当前位置： SCI文献检索 > MOLECULAR AND CELLULAR BIOCHEMISTRY期刊下所有文献 > Changes in gene expression of kringle domain-containing proteins in murine brains and neuroblastoma cells infected by prions.

Changes in gene expression of kringle domain-containing proteins in murine brains and neuroblastoma cells infected by prions.

Abstract：

:Prion protein (PrP) interacts with some kringle domain-containing proteins. Kringle domains serve as binding domains in the interaction with PrP. The structural conservation among kringle domains leads to the hypothesis that any protein containing these domains can interact with PrP and be involved in prion pathogenesis. Because prion pathogenesis occurs in the brain, kringle domain-containing proteins should be available in the same tissue if they are relevant to prion pathogenesis. However, gene expression of these proteins in brains infected by prions has not been examined. Here, we showed that plasminogen (plg), urokinase type plasminogen activator (upa), tissue type plasminogen activator (tpa), prothrombin (prothr), and hepatocyte growth factor (hgf) genes were expressed in murine brains and neuroblastoma cells. The changes in upa, prothr, and hgf gene expression correlated with prion disease, but those in plg and tpa gene expression did not. Our data suggest association of gene expression of kringle domain-containing proteins in brains with prion disease.

journal_name

Mol Cell Biochem

journal_title

Molecular and cellular biochemistry

authors

Kim Y,Song J,Mays CE,Titlow W,Yoon D,Ryou C

doi

10.1007/s11010-009-0087-4

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

177-82

issue

1-2

eissn

0300-8177

issn

1573-4919

journal_volume

328

pub_type

杂志文章

相关文献

MOLECULAR AND CELLULAR BIOCHEMISTRY文献大全
  • Intracellular distribution of lysosomal enzymes in the mouse pigment mutants pale ear and pallid.

    abstract：:The size distribution of lysosomes was determined in kidney proximal tubule cells of two mouse pigment mutants, pale ear and pallid, which have an increase in kidney lysosomal enzyme content caused by a decreased rate of secretion of lysosomal enzymes into urine. Both mutations have larger lysosomes when compared with...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00240814

    authors： Piccini AE,Jahreis GP,Novak EK,Swank RT

    更新日期：1980-06-18 00:00:00

  • HMGb1 promotes scratch wound closure of HaCaT keratinocytes via ERK1/2 activation.

    abstract：:HMGb1 is a DNA-binding protein whose role as an extracellular cytokine in inflammation and tissue regeneration has also been reported. Given the importance of keratinocytes in wound healing, we have studied the mechanism of action of HMGb1 on HaCaT keratinocytes during in vitro scratch wound repair. Western blot and c...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-009-0192-4

    authors： Ranzato E,Patrone M,Pedrazzi M,Burlando B

    更新日期：2009-12-01 00:00:00

  • NF-kappaB, a pivotal transcription factor in silica-induced diseases.

    abstract：:Inhalation of silica in a number of occupational settings can result in debilitating and costly lung disease. It is thought that the pathological replacement of functional lung tissue with fibrotic lesions in silica-induced lung disease is the result of chronic inflammation mediated by products of the silica-exposed a...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章,评审

    doi：

    authors： Chen F,Shi X

    更新日期：2002-05-01 00:00:00

  • Mitochondrial DAMPs and altered mitochondrial dynamics in OxLDL burden in atherosclerosis.

    abstract：:Atherosclerosis results in life-threatening cardiovascular pathologies, including ischemic heart disease, stroke, myocardial infarction, and peripheral arterial disease. The role of increased serum low-density lipoprotein (LDL) and resultant accumulation of oxidized-LDL (oxLDL) in atheroma formation is well establishe...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章,评审

    doi：10.1007/s11010-021-04061-0

    authors： Khwaja B,Thankam FG,Agrawal DK

    更新日期：2021-01-25 00:00:00

  • Comparative studies on human and bovine nasal cartilage proteoglycan complex components.

    abstract：:Human and bovine nasal proteoglycan complex components were prepared in parallel. Some molecular properties of human and bovine proteoglycan subunits (PGS) were compared. Two major human "link-like proteins" have been characterized and purified; their compositions and molecular weights were very similar to those obser...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00240278

    authors： Périn JP,Bonnet F,Jollès P

    更新日期：1978-11-01 00:00:00

  • Alterations of beta3-adrenoceptors expression and their myocardial functional effects in physiological model of chronic exercise-induced cardiac hypertrophy.

    abstract：:Physical training induces cardiovascular autonomic nervous system regulation adaptations, which could result from beta adrenergic receptor (AR) modifications. Among them, beta(3 )AR alterations have been recently reported but their functional effect remained to discuss. To explain the beta(3) AR gene expression in rel...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-006-9370-9

    authors： Barbier J,Rannou-Bekono F,Marchais J,Tanguy S,Carré F

    更新日期：2007-06-01 00:00:00

  • MALAT1 affects hypoxia-induced vascular endothelial cell injury and autophagy by regulating miR-19b-3p/HIF-1α axis.

