-01 00:00:00

  • A fluorescent probe for cysteine depalmitoylation reveals dynamic APT signaling.

    abstract::Hundreds of human proteins are modified by reversible palmitoylation of cysteine residues (S-palmitoylation), but the regulation of depalmitoylation is poorly understood. Here, we develop 'depalmitoylation probes' (DPPs), small-molecule fluorophores, to monitor the endogenous activity levels of 'erasers' of S-palmitoy...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/nchembio.2262

    authors: Kathayat RS,Elvira PD,Dickinson BC

    更新日期:2017-02-01 00:00:00

  • Membranes: first steps to rafts?

    abstract::Single-molecule observations reveal that lipid- and protein-based interactions jointly contribute to the interactions among glycosylphosphatidylinositol-anchored proteins in membranes. Understanding these interactions will help to refine long-evolving (and still debated) models of 'raft' domains in biological membrane...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/nchembio.1045

    authors: Silvius JR

    更新日期:2012-09-01 00:00:00

  • Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs.

    abstract::Cholinesterase inhibitors, the current frontline symptomatic treatment for Alzheimer's disease (AD), are associated with low efficacy and adverse effects. M1 muscarinic acetylcholine receptors (M1 mAChRs) represent a potential alternate therapeutic target; however, drug discovery programs focused on this G protein-cou...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/s41589-019-0453-9

    authors: Bradley SJ,Molloy C,Valuskova P,Dwomoh L,Scarpa M,Rossi M,Finlayson L,Svensson KA,Chernet E,Barth VN,Gherbi K,Sykes DA,Wilson CA,Mistry R,Sexton PM,Christopoulos A,Mogg AJ,Rosethorne EM,Sakata S,John Challiss RA,B

    更新日期:2020-03-01 00:00:00

  • Nitric oxide activates TRP channels by cysteine S-nitrosylation.

    abstract::Transient receptor potential (TRP) proteins form plasma-membrane cation channels that act as sensors for diverse cellular stimuli. Here, we report a novel activation mechanism mediated by cysteine S-nitrosylation in TRP channels. Recombinant TRPC1, TRPC4, TRPC5, TRPV1, TRPV3 and TRPV4 of the TRPC and TRPV families, wh...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/nchembio821

    authors: Yoshida T,Inoue R,Morii T,Takahashi N,Yamamoto S,Hara Y,Tominaga M,Shimizu S,Sato Y,Mori Y

    更新日期:2006-11-01 00:00:00

  • Oxidation increases the strength of the methionine-aromatic interaction.

    abstract::Oxidation of methionine disrupts the structure and function of a range of proteins, but little is understood about the chemistry that underlies these perturbations. Using quantum mechanical calculations, we found that oxidation increased the strength of the methionine-aromatic interaction motif, a driving force for pr...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/nchembio.2159

    authors: Lewis AK,Dunleavy KM,Senkow TL,Her C,Horn BT,Jersett MA,Mahling R,McCarthy MR,Perell GT,Valley CC,Karim CB,Gao J,Pomerantz WC,Thomas DD,Cembran A,Hinderliter A,Sachs JN

    更新日期:2016-10-01 00:00:00

  • Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.

    abstract::Cyclin-dependent kinase 9 (CDK9), an important regulator of transcriptional elongation, is a promising target for cancer therapy, particularly for cancers driven by transcriptional dysregulation. We characterized NVP-2, a selective ATP-competitive CDK9 inhibitor, and THAL-SNS-032, a selective CDK9 degrader consisting ...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/nchembio.2538

    authors: Olson CM,Jiang B,Erb MA,Liang Y,Doctor ZM,Zhang Z,Zhang T,Kwiatkowski N,Boukhali M,Green JL,Haas W,Nomanbhoy T,Fischer ES,Young RA,Bradner JE,Winter GE,Gray NS

    更新日期:2018-02-01 00:00:00

  • Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3.

