Cytomegalovirus colitis in a patient with Behcet's disease receiving tumor necrosis factor alpha inhibitory treatment.

Abstract:

:Anti-tumor necrosis factor alpha (TNF-alpha) inhibitors are effective in the treatment of various inflammatory rheumatic conditions. Increased risks of serious infections are the major issues concerning the long-term safety of these agents. We present a case of a young male Behcet's patient whose disease was complicated by cytomegalovirus (CMV) colitis. Colitis started 10 d after the third Infliximab dose and responded to the cessation of TNF blocking treatment and administration of ganciclovir. Tumor necrosis factor alpha and interferon gamma act at several levels in combating viral infections. CMV infections should be kept in mind and included in the differential diagnosis of severe gastrointestinal symptoms in patients receiving anti-TNF agents.

journal_name

World J Gastroenterol

authors

Sari I,Birlik M,Gonen C,Akar S,Gurel D,Onen F,Akkoc N

doi

10.3748/wjg.14.2912

subject

Has Abstract

pub_date

2008-05-14 00:00:00

pages

2912-4

issue

18

eissn

1007-9327

issn

2219-2840

journal_volume

14

pub_type

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