    abstract：:Cardiovascular disease has become the leading cause of death in the world. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) plays an important role in cardiovascular disease, such as stroke. However, the role of MALAT1 in hypoxia (HYP)-induced vascular endothelial cells (VECs) remains unclear. In the pr...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-020-03684-z

    authors： Liu H,Shi C,Deng Y

    更新日期：2020-03-01 00:00:00

  • Import and export of nuclear proteins: focus on the nucleocytoplasmic movements of two different species of mammalian estrogen receptor.

    abstract：:There is a wealth of information regarding the import and export of nuclear proteins in general. Nevertheless, the available data that deals with the nucleocytoplasmic movement of steroid hormone receptors remains highly limited. Some research findings reported during the past five years have succeeded in identifying ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章,评审

    doi：10.1023/b:mcbi.0000026060.81570.35

    authors： Sebastian T,Sreeja S,Thampan RV

    更新日期：2004-05-01 00:00:00

  • Purification of xanthine oxidase from the fat-globule membrane of bovine milk by electrofocusing.

    abstract：:Xanthine oxidase was purified from bovine milk-fat globule membrane by extraction with butan-1-ol, precipitation with ammonium sulphate, separation by preparative electrofocusing and chromatography on Concanavalin-A/Agarose. The enzyme had an A280/A450 ratio of 4.8 and a specific activity of 3.09. At least five to sev...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00573841

    authors： Sullivan CH,Mather IH,Greenwalt DE,Madara PJ

    更新日期：1982-04-16 00:00:00

  • Effect of interleukin-1 receptor antagonist (IL-1RA) on histamine and serotonin release by rat basophilic leukemia cells (RBL-2H3) and peritoneal mast cells.

    abstract：:Recently, it has been appreciated that cultured mast cells are significant sources of cytokines. However, the role of interkeukin-1 (IL-1) on mast cells and/or basophil degranulation is still unclear. In this report we provide evidence that rat basophilic leukemia cells (RBLC) cultured with a natural inhibitor of IL-1...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00714334

    authors： Conti P,Bouchet W,Feliciani C,Mammarella S,Kudchadker L,Barbacane RC,Reale M,Haggag I,Bruneau G,Thibault J,Theoharides TC

    更新日期：1996-02-09 00:00:00

  • The m6A methyltransferase METTL3 cooperates with demethylase ALKBH5 to regulate osteogenic differentiation through NF-κB signaling.

    abstract：:As a m6A methylation modifier, METTL3 is functionally involved in various biological processes. Nevertheless, the role of METTL3 in osteogenesis is not determined up to date. In the current study, METTL3 is identified as a crucial regulator in the progression of osteogenic differentiation. Loss of METTL3 significantly...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-019-03641-5

    authors： Yu J,Shen L,Liu Y,Ming H,Zhu X,Chu M,Lin J

    更新日期：2020-01-01 00:00:00

  • Alterations in the activities of rat tissue hexose monophosphate dehydrogenases in response to premature weaning and dietary restriction at mid-lactation.

    abstract：:The activities of the hexose monophosphate dehydrogenases increased in adipose tissue, remained unchanged in liver and decreased in mammary gland following the weaning of rats at mid-lactation (day 14). When dietary intake was restricted at mid-lactation, the activities of the hexose monophosphate dehydrogenases incre...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00223478

    authors： Martins RN,Stokes GB

    更新日期：1987-08-01 00:00:00

  • Photoreactive fatty acid analogues that bind to the rat liver fatty-acid binding protein: 11-(5'-azido-salicylamido)-undecanoic acid derivatives.

    abstract：:Photoreactive probes for the hydrophobic pocket of the liver fatty acid-binding protein, 11-(5'-azido-salicylamido)-undecanoic acid (5' ASU) and its acetyl ester (Ac5' ASU), were synthesized and their interaction with the protein was assessed. Fatty acid-binding proteins are closely related proteins which are abundant...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00925980

    authors： Atlasovich F,Santomé JA,Fernández HN

    更新日期：1993-03-10 00:00:00

  • Glioma: what is the role of c-Myc, hsp90 and telomerase?

    abstract：:The continuous advancements in cancer research have contributed to the overwhelming evidence of the presence of telomerase in primary and secondary tumours together with hsp90 and c-Myc. This review will discuss the important role of telomerase together with hsp90 and c-Myc within the initiation and progression of gli...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章,评审

    doi：10.1007/s11010-006-2495-z

    authors： Shervington A,Cruickshanks N,Wright H,Atkinson-Dell R,Lea R,Roberts G,Shervington L

