[Initial response to therapy as an important prognostic factor in acute lymphoblastic leukemia in childhood. COALL study group].

Abstract:

:Prognostic factors to estimate the risk of relapse are crucial for risk-adapted therapy in acute lymphoblastic leukemia (ALL). In a cooperative multicenter treatment study for childhood ALL (COALL-03-85) the prognostic relevance of the bone marrow (BM) blast count at day 28 was evaluated. Treatment was adjusted to the initial risk factors; patients with high risk (white blood count (WBC) greater than or equal to 25/nl, age greater than or equal to 10 years, T- or NULL-ALL) received intensified therapy consisting of rotation of 6 non cross-resistant drug combinations with 12 different agents. After 4 weeks 289/305 (94.8%) children were in complete remission (CR); one child died of infection, and 15 (14 high-risk patients) still had more than 5% blasts in the BM. Twelve of these 15 patients were in remission after 2 to 4 weeks additional treatment. Poor responders often had a high initial WBC, age above 10 years of T- or NULL-ALL. In spite of continuation of intensive therapy all children with more than 10% blasts in the BM on day 28 suffered an early relapse except 2 who were transplanted in first remission. Event-free survival for the poor responders is 0.15 compared to 0.71 (p = 0.0001) for the good responders (median observation time 48 months). In multivariate analysis remission status on day 28 was the only significant prognostic factor in high-risk patients above one year of age; traditional risk factors as initial WBC, age above 10 years, hepatosplenomegaly, and immunological subtype were of no prognostic significance in this study. (ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Klin Padiatr

journal_title

Klinische Padiatrie

authors

Janka-Schaub GE,Stührk H,Kortüm B,Graubner U,Jürgens H,Spaar HJ,Schöck V,Dohrn B,Bahr R,Winkler K

doi

10.1055/s-2007-1025434

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

231-5

issue

4

eissn

0300-8630

issn

1439-3824

journal_volume

203

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Long-term outcome after neonatal parenchymatous brain lesions.

    abstract:BACKGROUND:Although considered of high prognostic impact, knowledge on the long-term outcome after neonatal parenchymatous brain lesions (PBL) is limited. PATIENTS:29 children with either unilateral (n = 19) or bilateral (n = 10) hemorrhagic/ischemic PBL. METHODS:The patients were reinvestigated at 9 9/12 +/- 3 4/12 ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2004-44900

    authors: Häusler M,Merz U,Van Tuil C,Ramaekers VT

    更新日期:2004-07-01 00:00:00

  • [Comparison of the acetylcholine receptor antibody titer and clinical course in neonatal myasthenia].

    abstract::Ten to fifteen percent of infants of myasthenic mothers develop neonatal myasthenia independent of the severity of the maternal disease. The antiacetylcholin receptor-protein antibodytiter (AChR-AK) was followed through the first twelve months in a boy who's mother suffered from myasthenia gravis (M.G.) since twelve y...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034089

    authors: Lischka A,Grisold W,Pollak A,Zeitelhofer J,Riegler R,Weninger M

    更新日期:1984-09-01 00:00:00

  • A Snapshot of Pediatric Patients with COVID-19 in a Pandemic Hospital.

    abstract:AIM:Reports describing coronavirus disease 2019 (Covid-19) in children are fewer than adult studies due to milder clinical picture. We aimed to share our experience at a single center with an emphasis on collective decision making. MATERIALS AND METHODS:A suspected case was defined as the presence of symptoms suggesti...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/a-1263-1222

    authors: Duramaz BB,Turel O,Korkmaz C,Karadogan MT,Yozgat CY,Iscan A,Sümbül B,Erenberk U

    更新日期:2021-01-01 00:00:00

  • [Cytogenetic aspects of pediatric germ cell tumors].

