Recovery of functional impairment after acute illness and mortality: one-year follow-up study.

Abstract:

BACKGROUND:Functional status in older people is a dynamic situation, which makes it necessary to evaluate functional capacity at different times to determinate their prognostic value. OBJECTIVE:To examine the association between functional status (baseline and change after acute illness) and mortality and functional changes at 1 year. METHODS:Hospital-based prospective longitudinal cohort study of all patients over 65 years old, admitted for multidisciplinary treatment of functional impairment after acute illness in a medium-stay unit (post-acute geriatric unit) of a teaching hospital ascribed to the Spanish National Health Service from Spain during 15 consecutive months. Functional status (Barthel Index, BI) was assessed prior to the acute illness, at admission in a post-acute unit, at discharge and 1 year later. At admission, other variables were collected: sociodemographic, main diagnostic for hospitalization (stroke, orthopedic process, or deconditioning), serum albumin, comorbidity (Charlson Index), cognitive status (Pfeiffer s Short Portable Mental Status Questionnaire). In order to analyze mortality 1 year after discharge, a Cox regression analysis was performed. RESULTS:Three hundred and sixty-nine patients constituted the study population, mean age was 80.74 years (SD 7.4), 66.6% were female and 1 year after discharge mortality was 20%. In the multivariate analysis, variables associated with a higher 1-year mortality were age (HR 1.06; 95% CI = 1.00-1.07) male gender (HR 2.11; 95% CI = 1.26-3.55), worse prior functional status (HR 0.98; 95% CI = 0.96-0.99), and higher functional loss in BI at admission (HR 1.02; 95% CI = 1.00-1.04). On the other hand, a greater functional gain in BI at discharge was associated with a lower 1-year mortality (HR 0.98; 95% CI = 0.96-0.99). CONCLUSIONS:The main functional gain obtained after treatment in a multidisciplinary post-acute geriatric unit is independently associated with a reduction in long-term mortality. In addition to baseline functional status and after acute illness, the subsequent potential recovery is very important to predict poor long-term outcomes.

journal_name

Gerontology

journal_title

Gerontology

authors

Baztán JJ,Gálvez CP,Socorro A

doi

10.1159/000193068

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

269-74

issue

3

eissn

0304-324X

issn

1423-0003

pii

000193068

journal_volume

55

pub_type

杂志文章
  • Potential mechanisms contributing to decision-making difficulties in late adulthood.

    abstract::This paper critiques Brand and Markowitsch's viewpoint that the decision-making difficulties experienced by older adults during laboratory-based gambling tasks can be attributed to deficits in executive control and feedback operations. While Brand and Markowitsch provide an important platform with which to understand ...

    journal_title:Gerontology

    pub_type: 评论,杂志文章

    doi:10.1159/000275060

    authors: McCarrey AC,Henry JD,Luszcz M

    更新日期:2010-01-01 00:00:00

  • Binding interactions of ergot alkaloids with monoaminergic receptors in the brain.

    abstract::The interactions of ergot alkaloids and of other drugs with dopamine (DA) and alpha-adrenergic receptors were investigated. The tested ergot alkaloids inhibit synaptosomal tyrosine hydroxylase activity and reverse the apomorphine-elicited inhibition of synaptosomal tyrosine hydroxylase activity. Thus, ergot alkaloids ...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000212301

    authors: Goldstein M,Lew JY,Hata F,Lieberman A

    更新日期:1978-01-01 00:00:00

  • Cytoplasmic and nuclear binding of estradiol in the brain and pituitary of old female rats.

    abstract::The subcellular distribution of estradiol following the in vivo administration of 3H-estradiol, cytosol and nuclear estrogen receptor after in vitro incubation with 3H-estradiol were studied in young adult female rats (3-6 months old) and old female rats (over 18 months old). After intravenous injection of 3H-estradio...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000212449

    authors: Jiang MJ,Peng MT

    更新日期:1981-01-01 00:00:00

  • The variable topography of Alzheimer type changes in senile dementia and normal old age.

    abstract::Alzheimer neurofibrillary changes and senile plaques were found in a variety of distribution patterns and intensities in 50 brains of patients older than 73 years who had been carefully examined for signs of organic dementia in a geriatric unit. As noted by earlier observers, the severity of dementia usually correspon...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000212633

    authors: Ulrich J,Stähelin HB

    更新日期:1984-01-01 00:00:00

  • Evaluation of the nucleolar organizer regions in Alzheimer's disease.

