Neuropharmacology of glucocorticoids: focus on emotion, cognition and cocaine.

abstract：:Population spikes associated with the paired pulse ratio protocol were used to measure the presynaptic inhibition of corticostriatal transmission caused by mu-opioid receptor activation. A 1 microM of [D-Ala(2), N-MePhe(4), Gly-ol(5)]-enkephalin (DAMGO), a selective mu-opioid receptor agonist, enhanced paired pulse fa...

journal_title：European journal of pharmacology

authors： Barral J,Mendoza E,Galarraga E,Bargas J

更新日期：2003-02-21 00:00:00

abstract：:The effect of the pro-inflammatory cytokine, interleukin-1beta on an NMDA receptor-independent form of synaptic plasticity brought about by the application of the K+ channel blocker tetraethylammonium, was examined in the rat dentate gyrus in vitro. Field excitatory postsynaptic potentials (EPSPs) were recorded from t...

journal_title：European journal of pharmacology

authors： Coogan AN,O'Connor JJ

更新日期：1999-06-18 00:00:00

abstract：:Bone marrow stem cells are able to differentiate into nervous and endothelial cells. In our study, we found that administration of a bone marrow-stimulating factor (granulocyte colony-stimulating factor; G-CSF 50 microg/kg) decrease the brain infarct volume and enhance survival rate in a model of cerebral ischemia. Ta...

journal_title：European journal of pharmacology

authors： Six I,Gasan G,Mura E,Bordet R

更新日期：2003-01-05 00:00:00

abstract：:The specific, irreversible binding of [3H]beta-funaltrexamine (beta-FNA) to mu opioid receptors in slices from the corpus striatum and midbrain region containing the ventral tegmentum area (VTA) was accomplished by incubation with [3H]beta-FNA followed by a washing procedure with 1 microM unlabeled naltrexone in the w...

journal_title：European journal of pharmacology

authors： Takahashi M,Portoghese PS,Takemori AE

更新日期：1988-05-10 00:00:00

abstract：:We investigated sex differences in the motor responses to the full and selective dopamine D1-like receptor agonist, (+/-)-6-chloro-7,8-dihydroxyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide (SKF-81297; 0.3, 3, and 10 mg/kg, s.c.), in non-habituated adult rats. In general, SKF-81297 produced a biphasic ef...

journal_title：European journal of pharmacology

authors： Heijtz RD,Beraki S,Scott L,Aperia A,Forssberg H

更新日期：2002-06-07 00:00:00

abstract：:Stress and renewed contact with drug (a "slip") have been linked to persisting relapse of methamphetamine abuse. Human brain microglial activation has been linked with methamphetamine abuse, and inhibitors of glial cell activation, certain phosphodiesterase (PDE) inhibitors, and glial cell derived neurotrophic factor ...

journal_title：European journal of pharmacology

authors： Beardsley PM,Shelton KL,Hendrick E,Johnson KW

更新日期：2010-07-10 00:00:00

abstract：:We tested the hypothesis that calcium from the sarcoplasmic reticulum contributes to exercise-induced muscle damage. Dantrolene sodium (Dantrium) is a muscle relaxant that affects the flux of calcium over the sarcoplasmic membrane. Rats were treated with dantrolene sodium for a week before a 2 h run on a treadmill. We...

journal_title：European journal of pharmacology

authors： Amelink GJ,Van der Kallen CJ,Wokke JH,Bär PR

更新日期：1990-04-10 00:00:00

abstract：:Levodopa is the standard-of-care for Parkinson's disease, but continued loss of dopamine neurons with disease progression decreases its bioconversion to dopamine, leading to increased side effects and decreased efficacy. In theory, dopamine agonists could equal levodopa, but no approved oral "dopamine agonist" matches...

journal_title：European journal of pharmacology

authors： Mailman RB,Yang Y,Huang X

更新日期：2021-02-05 00:00:00

abstract：:It has been suggested that administration of a cannabinoid CB(1) (SR141716A ¿N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1-H-pyrazole-3-carboxamide) and CB(2) (SR144528 ¿N-[(1S)-endo-1, 3, 3-trimethyl bicyclo ¿2.2.1 heptan-2-yl]-5-(4-chloro-3-methylphenyl)-1-(4-methylbenzyl)-pyr azo le- 3-ca...

journal_title：European journal of pharmacology

authors： Beaulieu1 P,Bisogno1 T,Punwar S,Farquhar-Smith WP,Ambrosino G,Di Marzo V,Rice AS

更新日期：2000-05-19 00:00:00

abstract：:We examined the effects of YM-31636 (2-(1H-imidazol-4-ylmethyl)-8H-indeno[1,2-d]thiazole monofumarate), a novel 5-HT3 receptor agonist, on gastrointestinal functions including visceral pain reflex in rats. Injection of YM-31636 increased the number of fecal pellets. This effect was completely inhibited by ramosetron, ...