    abstract::We have performed in situ hybridization (ISH) studies predominantly on paraffin sections and on isolated nuclei of 22 pediatric germ cell tumors (GCTs) from 18 patients including 4 recurrences from three patients. In addition, we performed conventional cytogenetic analyses in three tumor samples. Because reports on cy...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1046547

    authors: Stock C,Ambros IM,Strehl S,Zoubek A,Fink FM,Gadner H,Ambros PF

    更新日期:1995-07-01 00:00:00

  • Evaluation of desmopressin effect on primary haemostasis in pediatric patients with aspirin-like defect as hereditary thrombocytopathy.

    abstract:OBJECTIVES:Despite about 3 decades of clinical experience with the therapy of inherited thrombocytopathies (HTP) with desmopressin (DDAVP) the mechanisms of haemostatic effects of DDAVP in these diseases remain unclear. Therefore platelet function diagnostics was carried out in whole blood (WB) from children with aspir...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-0031-1275347

    authors: Tauer JT,Gneuss A,Lohse JE,Jürgens T,Knöfler R

    更新日期:2011-05-01 00:00:00

  • Congenital erythrocytosis and polycythemia vera in childhood and adolescence.

    abstract::Polycythemia vera - the most frequent form of a primary erythrocytosis in adult patients - represents an extremely rare disease in pediatric and juvenile patients as do congenital primary and secondary erythrocytoses. Frequently, in patients with these diseases clinical problems do not occur before adulthood. Systemat...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2004-822628

    authors: Cario H,Schwarz K,Debatin KM,Kohne E

    更新日期:2004-05-01 00:00:00

  • [Delay of constitutional development--studies on therapy with growth hormone].

    abstract::Human growth hormone was given to 6 boys with constitutional delay of growth and development. Three patients had normal growth hormone responses following exercise or insulin-induced hypoglycemia. Subnormal growth rate (less than 2 SD below normal for bone age) was found in 4 patients. The mean growth rate of the pati...

    journal_title:Klinische Padiatrie

    pub_type: 临床试验,杂志文章

    doi:10.1055/s-2007-1025580

    authors: Butenandt O

    更新日期:1984-03-01 00:00:00

  • Bacteriological quality control in a human milk bank.

    abstract::The best nutrient for newborn babies is breast milk and preferably provided via breast feeding. Pooled human milk must be used when the babies' own mother's milk is not available. Very often pooled milk is pasteurised. Recent studies, however, suggest avoidance of any sterilisation procedures in view of the decreased ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1033821

    authors: Ikonen RS,Miettinen A,Grönroos P

    更新日期:1982-09-01 00:00:00

  • [Hypertension, dyslipoproteinemia and BMI-category characterise the cardiovascular risk in overweight or obese children and adolescents: data of the BZgA-observational study (EvAKu-J-project) and the KiGGS-study].

    abstract:BACKGROUND:The considerable increase of obesity in children and adolescents poses a major challenge to the health care system. METHODS:In an observation study of the Bundeszentrale für gesundheitliche Aufklärung (BZgA) somatic data of 1916 overweight and obese children and adolescents aged 8-17 years were compared to ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-0031-1280766

    authors: Flechtner-Mors M,Thamm M,Rosario AS,Goldapp C,Hoffmeister U,Mann R,Bullinger M,van Egmond-Fröhlich A,Ravens-Sieberer U,Reinehr T,Westenhöfer J,Holl RW

    更新日期:2011-12-01 00:00:00

  • [Acute erythromelalgia with hypertension in a 5-year old boy].

    abstract:BACKGROUND:Burning pain of red and warm hands and/or feet are the classical symptoms of erythromelalgia. CASE REPORT:We describe the symptoms of acute idiopathic erythromelalgia and arterial hypertension in a five-year-old boy. Five days after a gastroenteritis the patient developed burning hands and feet in combinati...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1043837

    authors: Zenz W,Zöhrer B,Zobel G,Schulze-Bauer C

    更新日期:1999-11-01 00:00:00

  • [Postoperative sonographic follow-up of brain tumors in childhood].

