CED-9 and mitochondrial homeostasis in C. elegans muscle.

abstract：:Glycosylphosphatidylinositol-anchored proteins on the egg surface have been proposed to play a role in gamete fusion on the basis of in vitro experiments. We tested this hypothesis by asking if oocyte GPI-anchored proteins are required for fertilization in vivo. Oocyte-specific knockout mice were created using the Cre...

journal_title：Journal of cell science

authors： Alfieri JA,Martin AD,Takeda J,Kondoh G,Myles DG,Primakoff P

更新日期：2003-06-01 00:00:00

abstract：:Embryonal rhabdomyosarcomas (ERMSs) show elevated levels of PAX7, a transcription factor that marks quiescent adult muscle stem (satellite) cells and is important for proliferation and survival of activated satellite cells and whose timely repression is required for myogenic differentiation. However, the mechanism of ...

journal_title：Journal of cell science

authors： Riuzzi F,Sorci G,Sagheddu R,Sidoni A,Alaggio R,Ninfo V,Donato R

更新日期：2014-04-15 00:00:00

abstract：:The interplay between pathogen-encoded virulence factors and host cell signaling networks is critical for both the establishment and clearance of microbial infections. Yersinia uptake into host cells serves as an in vitro model for exploring how host cells respond to Yersinia adherence. In this study, we provide insig...

journal_title：Journal of cell science

authors： Bruce-Staskal PJ,Weidow CL,Gibson JJ,Bouton AH

更新日期：2002-07-01 00:00:00

abstract：:The effect of a synthetic peptide consisting of Arg-Gly-Asp-Ser (RGDS), the amino acid sequence representing the fibroblast attachment site in fibronectin (FN), was tested on migrating newt epidermal cells. In one approach, skin explants were placed on the bottom of plastic dishes coated with human FN, human fibrinoge...

journal_title：Journal of cell science

authors： Donaldson DJ,Mahan JT,Smith GN Jr

更新日期：1987-05-01 00:00:00

abstract：:To clarify the involvement of actin in the formation of the yeast cell wall, reverting protoplasts of Schizosaccharomyces pombe were used as a simple model system. Actin of reverting protoplasts was labeled with rhodamine-conjugated phalloidin and observed by conventional fluorescence microscopy and laser scanning con...

journal_title：Journal of cell science

authors： Kobori H,Yamada N,Taki A,Osumi M

更新日期：1989-12-01 00:00:00

abstract：:When cultured human lymphocytes (IM-9) are exposed to 10(-6) M procine insulin for 6 h, washed, and incubated with 125I-insulin, the ability of the cell to bind the labelled hormone is reduced by a mean of 78%. Under these experimental conditions that induce insulin-receptor loss in this cell there is a mean 95% incre...

journal_title：Journal of cell science

authors： Gordon P,Carpentier JL,Van Obberghen E,Barazzone P,Roth J,Orci L

更新日期：1979-10-01 00:00:00

abstract：:African trypanosomes undergo extensive changes in cellular morphology, biochemistry and surface antigen expression as they differentiate from their bloodstream form to those forms that colonise the midgut of their tsetse fly vector. If initiated with stumpy-form cells, a non-dividing sub-type of the bloodstream parasi...

journal_title：Journal of cell science

authors： Matthews KR,Gull K

更新日期：1997-10-01 00:00:00

abstract：:Cells are internally organized into compartmentalized organelles that execute specialized functions. To understand the functions of individual organelles and their regulations, it is critical to resolve the compositions of individual organelles, which relies on a rapid and efficient isolation method for specific organ...

journal_title：Journal of cell science

authors： Xiong J,He J,Xie WP,Hinojosa E,Ambati CSR,Putluri N,Kim HE,Zhu MX,Du G

更新日期：2019-12-13 00:00:00

abstract：:The serine/threonine protein phosphatase-1 (PP1) complex is a key regulator of the cell cycle. However, the redundancy of PP1 isoforms and the lack of specific inhibitors have hampered studies on the global role of PP1 in cell cycle progression in vertebrates. Here, we show that the overexpression of nuclear inhibitor...

journal_title：Journal of cell science

authors： Winkler C,De Munter S,Van Dessel N,Lesage B,Heroes E,Boens S,Beullens M,Van Eynde A,Bollen M

更新日期：2015-12-15 00:00:00

abstract：:The effects of two inhibitors of 3-hydroxy 3-methyl glutaryl-coenzyme A reductase (tunicamycin and mevinolin) on nuclear division in the myxomycete Physarum polycephalum were examined. Tunicamycin exerted a minor effect on division in synchronized cultures, whereas mevinolin delayed the second, third and fourth nuclea...

