Abstract:
BACKGROUND:Hepatocellular carcinoma (HCC) is the most common primary liver cancer, causing approximately 660,000 deaths worldwide annually. The preferred treatment of HCC is surgical resection or orthotopic liver transplantation (OLT) for patients meeting specific criteria. For patients outside these criteria, options are limited and include medical therapy, radiofrequency ablation, chemoembolization, or palliative measures, and these result in poor outcomes. Various centers at Baylor are elucidating the genomics of HCC to improve treatment options, with a focus on three etiologies: hepatitis C virus, hepatitis B virus, and non-viral. METHODS:Through collaborative efforts, we have established an effective specimen biobanking protocol, and we are using several techniques to analyze HCC, including whole genome sequencing, whole exome sequencing, gene-specific analysis, gene expression, and epigenetic analysis. RESULTS:We have completed whole genome sequencing on two patient samples, whole exome sequencing on 47 patient samples, gene-specific analysis on 94 patient samples, gene expression on 4 patient samples, and epigenetic analysis on 1 patient sample. CONCLUSIONS:We hope to use these results to define novel genetic therapeutic strategies that may work in conjunction with surgical approaches to improve long-term patient and graft survival rates in patients with HCC. We also aim to provide a functional framework of a comprehensive program for genomic analysis that may be imitated by other institutions and for other tumors in the global quest toward personalized genomic medicine.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Harring TR,Guiteau JJ,Nguyen NT,Cotton RT,Gingras MC,Wheeler DA,O'Mahony CA,Gibbs RA,Brunicardi FC,Goss JAdoi
10.1007/s00268-010-0954-xsubject
Has Abstractpub_date
2011-08-01 00:00:00pages
1746-50issue
8eissn
0364-2313issn
1432-2323journal_volume
35pub_type
杂志文章abstract::The novel trend toward focused parathyroidectomy requires precise preoperative localization of the parathyroid adenoma in patients with primary hyperparathyroidism (PHPT). The present study evaluated the impact of hybrid single photon emission computed tomography/computed tomography (SPECT/CT), using 99mTc-sestamibi (...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-005-7849-2
更新日期:2006-01-01 00:00:00
abstract::From January, 1972 to June, 1989, 51 patients with liver hemangiomas (32 females and 19 males, mean age 35 years) were evaluated for surgical treatment. Diameters of the masses were 5 cm to 20 cm (median 8.5 cm). Nine of the patients had already been treated for cancer. Twenty-two (43.1%) of the 51 patients were sympt...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF02104457
更新日期:1992-05-01 00:00:00
abstract::At the time of laparotomy, peritoneal washings were collected from 155 gastric cancer patients and the levels of carcinoembryonic antigen (CEA) determined. The CEA levels in peritoneal washings were statistically independent of those in sera and could more reliably predict the presence of peritoneal metastasis than a ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF00316997
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:The incidence, pattern, and severity of sleep disturbance and cognitive dysfunction has not been well characterized for patients with primary hyperparathyroidism (PHPT). There is no agreement on the mechanism of the development or resolution of such symptoms, and in no previous study has cerebral activity be...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-005-0361-x
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to assess the safety and feasibility of performing robot-assisted pediatric surgery using the da Vinci Surgical System in a variety of surgical procedures. METHODS:A retrospective review of 144 robot-assisted pediatric surgical procedures performed in our institution between Ju...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-010-0431-6
更新日期:2010-05-01 00:00:00
abstract::This study was designed to investigate the optimal dose of garlic during long-term feeding and its preventive and therapeutic effects on colon cancer in rats induced by 1,2-dimethylhydrazine (DMH). A total of 240 male Sprague-Dawley rats were grouped and fed with either a basal or a garlic diet of different concentrat...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF00294738
更新日期:1995-07-01 00:00:00
abstract::Papillary thyroid carcinoma is a frequent thyroid cancer. Many factors have been reported to be of prognostic importance, but the significance of biologic factors suggesting aggressiveness and proliferating activity has not been sufficiently documented. Conventional prognostic factors such as age, extrathyroidal invas...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900551
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:The goal of the present study was to critically review and identify the strength of available evidence in the literature on the use of laparoscopic appendectomy (LA) in complicated appendicitis (CA). METHODS:The Cochrane Library and Controlled Trials Registry, MEDLINE (Ovid), PubMed, Web of knowledge, and S...