    abstract::Enzymatic incorporation of a halogen atom is a common feature in the biosyntheses of more than 4,500 natural products. Halogenation of unactivated carbon centers in the biosyntheses of several compounds of nonribosomal peptide origin is carried out by a class of mononuclear nonheme iron enzymes that require alpha-keto...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/nchembio856

    authors: Galonić DP,Barr EW,Walsh CT,Bollinger JM Jr,Krebs C

    更新日期:2007-02-01 00:00:00

  • Dynamic polymorphism of single actin molecules in the actin filament.

    abstract::Actin filament dynamics are critical in cell motility. The structure of actin filament changes spontaneously and can also be regulated by actin-binding proteins, allowing actin to readily function in response to external stimuli. The interaction with the motor protein myosin changes the dynamic nature of actin filamen...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/nchembio763

    authors: Kozuka J,Yokota H,Arai Y,Ishii Y,Yanagida T

    更新日期:2006-02-01 00:00:00

  • A cell wall recycling shortcut that bypasses peptidoglycan de novo biosynthesis.

    abstract::We report a salvage pathway in Gram-negative bacteria that bypasses de novo biosynthesis of UDP N-acetylmuramic acid (UDP-MurNAc), the first committed peptidoglycan precursor, and thus provides a rationale for intrinsic fosfomycin resistance. The anomeric sugar kinase AmgK and the MurNAc α-1-phosphate uridylyl transfe...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/nchembio.1289

    authors: Gisin J,Schneider A,Nägele B,Borisova M,Mayer C

    更新日期:2013-08-01 00:00:00

  • Learning biological networks: from modules to dynamics.

    abstract::Learning regulatory networks from genomics data is an important problem with applications spanning all of biology and biomedicine. Functional genomics projects offer a cost-effective means of greatly expanding the completeness of our regulatory models, and for some prokaryotic organisms they offer a means of learning ...

    journal_title:Nature chemical biology

    pub_type: 杂志文章,评审

    doi:10.1038/nchembio.122

    authors: Bonneau R

    更新日期:2008-11-01 00:00:00

  • Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5.

    abstract::A 2.4-Å-resolution X-ray crystal structure of the carrier-protein-independent halogenase WelO5 in complex with its welwitindolinone precursor substrate, 12-epi-fischerindole U, reveals that the C13 chlorination target is proximal to the anticipated site of the oxo group in a presumptive cis-halo-oxo-iron(IV) (haloferr...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/nchembio.2112

    authors: Mitchell AJ,Zhu Q,Maggiolo AO,Ananth NR,Hillwig ML,Liu X,Boal AK

    更新日期:2016-08-01 00:00:00

  • Actin microfilament aggregation induced by withaferin A is mediated by annexin II.

    abstract::The actin cytoskeleton supports diverse cellular processes such as endocytosis, oriented growth, adhesion and migration. The dynamic nature of the cytoskeleton, however, has made it difficult to define the roles of the many accessory molecules that modulate actin organization, especially the multifunctional adapter pr...

    journal_title:Nature chemical biology

    pub_type: 信件

    doi:10.1038/nchembio755

    authors: Falsey RR,Marron MT,Gunaherath GM,Shirahatti N,Mahadevan D,Gunatilaka AA,Whitesell L

    更新日期:2006-01-01 00:00:00

  • Transcriptome-wide mapping reveals reversible and dynamic N(1)-methyladenosine methylome.

    abstract::N(1)-Methyladenosine (m(1)A) is a prevalent post-transcriptional RNA modification, yet little is known about its abundance, topology and dynamics in mRNA. Here, we show that m(1)A is prevalent in Homo sapiens mRNA, which shows an m(1)A/A ratio of ∼0.02%. We develop the m(1)A-ID-seq technique, based on m(1)A immunoprec...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/nchembio.2040

    authors: Li X,Xiong X,Wang K,Wang L,Shu X,Ma S,Yi C

    更新日期:2016-05-01 00:00:00

  • Symbiosis in chemistry and biology.

    abstract::What do organic synthesis, mechanistic enzymology, structural biology and glycoscience have in common? They all span chemistry and biology, benefit from and contribute to multidisciplinary approaches, and were up for discussion at a recent symposium in Dublin. ...

