Abstract:
BACKGROUND:Medullary thyroid carcinoma (MTC) accounts only for 1.4% of all thyroid malignancies in Japan. Since 1996, we have performed hemithyroidectomy, instead of total thyroidectomy, for sporadic nonhereditary MTC when the primary lesion is located in only one lobe. Regarding lymph node dissection, modified radical neck dissection (MND) at least ipsilateral to the tumor has been routinely performed, even if there is no clinically apparent metastasis. We investigated the clinical outcomes of MTC patients in our department. METHODS:A series of 118 patients with MTC who underwent initial surgery between 1975 and 2005 were enrolled in this study. The RET gene mutations were analyzed for all patients and 46 had germline RET gene mutations. Of those 46 patients, 26 were diagnosed as MEN 2A and 2 were diagnosed as MEN 2B. Postoperative follow-up periods averaged 141 months. RESULTS:Of 115 patients who did not have distant metastasis at surgery and who underwent locally curative surgery, 78 (67.8%) were biochemically cured. All patients without pathological lymph node metastasis were biochemically cured, and 44.8% of patients with node metastasis were also biochemically cured. The 10-year and 20-year disease-free survival rates were 89.0% and 82.5%, respectively. None of the patients who did not show lymph node metastasis and only 2 (2.6%) of 78 patients who were biochemically cured showed clinically apparent carcinoma recurrence. The 10-year and 20-year cause-specific survival rates were 96.6% and 91.7%, respectively. Lymph node metastasis, tumor size>4 cm, extrathyroid and extranodal tumor extensions significantly affected cause-specific survival of patients. CONCLUSIONS:Clinical outcomes of MTC patients in our series were better than those in Western countries, a result that might have resulted in part because of our routine MND regardless of whether clinically apparent node metastasis was detected.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Ito Y,Miyauchi A,Yabuta T,Fukushima M,Inoue H,Tomoda C,Uruno T,Kihara M,Higashiyama T,Takamura Y,Miya A,Kobayashi K,Matsuzuka Fdoi
10.1007/s00268-008-9795-2subject
Has Abstractpub_date
2009-01-01 00:00:00pages
58-66issue
1eissn
0364-2313issn
1432-2323journal_volume
33pub_type
杂志文章abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is the most common primary liver cancer, causing approximately 660,000 deaths worldwide annually. The preferred treatment of HCC is surgical resection or orthotopic liver transplantation (OLT) for patients meeting specific criteria. For patients outside these criteria, options ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-010-0954-x
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Laparoscopic rectal resection (LRR) for cancer is a challenging procedure, with conversion to open surgery being reported in up to 30% of cases. Since only a few studies with short follow-up have compared converted LRR and open RR (ORR), it is unclear if conversion to open surgery should be prevented by pref...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-018-4614-x
更新日期:2018-10-01 00:00:00
abstract::The aim of this study was to clarify the role of ganglion cells in the development and recurrence of sigmoid volvulus. We analyzed 9 samples obtained from 9 patients who had undergone sigmoidectomy for sigmoid volvulus, and, for comparison, 18 samples from 18 patients who had undergone sigmoidectomy or low anterior re...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-004-7462-9
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Awake tracheostomy (AT) is aimed at securing the airway of patients with upper airway obstruction when other means are not feasible or have failed. Reports on AT in the literature are scarce. The goal of this study was to review our experience with the indications, complications and outcome of AT. METHODS:A...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-018-4578-x
更新日期:2018-09-01 00:00:00
abstract::In the original article Dennis Den Hartog's name was tagged incorrectly. It is correct as reflected here. ...
