Abstract:
:Nowadays, flavonoids are present in many cosmetic formulations, mainly in the form of plant extracts. The main reason of still increasing popularity of these substances is their beneficial biochemical activity. The main factor affecting activity of flavonoids in the skin is their skin penetration ability. The studies have evidenced that flavonoids from grape leaf extract as well as flavonoids like quercetin, rutin and catechin can migrate through the model lipophilic membrane from aqueous solution. The influence of common hydrophilic cosmetic additives on the permeation profile of flavonoids has been checked. The partition coefficients of examined flavonoids in the octanol-water extraction system were determined. Correlations between permeation coefficients and log P of particular flavonoids were plotted. To determine the mechanism of influence of hydrophilic substances on the permeation profile of flavonoids, the solubility of these compounds was investigated. Studies suggest that the presence of hydrophilic additives causes the increase in the flavonoid solubility that decreases the activity of flavonoids in the vehicle. In such a situation, the driving force for the penetration is reduced and the decrease of permeation coefficient can be observed.
journal_name
Int J Cosmet Scijournal_title
International journal of cosmetic scienceauthors
Arct J,Oborska A,Mojski M,Binkowska A,Swidzikowska Bdoi
10.1046/j.1467-2494.2002.00166.xsubject
Has Abstractpub_date
2002-12-01 00:00:00pages
357-66issue
6eissn
0142-5463issn
1468-2494pii
ICS166journal_volume
24pub_type
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更新日期:2018-05-05 00:00:00
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pub_type: 杂志文章
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更新日期:2000-10-01 00:00:00
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更新日期:2013-08-01 00:00:00
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