Abstract:
:The effects of two inhibitors of 3-hydroxy 3-methyl glutaryl-coenzyme A reductase (tunicamycin and mevinolin) on nuclear division in the myxomycete Physarum polycephalum were examined. Tunicamycin exerted a minor effect on division in synchronized cultures, whereas mevinolin delayed the second, third and fourth nuclear divisions with increasing efficiency. Mevinolin also appeared to be the more potent inhibitor of HMG-CoA reductase, which catalyses the rate-limiting step in the biosynthesis of cholesterol and other isoprene derivatives. These effects of mevinolin could be partially reversed by the addition of mevalonate, suggesting that mevinolin exerts its inhibitory effects on Physarum nuclear division by decreasing the activity of HMG-CoA reductase.
journal_name
J Cell Scijournal_title
Journal of cell scienceauthors
Engström W,Larsson O,Sachsenmaier Wsubject
Has Abstractpub_date
1989-03-01 00:00:00pages
341-4eissn
0021-9533issn
1477-9137journal_volume
92 ( Pt 3)pub_type
杂志文章abstract::Collective cellular migration within the epithelial layer impacts upon development, wound healing and cancer invasion, but remains poorly understood. Prevailing conceptual frameworks tend to focus on the isolated role of each particular underlying factor - taken one at a time or at most a few at a time - and thus migh...
journal_title:Journal of cell science
pub_type: 杂志文章,评审
doi:10.1242/jcs.187922
更新日期:2016-09-15 00:00:00
abstract::During growth, homeostasis and regeneration, stem cells are exposed to different energy demands. Here, we characterise the metabolic pathways that mediate the commitment and differentiation of mouse skeletal muscle stem cells, and how their modulation can influence the cell state. We show that quiescent satellite stem...
journal_title:Journal of cell science
pub_type: 杂志文章
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更新日期:2018-07-27 00:00:00
abstract::High endothelial cells lining the post capillary venules in the paracortical areas of rat lymph nodes were found by autoradiography to incorporate [35S]sulphate, whether it was injected into the footpad to reach the draining popliteal lymph node or added to short-term cultures of cervical lymph node slices. The early ...
journal_title:Journal of cell science
pub_type: 杂志文章
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更新日期:1982-10-01 00:00:00
abstract::Yeast Reb1 and its mammalian ortholog TTF1 are conserved Myb-type DNA-binding proteins that bind to specific sites near the 3'-end of rRNA genes (rDNA). Here, they participate in the termination of transcription driven by RNA polymerase I and block DNA replication forks approaching in the opposite direction. We found ...
journal_title:Journal of cell science
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
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更新日期:1998-03-01 00:00:00
abstract::Alpha-satellite (alphoid) DNA is necessary for de novo formation of human artificial chromosomes (HACs) in human cultured cells. To investigate the relationship among centromeric, transcriptionally permissive and non-permissive chromatin assemblies on de novo HAC formation, we constructed bacterial artificial chromoso...
journal_title:Journal of cell science
pub_type: 杂志文章
doi:10.1242/jcs.02702
更新日期:2005-12-15 00:00:00
abstract::We have shown previously, by fluorescent antibody staining, that desmosomal antigens are widely distributed in the tissues of vertebrate animals. Furthermore, we have demonstrated mutual desmosome formation between cells derived from man, cow, dog, chicken and frog. In this paper we have studied the components of desm...
journal_title:Journal of cell science
pub_type: 杂志文章
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更新日期:1986-03-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章,评审
doi:10.1242/jcs.02745
更新日期:2005-12-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
doi:
更新日期:1982-06-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
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更新日期:2010-05-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
doi:10.1242/jcs.111674
更新日期:2013-01-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
doi:10.1242/jcs.065698
更新日期:2010-04-15 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
doi:10.1242/jcs.105163
更新日期:2012-11-15 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
doi:10.1242/jcs.01488
更新日期:2004-11-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are among the most promising and suitable stem cell types for vascular tissue engineering. Substantial effort has been made to differentiate MSCs towards vascular cell phenotypes, including endothelial cells and smooth muscle cells (SMCs). The microenvironment of vascular cells not only c...
journal_title:Journal of cell science
pub_type: 杂志文章,评审
doi:10.1242/jcs.167783
更新日期:2015-07-15 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
doi:10.1242/jcs.113233
更新日期:2014-05-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
doi:
更新日期:1978-04-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
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更新日期:2018-05-21 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
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更新日期:2014-04-15 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
doi:
更新日期:1982-04-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
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更新日期:2009-08-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
doi:
更新日期:1991-09-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
doi:10.1242/jcs.084038
更新日期:2011-07-01 00:00:00
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journal_title:Journal of cell science
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更新日期:2006-10-15 00:00:00
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更新日期:2017-07-15 00:00:00