    abstract::Postoperative neurosonography was performed in 69 babies and children after osteoclastic neurosurgery for primary cerebral tumors. Astrocytoma of the posterior fossa (26 cases) and medulloblastoma (25 cases) were frequent histological findings. Early postoperative bed-side examinations revealed reliably complications ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1026831

    authors: Dittrich M,Gutjahr P,Dinkel E,Higer HP,Müller W

    更新日期:1987-11-01 00:00:00

  • [Analysis of a Family-centred Care Programme with Follow-up Home-visits in Neonatology - In Times of the Directive from G-BA].

    abstract:BACKGROUND:Marked progress in neonatology changed care of very preterm infants (VLBW) over the last decades - but also the attitude towards family-centred care (FCC). With the directive of the German Federal Joined Committee (G-BA), politicians recognize the necessity of neonatal FCC. AIM:To evaluate time and personne...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-0042-102787

    authors: Hüning BM,Reimann M,Sahlmen S,Leibold S,Nabring JC,Felderhoff-Müser U

    更新日期:2016-07-01 00:00:00

  • [Malignant testicular tumors in children and adolescents: concept of the MAHO 82 cooperative therapeutic study of the Society for Pediatric Oncology].

    abstract::The German Society of Pediatric Oncology (GPO) designed a cooperative study to improve the outlook of patients with malignant (testicular) germ cell tumors. According to stage and histology of the tumor different surgical approaches to retroperitoneal lymphadenectomy are suggested. Local radiotherapy is not recommende...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034068

    authors: Haas RJ,Brämswig J,Göbel U,Harms D,Janka G,Weissbach L

    更新日期:1983-05-01 00:00:00

  • [Doppler echocardiographic investigation of left ventricular diastolic function in preterm infants with and without a patent ductus arteriosus].

    abstract::We studied the influence of preload augmentation on Doppler-derived left ventricular diastolic function parameters in infants with a birth weight <1500 g. In 44 neonates with a closed duct and 29 neonates with an open ductus arteriosus a complete echocardiographic study including Doppler investigations of the mitral i...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2004-817684

    authors: Schmitz L,Stiller B,Koehne P,Koch H,Lange PE

    更新日期:2004-01-01 00:00:00

  • [Antacids for postoperative prevention of stress ulcer in infants: a dose finding study].

    abstract:UNLABELLED:In the prophylaxis of stress ulcers with antacids in young infants there are no recommendations of dosages that consider the physiologic maturation of gastric acid secretion. During the first six month of life the amount of gastric acid secretion in relation to body weight and body surface area increases exp...

    journal_title:Klinische Padiatrie

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1055/s-2008-1043985

    authors: Kentrup H,Skopnik H,Wolter L,Engelhart W,Nauert C,Heimann G

    更新日期:1996-01-01 00:00:00

  • [Arteriovenous intracranial and extracranial angiomas in infants and children (author's transl)].

    abstract::Five patients with arteriovenous angiomas in the head (2 galea angiomas, 1 mixed form with extracranial and intracranial localization of the arteriovenous fistulas and 2 intracranial arteriovenous fistulas) were described. Four patients were examined as newborns or infants. Oximetric data, intracardial pressure and ci...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:

    authors: Pohl V

    更新日期:1976-05-01 00:00:00

  • [Neoadjuvant therapy for localized osteosarcoma of extremities. Results from the Cooperative osteosarcoma study group COSS of 925 patients].

    abstract:BACKGROUND:Owing to twenty years of multicentric interdisciplinary cooperation, the COSS group has been able to collect data on a large group of osteosarcoma patients treated by neoadjuvant therapy. This paper reviews results achieved in patients with localized extremity tumors. PATIENTS AND METHODS: INCLUSION CRITER...