    journal_title:Nature chemical biology

    pub_type:

    doi:10.1038/nchembio0206-59

    authors: Murphy PV,Rutledge PJ

    更新日期:2006-02-01 00:00:00

  • A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.

    abstract::Serine is both a proteinogenic amino acid and the source of one-carbon units essential for de novo purine and deoxythymidine synthesis. In the canonical pathway of glucose-derived serine synthesis, Homo sapiens phosphoglycerate dehydrogenase (PHGDH) catalyzes the first, rate-limiting step. Genetic loss of PHGDH is tox...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/nchembio.2070

    authors: Pacold ME,Brimacombe KR,Chan SH,Rohde JM,Lewis CA,Swier LJ,Possemato R,Chen WW,Sullivan LB,Fiske BP,Cho S,Freinkman E,Birsoy K,Abu-Remaileh M,Shaul YD,Liu CM,Zhou M,Koh MJ,Chung H,Davidson SM,Luengo A,Wang AQ,

    更新日期:2016-06-01 00:00:00

  • Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing.

    abstract::We describe a new technology for recruiting specific proteins to RNA through selective recognition of heteroduplexes formed with chemically modified antisense oligonucleotides (ASOs). Typically, ASOs function by hybridizing to their RNA targets and blocking the binding of single-stranded RNA-binding proteins. Unexpect...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/nchembio.939

    authors: Rigo F,Hua Y,Chun SJ,Prakash TP,Krainer AR,Bennett CF

    更新日期:2012-04-15 00:00:00

  • CueR activates transcription through a DNA distortion mechanism.

    abstract::The MerR-family transcription factors (TFs) are a large group of bacterial proteins responding to cellular metal ions and multiple antibiotics by binding within central RNA polymerase-binding regions of a promoter. While most TFs alter transcription through protein-protein interactions, MerR TFs are capable of reshapi...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/s41589-020-00653-x

    authors: Fang C,Philips SJ,Wu X,Chen K,Shi J,Shen L,Xu J,Feng Y,O'Halloran TV,Zhang Y

    更新日期:2021-01-01 00:00:00

  • Mixture of new sulfated steroids functions as a migratory pheromone in the sea lamprey.

    abstract::The sea lamprey is an ancient, parasitic fish that invaded the Great Lakes a century ago, where it triggered the collapse of many fisheries. Like many fishes, this species relies on chemical cues to mediate key aspects of its life, including migration and reproduction. Here we report the discovery of a multicomponent ...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/nchembio739

    authors: Sorensen PW,Fine JM,Dvornikovs V,Jeffrey CS,Shao F,Wang J,Vrieze LA,Anderson KR,Hoye TR

    更新日期:2005-11-01 00:00:00

  • Ubiquinone accumulation improves osmotic-stress tolerance in Escherichia coli.

    abstract::Bacteria are thought to cope with fluctuating environmental solute concentrations primarily by adjusting the osmolality of their cytoplasm. To obtain insights into the underlying metabolic adaptations, we analyzed the global metabolic response of Escherichia coli to sustained hyperosmotic stress using nontargeted mass...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/nchembio.1437

    authors: Sévin DC,Sauer U

    更新日期:2014-04-01 00:00:00

  • Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells.

    abstract::Glycosyltransferases are ubiquitous enzymes that catalyze the assembly of glycoconjugates throughout all kingdoms of nature. A long-standing problem is the rational design of probes that can be used to manipulate glycosyltransferase activity in cells and tissues. Here we describe the rational design and synthesis of a...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/nchembio.520

    authors: Gloster TM,Zandberg WF,Heinonen JE,Shen DL,Deng L,Vocadlo DJ

    更新日期:2011-03-01 00:00:00

  • NMR spectroscopy brings invisible protein states into focus.

    abstract::Molecular dynamics are essential for protein function. In some cases these dynamics involve the interconversion between ground state, highly populated conformers and less populated higher energy structures ('excited states') that play critical roles in biochemical processes. Here we describe recent advances in NMR spe...

