Reduced expression and defective modulation of TNF receptor/ligand family molecules on proB-ALL blasts.

abstract：:Serum IgA deficiency was first noted in a 10 year old boy 8 months after the onset of D-penicillamine therapy. Special immunological examinations revealed a deficiency of the secretory component of IgA while cellular functions of T- and B-lymphocytes were normal. The patient showed discrete clinical signs compatible w...

journal_title：Klinische Padiatrie

authors： Ibel H,Feist D,Endres W,Belohradsky BH

更新日期：1990-11-01 00:00:00

abstract：:The secretory IgA system is common to all mucosal membranes and is presumably of great importance for their defense. In addition to the secretory IgA antibodies produced in a mucosa in response to a local antigenic stimulus there is a spread of this type of IgA response via committed lymphocytes. They originate from c...

journal_title：Klinische Padiatrie

authors： Hanson LA,Andersson B,Carlsson B,Dahlgren U,Mellander L,Porras O,Svanborg Edén C,Söderström T

更新日期：1985-07-01 00:00:00

abstract：:In 25 very low birth weight infants appropriate for gestational age the influences of different human milk (HM) preparations on weight gain, gross indices of nitrogen metabolism and energy balance were studied during the second month of postnatal life. HM was fortified either by HM-protein (HMP) or by an enzymatic mea...

journal_title：Klinische Padiatrie

authors： Boehm G,Senger H,Friedrich M,Müller DM,Beyreiss K

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:Supraventricular reentrant tachycardias are the most common cardiac arrhythmia observed in infancy and childhood. The often benign clinical course of the disease warrants careful selection of any antiarrhythmic drug given to prevent recurrencies, in order to avoid potentially dangerous side-effects such as p...

journal_title：Klinische Padiatrie

authors： Pfammatter JP,Weber JW,Stocker FP

更新日期：1998-09-01 00:00:00

abstract：UNLABELLED:Sickle cell disease is a chronic hematologic disease with variable but often severe systemic symptoms. In this report, we describe a 6-year-old boy presenting with acute bowel pseudo-obstruction. During this episode, previously undiagnosed sickle cell disease was discovered upon peripheral blood smear analys...

journal_title：Klinische Padiatrie

authors： Knorr M,Bienemann K,Walde G,Kaufhold A,Schündeln MM

更新日期：2014-11-01 00:00:00

abstract：UNLABELLED:It was the aim of the cooperative therapy study HD-82 for children with Hodgkin's disease to reduce chemo- and radiotherapy and to investigate of a strategy for selective splenectomy previously developed in the Hodgkin study HD-78. Between December 1981 and December 1984 207 patients (131 boys and 76 girls) ...

journal_title：Klinische Padiatrie

authors： Schellong G,Brämswig J,Ludwig R,Gerein V,Jobke A,Jürgens H,Kabisch H,Stollmann B,Weinel P,Gadner H

更新日期：1986-05-01 00:00:00

abstract：:Iron concentration was determined by the aid of the ESA Ferrochem 3050 analyzer and the bathophenanthroline method with deproteinization. Both methods showed a good precision and accuracy. The investigation was carried out in 505 sera with an iron concentration between 9 and 333 micrograms/dl. The comparison of the tw...

journal_title：Klinische Padiatrie

authors： Liappis N

更新日期：1982-01-01 00:00:00

abstract：:The oscillatory resistance to respiration (Ros) was measured in 218 children and 260 adults using the Siregnost FD5 (Siemens, Erlangen), and compared with whole body plethysmography (Raw) and with spirometry. There was a markedly better correlation between Ros and Raw (r=0.82;n=88) in children than in adults (r=0.53;n...

journal_title：Klinische Padiatrie

authors： Berdel D,Holle JP,Hartmann V,Magnussen H

更新日期：1981-03-01 00:00:00

abstract：:Cytological examination of cerebrospinal fluid needs special techniques of cell collecting and staining. On condition of realizing the methodical requirements cytology of the cerebrospinal fluid brings more advancement in diagnostics than other laboratory examinations. The advantages of this procedure are: 1. Meningit...

journal_title：Klinische Padiatrie

authors： Harms D

更新日期：1975-03-01 00:00:00

abstract：BACKGROUND:One of the strongest predictive factors for therapy outcome in childhood acute lymphoblastic leukaemia (ALL), treated according to ALL-BFM protocols, is the response to initial prednisone treatment. Prednisone response is characterized by the peripheral leukaemic blast count. The threshold value for the char...

