Abstract:
BACKGROUND:Functional status in older people is a dynamic situation, which makes it necessary to evaluate functional capacity at different times to determinate their prognostic value. OBJECTIVE:To examine the association between functional status (baseline and change after acute illness) and mortality and functional changes at 1 year. METHODS:Hospital-based prospective longitudinal cohort study of all patients over 65 years old, admitted for multidisciplinary treatment of functional impairment after acute illness in a medium-stay unit (post-acute geriatric unit) of a teaching hospital ascribed to the Spanish National Health Service from Spain during 15 consecutive months. Functional status (Barthel Index, BI) was assessed prior to the acute illness, at admission in a post-acute unit, at discharge and 1 year later. At admission, other variables were collected: sociodemographic, main diagnostic for hospitalization (stroke, orthopedic process, or deconditioning), serum albumin, comorbidity (Charlson Index), cognitive status (Pfeiffer s Short Portable Mental Status Questionnaire). In order to analyze mortality 1 year after discharge, a Cox regression analysis was performed. RESULTS:Three hundred and sixty-nine patients constituted the study population, mean age was 80.74 years (SD 7.4), 66.6% were female and 1 year after discharge mortality was 20%. In the multivariate analysis, variables associated with a higher 1-year mortality were age (HR 1.06; 95% CI = 1.00-1.07) male gender (HR 2.11; 95% CI = 1.26-3.55), worse prior functional status (HR 0.98; 95% CI = 0.96-0.99), and higher functional loss in BI at admission (HR 1.02; 95% CI = 1.00-1.04). On the other hand, a greater functional gain in BI at discharge was associated with a lower 1-year mortality (HR 0.98; 95% CI = 0.96-0.99). CONCLUSIONS:The main functional gain obtained after treatment in a multidisciplinary post-acute geriatric unit is independently associated with a reduction in long-term mortality. In addition to baseline functional status and after acute illness, the subsequent potential recovery is very important to predict poor long-term outcomes.
journal_name
Gerontologyjournal_title
Gerontologyauthors
Baztán JJ,Gálvez CP,Socorro Adoi
10.1159/000193068subject
Has Abstractpub_date
2009-01-01 00:00:00pages
269-74issue
3eissn
0304-324Xissn
1423-0003pii
000193068journal_volume
55pub_type
杂志文章相关文献
GERONTOLOGY文献大全abstract::This paper critiques Brand and Markowitsch's viewpoint that the decision-making difficulties experienced by older adults during laboratory-based gambling tasks can be attributed to deficits in executive control and feedback operations. While Brand and Markowitsch provide an important platform with which to understand ...
journal_title:Gerontology
pub_type: 评论,杂志文章
doi:10.1159/000275060
更新日期:2010-01-01 00:00:00
abstract::The interactions of ergot alkaloids and of other drugs with dopamine (DA) and alpha-adrenergic receptors were investigated. The tested ergot alkaloids inhibit synaptosomal tyrosine hydroxylase activity and reverse the apomorphine-elicited inhibition of synaptosomal tyrosine hydroxylase activity. Thus, ergot alkaloids ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212301
更新日期:1978-01-01 00:00:00
abstract::The subcellular distribution of estradiol following the in vivo administration of 3H-estradiol, cytosol and nuclear estrogen receptor after in vitro incubation with 3H-estradiol were studied in young adult female rats (3-6 months old) and old female rats (over 18 months old). After intravenous injection of 3H-estradio...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212449
更新日期:1981-01-01 00:00:00
abstract::Alzheimer neurofibrillary changes and senile plaques were found in a variety of distribution patterns and intensities in 50 brains of patients older than 73 years who had been carefully examined for signs of organic dementia in a geriatric unit. As noted by earlier observers, the severity of dementia usually correspon...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212633
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Alzheimer's disease (AD) is a neurodegenerative disorder in middle and late age. Ribosomal RNA (rRNA) genes are located in the nucleolus (nucleolar organizer regions = NORs). There are increased deposits of beta-amyloid protein in the brains of the patients with AD and aged individuals with Down's syndrome (...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000086365
更新日期:2005-09-01 00:00:00
abstract::The Hermansky-Pudlak syndrome (HPS) is an autosomal recessive disease characterized by a triad of oculocutaneous albinism, accumulation of auto-fluorescent ceroid-like pigments within macrophages, and bleeding tendency due to a storage pool disease of the platelets. We report an autopsy case (39y, male), who died of p...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213751