    abstract:BACKGROUND:Alzheimer's disease (AD) is a neurodegenerative disorder in middle and late age. Ribosomal RNA (rRNA) genes are located in the nucleolus (nucleolar organizer regions = NORs). There are increased deposits of beta-amyloid protein in the brains of the patients with AD and aged individuals with Down's syndrome (...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000086365

    authors: Dönmez-Altuntaş H,Akalin H,Karaman Y,Demirtaş H,Imamoğlu N,Ozkul Y

    更新日期:2005-09-01 00:00:00

  • Hermansky-Pudlak syndrome; a case report with analysis of auto-fluorescent ceroid-like pigments.

    abstract::The Hermansky-Pudlak syndrome (HPS) is an autosomal recessive disease characterized by a triad of oculocutaneous albinism, accumulation of auto-fluorescent ceroid-like pigments within macrophages, and bleeding tendency due to a storage pool disease of the platelets. We report an autopsy case (39y, male), who died of p...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000213751

    authors: Ohbayashi C,Kanomata N,Imai Y,Ito H,Shimasaki H

    更新日期:1995-01-01 00:00:00

  • The impact of environment in comparison with moderate physical exercise and dietary restriction on BDNF in the cerebral parietotemporal cortex of aged Sprague-Dawley rats.

    abstract:BACKGROUND AND AIMS:Moderate physical exercise, dietary restriction as well as enriched environment in separate studies have been reported to delay some of the adverse effects of aging on brain function, parallel to an increase in brain-derived neurotrophic factor (BDNF). In order to elucidate these influences in a com...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000095117

    authors: Strasser A,Skalicky M,Hansalik M,Viidik A

    更新日期:2006-01-01 00:00:00

  • Combined effects of cognitive impairment and hypertension on total mortality in elderly people: the Kangwha Cohort study.

    abstract:BACKGROUND:Previous studies have shown links between cognitive impairment and hypertension as well as mortality. However, combined effects of these two conditions on mortality have not been fully explored. OBJECTIVE:To assess the combined effect of cognitive impairment and hypertension on all-cause mortality among the...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000323759

    authors: Gombojav B,Yi SW,Sull JW,Nam CM,Ohrr H

    更新日期:2011-01-01 00:00:00

  • The symptomatic post-surgical stomach--an endoscopic review.

    abstract::100 consecutive endoscopies in elderly patients referred with symptoms after previous gastric surgery are reviewed. 57% showed positive findings, and the procedure was found particularly useful in making definitive diagnoses in patients presenting with dyspepsia and upper gastro-intestinal bleeding. The incidence of g...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000212699

    authors: Gibbins FJ,Gupta SD,Sen I

    更新日期:1985-01-01 00:00:00

  • Lamarckism and ageing.

    abstract::Although it is usually assumed that Lamarckian inheritance does not and cannot occur, molecular mechanisms by which non-mutational changes acquired in one generation can be transmitted to the next are now known. These mechanisms involve changes in chromatin structure, rather than changes in DNA base sequence. It is ar...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000213217

    authors: Jablonka E,Lamb MJ

    更新日期:1990-01-01 00:00:00

  • Alkylation damage and repair in Alzheimer's disease lymphocytes.

    abstract::We have previously shown that lymphocytes from Alzheimer's disease (AD) patients are hypersensitive to ionising radiation, as revealed by their higher levels of dicentrics than those from age-matched, normal individuals. We have now examined the sensitivity of these cells to N-methyl-N-nitrosourea or methyl methanesul...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000213539

    authors: Tobi SE,Neary D,Itzhaki RF

    更新日期:1993-01-01 00:00:00

  • No neuron loss from hypothalamic nuclei of old male rats.

    abstract::Neuron density, volume of the area and total neuron number were measured in the medial preoptic area, supraoptic nucleus, paraventricular nucleus, anterior hypothalamic area, ventromedial nucleus, dorsomedial nucleus and arcuate nucleus of the hypothalamus in young adult male rats (3.5-5 months old) and in old male ra...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000212507

    authors: Peng MT,Hsü HK

    更新日期:1982-01-01 00:00:00

  • Effect of age on the febrile response of rats to endogenous pyrogen.

    abstract::Mechanisms underlying the decreased febrile response in the elderly have not been elucidated. One hypothesis is that elderly persons have a decreased response at the hypothalamic or peripheral effector level to endogenous pyrogen (EP). We studied the response to human monocyte-derived EP in young adult and aged Fische...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000212723

    authors: Tocco-Bradley R,Singer R,Kluger MJ,Kauffman CA

    更新日期:1985-01-01 00:00:00

  • Effect of donor age on inter- and intrachromosomal distribution of sister chromatid exchanges in cultured human lymphocytes.