journal_title：Journal of cell science

authors： Engström W,Larsson O,Sachsenmaier W

更新日期：1989-03-01 00:00:00

abstract：:A specific mechanism for the intracellular translocation of nonvesicle-associated proteins is proposed. This movement machinery is based on the assumption that the cytoskeleton represents an interconnected network of filamentous macromolecules, which extends over the entire cytoplasm. Diffusion along the filaments pro...

journal_title：Journal of cell science

authors： Shafrir Y,ben-Avraham D,Forgacs G

更新日期：2000-08-01 00:00:00

abstract：:Actin polymerization is a crucial process during sperm capacitation. We have recently described the participation of FAK during actin polymerization in guinea pig spermatozoa. However, the mechanism by which FAK mediates these processes is unknown. Our previous data have shown that MAPK1 (hereafter referred to as ERK2...

journal_title：Journal of cell science

authors： Salgado-Lucio ML,Ramírez-Ramírez D,Jorge-Cruz CY,Roa-Espitia AL,Hernández-González EO

更新日期：2020-04-28 00:00:00

abstract：:Regulation of cell-cell contacts is essential for integrity of the vascular endothelium. Here, a critical role of the F-actin-binding protein drebrin in maintaining endothelial integrity is revealed under conditions mimicking vascular flow. Drebrin knockdown leads to weakening of cell-cell contacts, characterized by l...

journal_title：Journal of cell science

authors： Rehm K,Panzer L,van Vliet V,Genot E,Linder S

更新日期：2013-08-15 00:00:00

abstract：:Podosomes, adhesion structures capable of matrix degradation, have been linked with the ability of cells to perform chemotaxis and invade tissues. Wiskott-Aldrich Syndrome protein (WASp), an effector of the RhoGTPase Cdc42 and a Src family kinase substrate, regulates macrophage podosome formation. In this study, we de...

journal_title：Journal of cell science

authors： Dovas A,Gevrey JC,Grossi A,Park H,Abou-Kheir W,Cox D

更新日期：2009-11-01 00:00:00

abstract：:The adaptive immune response depends on the interaction of T cells and antigen-presenting cells at the immune synapse. Formation of the immune synapse and the subsequent T-cell activation are highly dependent on the actin cytoskeleton. In this work, we describe that T cells express drebrin, a neuronal actin-binding pr...

journal_title：Journal of cell science

authors： Pérez-Martínez M,Gordón-Alonso M,Cabrero JR,Barrero-Villar M,Rey M,Mittelbrunn M,Lamana A,Morlino G,Calabia C,Yamazaki H,Shirao T,Vázquez J,González-Amaro R,Veiga E,Sánchez-Madrid F

更新日期：2010-04-01 00:00:00

abstract：:There is a limited number of methods to examine transbilayer lipid distribution in biomembranes. We employed freeze-fracture replica-labelling immunoelectron microscopy in combination with lipid-binding proteins and a peptide to examine both transbilayer distribution and lateral distribution of various phospholipids i...

journal_title：Journal of cell science

authors： Murate M,Abe M,Kasahara K,Iwabuchi K,Umeda M,Kobayashi T

更新日期：2015-04-15 00:00:00

abstract：:To examine the role of the keratin head region and its subdomains in filament assembly we constructed several deletion mutants of type I and type II keratins and analysed their in vitro IF forming capacity. The delta K8 (1-74) and delta K18 (1-56), mutants formed only soluble oligomers, predominantly tetramers with th...

journal_title：Journal of cell science

authors： Hatzfeld M,Burba M

更新日期：1994-07-01 00:00:00

abstract：:Bone erosion both demands that the osteoclast resorbs bone matrix and moves over the bone surface. It is widely accepted that these two activities alternate, because they are considered mutually exclusive since resorption is believed to involve an immobilizing seal to the bone surface. However, clear real-time observa...

journal_title：Journal of cell science

authors： Søe K,Delaissé JM

更新日期：2017-06-15 00:00:00

abstract：:Previous studies have shown that unactivated lymphocytes bind to CS1 peptide and that the adhesion of these cells to high endothelium is inhibited by CS1 peptide. These results suggest that lymphocyte binding occurs via recognition of the CS1-containing splice variant of fibronectin expressed on the high endothelial s...

journal_title：Journal of cell science

authors： May MJ,Entwistle G,Humphries MJ,Ager A

更新日期：1993-09-01 00:00:00

abstract：:The cell nucleus is highly organized. Many nuclear functions are localized in discrete domains, suggesting that compartmentalization is an important aspect of the regulation and coordination of nuclear functions. We investigated the subnuclear distribution of the glucocorticoid receptor, a hormone-dependent transcript...

journal_title：Journal of cell science

authors： van Steensel B,Brink M,van der Meulen K,van Binnendijk EP,Wansink DG,de Jong L,de Kloet ER,van Driel R

