Central nervous system-specific knockout of steroidogenic factor 1.

abstract：:While the role of dietary fats in breast cancer remains controversial, the recent cloning of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear hormone receptor, from human breast cancer cells lines provides a potential molecular link. Several fatty acids from four classes of dietary fats were tes...

journal_title：Molecular and cellular endocrinology

authors： Thoennes SR,Tate PL,Price TM,Kilgore MW

更新日期：2000-02-25 00:00:00

abstract：:Hyperthyroidism was induced in rats and somatic indices and metabolic parameters were analyzed in testis. In addition, the morphological analysis evidenced testes maturation and intense protein synthesis and processing, supporting the enhancement in vimentin synthesis in hyperthyroid testis. Furthermore, vimentin phos...

journal_title：Molecular and cellular endocrinology

authors： Zamoner A,Barreto KP,Filho DW,Sell F,Woehl VM,Guma FC,Silva FR,Pessoa-Pureur R

更新日期：2007-03-15 00:00:00

abstract：:Previous studies have indicated that following nutrient ingestion, GIP is released principally from the upper small intestine. In addition to its presence in the rat small intestine, GIP transcripts have also been localized to the submandibular salivary gland (SSG). The present studies were directed to further charact...

journal_title：Molecular and cellular endocrinology

authors： Tseng CC,Boylan MO,Jarboe LA,Williams EK,Sunday ME,Wolfe MM

更新日期：1995-11-30 00:00:00

abstract：:The recent cloning of several cDNAs encoding prostaglandin (PG) receptors has paved the way for a more detailed investigation of the postulated regulatory role of prostaglandins in corpus luteum function. We have utilized the reverse transcription-polymerase chain reaction (RT-PCR) to isolate a mRNA encoding the ovari...

journal_title：Molecular and cellular endocrinology

authors： Olofsson JI,Leung CH,Bjurulf E,Ohno T,Selstam G,Peng C,Leung PC

更新日期：1996-10-14 00:00:00

abstract：:Although earlier studies focused on the hormonal regulation of antral and preovulatory follicles, recent studies indicate the importance of the hormonal control mechanism for preantral follicles. The endocrine hormone FSH is not only a survival factor for early antral follicles but also a potent growth and differentia...

journal_title：Molecular and cellular endocrinology

authors： Hsueh AJ,McGee EA,Hayashi M,Hsu SY

更新日期：2000-05-25 00:00:00

abstract：:Transforming growth factor beta (TGF beta) caused a dose-dependent increase in both basal and follicle-stimulating hormone (FSH)-stimulated inhibin production by rat granulosa cells in culture. The TGF beta dose-response curve in the absence of FSH was approximately parallel to that in the presence of either a minimal...

journal_title：Molecular and cellular endocrinology

authors： Zhang ZW,Findlay JK,Carson RS,Herington AC,Burger HG

更新日期：1988-08-01 00:00:00

abstract：:To identify cis-acting prolactin (PRL) response elements within the sheep beta-lactoglobulin (BLG) promoter, CHO cells were co-transfected with a rabbit PRL-receptor (PRL-R) expression plasmid and a number of BLG-CAT constructs. Resection through the 4200 bp BLG promoter diminished the PRL response. Mutation of the pr...

journal_title：Molecular and cellular endocrinology

authors： Demmer J,Burdon TG,Djiane J,Watson CJ,Clark AJ

更新日期：1995-01-01 00:00:00

abstract：:mRNA differential display polymerase chain reaction analysis was used to screen systematically for novel androgen-regulated genes in the human prostatic adenocarcinoma cell line LNCaP. A 232 bp PCR fragment was found to be consistently down-regulated by the synthetic androgen R1881. Sequencing revealed complete identi...

journal_title：Molecular and cellular endocrinology

authors： Ulrix W,Swinnen JV,Heyns W,Verhoeven G

更新日期：1999-09-10 00:00:00

abstract：:We previously reported that testicular zinc finger protein (TZF) is a corepressor for androgen receptor (AR). The present study demonstrated that a central portion (amino acids 512-663) of TZF, TZF(512-663), is responsible for both binding to AR and repressing the transactivation. TZF recruited endogenous histone deac...

journal_title：Molecular and cellular endocrinology

authors： Tao RH,Kawate H,Wu Y,Ohnaka K,Ishizuka M,Inoue A,Hagiwara H,Takayanagi R

更新日期：2006-03-09 00:00:00

abstract：CONTEXT:Apart from 21 Hydroxylase deficiency, other subtypes of congenital adrenal hyperplasia (CAH) are rare. We studied the clinical features and molecular genetics of a relatively large series of patients with CYP17A1, HSD3β2 and StAR deficiencies. PATIENTS AND METHODS:We studied 21 patients including 7 patients wi...

journal_title：Molecular and cellular endocrinology

authors： Alswailem MM,Alzahrani OS,Alhomaidah DS,Alasmari R,Qasem E,Murugan AK,Alsagheir A,Brema I,Abbas BB,Almehthel M,Almeqbali A,Alzahrani AS

