Abstract:
:Methylation of nucleotides in ribosomal RNAs (rRNAs) is a ubiquitous feature that occurs in all living organisms. Identification of all enzymes responsible for rRNA methylation, as well as mapping of all modified rRNA residues, is now complete for a number of model species, such as Escherichia coli and Saccharomyces cerevisiae. Recent high-resolution structures of bacterial ribosomes provided the first direct visualization of methylated nucleotides. The structures of ribosomes from various organisms and organelles have also lately become available, enabling comparative structure-based analysis of rRNA methylation sites in various taxonomic groups. In addition to the conserved core of modified residues in ribosomes from the majority of studied organisms, structural analysis points to the functional roles of some of the rRNA methylations, which are discussed in this Review in an evolutionary context.
journal_name
Nat Chem Bioljournal_title
Nature chemical biologyauthors
Sergiev PV,Aleksashin NA,Chugunova AA,Polikanov YS,Dontsova OAdoi
10.1038/nchembio.2569subject
Has Abstractpub_date
2018-02-14 00:00:00pages
226-235issue
3eissn
1552-4450issn
1552-4469pii
nchembio.2569journal_volume
14pub_type
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