The leucine-responsive regulatory protein, Lrp, modulates microcin J25 intrinsic resistance in Escherichia coli by regulating expression of the YojI microcin exporter.

Abstract:

:Many Escherichia coli K-12 strains display an intrinsic resistance to the peptide antibiotic microcin J25. In this study, we present results showing that the leucine-responsive regulatory protein, Lrp, is involved in this phenotype by acting as a positive regulator of YojI, a chromosomally encoded efflux pump which expels microcin out of cells. Exogenous leucine antagonizes the effect of Lrp, leading to a diminished expression of the pump and an increased susceptibility to microcin J25.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Socías SB,Vincent PA,Salomón RA

doi

10.1128/JB.01074-08

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

1343-8

issue

4

eissn

0021-9193

issn

1098-5530

pii

JB.01074-08

journal_volume

191

pub_type

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