journal_title：European journal of pharmacology

authors： Kiso T,Ito H,Miyata K,Kamato T,Naitoh Y,Iwaoka K,Yamaguchi T

更新日期：2001-11-09 00:00:00

abstract：:Corticotropin-releasing factor (CRF) is a neurohormone that mediates stress, anxiety, and affects serotonergic activity. Studies have shown that CRF has dose-dependent opposing effects on serotonergic activity. This effect has been hypothesized to be differentially mediated by CRF(1) and CRF(2) receptors in the dorsal...

journal_title：European journal of pharmacology

authors： Lukkes JL,Forster GL,Renner KJ,Summers CH

更新日期：2008-01-14 00:00:00

abstract：:In this study the desensitizing power of increasing concentrations of resiniferatoxin applied topically to the bladder mucosa, and the irritating properties of the most effective desensitizing dose, were determined with the aid of the spinal expression of the proto-oncogene c-fos. Desensitization was assessed by the d...

journal_title：European journal of pharmacology

authors： Avelino A,Cruz F,Coimbra A

更新日期：1999-07-28 00:00:00

abstract：:We examined the effect of HSR-81 ((-)-(R)-alpha-[(tert-butylamino)methyl]-2-chloro-4-hydroxybenzyl alcohol L-tartrate), a newly developed, potent and selective beta 2-adrenoceptor agonist, as well as ritodrine and isoproterenol, on the spontaneous rhythmic contraction in uteri isolated from late pregnant, middle pregn...

journal_title：European journal of pharmacology

authors： Ohashi T,Hashimoto S,Morikawa K,Kato H,Ito Y,Asano M,Azuma H

更新日期：1996-07-04 00:00:00

abstract：:The regulation of the 5-HT2 receptor-mediated head twitch response and of 5-HT2 receptor binding in the frontal cortex was studied in rats treated repeatedly with the 5-HT2 agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) (2.5 mg/kg, s.c.). Four injections in 24 h produced a near maximal reduction in the ...

journal_title：European journal of pharmacology

authors： Leysen JE,Janssen PF,Niemegeers CJ

更新日期：1989-04-12 00:00:00

abstract：:Hops (Humulus lupulus L.), a major component of beer, contain potentially neuroactive compounds that made it useful in traditional medicine as a sleeping aid. The present study aims to investigate the individual components in hops acting as allosteric modulators in GABAA receptors and bring further insight into the mo...

journal_title：European journal of pharmacology

authors： Benkherouf AY,Logrén N,Somborac T,Kortesniemi M,Soini SL,Yang B,Salo-Ahen OMH,Laaksonen O,Uusi-Oukari M

更新日期：2020-04-15 00:00:00

abstract：:The aim of this study was to examine the therapeutic effect of oxymatrine, a monomer isolated from the medicinal plant Sophora flavescens Ait, on the hepatic lipid metabolism in non-alcoholic fatty liver (NAFLD) rats and to explore the potential mechanism. Rats were fed with high fructose diet for 8 weeks to establish...

journal_title：European journal of pharmacology

authors： Shi LJ,Shi L,Song GY,Zhang HF,Hu ZJ,Wang C,Zhang DH

更新日期：2013-08-15 00:00:00

abstract：:Wasp venoms contain several active components, among them kinin-related peptides. Like bradykinin and [Thr6]bradykinin, Vespula vulgaris venom caused paw oedema following subplantar injection in anaesthetized rats. The oedema was partly inhibited by the bradykinin B2 receptor antagonist icatibant (Hoe 140); the remain...

journal_title：European journal of pharmacology

authors： Griesbacher T,Althuber P,Zenz M,Rainer I,Griengl S,Lembeck F

更新日期：1998-06-12 00:00:00

abstract：:Infusion of arachidonic acid through the guinea pig lung or the cat spleen causes a release of thromboxane A2 and prostaglandins, as measured by bioassay. After incubation of human platelets with arachidonate similar metabolites are formed, as demonstrated chromatographically. Infusion of imidazole (50-75 microgram/ml...

journal_title：European journal of pharmacology

authors： Nijkamp FP,Moncada S,White HL,Vane JR

更新日期：1977-07-15 00:00:00

abstract：:In vitro effects of d,l-methadone and morphine on [3H]serotonin (3H-5-HT) uptake in rat periaqueductal gray (PAG) slices were investigated. Only methadone had a significant inhibitory effect on 3H-5-HT uptake which was significantly enhanced by naloxone. The systemic administration of methadone did not affect 3H-5-HT ...

journal_title：European journal of pharmacology

authors： Donzanti BA,Warwick RO

更新日期：1979-10-26 00:00:00

abstract：:Thirty percent of osteosarcoma patients die within 5 years. New agents that induce apoptosis of osteosarcoma cells might be therapeutically useful. Here, we characterized the apoptotic mechanism induced by capsaicin in G292 osteosarcoma cells. Our results show that capsaicin induces an increase in the cytosolic Ca(2+)...