journal_title:World journal of surgery
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00268-010-0669-z
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:The selection of the type of fundoplication or the necessity for an added fundoplication after esophagomyotomy (Heller's operation) for the treatment of achalasia remains controversial. The present retrospective study was designed to compare the long-term results of total and partial fundoplication on the my...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-007-9385-8
更新日期:2008-03-01 00:00:00
abstract::Different types of vagotomy have been widely used in the treatment of peptic ulcer disease. A close relationship between the vagus nerve and the release or action of gastrointestinal hormones is necessary for the optimal activation of the gastrointestinal tract. The serum concentrations of the antral hormone gastrin a...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/BF01654771
更新日期:1979-09-20 00:00:00
abstract:BACKGROUND:Although multidetector-row computed tomography (MDCT) before biliary drainage is useful for the assessment of the resectability of perihilar cholangiocarcinoma (PHC), the impact of biliary drainage on MDCT images before surgical resection for PHC has been poorly studied, and its possible consequences for R0 ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-018-4654-2
更新日期:2018-11-01 00:00:00
abstract::To characterize hepatocellular carcinoma (HCC) cells with mutant (m) p53 protein histologically, we examined 68 main nodules and 20 accessory lesions of 72 patients with HCC who underwent hepatic resection between October 1990 and September 1993. Some sections were fixed in periodate-lysine-paraformaldehyde, embedded ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900033
更新日期:1996-02-01 00:00:00
abstract:INTRODUCTION:Response rates to systemic chemotherapy for patients who have failed irinotecan-based chemotherapy for liver-dominant metastatic colorectal cancer range between 10 and 18 % with overall survival between 7 and 9 months. The aim of this study was to assess the efficacy and safety of hepatic arterial irinotec...
journal_title:World journal of surgery
pub_type: 杂志文章,多中心研究
doi:10.1007/s00268-015-3386-9
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVES:We report three cases of isolated infrarenal aortic dissecting aneurysms managed with stent-graft. MATERIALS AND METHODS:Three patients, two men and one woman, with a mean age at diagnosis of 69 years were identified. In all cases, chest CT-A did not reveal evidence of thoracic aortic dissection. The mean m...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-005-0704-7
更新日期:2006-07-01 00:00:00
abstract::Factors responsible for recurrence of esophageal cancer were investigated in 90 patients who underwent extended radical esophagectomy with three-field dissection for a squamous cell carcinoma in the thoracic esophagus. The initial tumor recurrence was grouped as either locoregional (site of the primary tumor, anastomo...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900228
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:The aim of this work was to study the impact of anemia on surgical outcomes and the impact of instituting appropriate workup and treatment of anemia on surgical outcomes. METHODS:We conducted a case-control retrospective chart review of all hernia repair, hydrocele repair, and hysterectomy cases at the SEAR...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-012-1615-z
更新日期:2012-09-01 00:00:00
abstract::Lower esophageal sphincter pressure has been assessed pre-operatively, intra-operatively,and more than 6 months postoperatively in 34 patients having antireflux surgery for gastro-esophageal reflux disease. The sphincter pressures associated with the outcome in relation to pH measured reflux and the symptoms of recurr...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF02071543
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND:Teamwork is fundamental to effective surgery, yet there are currently no measures of teamwork to guide training, evaluate team interventions or assess the impact of teamwork on outcomes. We report the first steps in the development of an observational assessment of teamwork and preliminary findings. METHOD:...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-005-0488-9
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:The majority of small bowel obstructions (SBO) are the result of adhesions caused by a previous abdominal operation. On rare occasions, adhesional SBO occurs in the absence of such an operation. Our objective was to describe the management, findings, and outcomes of unexplained adhesional SBO (UA-SBO) and ex...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-009-0200-6
