Building a comprehensive genomic program for hepatocellular carcinoma.

Abstract:

BACKGROUND:Hepatocellular carcinoma (HCC) is the most common primary liver cancer, causing approximately 660,000 deaths worldwide annually. The preferred treatment of HCC is surgical resection or orthotopic liver transplantation (OLT) for patients meeting specific criteria. For patients outside these criteria, options are limited and include medical therapy, radiofrequency ablation, chemoembolization, or palliative measures, and these result in poor outcomes. Various centers at Baylor are elucidating the genomics of HCC to improve treatment options, with a focus on three etiologies: hepatitis C virus, hepatitis B virus, and non-viral. METHODS:Through collaborative efforts, we have established an effective specimen biobanking protocol, and we are using several techniques to analyze HCC, including whole genome sequencing, whole exome sequencing, gene-specific analysis, gene expression, and epigenetic analysis. RESULTS:We have completed whole genome sequencing on two patient samples, whole exome sequencing on 47 patient samples, gene-specific analysis on 94 patient samples, gene expression on 4 patient samples, and epigenetic analysis on 1 patient sample. CONCLUSIONS:We hope to use these results to define novel genetic therapeutic strategies that may work in conjunction with surgical approaches to improve long-term patient and graft survival rates in patients with HCC. We also aim to provide a functional framework of a comprehensive program for genomic analysis that may be imitated by other institutions and for other tumors in the global quest toward personalized genomic medicine.

journal_name

World J Surg

journal_title

World journal of surgery

authors

Harring TR,Guiteau JJ,Nguyen NT,Cotton RT,Gingras MC,Wheeler DA,O'Mahony CA,Gibbs RA,Brunicardi FC,Goss JA

doi

10.1007/s00268-010-0954-x

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

1746-50

issue

8

eissn

0364-2313

issn

1432-2323

journal_volume

35

pub_type

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