    journal_title:Klinische Padiatrie

    pub_type: 临床试验,杂志文章

    doi:10.1055/s-2008-1043798

    authors: Bielack S,Kempf-Bielack B,Schwenzer D,Birkfellner T,Delling G,Ewerbeck V,Exner GU,Fuchs N,Göbel U,Graf N,Heise U,Helmke K,von Hochstetter AR,Jürgens H,Maas R,Münchow N,Salzer-Kuntschik M,Treuner J,Veltmann U,Werner

    更新日期:1999-07-01 00:00:00

  • [Neonatal form of a nonketotic hyperglycinemia in consanguinous parents].

    abstract::This is a report of the neonatal form of nonketotic hyperglycinemia with rapid progressing neurological symptoms, respiratory distress and seizures. The EEG pattern is characteristic, the ratio of cerebrospinal fluid to plasma glycine abnormally high. The result of cranial computerized tomography demonstrates also in ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2007-1025473

    authors: Plöchl E,Rittinger O,Doringer E,Laubichler W

    更新日期:1991-11-01 00:00:00

  • Ceftriaxone alone or in Combination with Teicoplanin in the Management of Febrile Episodes in Neutropenic Children and Adolescents with Cancer on an Outpatient Base.

    abstract:STUDY OBJECTIVE:This study prospectively investigated the outpatient once daily therapy with ceftriaxone alone or if necessary in combination with teicoplanin, in the treatment of infections in children and adolescents with chemotherapy-induced neutropenia or aplastic anemia. PATIENTS:42 patients 1-22 years of age suf...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2007-1025240

    authors: Preis S,Jürgens H,Friedland C,Oudekotte-David AA,Thomas L,Göbel U

    更新日期:1993-07-01 00:00:00

  • Megestrol acetate to correct the nutritional status in an adolescent with growth hormone deficiency: Increase of appetite and body weight but only by increase of body water and fat mass followed by profound cortisol and testosterone depletion.

    abstract::Megestrol acetate (MA) is a synthetic, orally active derivative of the naturally occurring hormone progesterone. MA is increasingly used to correct loss of appetite and improve the nutritional status. We used MA in an adolescent with growth hormone (GH) deficiency due to former irradiation therapy in order to evaluate...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2002-25268

    authors: Schmid I,Stachel DK,Freudenberg S,Schmitt M,Schuster F,Haas RJ

    更新日期:2002-03-01 00:00:00

  • Early and long term outcome in children with esophageal atresia treated over the last 22 years.

    abstract:BACKGROUND:The survival of infants born with esophageal atresia (EA) is > 90% at present. The purpose of this study was to evaluate early complications and long term outcome in children with EA treated at our institution. METHODS AND PATIENTS:Retrospective analysis of 111 children with EA undergoing repair of EA or tr...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-0030-1249610

    authors: Lacher M,Froehlich S,von Schweinitz D,Dietz HG

    更新日期:2010-09-01 00:00:00

  • [Validity of a parent questionnaire for identification of children with developmental language disorders at the age of 3 years (SBE-3-KT)].

    abstract:BACKGROUND:Up to now, no German language test for children has been controlled for diagnostic accuracy. Therefore the application of language tests in clinical diagnostics is limited. The aim of the study was to determine the diagnostic validity of the SBE-3-KT, a parent questionnaire for identification of children wit...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-0030-1267156

    authors: Tippelt S,Kademann S,von Suchodoletz W

    更新日期:2010-12-01 00:00:00

  • [Anaerobic microflora of praepubertal children (author's transl)].

    abstract::Bacteriologic cultures of the vagina and the cervix of 38 praepubertal children, aged 3 months to 16 years (average age 9 years) from the outpatient department for infants and juveniles of the 1st Department of Obstetrics and Gynecology of the University of Vienna were obtained vaginascopically using anaerobic transpo...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1033769

    authors: Gerstner G,Boschitsch E,Grünberger W,Rotter M

    更新日期:1982-01-01 00:00:00

  • Congenital Central Hypoventilation Syndrome due to PHOX2b gene defects: inheritance from asymptomatic parents.