更新日期:2009-11-01 00:00:00
abstract::Pancreas transplantation has emerged as the single most effective way to achieve normal glucose homeostasis inpatients with type I insulin-dependent diabetes mellitus. Optimal immunosuppressive strategies for pancreas transplantation continue to evolve with the use of newer, more potent immunosuppressive agents,partic...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s00268-001-0207-0
更新日期:2002-02-01 00:00:00
abstract::The most common causes of variceal bleeding are cirrhosis, schistosomiasis, and extrahepatic portal venous obstruction. The prognosis for an individual patient depends on the severity of the bleeding episode and the underlying liver function. Liver function is determined to a large extent by the underlying liver patho...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/BF00294397
更新日期:1994-03-01 00:00:00
abstract::Surgical resection remains the therapy of choice for the treatment of potentially curable gastrointestinal tract (GI) malignancies. Many of these tumors are incurable at the time of diagnosis and therapy should be directed towards palliation with the intent of minimizing pain, bleeding, obstruction, and potential morb...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF02067061
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Surgery is increasingly recognized as a means to reduce the morbidity and mortality of disabling impairments in resource-limited environments. We sought to estimate the burden of surgically correctable disabling impairments and the cost-effectiveness of their treatment among children in a large refugee camp....
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-012-1899-z
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:Most reconstructive surgery in Sub-Saharan Africa is provided by numerous noncoordinated individuals and organizations, in multiple short trips, or "surgical blitzes." Because many such groups do not train local surgeons, these communities have become dependent on unsustainable systems. By providing much-nee...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-009-0256-3
更新日期:2010-03-01 00:00:00
abstract::To evaluate quality of life and functional results following surgery for gastric cancer we studied 104 patients with no evidence of disease at a minimum of 12 months postoperatively. Patients were treated with total gastrectomy and jejunal pouch reconstruction according to Hunt-Lawrence-Rodino (n = 59) or simple esoph...
journal_title:World journal of surgery
pub_type: 临床试验,杂志文章
doi:10.1007/BF00294722
更新日期:1995-07-01 00:00:00
abstract::The acid-base balance from the postoperative day (POD) 1 to POD 3 after cirrhotic liver resection was investigated in relation to operative outcome by conducting a retrospective study on the changes in arterial ketone body ratio (AKBR), which reflects the hepatic mitochondrial redox state, and arterial blood gas analy...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF01655722
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Postoperative outcome prediction in elderly is based on preoperative physical status but its predictive value is uncertain. The goal was to evaluate the value of risk assessment performed perioperatively in predicting outcome in case of admission to an intensive care unit (ICU). METHODS:A total of 108 posts...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-020-05742-5
更新日期:2020-12-01 00:00:00
abstract::The aim of this study was to identify the risk factors for bacterial translocation and to determine the clinical significance of bacterial translocation in patients with colorectal cancer. Mesenteric lymph node sampling was performed to identify the presence of bacterial translocation in 75 patients with colorectal ca...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-004-7576-0
更新日期:2005-02-01 00:00:00
abstract:INTRODUCTION:The impact of diabetes mellitus (DM) on outcomes in patients undergoing emergency laparotomy for adhesive small bowel obstruction (ASBO) remains unknown. METHODS:Low-risk (ASA class of I and II) patients requiring emergency operation for ASBO were identified using the ACS NSQIP database. Propensity score ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-015-3338-4
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Laparoscopic hepatectomy (LH) is established as a safe and feasible treatment option for liver tumors. However, whether the adoption of laparoscopic approach for malignant tumors, such as hepatocellular carcinoma (HCC), will compromise the long-term result is still unknown. This study was designed to evaluat...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-011-1212-6
更新日期:2011-10-01 00:00:00