    journal_title:Nature chemical biology

    pub_type: 杂志文章,评审

    doi:10.1038/nchembio.238

    authors: Baldwin AJ,Kay LE

    更新日期:2009-11-01 00:00:00

  • Identifying polyglutamine protein species in situ that best predict neurodegeneration.

    abstract::Polyglutamine (polyQ) stretches exceeding a threshold length confer a toxic function to proteins that contain them and cause at least nine neurological disorders. The basis for this toxicity threshold is unclear. Although polyQ expansions render proteins prone to aggregate into inclusion bodies, this may be a neuronal...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/nchembio.694

    authors: Miller J,Arrasate M,Brooks E,Libeu CP,Legleiter J,Hatters D,Curtis J,Cheung K,Krishnan P,Mitra S,Widjaja K,Shaby BA,Lotz GP,Newhouse Y,Mitchell EJ,Osmand A,Gray M,Thulasiramin V,Saudou F,Segal M,Yang XW,Masliah

    更新日期:2011-10-30 00:00:00

  • Gut microbiota-generated metabolites in animal health and disease.

    abstract::Gut microbiota is found in virtually any metazoan, from invertebrates to vertebrates. It has long been believed that gut microbiota, more specifically, the activity of the microbiome and its metabolic products, directly influence a variety of aspects in metazoan physiology. However, the exact molecular relationship am...

    journal_title:Nature chemical biology

    pub_type: 杂志文章,评审

    doi:10.1038/nchembio.1535

    authors: Lee WJ,Hase K

    更新日期:2014-06-01 00:00:00

  • Progressive ordering with decreasing temperature of the phospholipids of influenza virus.

    abstract::Using linewidth and spinning sideband intensities of lipid hydrocarbon chain resonances in proton magic angle spinning NMR spectra, we detected the temperature-dependent phase state of naturally occurring lipids of intact influenza virus without exogenous probes. Increasingly, below 41 degrees C ordered and disordered...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/nchembio.77

    authors: Polozov IV,Bezrukov L,Gawrisch K,Zimmerberg J

    更新日期:2008-04-01 00:00:00

  • Structural and evolutionary insights into ribosomal RNA methylation.

    abstract::Methylation of nucleotides in ribosomal RNAs (rRNAs) is a ubiquitous feature that occurs in all living organisms. Identification of all enzymes responsible for rRNA methylation, as well as mapping of all modified rRNA residues, is now complete for a number of model species, such as Escherichia coli and Saccharomyces c...

    journal_title:Nature chemical biology

    pub_type: 杂志文章,评审

    doi:10.1038/nchembio.2569

    authors: Sergiev PV,Aleksashin NA,Chugunova AA,Polikanov YS,Dontsova OA

    更新日期:2018-02-14 00:00:00

  • Mammalian circadian signaling networks and therapeutic targets.

    abstract::Virtually all cells in the body have an intracellular clockwork based on a negative feedback mechanism. The circadian timekeeping system in mammals is a hierarchical multi-oscillator network, with the suprachiasmatic nuclei (SCN) acting as the central pacemaker. The SCN synchronizes to daily light-dark cycles and coor...

    journal_title:Nature chemical biology

    pub_type: 杂志文章,评审

    doi:10.1038/nchembio.2007.37

    authors: Liu AC,Lewis WG,Kay SA

    更新日期:2007-10-01 00:00:00

  • Small molecule-triggered Cas9 protein with improved genome-editing specificity.

    abstract::Directly modulating the activity of genome-editing proteins has the potential to increase their specificity by reducing activity following target locus modification. We developed Cas9 nucleases that are activated by the presence of a cell-permeable small molecule by inserting an evolved 4-hydroxytamoxifen-responsive i...

    journal_title:Nature chemical biology

    pub_type: 杂志文章

    doi:10.1038/nchembio.1793

    authors: Davis KM,Pattanayak V,Thompson DB,Zuris JA,Liu DR

    更新日期:2015-05-01 00:00:00