journal_title:World journal of surgery
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00268-019-04957-5
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:Mirizzi syndrome (MS) is an uncommon presentation of cholelithiasis. This study aims to find the incidence and analyze the outcome of management of this condition at Riyadh Medical Complex (RMC) with particular reference to diagnostic methods and outcome of surgical treatment. METHODS:Retrospective study on ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-005-0100-3
更新日期:2005-12-01 00:00:00
abstract::Bacterial biofilms develop on a number of living and inert surfaces within the urinary tract, producing chronic intractable infections. The role of exopolysaccharides in producing a variety of extracellular polymeric substances according to the infection site and bacterial species and the clinical features of the resu...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s002680010203
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND:Laparoscopic reoperative anti-reflux surgery (ARS) has a significantly higher morbidity than laparoscopic primary ARS; however, it is not known whether the same pattern exists within the robotic approach. We aimed to evaluate the safety and efficacy of robotic reoperative ARS in comparison with primary robot...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-018-4708-5
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:The most important problem in pancreatic fistula is whether one can distinguish clinical pancreatic fistula, grade B + C fistula by the International Study Group on Pancreatic Fistula (ISGPF), from transient pancreatic fistula (grade A), in the early period after pancreaticoduodenectomy (PD). It remains uncl...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-009-0220-2
更新日期:2009-12-01 00:00:00
abstract::The aim of this study was to investigate the epidemiologic characteristics and changing patterns of gallstone disease in Korea over a recent 20-year period. A total of 4020 gallstone patients who had undergone surgery at Seoul National University Hospital during 1981-2000 were analyzed according to periods: period I (...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-003-6879-x
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND:Laparoscopic proximal gastrectomy (LPG) is performed as a function-preserving surgery for patients with early proximal gastric malignant tumors; however, whether LPG has advantages postoperatively compared with laparoscopic total gastrectomy (LTG) is debatable, especially with regard to nutritional outcomes....
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-018-4625-7
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:We analyzed perioperative platelet counts as a potential clinical marker for survival after transthoracic en bloc resection for esophageal cancer. Recent data described preoperative thrombocytosis in malignancies to be associated with poor prognosis. METHODS:A retrospective analysis from a prospective datab...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-010-0707-x
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:The importance of safe anesthesia for the best possible surgical outcomes in every patient is not disputed in high resource settings. Low-income countries lag far behind in the provision of, and training for, safe anesthesia practice. Too little is known about numbers and types of providers in a majority of ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-014-2775-9
更新日期:2015-04-01 00:00:00
abstract::Worldwide, traffic deaths are 500,000 per year and growing. Four nations, China, India, Russia, and the United States of America, have reached levels of 45,000-50,000 traffic deaths per year, although the nature of the problem is quite different in fully motorized countries from what it is in motorizing countries. In ...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/BF02104436
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:The appropriate surgical approach for hepatocellular carcinoma (HCC) patients of Child-Pugh class B is unclear. The aim of this study was to clarify the prognostic factors after hepatectomy in Child-Pugh class B patients and to delineate the selection criteria for hepatectomy. METHODS:One hundred fifty pati...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-010-0929-y
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Efficient DNA damage repair by MutL-homolog DNA mismatch repair (MMR) enzymes, MLH1, MLH3, PMS1 and PMS2, are required to maintain thyrocyte genomic integrity. We hypothesized that persistent oxidative stress and consequent transcriptional dysregulation observed in thyroid follicles will lead to MMR deficien...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-017-4299-6
更新日期:2018-02-01 00:00:00
abstract:: ...