    abstract::The distribution of sister chromatid exchange (SCE) points has been analyzed in cultured lymphocytes from three age-groups of 30 females (n = 10; young: 13-20, middle-aged: 30-55, old: 75-84 years). The observed interchromosomal SCE distribution is in good agreement with the results of previous workers, significant ag...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000213147

    authors: Vormittag W

    更新日期:1983-01-01 00:00:00

  • The Increasing Importance of Friendship in Late Life: Understanding the Role of Sociohistorical Context in Social Development.

    abstract::Historically, family ties have been understood as the primary source of support for aging adults, and past empirical and theoretical work has highlighted the tendency of older adults to focus on close family. However, in line with demographic changes and historical increases in the diversity of social structures, frie...

    journal_title:Gerontology

    pub_type: 杂志文章,评审

    doi:10.1159/000505547

    authors: Fiori KL,Windsor TD,Huxhold O

    更新日期:2020-01-01 00:00:00

  • Decreased plasma taurine in aged rats.

    abstract::Taurine (TAU) is thought to be a neuromodulator or an inhibitory neurotransmitter in the mammalian brain. In the periphery, TAU is involved in a wide spectrum of physiological functions. One of the most important putative physiological function of TAU is the modulation of cardiovascular activity including blood pressu...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000213171

    authors: Wallace DR,Dawson R Jr

    更新日期:1990-01-01 00:00:00

  • Walking habits and health-related factors in a 70-year-old population.

    abstract::Walking and other physical activities were studied in a representative population sample of 619 70-year-old people in the city of Gothenburg, Sweden. Walking was the most common physical activity declared, and two thirds of those without an obvious disability walked 30 min or more every day. Subjects who took a daily ...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000213272

    authors: Frändin K,Grimby G,Mellström D,Svanborg A

    更新日期:1991-01-01 00:00:00

  • Changes in brain glucose metabolism as a key to the pathogenesis of Alzheimer's disease.

    abstract::The article discusses some aspects demonstrating that a decrease in acetylcholine synthesis in senile dementia of the Alzheimer type (SDAT) is a consequence of the strong decline in glucose turnover in the brain. This becomes obvious by the fact that acetylcoenzyme A, the key substrate of acetylcholine synthesis, is e...

    journal_title:Gerontology

    pub_type: 杂志文章,评审

    doi:10.1159/000213592

    authors: Meier-Ruge W,Bertoni-Freddari C,Iwangoff P

    更新日期:1994-01-01 00:00:00

  • Underweight in Nursing Homes: Differences between Men and Women.

    abstract:OBJECTIVE:In Germany, there is an ongoing concern about the high prevalence of underweight on admission to health-care institutions. In order to assess possible sex-specific differences, the aim of this study is to provide valid figures about the prevalence and risk factors of underweight of men and women in German nur...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000512459

    authors: Strube-Lahmann S,Müller-Werdan U,Norman K,Skarabis H,Lahmann NA

    更新日期:2021-01-20 00:00:00

  • Defective self-recognition in subjects of far-advanced age.

    abstract::The immunocompetence of 22 subjects aged 85-104 years (mean 90 +/- 1 years) was studied and compared to 21 young subjects aged 19-37 years (mean 30 +/- 1 years). The absolute lymphocyte number and the percentage of T and B lymphocytes in the peripheral blood was similar in the two groups. A marked decrease in phytohem...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000213095

    authors: Licastro F,Tabacchi PL,Chiricolo M,Parente R,Cenci M,Barboni F,Franceschi C

    更新日期:1983-01-01 00:00:00

  • Postural influences on urinary incontinence in the elderly.

    abstract::To evaluate the requirement for provocative cystometry in urodynamic investigation in the elderly with urinary incontinence, 100 consecutive patients, who were referred on the basis of defined clinical criteria, were first studied by supine cystometry followed by provocative tests where necessary. The most satisfactor...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000212791

    authors: Eastwood HD

    更新日期:1986-01-01 00:00:00

  • Does change in gait while counting backward predict the occurrence of a first fall in older adults?

