Abstract:
:Molecular dynamics are essential for protein function. In some cases these dynamics involve the interconversion between ground state, highly populated conformers and less populated higher energy structures ('excited states') that play critical roles in biochemical processes. Here we describe recent advances in NMR spectroscopy methods that enable studies of these otherwise invisible excited states at an atomic level and that help elucidate their important relation to function. We discuss a range of examples from molecular recognition, ligand binding, enzyme catalysis and protein folding that illustrate the role that motion plays in 'funneling' conformers along preferred pathways that facilitate their biological function.
journal_name
Nat Chem Bioljournal_title
Nature chemical biologyauthors
Baldwin AJ,Kay LEdoi
10.1038/nchembio.238subject
Has Abstractpub_date
2009-11-01 00:00:00pages
808-14issue
11eissn
1552-4450issn
1552-4469pii
nchembio.238journal_volume
5pub_type
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