更新日期：1995-09-01 00:00:00

abstract：:Arf GTPases regulate both the morphological and protein sorting events that are essential for membrane trafficking. Guanine nucleotide exchange factors (GEFs) specific for Arf proteins determine when and where Arf GTPases will be activated in cells. The yeast Gea2p Arf GEF is a member of an evolutionarily conserved fa...

journal_title：Journal of cell science

authors： Chantalat S,Park SK,Hua Z,Liu K,Gobin R,Peyroche A,Rambourg A,Graham TR,Jackson CL

更新日期：2004-02-15 00:00:00

abstract：:TAR DNA-binding protein (TDP-43, also known as TARDBP) is the major pathological protein in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Large TDP-43 aggregates that are decorated with degradation adaptor proteins are seen in the cytoplasm of remaining neurons in ALS and FTD patients post mor...

journal_title：Journal of cell science

authors： Scotter EL,Vance C,Nishimura AL,Lee YB,Chen HJ,Urwin H,Sardone V,Mitchell JC,Rogelj B,Rubinsztein DC,Shaw CE

更新日期：2014-03-15 00:00:00

abstract：:Freeze-fracture cytochemistry with digitonin has been used to examine the cholesterol content of the plasma membrane of uterine epithelial cells during the early stages of pregnancy in the rat. Lesions caused by digitonin complexing with cholesterol were seen on both lateral and apical portions of the membrane but tig...

journal_title：Journal of cell science

authors： Murphy CR,Martin B

更新日期：1985-10-01 00:00:00

abstract：:Tissue development and homeostasis are controlled by mechanical cues. Perturbation of the mechanical equilibrium triggers restoration of mechanostasis through changes in cell behavior, while defects in these restorative mechanisms lead to mechanopathologies, for example, osteoporosis, myopathies, fibrosis or cardiovas...

journal_title：Journal of cell science

authors： Stassen OMJA,Ristori T,Sahlgren CM

更新日期：2020-12-21 00:00:00

abstract：:The 5T4 oncofoetal antigen is a 72 kDa glycoprotein defined by a monoclonal antibody raised against human placental trophoblast and is expressed in many different carcinomas but detected only at low levels in some normal epithelia. Immunohistochemical analysis of the patterns of expression in colorectal carcinomas has...

journal_title：Journal of cell science

authors： Carsberg CJ,Myers KA,Evans GS,Allen TD,Stern PL

更新日期：1995-08-01 00:00:00

abstract：:The activation of phospholipase C (PLC) is a conserved mechanism of receptor-activated cell signaling at the plasma membrane. PLC hydrolyzes the minor membrane lipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], and continued signaling requires the resynthesis and availability of PI(4,5)P2 at the plasma membrane....

journal_title：Journal of cell science

authors： Balakrishnan SS,Basu U,Shinde D,Thakur R,Jaiswal M,Raghu P

更新日期：2018-08-03 00:00:00

abstract：:A number of epithelia form tubulocysts in vitro when overlaid with type I collagen gel. Because collagen receptors are generally believed to be expressed on the basolateral domain, the mechanism by which collagen elicits this morphogenetic response from the apical surface is unclear. To investigate the role of beta 1 ...

journal_title：Journal of cell science

authors： Zuk A,Matlin KS

更新日期：1996-07-01 00:00:00

abstract：:Atherosclerosis depends on risk factors such as hyperlipidemia, smoking, hypertension and diabetes. Although these risk factors are relatively constant throughout the arterial circulation, atherosclerotic plaques occur at specific sites where flow patterns are disturbed, with lower overall magnitude and complex change...

journal_title：Journal of cell science

authors： Conway DE,Schwartz MA

更新日期：2013-11-15 00:00:00

abstract：:Sox7, Sox17 and Sox18 constitute group F of the Sox family of HMG box transcription factor genes. Dominant-negative mutations in Sox18 underlie the cardiovascular defects observed in ragged mutant mice. By contrast, Sox18(-/-) mice are viable and fertile, and display no appreciable anomaly in their vasculature, sugges...

journal_title：Journal of cell science

authors： Matsui T,Kanai-Azuma M,Hara K,Matoba S,Hiramatsu R,Kawakami H,Kurohmaru M,Koopman P,Kanai Y

更新日期：2006-09-01 00:00:00

abstract：:Rab GTPases regulate various membrane trafficking pathways but the mechanisms by which GTPase-activating proteins recognise specific Rabs are not clear. Rab8 is involved in controlling several trafficking processes, including the trafficking of transferrin receptor from the early endosome to the recycling endosome. He...

journal_title：Journal of cell science

authors： Vaibhava V,Nagabhushana A,Chalasani ML,Sudhakar C,Kumari A,Swarup G

更新日期：2012-11-01 00:00:00