    更新日期：2006-02-01 00:00:00

  • Mitogen-activated protein kinases: a new therapeutic target in cardiac pathology.

    abstract：:Eukaryotic cells respond to different external stimuli by activation of mechanisms of cell signaling. One of the major systems participating in the transduction of signal from the cell membrane to nuclear and other intracellular targets is the highly conserved mitogen-activated protein kinase (MAPK) superfamily. The m...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章,评审

    doi：10.1023/a:1024119224033

    authors： Ravingerová T,Barancík M,Strnisková M

    更新日期：2003-05-01 00:00:00

  • FT-IR spectroscopy of methylmercury-exposed mouse lung.

    abstract：:Infrared spectroscopy which has traditionally been utilized by chemists and physicists for characterization and identification of the structural properties of chemical compounds is now becoming more relevant as a biodiagnostic tool. Recent reports suggest that arthritis and Alzheimer's disease can be diagnosed by usin...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00925716

    authors： Das RM,Ahmed MK,Mantsch HH,Scott JE

    更新日期：1995-04-12 00:00:00

  • Protein kinase C activation and cardioprotective effect of preconditioning with oxidative stress in isolated rat heart.

    abstract：:The present study is designed to investigate the effect of myocardial preconditioning with oxidative stress induced by pyrogallol or H2O2, on ischaemia-reperfusion induced myocardial injury. Isolated perfused rat heart was subjected to global ischaemia for 30 min followed by reperfusion for 120 min. Coronary effluent ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1011038531656

    authors： Sharma A,Singh M

    更新日期：2001-03-01 00:00:00

  • Transport kinetics of zinc, copper, selenium, and iron in perfused human placental lobule in vitro.

    abstract：:Transport characteristics of essential trace elements as zinc, copper, selenium and iron have been studied in maternal-fetal direction in normal pregnancies, using in vitro perfusion of human placental lobules. Solutions of trace elements corresponding to twice the physiological concentrations were injected (100 micro...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1023/a:1025565720489

    authors： Nandakumaran M,Dashti HM,Al-Saleh E,Al-Zaid NS

    更新日期：2003-10-01 00:00:00

  • Catalytic properties of porcine pancreatic elastase: a steady-state and pre-steady-state study.

    abstract：:Pre-steady-state and steady-state kinetics for the p.p. elastase-catalysed hydrolysis of ZAlaONp, one of the most favourable substrates for this serine protease, have been studied between pH 4.0 and 8.0. The results are consistent with the minimum three-step mechanism: (formula; see text) Under pre-steady-state condit...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00228766

    authors： Ascenzi P,Menegatti E,Guarneri M,Antonini E

    更新日期：1983-01-01 00:00:00

  • Involvement of rhodopsin and ATP in the activation of membranous guanylate cyclase in retinal photoreceptor outer segments (ROS-GC) by GC-activating proteins (GCAPs): a new model for ROS-GC activation and its link to retinal diseases.

    abstract：:Membranous guanylate cyclase in retinal photoreceptor outer segments (ROS-GC), a key enzyme for the recovery of photoreceptors to the dark state, has a topology identical to and cytoplasmic domains homologous to those of peptide-regulated GCs. However, under the prevailing concept, its activation mechanism is signific...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章,评审

    doi：10.1007/s11010-009-0323-y

    authors： Bondarenko VA,Hayashi F,Usukura J,Yamazaki A

    更新日期：2010-01-01 00:00:00

  • CDK11(p58) protein kinase activity is associated with Bcl-2 down-regulation in pro-apoptosis pathway.

    abstract：:CDK11(p58), a G2/M-specific protein kinase, has been shown to be associated with apoptosis in many cell lines, with largely unknown mechanisms. Our previous study proved that CDK11(p58)-enhanced cycloheximide (CHX)-induced apoptosis in SMMC-7721 hepatocarcinoma cells. Here we report for the first time that ectopic exp...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-007-9502-x

    authors： Yun X,Wu Y,Yao L,Zong H,Hong Y,Jiang J,Yang J,Zhang Z,Gu J

    更新日期：2007-10-01 00:00:00

  • Cytotoxicity of glucoevatromonoside alone and in combination with chemotherapy drugs and their effects on Na+,K+-ATPase and ion channels on lung cancer cells.

    abstract：:Cardiac glycosides (CGs) are useful drugs to treat cardiac illnesses and have potent cytotoxic and anticancer effects in cultured cells and animal models. Their receptor is the Na+,K+ ATPase, but other plasma membrane proteins might bind CGs as well. Herein, we evaluated the short- and long-lasting cytotoxic effects o...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-020-04040-x

    authors： Schneider NFZ,Menegaz D,Dagostin ALA,Persich L,Rocha SC,Ramos ACP,Cortes VF,Fontes CFL,de Pádua RM,Munkert J,Kreis W,Braga FC,Barbosa LA,Silva FRMB,Simões CMO