journal_title：Klinische Padiatrie

authors： Lauten M,Stanulla M,Zimmermann M,Welte K,Riehm H,Schrappe M

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Current resuscitation guidelines recommend the use of simulation-based medical education (SBME) as an instructional methodology to improve patient safety and health. We sought to investigate the evidence-base for the effectiveness of SBME for neonatal and pediatric resuscitation training. METHOD:Therefore, ...

journal_title：Klinische Padiatrie

authors： Mileder LP,Urlesberger B,Szyld EG,Roehr CC,Schmölzer GM

更新日期：2014-09-01 00:00:00

abstract：:The article reports on the case history of a 8 month old baby who fell ill of a ileocolic intussusception. The barium enema demonstrated the typical cupping in the head of the barium. The successful reposition by hydrostatic pressure was manifest by barium reflux in the small intestine. ...

journal_title：Klinische Padiatrie

authors： Klingmüller V

更新日期：1983-07-01 00:00:00

abstract：:Prognostic factors to estimate the risk of relapse are crucial for risk-adapted therapy in acute lymphoblastic leukemia (ALL). In a cooperative multicenter treatment study for childhood ALL (COALL-03-85) the prognostic relevance of the bone marrow (BM) blast count at day 28 was evaluated. Treatment was adjusted to the...

journal_title：Klinische Padiatrie

authors： Janka-Schaub GE,Stührk H,Kortüm B,Graubner U,Jürgens H,Spaar HJ,Schöck V,Dohrn B,Bahr R,Winkler K

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:The considerable increase of obesity in children and adolescents poses a major challenge to the health care system. METHODS:In an observation study of the Bundeszentrale für gesundheitliche Aufklärung (BZgA) somatic data of 1916 overweight and obese children and adolescents aged 8-17 years were compared to ...

journal_title：Klinische Padiatrie

authors： Flechtner-Mors M,Thamm M,Rosario AS,Goldapp C,Hoffmeister U,Mann R,Bullinger M,van Egmond-Fröhlich A,Ravens-Sieberer U,Reinehr T,Westenhöfer J,Holl RW

更新日期：2011-12-01 00:00:00

abstract：:The rapid institution of empirical broad-spectrum antibiotics has become the gold standard of treatment for febrile neutropenic children undergoing therapy for cancer. With this approach, morbidity and mortality have dropped significantly but have not been eliminated altogether. In recent randomized studies evaluating...

journal_title：Klinische Padiatrie

authors： Laws HJ,Ammann RA,Lehrnbecher T

更新日期：2005-11-01 00:00:00

abstract：:In children with primary immunodeficiencies, the onset of symptoms precedes the diagnosis and the initiation of appropriate treatment by months or years. This delay in diagnosis is due to the fact that while these disorders are rare, some of the infections seen in immunodeficient patients are common. Defective antibod...

journal_title：Klinische Padiatrie

authors： Vancikova Z,Freiberger T,Vach W,Trojanek M,Rizzi M,Janda A

更新日期：2013-11-01 00:00:00

abstract：:The best nutrient for newborn babies is breast milk and preferably provided via breast feeding. Pooled human milk must be used when the babies' own mother's milk is not available. Very often pooled milk is pasteurised. Recent studies, however, suggest avoidance of any sterilisation procedures in view of the decreased ...

journal_title：Klinische Padiatrie

authors： Ikonen RS,Miettinen A,Grönroos P

更新日期：1982-09-01 00:00:00

abstract：BACKGROUND:Modern neonatal and pediatric intensive care includes a sophisticated pharmacotherapy with numerous drugs, mainly administered intravenously. Often, despite the use of multi-lumen central venous lines, more peripheral venous accesses are required. To reduce the necessity of numerous venous lines on one hand ...

journal_title：Klinische Padiatrie

authors： Höpner JH,Schulte A,Thiessen J,Knuf M,Huth RG

更新日期：2007-01-01 00:00:00

abstract：:Severe combined immunodeficiency (SCID) is a heterogeneous group of congenital diseases characterized by their presentation with life threatening infections in the first months of life. The clinical presentation and the therapeutic outcome is influenced by multiple factors: the genetic defect, infectious complications...

journal_title：Klinische Padiatrie

authors： Hönig M,Schulz A,Friedrich W

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Children suffering from life limiting diseases are frequently cared for by adult palliative care teams due to missing paediatric structures in that field. However it is questionable whether palliative care curricula for physicians comprehensively cover issues of paediatric palliative care (PaedPC). AIM:To i...

journal_title：Klinische Padiatrie

authors： Schiessl C,Gottschling S,Gronwald BM

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:First-line treatment in AML commonly included high cumulative doses of anthracyclines with an increasing risk of cardiotoxicity. Liposomal daunorubicin (L-DNR) is thought to be less cardiotoxic without impairment of efficacy. METHODS:The AML-BFM REZ 97 study included two reinduction blocks with L-DNR (2 x 6...