更新日期：2018-02-05 00:00:00

abstract：:MicroRNAs (miRNAs or miRs)-9 expression was reported to be upregulated in the follicular fluid of patients with polycystic ovary syndrome (PCOS). However, whether miR-9 affects ovarian dysfunction of PCOS and the related mechanisms are still unclear. Here we detected miR-9 and vitamin D receptor (VDR) expression in wo...

journal_title：Molecular and cellular endocrinology

authors： Kong F,Du C,Wang Y

更新日期：2019-04-15 00:00:00

abstract：:Inhibin A and B are dimeric proteins capable of suppressing FSH both in vitro and in vivo. The principal form in the male is inhibin B which is produced in the testis and circulates to inhibit pituitary FSH secretion. Activin A, B and AB are dimeric proteins that share the same beta subunits with the inhibins but, in ...

journal_title：Molecular and cellular endocrinology

authors： de Kretser DM,Meinhardt A,Meehan T,Phillips DJ,O'Bryan MK,Loveland KA

更新日期：2000-03-30 00:00:00

abstract：:The fibromuscular stroma (FMS) separated from the seminal vesicles of adult guinea pigs incorporated [35S]methionine into a 12 500 X g soluble fraction in vitro. Incorporation decreased 60% in tissues from 7-day castrates with no further change up to 21 days post-castration. Administration of 5 alpha-dihydrotestostero...

journal_title：Molecular and cellular endocrinology

authors： Weinberger MJ

更新日期：1984-12-01 00:00:00

abstract：:Glucocorticoids play a primary role in the maturation of fetal organs and may contribute to the onset of labour. Glucocorticoid activity depends on the 11β-hydroxysteroid dehydrogenase family (11β-HSDs), catalysing the interconversion between "active" cortisol into inactive cortisone. No definitive study exists on 11β...

journal_title：Molecular and cellular endocrinology

authors： Damiani F,Makieva S,Rinaldi SF,Hua L,Marcolongo P,Petraglia F,Norman JE

更新日期：2017-05-15 00:00:00

abstract：:During normal early pregnancy circulating monocytes are recruited to the maternal-placental interface where they differentiate to macrophages expressing different functional phenotypes for the maintenance of tissue homeostasis. Pregnancy in the nonobese diabetic (NOD) mouse model presents some pathological features in...

journal_title：Molecular and cellular endocrinology

authors： Larocca L,Hauk V,Calafat M,Roca V,Fraccaroli L,Franchi A,Ramhorst R,Leirós CP

更新日期：2011-02-20 00:00:00

abstract：:Sex steroids have been known to play important roles in the homeostasis of human skin, but little is known about their biosyntheses in that tissue. In this study, we characterized the correlation between the concentrations of sex steroids and the expression levels of the factors involved in their synthesis or metaboli...

journal_title：Molecular and cellular endocrinology

authors： Inoue T,Miki Y,Abe K,Hatori M,Hosaka M,Kariya Y,Kakuo S,Fujimura T,Hachiya A,Honma S,Aiba S,Sasano H

更新日期：2012-10-15 00:00:00

abstract：:The present study examined the influence of the calcium ionophores A23187 and X537A on the calcitonin (CT) secretory process. The isolated perfused porcine thyroid was used to evaluate ionophore effects on CT secretion and thyroid slices were used to measure 45Ca uptake. Both A23187 and X537A enhanced the rate of CT r...

journal_title：Molecular and cellular endocrinology

authors： Pento JT

更新日期：1986-04-01 00:00:00

abstract：:Four abundant cDNA clones have been isolated from a rat epididymal cDNA library. Northern blot analysis has shown that these clones partially encode 4.5 kb, 2.8 kb, 1.2 kb and 0.85 kb mRNAs and that their expression is not detectable in total RNA preparations from heart, kidney, liver or testis. Fourteen days after ca...

journal_title：Molecular and cellular endocrinology

authors： Walker JE,Jones R,Moore A,Hamilton DW,Hall L

更新日期：1990-11-12 00:00:00

abstract：:We studied the functional properties of hepatic glucagon receptors during rat development. Glucagon binding to liver membranes and isolated hepatocytes was significantly less in foetuses and weaning rats than in adult animals, reflecting changes in the number of receptors rather than any change in receptor affinity fo...

journal_title：Molecular and cellular endocrinology

authors： Blázquez E,Perez Castillo A,de Diego JG

更新日期：1987-02-01 00:00:00

abstract：:The major source for dehydroepiandrosterone (DHEA) and its sulphate compound DHEA-S is the inner zone of the adrenal cortex, which is in direct contact to adrenomedullary chromaffin cells. Due to their close proximity, direct interactions of DHEA and DHEA-S with chromaffin cells during adrenal gland development and th...

journal_title：Molecular and cellular endocrinology

authors： Krug AW,Langbein H,Ziegler CG,Bornstein SR,Eisenhofer G,Ehrhart-Bornstein M