journal_title:World journal of surgery
pub_type: 评论,信件
doi:10.1007/s00268-018-4704-9
更新日期:2019-03-01 00:00:00
abstract::This article attempts to put into a risk-related perspective modern red blood cell (RBC) transfusion therapy. When making the decision to transfuse, RBCs or blood products, it is important to weigh the risks and benefits of the proposed therapy. It is equally important to evaluate the risk of not transfusing and the m...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900181
更新日期:1996-11-01 00:00:00
abstract::Neoadjuvant therapy for locally advanced breast cancer improves disease control, but the complications of treatment are not well established. The aim of this study was to assess the operative morbidity in 20 consecutive patients with locally advanced, noninflammatory breast cancer treated with preoperative chemotherap...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF01658934
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:Strictures at the pharyngoesophageal junction represent a subgroup of corrosive esophageal strictures requiring a specialized management approach. Non-dilatable cricopharyngeal strictures need surgical intervention. We report the use of the sternocleidomastoid muscle myocutaneous inlay flap (SCMMIF) for reco...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-007-9120-5
更新日期:2007-08-01 00:00:00
abstract::Although emergency department thoracotomy (EDT) is often considered a controversial "last chance" method of resuscitation, we hypothesized that EDT performed in a busy urban Level I trauma center has significant salvage rates despite the absence of traditional survival predictors. A retrospective review revealed that ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-007-9392-9
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:Geriatric collaborative care models improve postoperative outcomes for older adults. However, there are limited data exploring how preoperative geriatric assessment may affect surgical cancellations. METHODS:This is a single-center retrospective cohort analysis. Patients enrolled in the Perioperative Optimi...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-020-05772-z
更新日期:2021-01-01 00:00:00
abstract::Medical errors from communication failures are enormous during the perioperative period of cardiac surgical patients. As caregivers change shifts or surgical patients change location within the hospital, key information is lost or misconstrued. After a baseline cognitive study of information need and caregiver workflo...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-009-0319-5
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Peritoneal adhesions are recognized as an important cause for patient morbidity, but complications related to adhesions occur relatively late after the original operation. Therefore preoperative consent may not adequately reflect the proportions of the problem. METHODS:A total of 200 patients admitted for i...
journal_title:World journal of surgery
pub_type: 杂志文章,多中心研究
doi:10.1007/s00268-008-9917-x
更新日期:2009-04-01 00:00:00
abstract::The role of nitric oxide in mediating smooth muscle relaxation is well established. Less is known about the downstream signaling events inside the smooth muscle cell that produce relaxation of the contractile machinery. One possible effector molecule is the small heat shock protein HSP20. Increased phosphorylation of ...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s00268-002-4052-6
更新日期:2002-07-01 00:00:00
abstract:INTRODUCTION:Although seemingly straightforward, tube thoracostomy (TT) has been associated with complication rates as high as 30 %. A lack of a standardized nomenclature for reporting TT complications makes comparison and evaluation of reports impossible. We aim to develop a classification method in order to standardi...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s00268-015-3158-6
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Delayed recovery of gastrointestinal (GI) motility is a common complication following surgery. TZP-101/ulimorelin is a macrocyclic peptidomimetic ghrelin receptor agonist with GI promotility effects that significantly accelerates time to recovery of GI motility compared to placebo following partial colectomy...
journal_title:World journal of surgery
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00268-011-1335-9
更新日期:2012-01-01 00:00:00
abstract::Whether for hepatic trauma or transplantation, a surgeon's knowledge of hepatic anatomy commonly determines a patient's outcome. The first medically relevant anatomic studies of the liver emerged with the endeavors of Herophilus and Erasistratus between 310 and 280 bc. Yet it was not until after the development of ane...
journal_title:World journal of surgery
pub_type: 传,历史文章,杂志文章
doi:10.1007/s002689900238
更新日期:1997-03-01 00:00:00
abstract::The lack of sufficient suitable human donor lungs for the many patients requiring pulmonary transplantation as life-saving therapy for end-stage lung diseases has generated extensive interest in cross-species lung transplantation. Ethical concerns and those of animal rights advocates have prompted studies of nonprimat...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s002689900332
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:The goal of this study was to evaluate the outcome of patients who had the Nuss procedure for repair of pectus excavatum. METHODS:Thirty-nine patients (26 male, 13 female) of 61 (63.9%) who had bar removal after the Nuss procedure agreed to participate in an interview. All patients and their parents were as...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-011-1111-x
更新日期:2011-07-01 00:00:00