journal_title：Klinische Padiatrie

authors： Reinhardt D,Hempel G,Fleischhack G,Schulz A,Boos J,Creutzig U

更新日期：2002-07-01 00:00:00

abstract：:Initially a right sided pulmonary hypoplasia was diagnosed in our patient at the age of 9 years. The previous years were characterized by recurrent pneumonia, bronchitis and daily coughing fits. Findings of the chest radiograph suggested the diagnosis of right sided hypoplasia. The right hemithorax was small with medi...

journal_title：Klinische Padiatrie

authors： Riedler J,Rettenbacher L,Weiss P

更新日期：1990-03-01 00:00:00

abstract：:A paralysis of the left vocal cord was seen by laryngoscopy in a 3-days-old boy with inspiratory stridor. A ductus aneurysm was established by angiocardiography, which was believed to be the cause of the vocal cord paralysis. Within 8 days after the angiocardiography the aneurysm became smaller and the stridor disappe...

journal_title：Klinische Padiatrie

authors： Scharf J,Richter K,Singer H,Deeg KH

更新日期：1986-01-01 00:00:00

abstract：:Neurological symptoms developed in a girl aged three-and-a-half years during treatment with nalidixic acid. The symptoms progressed even after the preparation had been discontinued, and culminated in the development of a transient intracranial pressure increase. ...

journal_title：Klinische Padiatrie

authors： Lorenz R

更新日期：1979-07-01 00:00:00

abstract：:Central nervous system (CNS) tumors account for the highest mortality among pediatric malignancies. Accurate diagnosis is essential for optimal clinical management. The increasing use of molecular diagnostics has opened up novel possibilities for more precise classification of CNS tumors. We here report a single-insti...

journal_title：Klinische Padiatrie

authors： Bächli H,Ecker J,van Tilburg C,Sturm D,Selt F,Sahm F,Koelsche C,Grund K,Sutter C,Pietsch T,Witt H,Herold-Mende C,von Deimling A,Jones D,Pfister S,Witt O,Milde T

更新日期：2018-10-01 00:00:00

abstract：:The aetiology and pathogenesis of the Duchenne-type muscular dystrophy (pseudohypertrophic muscular dystrophy) are still largely unknown. The possibilities of treating the disease are rather limited. Treatment is the more successful, the earlier diagnosis was possible, and the earlier treatment is initiated. The CK-Sc...

journal_title：Klinische Padiatrie

authors： Beckmann R

更新日期：1978-11-01 00:00:00

abstract：:23 children with acute spinal syndromes are presented. The clinical signs were caused by trauma in 11 patients, by extramedullary tumors in 6, by operations (coarctation of the aorta, scoliosis) in 4 and by encephalomyelitis in 2. Motor signs (flaccid paraplegia or paraparesis, monoplegia, bilateral weakness) and chan...

journal_title：Klinische Padiatrie

authors： Bode H,Bubl R,Hefti F,Signer E,Wyler F

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:Acute viral bronchiolitis is a frequent disease in infancy. There is little knowledge on medical care of severely affected infants in different European countries. PATIENTS:Infants (n=146) with bronchiolitis requiring respiratory support in winter season 2015/2016 treated in either one of two regions in Cen...

journal_title：Klinische Padiatrie

authors： Dohna-Schwake C,Mücher K,Stehling F,Rothoeft T,Roll C,Brevis Nuńez F,Seiffert P,Heister P,Hofmann M,Stein A,Jacobs A,Zuzak T,Durand P,Felderhoff-Müser U,Tissières P

更新日期：2018-09-01 00:00:00

abstract：:During the last 6 years 73 previously untreated children and adolescents with acute lymphoblastic leukemia were enrolled on a non-randomized therapy protocol. In this longitudinal study the specific accent was put on the intensified induction treatment of 8 weeks' duration which was thought to achieve a higher remissi...

journal_title：Klinische Padiatrie

authors： Riehm H,Gadner H,Welte K

更新日期：2013-05-01 00:00:00

abstract：:A boy aged 15 years is described in whom a combined autoimmune neutro- and thrombocytopenia developed since the age of 11. Cell-membrane bound IgG antibodies were detected on neutrophils and platelets. A therapy with prednisone and/or immunoglobulins showed only a transient normalization of the peripheral blood values...

journal_title：Klinische Padiatrie

authors： Schneider H,Jobke A,Böhm N

更新日期：1988-01-01 00:00:00