更新日期：2009-03-05 00:00:00

abstract：:In clinical trials of heart failure, spironolactone, an antagonist of the mineralocorticoid receptor (MR), reduced mortality rates by unknown mechanisms. We hypothesized that spironolactone functions by upregulating expression of certain cardiovascular genes. An RNA differential display technique was used to identify ...

journal_title：Molecular and cellular endocrinology

authors： Chun TY,Bloem L,Pratt JH

更新日期：2002-08-30 00:00:00

abstract：:The enzyme aromatase converts androgens to estrogens, which have recently been postulated to be essential for testicular development and fertility. Understanding the mechanisms that regulate aromatase activity in the testis may therefore have implications for treatment of male infertility. Aromatase is encoded by the ...

journal_title：Molecular and cellular endocrinology

authors： Sierens J,Jakody I,Poobalan Y,Meachem SJ,Knower K,Young MJ,Sirianni R,Pezzi V,Clyne CD

更新日期：2010-07-29 00:00:00

abstract：:This study demonstrates that a single subcutaneous injection of gonadotrophin-releasing hormone (GnRH) (60 ng) to GnRH-deficient (hpg) male mice causes a doubling of pituitary GnRH receptors (GnRH-R). No change in GnRH-R occurs during the time of LH release (15-60 min) or up until 4 h post-GnRH. Between 4 and 12 h the...

journal_title：Molecular and cellular endocrinology

authors： Detta A,Naik SI,Charlton HM,Young LS,Clayton RN

更新日期：1984-09-01 00:00:00

abstract：:Individual variation in sensitivity to glucocorticoids (GCs) poses a dilemma to the clinician. Currently available assays to determine individual sensitivity to GCs either seem imprecise, or they are based on mitogen-activated lymphocytes, although mitogens themselves may affect cellular GC sensitivity. To avoid these...

journal_title：Molecular and cellular endocrinology

authors： Vermeer H,Hendriks-Stegeman BI,van Suylekom D,Rijkers GT,van Buul-Offers SC,Jansen M

更新日期：2004-04-15 00:00:00

abstract：:Gonadotropins (GTHs; FSH and LH) require two major steroidal mediators, estradiol-17 beta (E(2)) and 17 alpha,20 beta-dihydroxy-4-pregnen-3-one (17 alpha,20 beta-DP) to act as critical hormones to execute oocyte growth and maturation, respectively. A two-cell type model has been proposed, where the theca cells provide...

journal_title：Molecular and cellular endocrinology

authors： Senthilkumaran B,Yoshikuni M,Nagahama Y

更新日期：2004-02-27 00:00:00

abstract：:The ovulatory process is characterized by tissue wounding and, after oocyte expulsion, by healing being connected to the formation of a corpus luteum (CL). The ovulatory event thus compares with a sterile inflammation. The concept is forwarded that the ovulatory process depends on innate immunity (INIM) function. The ...

journal_title：Molecular and cellular endocrinology

authors： Spanel-Borowski K

更新日期：2011-02-10 00:00:00

abstract：:Signaling mechanisms for Blaberus discoidalis hypertrehalosemic hormone (Bld-HrTH)-dependent glycogen phosphorylase activation were investigated in vitro using fat body of the tropical cockroach, B. discoidalis. Brief treatment of fat bodies with Bld-HrTH in the absence of extracellular Ca2+ showed a significant activ...

journal_title：Molecular and cellular endocrinology

authors： Park JH,Keeley LL

更新日期：1996-02-05 00:00:00

abstract：:People with Type 2 diabetes mellitus (T2DM) have reduced bone mineral density and an increased risk of fractures due to altered mesenchymal stem cell (MSC) differentiation in the bone marrow. This leads to a shift in the balance of differentiation away from bone formation (osteogenesis) in favour of fat cell developme...

journal_title：Molecular and cellular endocrinology

authors： Chen SC,Brooks R,Houskeeper J,Bremner SK,Dunlop J,Viollet B,Logan PJ,Salt IP,Ahmed SF,Yarwood SJ

更新日期：2017-01-15 00:00:00

abstract：:Inhibin is a member of the TGF-beta superfamily of growth and differentiation factors and a tumor suppressor. Consistent with the tumor suppressive function of the inhibin alpha subunit in prostate cancer, we reported a loss of gene expression due to DNA hypermethylation and loss of heterozygosity (LOH) as well as dow...

journal_title：Molecular and cellular endocrinology

authors： Risbridger GP,Ball EM,Wang H,Mellor SL,Peehl DM

更新日期：2004-10-15 00:00:00

abstract：:Extracellular nucleotides like ATP that activate the Ca2+ -phosphatidylinositol (PI) signalling pathway have been suggested to participate in the regulation of normal human thyroid function. We examined, whether P2y-purinergic receptors are expressed on human thyroid cancer cells and whether post-receptor Ca2+ signall...

journal_title：Molecular and cellular endocrinology

authors： Schöfl C,Rössig L,Mader T,Börger J,Pötter E,von zur Mühlen A,Brabant G

更新日期：1997-09-30 00:00:00