    abstract:BACKGROUND:Dual-task-based assessment tests failed to establish a dependable relationship between dual-task-related gait changes and the risk of falls in the elderly. OBJECTIVE:The aim of this study was to examine whether changes in gait while counting backward could be associated with the occurrence of a first fall a...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000127318

    authors: Beauchet O,Allali G,Annweiler C,Berrut G,Maarouf N,Herrmann FR,Dubost V

    更新日期:2008-01-01 00:00:00

  • Subjective and Objective Memory Changes in Old Age across Five Years.

    abstract::Typically, subjective memory assessments (be it in form of single items or questionnaires) in old age only weakly correlate with the performance in objective memory tests at cross-section. It thus appears as if individual differences in subjective memory assessments hardly reflect individual differences in memory in o...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000369927

    authors: Zimprich D,Kurtz T

    更新日期:2015-01-01 00:00:00

  • Influence of age on the relationship between alcohol consumption and metabolic syndrome.

    abstract:BACKGROUND:Relationships between alcohol consumption and risks for metabolic syndrome in general populations are very controversial. It is unknown whether age influences the relationship between alcohol intake and the prevalence of metabolic syndrome. OBJECTIVE:The purpose of this study was to determine whether age in...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000323080

    authors: Wakabayashi I

    更新日期:2012-01-01 00:00:00

  • Use of in-patient hospital beds by people living in residential care.

    abstract:BACKGROUND:There is concern that people living in residential care in Australia make significant and often inappropriate use of acute in-patient hospital services. To date, no factual information has been collected in Australia and its absence may allow myths and negative stereotypes to proliferate. OBJECTIVE:To deter...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000022148

    authors: Finucane P,Wundke R,Whitehead C,Williamson L,Baggoley C

    更新日期:2000-05-01 00:00:00

  • Future time perspective: opportunities and limitations are differentially associated with subjective well-being and hair cortisol concentration.

    abstract:BACKGROUND:Future time perspective has been associated with subjective well-being, though depending on the line of research considered either an open-ended future time perspective or a limited future time perspective has been associated with high well-being. Most of this research however has conceptualized future time ...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000368716

    authors: Kozik P,Hoppmann CA,Gerstorf D

    更新日期:2015-01-01 00:00:00

  • Effects of centrophenoxine on the monovalent electrolyte contents of the large brain cortical cells of old rats.

    abstract::The effect of centrophenixine has been studied on the monovalent electrolyte contents of the brain cortical cells of old female Wistar rats by means of energy dispersive x-ray microanalysis. The drug was administered in form of an intraperitoneal injection of 100 mg/kg body weight for 20 days. The treatment decreased ...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000212326

    authors: Zs-Nagy I,Pieri C,Giuli C,Del Moro M

    更新日期:1979-01-01 00:00:00

  • Complex Gait Is Related to Cognitive Functioning in Older People: A Cross-Sectional Study Providing an Innovative Test.

    abstract:BACKGROUND:Many studies have demonstrated an inverse relationship between gait performance and cognitive impairment. The main purposes of this study were: (1) to design and validate a complex gait test (CGT) in older people, (2) to analyze the effects of age and sex on CGT, and (3) to analyze the association between CG...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000508245

    authors: Latorre Román PÁ,Muñoz Jiménez M,Salas Sánchez J,Consuegra González P,Moreno Del Castillo R,Herrador Sánchez JA,López Ivanco MDA,Linares Jiménez C,Navas Morales JF,Párraga Montilla JA

    更新日期:2020-01-01 00:00:00

  • Association between serum vitamin D status and functional mobility in memory clinic patients aged 65 years and older.

    abstract:BACKGROUND:Recent studies have shown that vitamin D status may be relevant for physical and cognitive performance in the older population. This association may be of particular interest to older people at risk for cognitive impairment and functional decline. OBJECTIVE:The aim of this study was to determine the associa...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000355667

    authors: Gschwind YJ,Bischoff-Ferrari HA,Bridenbaugh SA,Härdi I,Kressig RW

    更新日期:2014-01-01 00:00:00

  • Surface labelling of senescent chick fibroblasts by lactoperoxidase-catalysed iodination.

    abstract::Cell surface of chick fibroblasts were labelled by a short treatment with 125I in presence of lactoperoxidase. A glycoprotein (220,000 molec. wt) was iodinated and was present in a more exposed position or in greater amounts at the surface of old phase III cells compared to young phase II cells. The findings extend ou...

    journal_title:Gerontology

    pub_type: 杂志文章

    doi:10.1159/000212149

    authors: Courtois Y,Hughes RC

    更新日期:1976-01-01 00:00:00