    更新日期：2021-01-18 00:00:00

  • NF45 overexpression is associated with poor prognosis and enhanced cell proliferation of pancreatic ductal adenocarcinoma.

    abstract：:NF45, also referred to as nuclear factor of activated T cells, has been reported to promote the progression of multiple cancer types. However, the expression and physiological significance of NF45 in pancreatic ductal adenocarcinoma (PDAC) remain largely elusive. In this study, we investigated the clinical relevance a...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-015-2535-7

    authors： Wan C,Gong C,Ji L,Liu X,Wang Y,Wang L,Shao M,Yang L,Fan S,Xiao Y,Wang X,Li M,Zhou G,Zhang Y

    更新日期：2015-12-01 00:00:00

  • Hamster liver chromatin immunospecific non-histone proteins.

    abstract：:Three antisera were prepared against non-histone protein classes named NHCP1, NHCP2 and dehistonized chromatin (with different affinity to DNA) from hamster liver. Two main antigenic bands of MW 17,000 and 36,000 were specific in the NHCP1 fraction and one antigen of MW 56,000 was specific for the NHCP2 fraction from ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00220720

    authors： Wojtkowiak Z,Kiliańska Z,Kłyszejko-Stefanowicz L

    更新日期：1990-01-18 00:00:00

  • Ubiquitous and bifunctional 180 kDa atrial natriuretic factor-dependent guanylate cyclase.

    abstract：:Original studies with rat adrenocortical carcinoma identified a 180 kDa cell-surface protein which contained both guanylate cyclase and atrial natriuretic factor (ANF) receptor, representing a potentially new type of bifunctional receptor protein. It is both a receptor and a guanylate cyclase. This critical conclusion...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00230806

    authors： Marala RB,Sharma RK

    更新日期：1991-01-16 00:00:00

  • Inhibition of cytosolic and mitochondrial creatine kinase by siRNA in HaCaT- and HeLaS3-cells affects cell viability and mitochondrial morphology.

    abstract：:The creatine kinase (CK) system is essential for cellular energetics in tissues or cells with high and fluctuating energy requirements. Creatine itself is known to protect cells from stress-induced injury. By using an siRNA approach to silence the CK isoenzymes in human keratinocyte HaCaT cells, expressing low levels ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/s11010-007-9565-8

    authors： Lenz H,Schmidt M,Welge V,Kueper T,Schlattner U,Wallimann T,Elsässer HP,Wittern KP,Wenck H,Staeb F,Blatt T

    更新日期：2007-12-01 00:00:00

  • Alterations in cardiac function and subcellular membrane activities after hypervitaminosis D3.

    abstract：:The present study was designed to induce massive accumulation of calcium in the myocardium and to evaluate the effect of calcium overload on myocardial contractile function and biochemical activity of cardiac subcellular membranes. Rats were treated with an oral administration of 500,000 units/kg of vitamin D3 for 3 c...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00225520

    authors： Takeo S,Tanonaka R,Tanonaka K,Miyake K,Hisayama H,Ueda N,Kawakami K,Tsumura H,Katsushika S,Taniguchi Y

    更新日期：1991-10-16 00:00:00

  • BTF3 is a potential new substrate of protein kinase CK2.

    abstract：:BTF3, initially discovered as a factor required for transcription inititation of RNA polymerase II, is expressed in two isoforms, termed a and b. BTF3b, the transcriptionally inactive isoform, was identified as an interaction partner of protein kinase CK2 subunit beta employing the interaction trap system for screenin...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：

    authors： Grein S,Pyerin W

    更新日期：1999-01-01 00:00:00

  • Characteristics of an ADP receptor mediating platelet activation.

    abstract：:Adenosine diphosphate (ADP) is known to induce platelet shape change, aggregation and fibrinogen binding, followed by secretion. These processes are mediated by the binding of ADP to an externally oriented protein of the platelet plasma membrane. An affinity analog of ATP, a competitive inhibitor of the action of ADP,...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章,评审

    doi：10.1007/BF00231307

    authors： Colman RW,Figures WR

    更新日期：1984-01-01 00:00:00

  • Hexose metabolism in pancreatic islets: the glucose-6-phosphatase riddle.

    abstract：:Glucose-6-phosphatase activity was measured in rat liver or pancreatic islet crude homogenates and microsomes. The data recorded in the liver were comparable to those reported in prior studies. However, in the islets, the hydrolysis of D-glucose 6-phosphate by disrupted microsomes represented, when expressed relative ...

    journal_title：Molecular and cellular biochemistry

    pub_type： 杂志文章

    doi：10.1007/BF00238439

    authors： Perales MA,Sener A,Malaisse WJ

    更新日期：1991-02-27 00:00:00