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Gut microbiota-generated metabolites in animal health and disease.

Abstract：

:Gut microbiota is found in virtually any metazoan, from invertebrates to vertebrates. It has long been believed that gut microbiota, more specifically, the activity of the microbiome and its metabolic products, directly influence a variety of aspects in metazoan physiology. However, the exact molecular relationship among microbe-derived gut metabolites, host signaling pathways, and host physiology remains to be elucidated. Here we review recent discoveries regarding the molecular links between gut metabolites and host physiology in different invertebrate and vertebrate animal models. We describe the different roles of gut microbiome activity and their metabolites in regulating distinct host physiology and the molecular mechanisms by which gut metabolites cause physiological homeostasis via regulating specific host signaling pathways. Future studies in this direction using different animal models will provide the key concepts to understanding the evolutionarily conserved chemical dialogues between gut microbiota and metazoan cells and also human diseases associated with gut microbiota and metabolites.

journal_name

Nat Chem Biol

journal_title

Nature chemical biology

authors

Lee WJ,Hase K

doi

10.1038/nchembio.1535

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

416-24

issue

6

eissn

1552-4450

issn

1552-4469

pii

nchembio.1535

journal_volume

10

pub_type

杂志文章,评审

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