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Moderate physical exercise, dietary restriction as well as enriched environment in separate studies have been reported to delay some of the adverse effects of aging on brain function, parallel to an increase in brain-derived neurotrophic factor (BDNF). In order to elucidate these influences in a com...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000095117
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Previous studies have shown links between cognitive impairment and hypertension as well as mortality. However, combined effects of these two conditions on mortality have not been fully explored. OBJECTIVE:To assess the combined effect of cognitive impairment and hypertension on all-cause mortality among the...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000323759
更新日期:2011-01-01 00:00:00
abstract::100 consecutive endoscopies in elderly patients referred with symptoms after previous gastric surgery are reviewed. 57% showed positive findings, and the procedure was found particularly useful in making definitive diagnoses in patients presenting with dyspepsia and upper gastro-intestinal bleeding. The incidence of g...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212699
更新日期:1985-01-01 00:00:00
abstract::Although it is usually assumed that Lamarckian inheritance does not and cannot occur, molecular mechanisms by which non-mutational changes acquired in one generation can be transmitted to the next are now known. These mechanisms involve changes in chromatin structure, rather than changes in DNA base sequence. It is ar...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213217
更新日期:1990-01-01 00:00:00
abstract::We have previously shown that lymphocytes from Alzheimer's disease (AD) patients are hypersensitive to ionising radiation, as revealed by their higher levels of dicentrics than those from age-matched, normal individuals. We have now examined the sensitivity of these cells to N-methyl-N-nitrosourea or methyl methanesul...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213539
更新日期:1993-01-01 00:00:00
abstract::Neuron density, volume of the area and total neuron number were measured in the medial preoptic area, supraoptic nucleus, paraventricular nucleus, anterior hypothalamic area, ventromedial nucleus, dorsomedial nucleus and arcuate nucleus of the hypothalamus in young adult male rats (3.5-5 months old) and in old male ra...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212507
更新日期:1982-01-01 00:00:00
abstract::Mechanisms underlying the decreased febrile response in the elderly have not been elucidated. One hypothesis is that elderly persons have a decreased response at the hypothalamic or peripheral effector level to endogenous pyrogen (EP). We studied the response to human monocyte-derived EP in young adult and aged Fische...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212723
更新日期:1985-01-01 00:00:00
abstract::The distribution of sister chromatid exchange (SCE) points has been analyzed in cultured lymphocytes from three age-groups of 30 females (n = 10; young: 13-20, middle-aged: 30-55, old: 75-84 years). The observed interchromosomal SCE distribution is in good agreement with the results of previous workers, significant ag...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213147
更新日期:1983-01-01 00:00:00
abstract::Historically, family ties have been understood as the primary source of support for aging adults, and past empirical and theoretical work has highlighted the tendency of older adults to focus on close family. However, in line with demographic changes and historical increases in the diversity of social structures, frie...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000505547
更新日期:2020-01-01 00:00:00
abstract::Taurine (TAU) is thought to be a neuromodulator or an inhibitory neurotransmitter in the mammalian brain. In the periphery, TAU is involved in a wide spectrum of physiological functions. One of the most important putative physiological function of TAU is the modulation of cardiovascular activity including blood pressu...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213171
更新日期:1990-01-01 00:00:00
abstract::Walking and other physical activities were studied in a representative population sample of 619 70-year-old people in the city of Gothenburg, Sweden. Walking was the most common physical activity declared, and two thirds of those without an obvious disability walked 30 min or more every day. Subjects who took a daily ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213272
更新日期:1991-01-01 00:00:00
abstract::The article discusses some aspects demonstrating that a decrease in acetylcholine synthesis in senile dementia of the Alzheimer type (SDAT) is a consequence of the strong decline in glucose turnover in the brain. This becomes obvious by the fact that acetylcoenzyme A, the key substrate of acetylcholine synthesis, is e...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000213592