    abstract:BACKGROUND:Congenital Central Hypoventilation Syndrome (CCHS, Ondine's curse) is a rare syndrome of dysfunction of the autonomic nervous system characterized by a decreased response to hypercarbia requiring mechanical ventilation in most cases. CCHS is an autosomal-dominant disease associated with tumors of neural cres...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-0029-1220941

    authors: Hammel M,Klein M,Trips T,Priessmann H,Ankermann T,Holzinger A

    更新日期:2009-09-01 00:00:00

  • Adenoviral infections after transplantation of positive selected stem cells from haploidentical donors in children: an update.

    abstract:UNLABELLED:We present updated results of stem cell transplantation with highly purified stem cells from haploidentical parental donors and infection with human adenovirus (HAdV) post stem cell transplantation (SCT). Survival post SCT is primarily determined by relapse, infections and far less by GvHD or other transplan...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2005-872530

    authors: Feuchtinger T,Richard C,Pfeiffer M,Neuhäuser F,Lücke J,Handgretinger R,Greil J,Bader P,Klingebiel T,Schlegel PG,Jahn G,Niethammer D,Lang P

    更新日期:2005-11-01 00:00:00

  • [Septicaemia in the neonatal and infant period (author's transl)].

    abstract::The paper reported about septicaemia in the neonatal and infant period. Continuing former investigations by Kienitz in the same pediatric clinic we have got a survey from 1933 to 1974. In the last years we saw increasingly more infections with gram-negative organisms, especially by Pyocyaneus with a severe prognosis. ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:

    authors: Diekmann L,Kotzur J

    更新日期:1976-03-01 00:00:00

  • Painful scoliosis.

    abstract::In case of painful scoliosis, a search for etiologic factors in the vertebral spinal canal and adjacent structures should be made. MRI with Gadolinium is useful to look for various pathology in and around the spine in particular of spinal cord. CT scanning is indispensible for bony details. Thus CT and MRI are complem...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1043932

    authors: Hoeffel C,Gaucher H,Hoeffel JC,Galloy MA,Arnould V

    更新日期:1997-03-01 00:00:00

  • [Non-immunologic hydrops fetalis (NIHF)--case report of double partial trisomy 15q and 17q resulting from familial translocation 15/17 and cytogenetic findings in 50 cases with hydrops fetalis].

    abstract::We report the first case of non-immune hydrops fetalis (NIHF) with trisomy 15q11/17q22.5 resulting from a familial translocation 15/17. Furthermore the cytogenetic findings of 50 cases with hydrops fetalis are presented. Of the 30 cytogenetic analyzable cases 7 showed chromosomal abnormalities (4x45,X; 2x47,XY,+21; 1x...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1026810

    authors: Schmid G,Haverkamp F,Rechmann J,Schwanitz G,Zerres K,Hansmann M,Kowalewski S

    更新日期:1987-07-01 00:00:00

  • [Supplementary intravenous nutrition in term and preterm neonates (author's transl)].

    abstract::16 term and preterm neonates received intravenous nutriton for at least three days. The dosage was 1--2 g amino acids, 1 g of fat, and 8--10 g glucose per kg body weight and day. Compatibility was investigated by daily determinations of the amino acid pattern in the serum and measurement of free fatty acids and trigly...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:

    authors: Petrich C,Stephan U,Remy R,von Voss H,Göbel U,Herpertz LM

    更新日期:1979-07-01 00:00:00

  • [Invagination: diagnosis and conservative therapy].

    abstract::The article reports on the case history of a 8 month old baby who fell ill of a ileocolic intussusception. The barium enema demonstrated the typical cupping in the head of the barium. The successful reposition by hydrostatic pressure was manifest by barium reflux in the small intestine. ...

    journal_title:Klinische Padiatrie

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034383

    authors: Klingmüller V

    更新日期:1983-07-01 00:00:00