journal_title：European journal of pharmacology

authors： Chien CS,Ma KH,Lee HS,Liu PS,Li YH,Huang YS,Chueh SH

更新日期：2013-10-15 00:00:00

abstract：:Although carbetapentane produces skin (peripheral) infiltrative analgesia, the underlying mechanism of carbetapentane in local anesthesia is not well understood. The purpose of the study was to examine the effect of carbetapentane on voltage-gated Na(+) channels and its efficacy on spinal (central) anesthesia. We eval...

journal_title：European journal of pharmacology

authors： Leung YM,Tzeng JI,Kuo CS,Chen YW,Chu CC,Wang JJ

更新日期：2013-08-15 00:00:00

abstract：:Ebselen, 2-phenyl-1,2-benzisoselenazole-3(2H)-one can preferentially inhibit the activity of inducible nitric oxide (NO) synthase with little inhibition of endothelial constitutive NO synthase within a certain concentration range. This suggests that ebselen deserves further in vivo studies to examine its possible appl...

journal_title：European journal of pharmacology

authors： Hattori R,Inoue R,Sase K,Eizawa H,Kosuga K,Aoyama T,Masayasu H,Kawai C,Sasayama S,Yui Y

更新日期：1994-04-15 00:00:00

abstract：:Molecular identification of two new transient receptor potential (TRP) channels, TRPM8 and TRPA1, has prompted an intense interest in their functional roles. We report that an acute exposure to the TRPM8/TRPA1 agonist icilin (0.01-100 microM), but not TRPV1 agonist capsaicin (10 microM), causes an atypical dose-relate...

journal_title：European journal of pharmacology

authors： Rawls SM,Gomez T,Ding Z,Raffa RB

更新日期：2007-12-01 00:00:00

abstract：:The aim of the present study was to further characterize [3H]clonidine binding in the ventrolateral medulla of the human brainstem, the region involved in the vasodepressor effect of imidazoline drugs of the clonidine type. Under basal conditions, [3H]clonidine can bind both to the imidazoline receptors and to the alp...

journal_title：European journal of pharmacology

authors： Bricca G,Greney H,Zhang J,Dontenwill M,Stutzmann J,Belcourt A,Bousquet P

更新日期：1994-01-01 00:00:00

abstract：:Animal models of arthritis are widely used to de-convolute disease pathways and to identify novel drug targets and therapeutic approaches. However, the high attrition rates of drugs in Phase II/III rates means that a relatively small number of drugs reach the market, despite showing efficacy in pre-clinical models. Th...

journal_title：European journal of pharmacology

authors： McNamee K,Williams R,Seed M

更新日期：2015-07-15 00:00:00

abstract：:All-night spectral analysis of the sleep EEG was used to study the effect and after-effect of a single bedtime dose of flunitrazepam (2 mg), flurazepam (30 mg) or triazolam (0.5 mg) in healthy young males. In the night of drug treatment all 3 hypnotics reduced the EEG slow waves and enhanced the activity in the freque...

journal_title：European journal of pharmacology

authors： Borbély AA,Mattmann P,Loepfe M,Fellmann I,Gerne M,Strauch I,Lehmann D

更新日期：1983-04-22 00:00:00

abstract：:3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are drugs very effective to decrease low-density lipoprotein (LDL) cholesterol. In addition, a number of studies suggest that statins have other beneficial clinical effects beyond cholesterol lowering. We recently reported that statins decr...

journal_title：European journal of pharmacology

authors： Ortego M,Hernández AG,Bustos C,Blanco-Colio LM,Hernández-Presa MA,Tuñón J,Egido J

更新日期：2002-07-19 00:00:00

abstract：:Basic fibroblast growth factor (bFGF) is a heparin-binding polypeptide with potent trophic and protective effects on brain neurons, glia and endothelia. In previous studies, we showed that intravenously administered bFGF reduced the volume of cerebral infarcts following permanent occlusion of the middle cerebral arter...

journal_title：European journal of pharmacology

authors： Ren JM,Finklestein SP

更新日期：1997-05-26 00:00:00

abstract：:Cabergoline 1-[(6-allylergolin-8 beta-yl)carbonyl]-1-[3-(dimethylamino) propyl]-3-ethylurea is a recently developed ergot derivative with a long-lasting dopamine agonist action. We now studied the ability of cabergoline to counteract the development of a prolactin-secreting tumor (prolactinoma) induced in female rats ...

journal_title：European journal of pharmacology

authors： Dall'Ara A,Lima L,Cocchi D,Di Salle E,Cancio E,Devesa J,Müller EE

更新日期：1988-06-22 00:00:00

abstract：:Bacterial lipopolysaccharide and other immunostimulants induce gene expression of an isoform of nitric oxide synthase (iNOS) in vascular smooth muscle cells. This process is dependent on nuclear factor-kappa B (NF-kappa B) activation. The aim of this study was to investigate whether the NF-kappa B and Akt signaling pa...

journal_title：European journal of pharmacology

authors： Hattori Y,Hattori S,Kasai K

更新日期：2003-11-28 00:00:00