Abstract：
:This Commentary clarifies the meaning of the funnel diagram, which has been widely cited in papers on protein folding. To aid in the analysis of the funnel diagram, this Commentary reviews historical approaches to understanding the mechanism of protein folding. The primary role of free energy in protein folding is discussed, and it is pointed out that the decrease [corrected] in the configurational entropy as the native state is approached hinders folding, rather than guiding it. Diagrams are introduced that provide a less ambiguous representation of the factors governing the protein folding reaction than the funnel diagram.
journal_name
Nat Chem Bioljournal_title
Nature chemical biologyauthors
Karplus Mdoi
10.1038/nchembio.565subject
Has Abstractpub_date
2011-06-17 00:00:00pages
401-4issue
7eissn
1552-4450issn
1552-4469pii
nchembio.565journal_volume
7pub_type
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