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:In Germany, there is an ongoing concern about the high prevalence of underweight on admission to health-care institutions. In order to assess possible sex-specific differences, the aim of this study is to provide valid figures about the prevalence and risk factors of underweight of men and women in German nur...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000512459
更新日期:2021-01-20 00:00:00
abstract::The immunocompetence of 22 subjects aged 85-104 years (mean 90 +/- 1 years) was studied and compared to 21 young subjects aged 19-37 years (mean 30 +/- 1 years). The absolute lymphocyte number and the percentage of T and B lymphocytes in the peripheral blood was similar in the two groups. A marked decrease in phytohem...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213095
更新日期:1983-01-01 00:00:00
abstract::To evaluate the requirement for provocative cystometry in urodynamic investigation in the elderly with urinary incontinence, 100 consecutive patients, who were referred on the basis of defined clinical criteria, were first studied by supine cystometry followed by provocative tests where necessary. The most satisfactor...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212791
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Dual-task-based assessment tests failed to establish a dependable relationship between dual-task-related gait changes and the risk of falls in the elderly. OBJECTIVE:The aim of this study was to examine whether changes in gait while counting backward could be associated with the occurrence of a first fall a...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000127318
更新日期:2008-01-01 00:00:00
abstract::Typically, subjective memory assessments (be it in form of single items or questionnaires) in old age only weakly correlate with the performance in objective memory tests at cross-section. It thus appears as if individual differences in subjective memory assessments hardly reflect individual differences in memory in o...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000369927
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Relationships between alcohol consumption and risks for metabolic syndrome in general populations are very controversial. It is unknown whether age influences the relationship between alcohol intake and the prevalence of metabolic syndrome. OBJECTIVE:The purpose of this study was to determine whether age in...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000323080
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:There is concern that people living in residential care in Australia make significant and often inappropriate use of acute in-patient hospital services. To date, no factual information has been collected in Australia and its absence may allow myths and negative stereotypes to proliferate. OBJECTIVE:To deter...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000022148
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Future time perspective has been associated with subjective well-being, though depending on the line of research considered either an open-ended future time perspective or a limited future time perspective has been associated with high well-being. Most of this research however has conceptualized future time ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000368716
更新日期:2015-01-01 00:00:00
abstract::The effect of centrophenixine has been studied on the monovalent electrolyte contents of the brain cortical cells of old female Wistar rats by means of energy dispersive x-ray microanalysis. The drug was administered in form of an intraperitoneal injection of 100 mg/kg body weight for 20 days. The treatment decreased ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212326
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:Many studies have demonstrated an inverse relationship between gait performance and cognitive impairment. The main purposes of this study were: (1) to design and validate a complex gait test (CGT) in older people, (2) to analyze the effects of age and sex on CGT, and (3) to analyze the association between CG...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000508245
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Recent studies have shown that vitamin D status may be relevant for physical and cognitive performance in the older population. This association may be of particular interest to older people at risk for cognitive impairment and functional decline. OBJECTIVE:The aim of this study was to determine the associa...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000355667
更新日期:2014-01-01 00:00:00
abstract::Cell surface of chick fibroblasts were labelled by a short treatment with 125I in presence of lactoperoxidase. A glycoprotein (220,000 molec. wt) was iodinated and was present in a more exposed position or in greater amounts at the surface of old phase III cells compared to young phase II cells. The findings extend ou...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212149
更新日期:1976-01-01 00:00:00